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GENE - TERM ANNOTATION REPORT

RGD ID: 3910
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
Acc ID: DOID:1459
Term: hypothyroidism
Definition: A thyroid gland disease which involves an underproduction of thyroid hormone. (DO)
Definition Source(s): https://medlineplus.gov/hypothyroidism.html "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tshb ISOTSHB (Homo sapiens)737692RGDDNA:nonsense mutation:exon:94G>T (p.E11X) (human) 
Tshb ISOTSHB (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:18031379 PMID:24729111
Tshb ISOTSHB (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: TSH deficiencyPMID:11297590 PMID:11549695 PMID:11788671 PMID:12364478 PMID:15292359 PMID:15297803 PMID:17576681 PMID:1971148 PMID:22606512 PMID:24423284 PMID:25741868 PMID:25950606 PMID:26416826 PMID:27362444 PMID:27387040 PMID:2792087 PMID:28492532 PMID:31166470 PMID:34780050 PMID:8636437 PMID:9536098 PMID:9589689
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