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Gene: Tnfsf11 (TNF superfamily member 11) Rattus norvegicus
Symbol: Tnfsf11
Name: TNF superfamily member 11
Description: Predicted to have cytokine activity; identical protein binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and response to immobilization stress. Predicted to localize to extracellular space; integral component of membrane; and plasma membrane. Biomarker of myocarditis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11); PARTICIPATES IN interleukin-6 signaling pathway; cytokine mediated signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH (20S)-ginsenoside Rg3; (S)-nicotine; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: ODF; OPGL; osteoclast differentiation factor; osteoprotegerin ligand; RANKL; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine; TRANCE; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11
Homo sapiens (human) : TNFSF11 (TNF superfamily member 11)  HGNC  Alliance
Mus musculus (house mouse) : Tnfsf11 (tumor necrosis factor (ligand) superfamily, member 11)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfsf11 (TNF superfamily member 11)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFSF11 (TNF superfamily member 11)
Canis lupus familiaris (dog) : TNFSF11 (TNF superfamily member 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfsf11 (TNF superfamily member 11)
Sus scrofa (pig) : TNFSF11 (TNF superfamily member 11)
Chlorocebus sabaeus (African green monkey) : TNFSF11 (TNF superfamily member 11)
Heterocephalus glaber (naked mole-rat) : Tnfsf11 (TNF superfamily member 11)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01560,482,527 - 60,512,704 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1560,482,527 - 60,512,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01564,155,680 - 64,186,116 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01565,726,538 - 65,757,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41559,397,837 - 59,428,014 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11559,413,616 - 59,443,794 (-)NCBI
Celera1553,271,197 - 53,300,935 (-)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tnfsf11
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620784
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.