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Gene: Slc22a1 (solute carrier family 22 member 1) Rattus norvegicus
Symbol: Slc22a1
Name: solute carrier family 22 member 1
Description: Exhibits cation transmembrane transporter activity and protein homodimerization activity. Involved in several processes, including catecholamine transport; establishment or maintenance of transmembrane electrochemical gradient; and protein homooligomerization. Localizes to the basolateral plasma membrane and integral component of plasma membrane. Used to study acute kidney failure. Biomarker of asthma; extrahepatic cholestasis; and intrahepatic cholestasis. Orthologous to human SLC22A1 (solute carrier family 22 member 1); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; tramadol pharmacokinetics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
Also known as: MGC93570; Oct1; Orct1; organic cation transporter; organic cation transporter 1; Roct1; solute carrier family 22 (organic cation transporter), member 1; solute carrier family 22, member 1
Homo sapiens (human) : SLC22A1 (solute carrier family 22 member 1)  HGNC  Alliance
Mus musculus (house mouse) : Slc22a1 (solute carrier family 22 (organic cation transporter), member 1)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : SLC22A1 (solute carrier family 22 member 1)
Canis lupus familiaris (dog) : SLC22A1 (solute carrier family 22 member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc22a1 (solute carrier family 22 member 1)
Sus scrofa (pig) : SLC22A1 (solute carrier family 22 member 1)
more info ...
Allele / Splice: Slc22a1em1Sage  
Genetic Models: SD-Slc22a1em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0148,273,639 - 48,300,645 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0151,452,604 - 51,479,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,351,239 - 42,378,295 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,354,183 - 42,381,239 (+)NCBI
Celera143,876,335 - 43,903,290 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc22a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3224
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-06-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.