Slc22a1 (solute carrier family 22 member 1) - Rat Genome Database

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Gene: Slc22a1 (solute carrier family 22 member 1) Rattus norvegicus
Analyze
Symbol: Slc22a1
Name: solute carrier family 22 member 1
RGD ID: 3224
Description: Enables several functions, including dopamine:sodium symporter activity; identical protein binding activity; and organic cation transmembrane transporter activity. Involved in several processes, including monoamine transport; monoatomic ion transmembrane transport; and toxin transport. Located in apical plasma membrane and basolateral plasma membrane. Used to study acute kidney failure. Biomarker of asthma; extrahepatic cholestasis; and intrahepatic cholestasis. Orthologous to human SLC22A1 (solute carrier family 22 member 1); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; tramadol pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93570; Oct1; Orct1; organic cation transporter; organic cation transporter 1; Roct1; solute carrier family 22 (organic cation transporter), member 1; solute carrier family 22, member 1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Slc22a1em1Sage  
Genetic Models: SD-Slc22a1em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2148,076,657 - 48,103,679 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,076,666 - 48,103,678 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,768,287 - 48,795,288 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0154,754,091 - 54,781,071 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0148,843,810 - 48,870,799 (+)NCBIRnor_WKY
Rnor_6.0148,273,639 - 48,300,645 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,273,611 - 48,300,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,452,604 - 51,479,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,351,239 - 42,378,295 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,354,183 - 42,381,239 (+)NCBI
Celera143,876,335 - 43,903,290 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1'-diethyl-2,2'-cyanine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylnicotinamide  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3-[2-(ethylamino)-1-hydroxyethyl]phenol  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
abacavir  (ISO)
acetamide  (EXP)
acetamiprid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP,ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
angelicin  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
atazanavir sulfate  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atropine  (ISO)
bacitracin  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (ISO)
biphenyl-4-amine  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
carvedilol  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroquine  (ISO)
chlorphenamine  (EXP)
cimetidine  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
digoxin  (ISO)
diltiazem  (ISO)
diosmetin  (ISO)
diphenhydramine  (ISO)
disopyramide  (EXP)
dopamine  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
ethidium  (ISO)
famotidine  (EXP,ISO)
fenthion  (ISO)
finasteride  (EXP)
flecainide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphite  (EXP)
harman  (ISO)
heptachlor  (ISO)
hyperforin  (ISO)
ibuprofen  (ISO)
imidacloprid  (ISO)
imipramine  (ISO)
imperatorin  (ISO)
indometacin  (ISO)
ipratropium  (ISO)
isoimperatorin  (ISO)
ketoprofen  (ISO)
L-ethionine  (EXP)
lamivudine  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
mefenamic acid  (ISO)
mefloquine  (ISO)
MeIQ  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methoxsalen  (ISO)
metoprolol  (ISO)
molsidomine  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
nadolol  (ISO)
nefazodone  (EXP,ISO)
nicotine  (ISO)
nifedipine  (ISO)
nimesulide  (EXP)
nitenpyram  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
omeprazole  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (ISO)
phenylephrine  (EXP)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium dichromate  (ISO)
prazosin  (ISO)
probenecid  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propafenone  (ISO)
propranolol  (ISO)
psoralen  (ISO)
pyrimethamine  (ISO)
quercetin  (EXP,ISO)
quinidine  (EXP,ISO)
quinine  (EXP,ISO)
ranitidine  (EXP,ISO)
resveratrol  (ISO)
Retrorsine  (ISO)
rifampicin  (ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
soybean oil  (EXP)
spironolactone  (ISO)
streptozocin  (EXP)
sulindac  (ISO)
Sunset Yellow FCF  (ISO)
synephrine  (EXP)
talinolol  (ISO)
tartrazine  (ISO)
terbufos  (ISO)
tetrabutylammonium  (EXP)
tetrachloromethane  (EXP,ISO)
tetraethylammonium  (EXP,ISO)
tetrahydropalmatine  (ISO)
tetrapentylammonium  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-piceid  (ISO)
trichloroethene  (EXP)
trimethoprim  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trospium chloride  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Amphoux A, etal., Neuropharmacology. 2006 Jun;50(8):941-52. doi: 10.1016/j.neuropharm.2006.01.005. Epub 2006 Mar 31.
2. Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Arndt P, etal., Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. doi: 10.1152/ajprenal.2001.281.3.F454.
3. Catecholamine transport by the organic cation transporter type 1 (OCT1). Breidert T, etal., Br J Pharmacol. 1998 Sep;125(1):218-24.
4. Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. Busch AE, etal., J Biol Chem. 1996 Dec 20;271(51):32599-604. doi: 10.1074/jbc.271.51.32599.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Metformin pathways: pharmacokinetics and pharmacodynamics. Gong L, etal., Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22.
7. Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate. Gorboulev V, etal., Mol Pharmacol. 1999 Dec;56(6):1254-61. doi: 10.1124/mol.56.6.1254.
8. Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes. Grover B, etal., J Pharmacol Exp Ther. 2004 Mar;308(3):949-56. Epub 2004 Jan 8.
9. Drug excretion mediated by a new prototype of polyspecific transporter. Grundemann D, etal., Nature 1994 Dec 8;372(6506):549-52.
10. Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia. Heemskerk S, etal., Eur J Pharmacol. 2008 Apr 28;584(2-3):390-7. doi: 10.1016/j.ejphar.2008.02.006. Epub 2008 Feb 12.
11. Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice. Hu QH, etal., Eur J Nutr. 2012 Aug;51(5):593-606. doi: 10.1007/s00394-011-0243-y. Epub 2011 Sep 10.
12. Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis. Jin HE, etal., Pharm Res. 2009 Mar;26(3):549-59. doi: 10.1007/s11095-008-9770-5. Epub 2008 Nov 11.
13. Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Kakehi M, etal., Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50.
14. Localization of organic cation transporters OCT1 and OCT2 in rat kidney. Karbach U, etal., Am J Physiol Renal Physiol. 2000 Oct;279(4):F679-87.
15. Cell free expression and functional reconstitution of eukaryotic drug transporters. Keller T, etal., Biochemistry. 2008 Apr 15;47(15):4552-64. doi: 10.1021/bi800060w. Epub 2008 Mar 25.
16. The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization. Keller T, etal., J Biol Chem. 2011 Oct 28;286(43):37874-86. doi: 10.1074/jbc.M111.289330. Epub 2011 Sep 6.
17. Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2. Kurata T, etal., Drug Metab Pharmacokinet. 2010;25(4):328-34.
18. Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents. Lin CJ, etal., J Neurochem. 2010 Aug;114(3):717-27. doi: 10.1111/j.1471-4159.2010.06801.x. Epub 2010 May 6.
19. Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Lips KS, etal., Am J Respir Cell Mol Biol. 2005 Jul;33(1):79-88. Epub 2005 Apr 7.
20. Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse. Lips KS, etal., Life Sci. 2007 May 30;80(24-25):2263-9. Epub 2007 Jan 23.
21. Transport of organic cations across the blood-testis barrier. Maeda T, etal., Mol Pharm. 2007 Jul-Aug;4(4):600-7. Epub 2007 Jul 7.
22. The affinity of the organic cation transporter rOCT1 is increased by protein kinase C-dependent phosphorylation. Mehrens T, etal., J Am Soc Nephrol. 2000 Jul;11(7):1216-1224. doi: 10.1681/ASN.V1171216.
23. Membrane localization of the electrogenic cation transporter rOCT1 in rat liver. Meyer-Wentrup F, etal.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease. Popp C, etal., Mol Pharmacol. 2005 May;67(5):1600-11. doi: 10.1124/mol.104.008839. Epub 2005 Jan 20.
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. The organic cation transporters rOCT1 and hOCT2 are inhibited by cGMP. Schlatter E, etal., J Membr Biol. 2002 Oct 1;189(3):237-44. doi: 10.1007/s00232-002-1023-7.
33. Nitric oxide-induced regulation of renal organic cation transport after renal ischemia-reperfusion injury. Schneider R, etal., Am J Physiol Renal Physiol. 2011 Nov;301(5):F997-F1004. doi: 10.1152/ajprenal.00264.2011. Epub 2011 Aug 10.
34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35. Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity. Sturm A, etal., Am J Physiol Renal Physiol. 2007 Sep;293(3):F767-79. doi: 10.1152/ajprenal.00106.2007. Epub 2007 Jun 13.
36. Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules. Sugawara-Yokoo M, etal., Histochem Cell Biol. 2000 Sep;114(3):175-80. doi: 10.1007/s004180000186.
37. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
38. Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury. Ulu R, etal., Food Chem Toxicol. 2012 May;50(5):1675-9. doi: 10.1016/j.fct.2012.02.082. Epub 2012 Mar 3.
39. Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. Urakami Y, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):800-5.
40. Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides. van Montfoort JE, etal., J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
41. Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Wang CP, etal., Planta Med. 2011 May;77(8):786-94. doi: 10.1055/s-0030-1250599. Epub 2010 Dec 10.
42. Renal tumours in a Tsc1(+)/(-) mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin. Yang J, etal., Eur J Cancer. 2013 Apr;49(6):1479-90. doi: 10.1016/j.ejca.2012.10.027. Epub 2012 Dec 7.
43. Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). Zhang L, etal., J Biol Chem 1997 Jun 27;272(26):16548-54.
Additional References at PubMed
PMID:15817654   PMID:16142924   PMID:16158334   PMID:17701831   PMID:19141712   PMID:19435783   PMID:20044581   PMID:22808265   PMID:22810231   PMID:23280877   PMID:30409791   PMID:32961667  


Genomics

Comparative Map Data
Slc22a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2148,076,657 - 48,103,679 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,076,666 - 48,103,678 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,768,287 - 48,795,288 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0154,754,091 - 54,781,071 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0148,843,810 - 48,870,799 (+)NCBIRnor_WKY
Rnor_6.0148,273,639 - 48,300,645 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,273,611 - 48,300,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,452,604 - 51,479,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,351,239 - 42,378,295 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,354,183 - 42,381,239 (+)NCBI
Celera143,876,335 - 43,903,290 (+)NCBICelera
Cytogenetic Map1q11NCBI
SLC22A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,121,815 - 160,158,718 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6160,121,815 - 160,158,718 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,542,847 - 160,579,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,462,853 - 160,499,740 (+)NCBINCBI36Build 36hg18NCBI36
Build 346160,513,273 - 160,550,159NCBI
Celera6161,188,634 - 161,224,539 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6158,013,550 - 158,049,540 (+)NCBIHuRef
CHM1_16160,805,108 - 160,841,995 (+)NCBICHM1_1
T2T-CHM13v2.06161,367,910 - 161,404,908 (+)NCBIT2T-CHM13v2.0
Slc22a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,867,761 - 12,894,725 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,867,756 - 12,894,716 (-)EnsemblGRCm39 Ensembl
GRCm381712,648,874 - 12,675,838 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,648,869 - 12,675,829 (-)EnsemblGRCm38mm10GRCm38
MGSCv371712,841,740 - 12,868,704 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,492,232 - 12,519,196 (-)NCBIMGSCv36mm8
Celera1712,680,587 - 12,707,864 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.63NCBI
SLC22A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan16178,125,295 - 178,169,671 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,004,545 - 158,046,428 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,014,522 - 163,054,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,014,663 - 163,054,681 (+)Ensemblpanpan1.1panPan2
SLC22A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,268,978 - 49,296,522 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,109,085 - 50,138,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,451,887 - 49,481,466 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,451,182 - 49,482,182 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,334,247 - 49,363,803 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,205,883 - 49,235,453 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,820,796 - 49,850,348 (+)NCBIUU_Cfam_GSD_1.0
Slc22a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,281,749 - 144,305,075 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,534,095 - 11,556,745 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648911,534,095 - 11,556,759 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,340,126 - 7,365,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,340,442 - 7,365,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,139,435 - 9,164,369 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,744,600 - 87,780,846 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,745,023 - 87,781,073 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,132,123 - 60,167,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Slc22a1
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:210
Count of miRNA genes:89
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000022068, ENSRNOT00000022254
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat


Genetic Models
This gene Slc22a1 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 23 23 23 23
Low 31 23 12 9 12 2 2 6 26 10 2
Below cutoff 12 9 4 9 4 6 8 31 6 9 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022068   ⟹   ENSRNOP00000022068
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,076,688 - 48,103,678 (+)Ensembl
Rnor_6.0 Ensembl148,273,639 - 48,300,495 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000022254   ⟹   ENSRNOP00000022254
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,076,666 - 48,103,678 (+)Ensembl
Rnor_6.0 Ensembl148,273,611 - 48,300,655 (+)Ensembl
RefSeq Acc Id: NM_012697   ⟹   NP_036829
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2148,076,666 - 48,103,679 (+)NCBI
Rnor_6.0148,273,639 - 48,300,645 (+)NCBI
Rnor_5.0151,452,604 - 51,479,610 (-)NCBI
RGSC_v3.4142,351,239 - 42,378,295 (+)RGD
Celera143,876,335 - 43,903,290 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101083   ⟹   XP_038957011
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2148,076,657 - 48,103,679 (+)NCBI
RefSeq Acc Id: XM_039101089   ⟹   XP_038957017
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2148,085,370 - 48,103,679 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036829   ⟸   NM_012697
- UniProtKB: Q6AYW1 (UniProtKB/Swiss-Prot),   Q63089 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022068   ⟸   ENSRNOT00000022068
RefSeq Acc Id: ENSRNOP00000022254   ⟸   ENSRNOT00000022254
RefSeq Acc Id: XP_038957011   ⟸   XM_039101083
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957017   ⟸   XM_039101089
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63089-F1-model_v2 AlphaFold Q63089 1-556 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689619
Promoter ID:EPDNEW_R143
Type:initiation region
Name:Slc22a1_1
Description:solute carrier family 22 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,273,628 - 48,273,688EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3224 AgrOrtholog
BioCyc Gene G2FUF-61571 BioCyc
Ensembl Genes ENSRNOG00000016337 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000022068 ENTREZGENE
  ENSRNOP00000022068.3 UniProtKB/Swiss-Prot
  ENSRNOP00000022254 ENTREZGENE
  ENSRNOP00000022254.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022068 ENTREZGENE
  ENSRNOT00000022068.6 UniProtKB/Swiss-Prot
  ENSRNOT00000022254 ENTREZGENE
  ENSRNOT00000022254.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130305 IMAGE-MGC_LOAD
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:24904 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93570 IMAGE-MGC_LOAD
NCBI Gene 24904 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 22 MEMBER 1 UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PharmGKB SLC22A1 RGD
PhenoGen Slc22a1 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGR TC230941
TIGRFAMs 2A0119 UniProtKB/Swiss-Prot
UniProt Q63089 ENTREZGENE
  Q6AYW1 ENTREZGENE
  S22A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary O35882 UniProtKB/Swiss-Prot
  Q6AYW1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc22a1  solute carrier family 22 member 1  Slc22a1  solute carrier family 22 (organic cation transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc22a1  solute carrier family 22 (organic cation transporter), member 1    solute carrier family 22, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc22a1  solute carrier family 22, member 1    Solute carrier family 22, member 1  Name updated 629478 APPROVED
2001-06-22 1-Oct  Organic cation transporter      Symbol and Name withdrawn 67952 WITHDRAWN
2001-06-22 Slc22a1  Solute carrier family 22, member 1      Symbol and Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function translocates hydrophobic and hydrophilic organic cations 634159
gene_protein 556-amino-acid membrane protein 634159