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Gene: Slc22a1 (solute carrier family 22 member 1) Rattus norvegicus
Symbol: Slc22a1
Name: solute carrier family 22 member 1
RGD ID: 3224
Description: Exhibits cation transmembrane transporter activity and identical protein binding activity. Involved in catecholamine transport; cation transport; and establishment or maintenance of transmembrane electrochemical gradient. Localizes to basolateral plasma membrane and integral component of plasma membrane. Used to study acute kidney failure. Biomarker of asthma; extrahepatic cholestasis; and intrahepatic cholestasis. Orthologous to human SLC22A1 (solute carrier family 22 member 1); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; tramadol pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Also known as: MGC93570; Oct1; Orct1; organic cation transporter; organic cation transporter 1; Roct1; solute carrier family 22 (organic cation transporter), member 1; solute carrier family 22, member 1
Homo sapiens (human) : SLC22A1 (solute carrier family 22 member 1)  HGNC  Alliance
Mus musculus (house mouse) : Slc22a1 (solute carrier family 22 (organic cation transporter), member 1)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : SLC22A1 (solute carrier family 22 member 1)
Canis lupus familiaris (dog) : SLC22A1 (solute carrier family 22 member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc22a1 (solute carrier family 22 member 1)
Sus scrofa (pig) : SLC22A1 (solute carrier family 22 member 1)
Chlorocebus sabaeus (African green monkey) : SLC22A1 (solute carrier family 22 member 1)
more info ...
Allele / Splice: Slc22a1em1Sage  
Genetic Models: SD-Slc22a1em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0148,273,639 - 48,300,645 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,273,611 - 48,300,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,452,604 - 51,479,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,351,239 - 42,378,295 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,354,183 - 42,381,239 (+)NCBI
Celera143,876,335 - 43,903,290 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc22a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3224
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.