Oprk1 (opioid receptor, kappa 1) - Rat Genome Database

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Gene: Oprk1 (opioid receptor, kappa 1) Rattus norvegicus
Analyze
Symbol: Oprk1
Name: opioid receptor, kappa 1
RGD ID: 69426
Description: Enables receptor serine/threonine kinase binding activity. Involved in several processes, including conditioned place preference; positive regulation of ion transport; and response to alkaloid. Located in several cellular components, including axon terminus; dendrite; and perikaryon. Used to study heroin dependence; myocardial infarction; and withdrawal disorder. Orthologous to human OPRK1 (opioid receptor kappa 1); PARTICIPATES IN nalbuphine pharmacodynamics pathway; INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; (R)-noradrenaline; (R,R)-tramadol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: K-OR-1; kappa-type opioid receptor; KOR-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2513,860,016 - 13,877,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl513,860,021 - 13,877,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx516,035,098 - 16,052,904 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0517,669,824 - 17,687,612 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0517,369,783 - 17,387,591 (-)NCBIRnor_WKY
Rnor_6.0513,742,655 - 13,760,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl513,744,658 - 13,760,305 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0518,519,763 - 18,534,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4514,040,848 - 14,055,273 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1514,037,659 - 14,055,460 (-)NCBI
Celera513,240,420 - 13,258,214 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
(R)-noradrenaline  (EXP)
(R,R)-tramadol  (EXP)
(S)-nicotine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-naphthylamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7-Hydroxymitragynine  (ISO)
acetylmethadol  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
buprenorphine  (EXP,ISO)
butorphanol  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
celastrol  (ISO)
CGP 52608  (ISO)
cocaine  (EXP,ISO)
codeine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cycloheximide  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
dextropropoxyphene  (EXP)
dextrorphan  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
DPDPE  (EXP)
dynorphin A  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
Ethylketocyclazocine  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
fomepizole  (ISO)
gedunin  (ISO)
gentamycin  (EXP)
hydrocodone  (EXP)
Levallorphan  (EXP)
Levorphanol  (EXP)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methadone  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
Mitragynine  (ISO)
morphine  (EXP,ISO)
Nalmefene  (ISO)
naloxone  (EXP)
naltrexone  (EXP)
nicotine  (ISO)
Norbinaltorphimine  (EXP,ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP)
pentetrazol  (ISO)
picrotoxin  (EXP)
progesterone  (ISO)
SB 431542  (ISO)
serotonin  (EXP)
tapentadol  (EXP)
thioglycolic acid  (EXP)
titanium dioxide  (ISO)
tramadol  (EXP)
trichostatin A  (ISO)
U50488  (ISO)
U69593  (EXP,ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Stress, kappa manipulations, and aversive effects of ethanol in adolescent and adult male rats. Anderson RI, etal., Neuroscience. 2013 Sep 26;249:214-22. doi: 10.1016/j.neuroscience.2012.12.028. Epub 2012 Dec 29.
2. Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy. Appleyard SM, etal., J Biol Chem. 2000 Dec 8;275(49):38281-5.
3. Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. Bruchas MR, etal., J Biol Chem. 2006 Jun 30;281(26):18081-9. Epub 2006 Apr 28.
4. Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. Chakrabarti S, etal., Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20115-9. doi: 10.1073/pnas.1009923107. Epub 2010 Nov 1.
5. G protein coupled receptor kinase-2 upregulation causes ¿-opioid receptor desensitization in diabetic heart. Chen X, etal., Biochem Biophys Res Commun. 2017 Jan 22;482(4):658-664. doi: 10.1016/j.bbrc.2016.11.090. Epub 2016 Nov 16.
6. Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors. Chen Y, etal., Biochem J 1993 Nov 1;295 ( Pt 3):625-8.
7. Kappa opioid receptors in the rostral ventromedial medulla of male and female rats. Drake CT, etal., J Comp Neurol. 2007 Jan 20;500(3):465-76.
8. Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5alpha-dihydrotestosterone-induced rat polycystic ovary syndrome model. Feng Y, etal., Exp Physiol. 2012 May;97(5):651-62. doi: 10.1113/expphysiol.2011.063131. Epub 2012 Feb 15.
9. Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593. Fuentealba JA, etal., Synapse. 2007 Sep;61(9):771-7.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats. Groblewski PA, etal., Addict Biol. 2015 Mar;20(2):297-301. doi: 10.1111/adb.12123. Epub 2014 Feb 15.
13. The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat. Jarosz PA Biol Res Nurs. 2007 Apr;8(4):294-9.
14. Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats. Jolivalt CG, etal., Diabetologia. 2006 Nov;49(11):2775-85. Epub 2006 Aug 19.
15. kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. Joshi SK, etal., J Neurosci. 2000 Aug 1;20(15):5874-9.
16. Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. Lee JW, etal., J Neurochem. 1998 May;70(5):2203-11.
17. Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44.
18. Molecular cloning and expression of a rat kappa opioid receptor. Li S, etal., Biochem J 1993 Nov 1;295 ( Pt 3):629-33.
19. Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. McLaughlin JP, etal., J Biol Chem. 2003 Sep 5;278(36):34631-40. Epub 2003 Jun 18.
20. Cloning and pharmacological characterization of a rat kappa opioid receptor. Meng F, etal., Proc Natl Acad Sci U S A 1993 Nov 1;90(21):9954-8.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Cloning and expression of a cDNA for the rat kappa-opioid receptor. Minami M, etal., FEBS Lett 1993 Aug 30;329(3):291-5.
23. dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. Mostari P, etal., J Reprod Dev. 2013;59(3):266-72. Epub 2013 Feb 8.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands. Nishi M, etal., FEBS Lett 1993 Sep 6;330(1):77-80.
26. Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. Peart JN, etal., J Cardiovasc Pharmacol. 2004 Mar;43(3):410-5.
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Rosin A, etal., Neurosci Lett. 1999 Nov 5;275(1):1-4.
32. Bi-phasic intensity-dependent opioid-mediated neural amplitude changes in the chinchilla cochlea: partial blockade by an N-Methyl-D-Aspartate (NMDA)-receptor antagonist. Sahley TL, etal., Eur J Pharmacol. 2008 Feb 2;580(1-2):100-15. Epub 2007 Oct 25.
33. The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety. Schank JR, etal., Addict Biol. 2012 May;17(3):634-47. doi: 10.1111/j.1369-1600.2012.00455.x.
34. Neurobehavioral and transcriptional effects of acrylamide in juvenile rats. Seale SM, etal., Pharmacol Biochem Behav. 2012 Mar;101(1):77-84. doi: 10.1016/j.pbb.2011.12.006. Epub 2011 Dec 16.
35. A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats. Sedki F, etal., Addict Biol. 2014 Apr 13. doi: 10.1111/adb.12133.
36. Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Silva RM, etal., J Pharmacol Exp Ther. 2002 May;301(2):513-8.
37. Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Svingos AL, etal., Synapse. 2001 Dec 1;42(3):185-92. doi: 10.1002/syn.10005.
38. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
39. Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression. Teodorov E, etal., Braz J Med Biol Res. 2012 Oct;45(10):982-7. Epub 2012 May 31.
40. Treatment with steroid hormones and morphine alters general activity, sexual behavior, and opioid gene expression in female rats. Teodorov E, etal., Life Sci. 2014 May 28;104(1-2):47-54. doi: 10.1016/j.lfs.2014.03.021. Epub 2014 Mar 31.
41. Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat. Teodorov E, etal., Neuroscience. 2006 Sep 1;141(3):1225-31. Epub 2006 Jun 6.
42. Regulation of kappa-opioid receptor mRNA level by cyclic AMP and growth factors in cultured rat glial cells. Tryoen-Toth P, etal., Brain Res Mol Brain Res. 1998 Mar 30;55(1):141-50.
43. Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats. Wu G, etal., J Ethnopharmacol. 2011 Jun 14;136(1):254-9. doi: 10.1016/j.jep.2011.04.041. Epub 2011 Apr 28.
44. Structure and expression of a rat kappa opioid receptor gene. Yakovlev AG, etal., J Biol Chem 1995 Mar 24;270(12):6421-4.
45. Alterations in kappa opioid receptor mRNA levels in the paraventricular nucleus of the hypothalamus by stress and sex steroids. Yukhananov RY and Handa RJ, Neuroreport. 1996 Jul 8;7(10):1690-4.
Additional References at PubMed
PMID:7624359   PMID:8755601   PMID:9463367   PMID:9915326   PMID:10385123   PMID:11726686   PMID:12842289   PMID:12855366   PMID:14580956   PMID:15467355   PMID:15778854   PMID:15950775  
PMID:16130146   PMID:17167054   PMID:17980907   PMID:18500486   PMID:19009591   PMID:19217659   PMID:19462402   PMID:19545549   PMID:19567249   PMID:19924112   PMID:20435099   PMID:20574683  
PMID:20653037   PMID:21338616   PMID:21531393   PMID:21723305   PMID:21849544   PMID:22072818   PMID:22316281   PMID:22437504   PMID:22487769   PMID:22735633   PMID:22796630   PMID:23212453  
PMID:23402995   PMID:23838631   PMID:23877505   PMID:24219160   PMID:24957331   PMID:24978951   PMID:25013167   PMID:25641629   PMID:26086860   PMID:26635353   PMID:26860203   PMID:27226238  
PMID:27523794   PMID:27899527   PMID:28163104   PMID:28531297   PMID:28987634   PMID:32948219   PMID:33444637   PMID:33546289   PMID:33908346   PMID:34016793  


Genomics

Comparative Map Data
Oprk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2513,860,016 - 13,877,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl513,860,021 - 13,877,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx516,035,098 - 16,052,904 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0517,669,824 - 17,687,612 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0517,369,783 - 17,387,591 (-)NCBIRnor_WKY
Rnor_6.0513,742,655 - 13,760,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl513,744,658 - 13,760,305 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0518,519,763 - 18,534,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4514,040,848 - 14,055,273 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1514,037,659 - 14,055,460 (-)NCBI
Celera513,240,420 - 13,258,214 (-)NCBICelera
Cytogenetic Map5q12NCBI
OPRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38853,225,724 - 53,251,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl853,225,724 - 53,251,637 (-)EnsemblGRCh38hg38GRCh38
GRCh37854,138,284 - 54,164,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36854,300,829 - 54,326,747 (-)NCBINCBI36Build 36hg18NCBI36
Build 34854,304,325 - 54,326,525NCBI
Celera850,129,111 - 50,155,030 (-)NCBICelera
Cytogenetic Map8q11.23NCBI
HuRef849,605,704 - 49,631,623 (-)NCBIHuRef
CHM1_1854,189,898 - 54,215,806 (-)NCBICHM1_1
T2T-CHM13v2.0853,602,209 - 53,628,122 (-)NCBIT2T-CHM13v2.0
Oprk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915,658,673 - 5,676,357 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15,658,689 - 5,676,354 (+)EnsemblGRCm39 Ensembl
GRCm3815,588,450 - 5,606,134 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15,588,466 - 5,606,131 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715,578,574 - 5,592,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615,578,574 - 5,592,947 (+)NCBIMGSCv36mm8
Celera15,572,638 - 5,587,007 (+)NCBICelera
Cytogenetic Map1A1NCBI
cM Map11.89NCBI
Oprk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545412,744,765 - 12,752,226 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545412,741,577 - 12,751,282 (-)NCBIChiLan1.0ChiLan1.0
OPRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1847,030,643 - 47,056,577 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl847,029,313 - 47,056,577 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0849,650,844 - 49,677,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
OPRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1295,022,270 - 5,054,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl295,025,786 - 5,051,919 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha295,465,554 - 5,491,602 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0295,094,906 - 5,125,355 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl295,094,910 - 5,125,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1295,025,124 - 5,051,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0295,246,074 - 5,272,177 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0295,327,765 - 5,353,862 (-)NCBIUU_Cfam_GSD_1.0
Oprk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530374,479,528 - 74,505,054 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936496280,593 - 305,900 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl477,399,183 - 77,426,879 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1477,399,298 - 77,429,025 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2484,469,581 - 84,499,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1849,337,308 - 49,364,724 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl849,341,427 - 49,362,947 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603992,601,556 - 92,627,383 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247352,301,101 - 2,325,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247352,301,248 - 2,325,678 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D5Wox26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2513,861,313 - 13,861,507 (+)MAPPERmRatBN7.2
Rnor_6.0513,743,953 - 13,744,146NCBIRnor6.0
Rnor_5.0518,517,868 - 18,518,061UniSTSRnor5.0
RGSC_v3.4514,038,953 - 14,039,146UniSTSRGSC3.4
Celera513,241,718 - 13,241,911UniSTS
Cytogenetic Map5q12UniSTS
RH94595  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2513,860,572 - 13,860,771 (+)MAPPERmRatBN7.2
Rnor_6.0513,743,212 - 13,743,410NCBIRnor6.0
Rnor_5.0518,517,127 - 18,517,325UniSTSRnor5.0
RGSC_v3.4514,038,212 - 14,038,410UniSTSRGSC3.4
Celera513,240,977 - 13,241,175UniSTS
Cytogenetic Map5q12UniSTS
BF403255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2513,860,189 - 13,860,395 (+)MAPPERmRatBN7.2
Rnor_6.0513,742,829 - 13,743,034NCBIRnor6.0
Rnor_5.0518,516,744 - 18,516,949UniSTSRnor5.0
RGSC_v3.4514,037,829 - 14,038,034UniSTSRGSC3.4
Celera513,240,594 - 13,240,799UniSTS
Cytogenetic Map5q12UniSTS
Oprk1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2513,867,261 - 13,867,388 (+)MAPPERmRatBN7.2
Rnor_6.0513,749,901 - 13,750,027NCBIRnor6.0
Rnor_5.0518,523,816 - 18,523,942UniSTSRnor5.0
RGSC_v3.4514,044,901 - 14,045,027UniSTSRGSC3.4
Celera513,247,666 - 13,247,792UniSTS
Cytogenetic Map5q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:658
Count of miRNA genes:294
Interacting mature miRNAs:360
Transcripts:ENSRNOT00000010254
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11
Low 16 7 7 72 18 19
Below cutoff 15 17 15 2 15 3 3 2 8 4 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010254   ⟹   ENSRNOP00000010255
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl513,860,021 - 13,877,823 (-)Ensembl
Rnor_6.0 Ensembl513,744,658 - 13,760,305 (-)Ensembl
RefSeq Acc Id: NM_001318742   ⟹   NP_001305671
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2513,860,016 - 13,877,823 (-)NCBI
Rnor_6.0513,742,655 - 13,760,460 (-)NCBI
Celera513,240,420 - 13,258,214 (-)NCBI
Sequence:
RefSeq Acc Id: NM_017167   ⟹   NP_058863
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2513,860,016 - 13,877,823 (-)NCBI
Rnor_6.0513,742,655 - 13,760,460 (-)NCBI
Rnor_5.0518,519,763 - 18,534,188 (-)NCBI
RGSC_v3.4514,040,848 - 14,055,273 (-)RGD
Celera513,240,420 - 13,258,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109359   ⟹   XP_038965287
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2513,860,016 - 13,877,486 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058863   ⟸   NM_017167
- Peptide Label: isoform 1
- UniProtKB: P34975 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001305671   ⟸   NM_001318742
- Peptide Label: isoform 1x
- Sequence:
RefSeq Acc Id: ENSRNOP00000010255   ⟸   ENSRNOT00000010254
RefSeq Acc Id: XP_038965287   ⟸   XM_039109359
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34975-F1-model_v2 AlphaFold P34975 1-380 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69426 AgrOrtholog
BioCyc Gene G2FUF-42160 BioCyc
Ensembl Genes ENSRNOG00000007647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000010255 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010254 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Kappa_opi_rcpt UniProtKB/Swiss-Prot
  Opioid_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:29335 UniProtKB/Swiss-Prot
NCBI Gene 29335 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Oprk1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  KAPPAOPIOIDR UniProtKB/Swiss-Prot
  OPIOIDR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
TIGR TC206180
UniProt OPRK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Oprk1  opioid receptor, kappa 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process involved in cardiovascular regulation, feeding behavior, fluid balance, modulation of anti-nociception, and temperature control 729017