(+)-pilocarpine decreases response to substance ISO RGD:69479 6480464 OPRK1 protein results in decreased susceptibility to Pilocarpine CTD PMID:7894264 (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin affects binding EXP 6480464 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein CTD PMID:7562497 (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin multiple interactions EXP 6480464 Magnesium promotes the reaction [Enkephalin more ... CTD PMID:2162496 (R)-noradrenaline multiple interactions EXP 6480464 [dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine more ... CTD PMID:7562497 (R,R)-tramadol affects binding EXP 6480464 Tramadol binds to OPRK1 protein CTD PMID:7562497 (R,R)-tramadol multiple interactions EXP 6480464 [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine, [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 (S)-nicotine decreases expression ISO RGD:69478 6480464 Nicotine results in decreased expression of OPRK1 mRNA CTD PMID:18247414 17beta-estradiol multiple interactions ISO RGD:69478 6480464 [Estradiol co-treated with Progesterone] results in increased expression of OPRK1 mRNA CTD PMID:20660070 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:69478 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of OPRK1 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of OPRK1 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:69478 6480464 Tetrachlorodibenzodioxin results in increased expression of OPRK1 mRNA CTD PMID:19684285 2,4-dinitrobenzenesulfonic acid decreases expression ISO RGD:69479 6480464 2, 4-dinitrobenzenesulfonic acid results in decreased expression of OPRK1 mRNA CTD PMID:30116771 2-naphthylamine decreases expression ISO RGD:69478 6480464 2-Naphthylamine results in decreased expression of OPRK1 mRNA CTD PMID:18247414 4,4'-sulfonyldiphenol increases expression ISO RGD:69479 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of OPRK1 mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol decreases methylation ISO RGD:69478 6480464 bis(4-hydroxyphenyl)sulfone results in decreased methylation of OPRK1 gene CTD PMID:31601247 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of OPRK1 mRNA CTD PMID:24780913 7-Hydroxymitragynine multiple interactions ISO RGD:69478 6480464 7-hydroxymitragynine inhibits the reaction [3 more ... CTD PMID:27192616 7-Hydroxymitragynine affects binding ISO RGD:69479 6480464 7-hydroxymitragynine binds to OPRK1 protein CTD PMID:27192616 7-Hydroxymitragynine affects binding ISO RGD:69478 6480464 7-hydroxymitragynine binds to OPRK1 protein CTD PMID:27192616 acetylmethadol multiple interactions EXP 6480464 [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Norepinephrine, [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 acetylmethadol affects binding EXP 6480464 Methadyl Acetate binds to OPRK1 protein CTD PMID:7562497 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of OPRK1 mRNA CTD PMID:22197712 aflatoxin B1 decreases methylation ISO RGD:69478 6480464 Aflatoxin B1 results in decreased methylation of OPRK1 gene CTD PMID:27153756 all-trans-retinoic acid decreases expression ISO RGD:69478 6480464 Tretinoin results in decreased expression of OPRK1 mRNA CTD PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of OPRK1 mRNA CTD PMID:16483693 arsenite(3-) increases expression ISO RGD:69479 6480464 arsenite results in increased expression of OPRK1 mRNA CTD PMID:33053406 Bardoxolone methyl decreases activity ISO RGD:69478 6480464 bardoxolone methyl results in decreased activity of OPRK1 protein CTD PMID:28790194 benzo[a]pyrene decreases expression ISO RGD:69478 6480464 Benzo(a)pyrene results in decreased expression of OPRK1 mRNA CTD PMID:18247414 benzo[a]pyrene increases methylation ISO RGD:69478 6480464 Benzo(a)pyrene results in increased methylation of OPRK1 5' UTR, Benzo(a)pyrene results in increased methylation of OPRK1 promoter CTD PMID:27901495 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of OPRK1 mRNA CTD PMID:21839799 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of OPRK1 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:69479 6480464 bisphenol F results in increased expression of OPRK1 mRNA CTD PMID:30951980 buprenorphine affects binding EXP 6480464 Buprenorphine binds to OPRK1 protein CTD PMID:7562497 buprenorphine multiple interactions ISO RGD:69478 6480464 Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein] CTD PMID:21866885 butorphanol affects activity EXP 6480464 Butorphanol affects the activity of OPRK1 protein CTD PMID:17909753 cadmium atom multiple interactions EXP 6480464 Cadmium inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein] CTD PMID:2162496 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of OPRK1 promoter CTD PMID:22457795 celastrol decreases expression ISO RGD:69478 6480464 celastrol results in decreased expression of OPRK1 mRNA CTD PMID:17010675 CGP 52608 multiple interactions ISO RGD:69478 6480464 CGP 52608 promotes the reaction [RORA protein binds to OPRK1 gene] CTD PMID:28238834 cocaine multiple interactions EXP 6480464 [U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine], Cocaine affects the reaction [enadoline binds to OPRK1 protein] CTD PMID:11113311 , PMID:17621646 cocaine increases expression ISO RGD:69479 6480464 Cocaine deficiency results in increased expression of OPRK1 mRNA CTD PMID:27126842 cocaine increases expression EXP 6480464 Cocaine results in increased expression of OPRK1 protein CTD PMID:17621646 codeine affects binding EXP 6480464 Codeine binds to OPRK1 protein CTD PMID:7562497 copper atom multiple interactions EXP 6480464 Copper inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein] CTD PMID:2162496 copper(0) multiple interactions EXP 6480464 Copper inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein] CTD PMID:2162496 cycloheximide multiple interactions ISO RGD:69478 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of OPRK1 mRNA CTD PMID:19684285 cycloheximide increases expression ISO RGD:69478 6480464 Cycloheximide results in increased expression of OPRK1 mRNA CTD PMID:19684285 dextran sulfate multiple interactions ISO RGD:69479 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of OPRK1 mRNA CTD PMID:29950665 dextromethorphan affects binding EXP 6480464 Dextromethorphan binds to OPRK1 protein CTD PMID:7562497 dextromethorphan multiple interactions EXP 6480464 [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine, [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 dextropropoxyphene multiple interactions EXP 6480464 [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine, [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 dextropropoxyphene affects binding EXP 6480464 Dextropropoxyphene binds to OPRK1 protein CTD PMID:7562497 dextrorphan multiple interactions EXP 6480464 [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine, [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 dextrorphan affects binding EXP 6480464 Dextrorphan binds to OPRK1 protein CTD PMID:7562497 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of OPRK1 mRNA CTD PMID:21266533 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] affects the expression of OPRK1 mRNA CTD PMID:18636392 dichlorine decreases expression EXP 6480464 Chlorine results in decreased expression of OPRK1 mRNA CTD PMID:18636392 dopamine multiple interactions EXP 6480464 [U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine] CTD PMID:11113311 dorsomorphin multiple interactions ISO RGD:69478 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 DPDPE affects binding EXP 6480464 Enkephalin more ... CTD PMID:7562497 dynorphin A increases activity ISO RGD:69478 6480464 Dynorphins results in increased activity of OPRK1 protein CTD PMID:26476280 dynorphin A affects binding EXP 6480464 Dynorphins analog binds to OPRK1 protein CTD PMID:11270320 dynorphin A multiple interactions EXP 6480464 Dynorphins binds to and results in increased activity of OPRK1 protein, norbinaltorphimine inhibits the reaction [Dynorphins binds to and results in increased activity of OPRK1 protein] CTD PMID:11676193 entinostat decreases expression ISO RGD:69478 6480464 entinostat results in decreased expression of OPRK1 mRNA CTD PMID:27188386 ethanol decreases expression ISO RGD:69478 6480464 Ethanol results in decreased expression of OPRK1 mRNA CTD PMID:17934066 ethanol multiple interactions ISO RGD:69478 6480464 fomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA] CTD PMID:17934066 Ethylketocyclazocine multiple interactions EXP 6480464 Cadmium inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein] more ... CTD PMID:2162496 Ethylketocyclazocine affects binding EXP 6480464 Ethylketocyclazocine binds to OPRK1 protein CTD PMID:2162496 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of OPRK1 mRNA CTD PMID:30307764 folic acid decreases expression ISO RGD:69478 6480464 Folic Acid results in decreased expression of OPRK1 mRNA CTD PMID:21867686 fomepizole multiple interactions ISO RGD:69478 6480464 fomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA] CTD PMID:17934066 gedunin decreases expression ISO RGD:69478 6480464 gedunin results in decreased expression of OPRK1 mRNA CTD PMID:17010675 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of OPRK1 mRNA CTD PMID:33387578 hydrocodone affects binding EXP 6480464 Hydrocodone binds to OPRK1 protein CTD PMID:7562497 Levallorphan affects binding EXP 6480464 Levallorphan binds to OPRK1 protein CTD PMID:7562497 Levallorphan multiple interactions EXP 6480464 [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine, [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 Levorphanol multiple interactions EXP 6480464 [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine, [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 Levorphanol affects binding EXP 6480464 Levorphanol binds to OPRK1 protein CTD PMID:7562497 magnesium atom multiple interactions EXP 6480464 Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein] CTD PMID:2162496 manganese atom multiple interactions EXP 6480464 Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein] CTD PMID:2162496 manganese(0) multiple interactions EXP 6480464 Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein] CTD PMID:2162496 mercury atom multiple interactions EXP 6480464 Mercury inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein] CTD PMID:2162496 mercury(0) multiple interactions EXP 6480464 Mercury inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein] CTD PMID:2162496 methadone affects binding EXP 6480464 Methadone binds to OPRK1 protein CTD PMID:7562497 methadone multiple interactions EXP 6480464 [Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine, [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 methotrexate increases expression ISO RGD:69478 6480464 Methotrexate results in increased expression of OPRK1 mRNA CTD PMID:17400583 methylmercury chloride decreases expression ISO RGD:69478 6480464 methylmercuric chloride results in decreased expression of OPRK1 mRNA CTD PMID:28001369 Mitragynine multiple interactions ISO RGD:69478 6480464 mitragynine inhibits the reaction [3 more ... CTD PMID:27192616 Mitragynine affects binding ISO RGD:69478 6480464 mitragynine binds to OPRK1 protein CTD PMID:27192616 Mitragynine affects binding ISO RGD:69479 6480464 mitragynine binds to OPRK1 protein CTD PMID:27192616 morphine affects activity ISO RGD:69479 6480464 Morphine affects the activity of OPRK1 protein CTD PMID:18385270 morphine increases activity ISO RGD:69478 6480464 Morphine results in increased activity of OPRK1 protein CTD PMID:26476280 morphine increases expression EXP 6480464 Morphine results in increased expression of OPRK1 mRNA CTD PMID:22661197 morphine affects binding EXP 6480464 Morphine binds to OPRK1 protein CTD PMID:7562497 morphine multiple interactions ISO RGD:69479 6480464 Morphine inhibits the reaction [Zymosan results in decreased expression of OPRK1 mRNA] CTD PMID:15979727 Nalmefene multiple interactions ISO RGD:69478 6480464 nalmefene binds to and results in decreased activity of OPRK1 protein CTD PMID:9862779 naloxone affects binding EXP 6480464 Naloxone binds to OPRK1 protein CTD PMID:7562497 naltrexone affects binding EXP 6480464 Naltrexone binds to OPRK1 protein CTD PMID:7562497 nicotine decreases expression ISO RGD:69478 6480464 Nicotine results in decreased expression of OPRK1 mRNA CTD PMID:18247414 Norbinaltorphimine multiple interactions ISO RGD:69479 6480464 norbinaltorphimine binds to and results in decreased activity of OPRK1 protein CTD PMID:18385270 Norbinaltorphimine multiple interactions EXP 6480464 norbinaltorphimine binds to and results in decreased activity of OPRK1 protein more ... CTD PMID:11676193 , PMID:15456805 oxycodone affects binding EXP 6480464 Oxycodone binds to OPRK1 protein CTD PMID:7562497 ozone increases expression ISO RGD:69479 6480464 Ozone results in increased expression of OPRK1 mRNA CTD PMID:12763052 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] affects the expression of OPRK1 mRNA CTD PMID:18636392 panobinostat multiple interactions ISO RGD:69478 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA CTD PMID:27188386 panobinostat decreases expression ISO RGD:69478 6480464 panobinostat results in decreased expression of OPRK1 mRNA CTD PMID:26272509 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of OPRK1 mRNA CTD PMID:33387578 pentetrazol decreases response to substance ISO RGD:69479 6480464 OPRK1 gene results in decreased susceptibility to Pentylenetetrazole CTD PMID:17126860 picrotoxin increases expression EXP 6480464 Picrotoxin results in increased expression of OPRK1 mRNA CTD PMID:15170462 progesterone multiple interactions ISO RGD:69478 6480464 [Estradiol co-treated with Progesterone] results in increased expression of OPRK1 mRNA CTD PMID:20660070 SB 431542 multiple interactions ISO RGD:69478 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serotonin multiple interactions EXP 6480464 [dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin more ... CTD PMID:7562497 tapentadol affects binding EXP 6480464 tapentadol binds to OPRK1 protein CTD PMID:17656655 thioglycolic acid affects response to substance EXP 6480464 OPRK1 exon affects the susceptibility to 2-mercaptoacetate CTD PMID:10802031 titanium dioxide multiple interactions ISO RGD:69479 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of OPRK1 mRNA CTD PMID:29950665 tramadol affects binding EXP 6480464 Tramadol binds to OPRK1 protein CTD PMID:7562497 tramadol multiple interactions EXP 6480464 [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine, [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 trichostatin A increases expression ISO RGD:69478 6480464 trichostatin A results in increased expression of OPRK1 mRNA CTD PMID:24935251 trichostatin A multiple interactions ISO RGD:69478 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA CTD PMID:27188386 trichostatin A decreases expression ISO RGD:69478 6480464 trichostatin A results in decreased expression of OPRK1 mRNA CTD PMID:26272509 U50488 multiple interactions ISO RGD:69479 6480464 3 more ... CTD PMID:18385270 U50488 increases activity ISO RGD:69479 6480464 3 more ... CTD PMID:27231154 U50488 affects response to substance ISO RGD:69479 6480464 OPRK1 protein affects the susceptibility to 3 more ... CTD PMID:29669290 U50488 multiple interactions ISO RGD:69478 6480464 3 more ... CTD PMID:27192616 U69593 multiple interactions EXP 6480464 [U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine], U 69593 binds to and results in increased activity of OPRK1 protein CTD PMID:11113311 , PMID:15456805 U69593 multiple interactions ISO RGD:69478 6480464 Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein], U 69593 binds to and results in increased activity of OPRK1 protein CTD PMID:21866885 , PMID:21958337 U69593 affects binding ISO RGD:69478 6480464 U 69593 binds to OPRK1 protein CTD PMID:21866885 U69593 affects binding EXP 6480464 U 69593 binds to OPRK1 protein CTD PMID:7562497 valproic acid affects expression ISO RGD:69478 6480464 Valproic Acid affects the expression of OPRK1 mRNA CTD PMID:25979313 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of OPRK1 mRNA CTD PMID:29427782 valproic acid decreases expression ISO RGD:69478 6480464 Valproic Acid results in decreased expression of OPRK1 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:69478 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OPRK1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:69478 6480464 Valproic Acid results in increased expression of OPRK1 mRNA CTD PMID:23179753 more ... vorinostat multiple interactions ISO RGD:69478 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA CTD PMID:27188386 vorinostat decreases expression ISO RGD:69478 6480464 vorinostat results in decreased expression of OPRK1 mRNA CTD PMID:26272509 , PMID:27188386
