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Gene: Oprk1 (opioid receptor, kappa 1) Rattus norvegicus
Symbol: Oprk1
Name: opioid receptor, kappa 1
RGD ID: 69426
Description: Exhibits receptor serine/threonine kinase binding activity. Involved in several processes, including conditioned place preference; positive regulation of ion transport; and response to alkaloid. Localizes to several cellular components, including integral component of postsynaptic membrane; integral component of synaptic vesicle membrane; and perikaryon. Used to study heroin dependence; myocardial infarction; and withdrawal disorder. Orthologous to human OPRK1 (opioid receptor kappa 1); PARTICIPATES IN nalbuphine pharmacodynamics pathway; INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; (R)-noradrenaline; (R,R)-tramadol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: K-OR-1; kappa-type opioid receptor; KOR-1
Homo sapiens (human) : OPRK1 (opioid receptor kappa 1)  HGNC  Alliance
Mus musculus (house mouse) : Oprk1 (opioid receptor, kappa 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Oprk1 (opioid receptor kappa 1)
Pan paniscus (bonobo/pygmy chimpanzee) : OPRK1 (opioid receptor kappa 1)
Canis lupus familiaris (dog) : OPRK1 (opioid receptor kappa 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Oprk1 (opioid receptor kappa 1)
Sus scrofa (pig) : OPRK1 (opioid receptor kappa 1)
Chlorocebus sabaeus (African green monkey) : OPRK1 (opioid receptor kappa 1)
Heterocephalus glaber (naked mole-rat) : Oprk1 (opioid receptor kappa 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0513,742,655 - 13,760,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl513,744,658 - 13,760,305 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0518,519,763 - 18,534,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4514,040,848 - 14,055,273 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1514,037,659 - 14,055,460 (-)NCBI
Celera513,240,420 - 13,258,214 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Oprk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69426
Created: 2001-11-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.