Cxcl3 (C-X-C motif chemokine ligand 3) - Rat Genome Database

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Gene: Cxcl3 (C-X-C motif chemokine ligand 3) Rattus norvegicus
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
RGD ID: 621812
Description: Enables chemokine activity. Involved in cellular response to lipopolysaccharide; neutrophil chemotaxis; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space. Biomarker of Coronavirus infectious disease and bacterial pneumonia. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); PARTICIPATES IN interleukin-23 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C motif chemokine 3; chemokine (C-X-C motif) ligand 3; Cinc-2; Cinc2; cytokine-induced neutrophil chemoattractant 2; cytokine-induced neutrophil chemoattractant-2; gene model 1960, (NCBI); Gm1960; macrophage inflammatory protein 2-alpha/beta; MIP2-alpha/beta
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21417,270,146 - 17,289,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,270,146 - 17,289,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,288,069 - 17,289,789 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01418,606,992 - 18,608,712 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01417,299,296 - 17,301,016 (-)NCBIRnor_WKY
Rnor_6.01418,820,168 - 18,839,659 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,820,168 - 18,839,595 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,729,345 - 18,748,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,767,306 - 18,787,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,767,305 - 18,787,340 (-)NCBI
Celera1416,646,603 - 16,666,030 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloroethane  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2''-galloylhyperin  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
AM-251  (ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
andrographolide  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
asperentin  (ISO)
astemizole  (EXP)
astressin 2B  (ISO)
atrazine  (ISO)
atropine  (ISO)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
budesonide  (EXP)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capecitabine  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
carrageenan  (ISO)
carvacrol  (ISO)
ceruletide  (ISO)
cetirizine  (ISO)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyanuric chloride  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
diethyl malate  (ISO)
diisopropyl fluorophosphate  (ISO)
dimercaprol  (ISO)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
domperidone  (ISO)
doramapimod  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
enniatin  (ISO)
epoxiconazole  (ISO)
Erionite  (ISO)
ethanol  (ISO)
eugenol  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
flucloxacillin  (ISO)
fluoranthene  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gadolinium trichloride  (ISO)
gemcitabine  (ISO)
glucose  (ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (ISO)
graphene oxide  (ISO)
halothane  (ISO)
heparan sulfate  (ISO)
hesperidin  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoflurane  (ISO)
isotretinoin  (ISO)
ketamine  (ISO)
L-methionine  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
maslinic acid  (ISO)
mesalamine  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metoclopramide  (ISO)
Microcystin la  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nonivamide  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
oleanolic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phalloidin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Phytolaccoside E  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
propofol  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
sterigmatocystin  (ISO)
succimer  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vitamin D  (ISO)
XL147  (ISO)
zaragozic acid A  (ISO)
zileuton  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,IEA,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Al Alam D, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):644-50. Epub 2009 Jul 13.
2. Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa. Amano H, etal., Cytokine. 2000 Nov;12(11):1662-8.
3. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Gauglitz GG, etal., Shock. 2008 Nov;30(5):503-7.
6. Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines. Miura TA, etal., Virology. 2007 Dec 20;369(2):288-98. Epub 2007 Sep 5.
7. Immunolocalization of CXC chemokine and recruitment of polymorphonuclear leukocytes in the rat molar periodontal tissue after topical application of lipopolysaccharide. Miyauchi M, etal., Histochem Cell Biol. 2004 Apr;121(4):291-7. Epub 2004 Mar 24.
8. Identification of cytokine-induced neutrophil chemoattractants (CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by granulation tissue in culture: purification, complete amino acid sequences and characterization. Nakagawa H, etal., Biochem J 1994 Jul 15;301 ( Pt 2):545-50.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Gene structure, cDNA cloning, and expression of the rat cytokine-induced neutrophil chemoattractant-2 (CINC-2) gene. Shibata F, etal., Cytokine 1998 Mar;10(3):169-74.
13. Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation. Shibata F, etal., Cytokine. 1996 Mar;8(3):222-6.
14. Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCs). Shibata F, etal., Cytokine. 2000 Sep;12(9):1368-73.
15. The expression of three types of CINCs by lipopolysaccharide-stimulated rat macrophages is inhibited similarly by anti-inflammatory steroids. Shibata F, etal., Inflamm Res. 2000 Feb;49(2):80-5.
Additional References at PubMed
PMID:8471066   PMID:8607872   PMID:12829448   PMID:12949249   PMID:14764687   PMID:16055671   PMID:18323732   PMID:19497959   PMID:20226088   PMID:20602290   PMID:27967265   PMID:31616413  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21417,270,146 - 17,289,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,270,146 - 17,289,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,288,069 - 17,289,789 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01418,606,992 - 18,608,712 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01417,299,296 - 17,301,016 (-)NCBIRnor_WKY
Rnor_6.01418,820,168 - 18,839,659 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,820,168 - 18,839,595 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,729,345 - 18,748,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,767,306 - 18,787,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,767,305 - 18,787,340 (-)NCBI
Celera1416,646,603 - 16,666,030 (-)NCBICelera
Cytogenetic Map14p22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38473,869,393 - 73,871,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl473,869,393 - 73,871,308 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,735,110 - 74,737,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,953,973 - 74,955,817 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,100,143 - 75,101,988NCBI
Celera472,095,237 - 72,097,087 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,546,248 - 70,548,158 (+)NCBIHuRef
CHM1_1474,771,032 - 74,772,942 (+)NCBICHM1_1
T2T-CHM13v2.0477,213,030 - 77,214,945 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39590,933,960 - 90,935,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,933,962 - 90,937,459 (+)EnsemblGRCm39 Ensembl
GRCm38590,786,101 - 90,788,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,786,103 - 90,789,600 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,215,129 - 91,217,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,861,303 - 91,863,290 (+)NCBIMGSCv36mm8
Celera588,937,720 - 88,939,708 (+)NCBICelera
Cytogenetic Map5E1NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1456,382,253 - 56,384,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,325,248 - 50,327,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,157,626 - 56,159,522 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,153,899 - 56,159,474 (-)Ensemblpanpan1.1panPan2


Variants in Cxcl3
89 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:43
Interacting mature miRNAs:50
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01418,833,818 - 18,834,102NCBIRnor6.0
Rnor_5.01418,742,995 - 18,743,279UniSTSRnor5.0
RGSC_v3.41418,781,071 - 18,782,022UniSTSRGSC3.4
Celera1416,660,252 - 16,660,493UniSTS
RH 3.4 Map14216.4RGD
RH 3.4 Map14216.4UniSTS
RH 2.0 Map14215.5RGD
SHRSP x BN Map146.92RGD
Cytogenetic Map14p22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,270,396 - 17,270,567 (+)MAPPERmRatBN7.2
Rnor_6.01418,820,419 - 18,820,589NCBIRnor6.0
Rnor_5.01418,729,596 - 18,729,766UniSTSRnor5.0
RGSC_v3.41418,767,557 - 18,767,727UniSTSRGSC3.4
Celera1416,646,854 - 16,647,024UniSTS
RH 3.4 Map14213.6UniSTS
Cytogenetic Map14p22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 11
Low 4 7 5 2 5 3 3 13 3 3
Below cutoff 2 13 33 21 15 21 5 5 34 15 21 5


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034090   ⟹   ENSRNOP00000038520
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,270,146 - 17,289,380 (-)Ensembl
Rnor_6.0 Ensembl1418,820,168 - 18,839,420 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078746   ⟹   ENSRNOP00000070985
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,287,726 - 17,289,511 (-)Ensembl
Rnor_6.0 Ensembl1418,837,821 - 18,839,595 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098120   ⟹   ENSRNOP00000077076
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,288,291 - 17,289,380 (-)Ensembl
RefSeq Acc Id: NM_138522   ⟹   NP_612531
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21417,270,146 - 17,289,380 (-)NCBI
Rnor_6.01418,820,168 - 18,839,420 (-)NCBI
Rnor_5.01418,729,345 - 18,748,734 (-)NCBI
RGSC_v3.41418,767,306 - 18,787,340 (-)RGD
Celera1416,646,603 - 16,666,030 (-)RGD
RefSeq Acc Id: XM_006250721   ⟹   XP_006250783
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21417,287,727 - 17,289,458 (-)NCBI
Rnor_6.01418,837,767 - 18,839,659 (-)NCBI
Rnor_5.01418,729,345 - 18,748,734 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_612531   ⟸   NM_138522
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006250783   ⟸   XM_006250721
- Peptide Label: isoform X1
- UniProtKB: Q10746 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038520   ⟸   ENSRNOT00000034090
RefSeq Acc Id: ENSRNOP00000070985   ⟸   ENSRNOT00000078746
RefSeq Acc Id: ENSRNOP00000077076   ⟸   ENSRNOT00000098120
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q10746-F1-model_v2 AlphaFold Q10746 1-101 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699227
Promoter ID:EPDNEW_R9751
Type:single initiation site
Description:chemokine (C-X-C motif) ligand 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,839,486 - 18,839,546EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621812 AgrOrtholog
BioCyc Gene G2FUF-16209 BioCyc
Ensembl Genes ENSRNOG00000028043 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000038520.2 UniProtKB/Swiss-Prot
  ENSRNOP00000070985.2 UniProtKB/TrEMBL
  ENSRNOP00000077076.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034090.4 UniProtKB/Swiss-Prot
  ENSRNOT00000078746.2 UniProtKB/TrEMBL
  ENSRNOT00000098120.1 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171551 UniProtKB/Swiss-Prot
  PTHR10179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cxcl3 PhenoGen
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R3J1_RAT UniProtKB/TrEMBL
UniProt Secondary Q10747 UniProtKB/Swiss-Prot
  Q5CZ55 UniProtKB/Swiss-Prot
  Q9EP62 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-12 Cxcl3  C-X-C motif chemokine ligand 3  Cxcl3  chemokine (C-X-C motif) ligand 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Cxcl3  chemokine (C-X-C motif) ligand 3  Gm1960  gene model 1960, (NCBI)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gm1960  gene model 1960, (NCBI)  Cinc2  cytokine-induced neutrophil chemoattractant-2  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cinc2  cytokine-induced neutrophil chemoattractant-2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the CXC chemokine family 632410
gene_transcript has two splicing isoforms, CINC-2 alpha and CINC-2 beta 632410