Trib2 (tribbles pseudokinase 2) - Rat Genome Database

Name: Trib2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Trib2 (tribbles pseudokinase 2) Rattus norvegicus

Analyze

Symbol:

Trib2

Name:

tribbles pseudokinase 2

RGD ID:

1564451

Description:

Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase regulator activity. Predicted to be involved in negative regulation of fat cell differentiation; negative regulation of interleukin-10 production; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Orthologous to human TRIB2 (tribbles pseudokinase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical protein LOC690207; LOC108351208; LOC313974; LOC690207; RGD1564451; similar to Tribbles homolog 2; tribbles homolog 2; tribbles homolog 2 (Drosophila); uncharacterized LOC108351208

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRIB2 (tribbles pseudokinase 2)	HGNC	Ensembl, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Trib2 (tribbles pseudokinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Trib2 (tribbles pseudokinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRIB2 (tribbles pseudokinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TRIB2 (tribbles pseudokinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Trib2 (tribbles pseudokinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRIB2 (tribbles pseudokinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRIB2 (tribbles pseudokinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Trib2 (tribbles pseudokinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TRIB2 (tribbles pseudokinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Trib2 (tribbles pseudokinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	trib2 (tribbles pseudokinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	trbl	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	trib2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	44,274,762 - 44,299,139 (-)	NCBI		GRCr8
mRatBN7.2	6	38,545,971 - 38,570,349 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	38,545,975 - 38,569,370 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	38,866,451 - 38,890,817 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	39,181,120 - 39,205,490 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	38,614,428 - 38,638,794 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	41,016,722 - 41,040,972 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	41,016,730 - 41,039,437 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	49,774,728 - 49,799,035 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	39,474,243 - 39,496,718 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	37,860,540 - 37,883,149 (-)	NCBI		Celera
Cytogenetic Map	6	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

4-nitrophenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amphetamine (EXP)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bilirubin IXalpha (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chrysene (ISO)

cisplatin (EXP,ISO)

copper atom (EXP)

copper(0) (EXP)

crocidolite asbestos (ISO)

cyclosporin A (EXP,ISO)

dextran sulfate (ISO)

diallyl trisulfide (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP,ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

entinostat (ISO)

ethanol (ISO)

etoposide (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

glycine betaine (EXP)

GW 501516 (ISO)

hydralazine (ISO)

ionomycin (ISO)

irinotecan (ISO)

iron dichloride (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

mifepristone (ISO)

mitomycin C (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nicotine (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

paraquat (ISO)

PD 0325901 (ISO)

phenobarbital (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

progesterone (ISO)

pyrrolidine dithiocarbamate (ISO)

raloxifene (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (EXP)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sulforaphane (ISO)

T-2 toxin (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

tetraphene (ISO)

thioacetamide (EXP)

topotecan (EXP)

trametinib (ISO)

trichostatin A (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of fat cell differentiation (ISO)

negative regulation of interleukin-10 production (ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

cytoplasm (ISO)

cytoskeleton (IEA)

Molecular Function

ATP binding (IEA)

nucleotide binding (ISO)

protein binding (ISO)

protein kinase activity (IEA,ISO)

protein kinase inhibitor activity (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

ubiquitin protein ligase binding (ISO)

ubiquitin-protein transferase regulator activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9342215	PMID:12477932	PMID:17576771	PMID:18643775	PMID:20410507	PMID:22012613	PMID:28364459	PMID:36626273

Genomics

Comparative Map Data

Trib2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	44,274,762 - 44,299,139 (-)	NCBI		GRCr8
mRatBN7.2	6	38,545,971 - 38,570,349 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	38,545,975 - 38,569,370 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	38,866,451 - 38,890,817 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	39,181,120 - 39,205,490 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	38,614,428 - 38,638,794 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	41,016,722 - 41,040,972 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	41,016,730 - 41,039,437 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	49,774,728 - 49,799,035 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	39,474,243 - 39,496,718 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	37,860,540 - 37,883,149 (-)	NCBI		Celera
Cytogenetic Map	6	q16	NCBI

TRIB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	12,716,936 - 12,742,734 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	12,716,910 - 12,742,734 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	12,857,062 - 12,882,860 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	12,774,659 - 12,800,311 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	12,807,805 - 12,833,454	NCBI
Celera	2	12,773,761 - 12,799,625 (+)	NCBI		Celera
Cytogenetic Map	2	p24.3	NCBI
HuRef	2	12,706,690 - 12,732,553 (+)	NCBI		HuRef
CHM1_1	2	12,786,401 - 12,812,238 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	12,746,001 - 12,771,799 (+)	NCBI		T2T-CHM13v2.0

Trib2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	15,841,726 - 15,866,963 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	15,841,728 - 15,866,923 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	15,791,725 - 15,816,962 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	15,791,727 - 15,816,922 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	15,798,533 - 15,823,591 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	15,817,277 - 15,842,335 (-)	NCBI		MGSCv36	mm8
Celera	12	16,119,723 - 16,144,805 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	7.25	NCBI

Trib2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955487	6,890,246 - 6,915,135 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955487	6,889,571 - 6,915,068 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRIB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	113,781,541 - 113,807,406 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	113,786,011 - 113,811,364 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	12,705,043 - 12,730,932 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	12,847,631 - 12,873,499 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	12,847,631 - 12,873,499 (+)	Ensembl	panpan1.1		panPan2

TRIB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	9,225,598 - 9,251,826 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	9,226,017 - 9,249,821 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	9,159,625 - 9,182,294 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	9,331,314 - 9,357,639 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	9,331,347 - 9,420,050 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	9,221,427 - 9,244,277 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	9,220,767 - 9,243,473 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	9,240,169 - 9,263,855 (+)	NCBI		UU_Cfam_GSD_1.0

Trib2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	53,599,159 - 53,622,876 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936532	8,354,205 - 8,377,924 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	124,172,098 - 124,196,210 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	124,170,677 - 124,196,253 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	132,790,605 - 132,816,697 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRIB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	94,887,152 - 94,913,219 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	17,401,176 - 17,427,297 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trib2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624865	3,475,141 - 3,503,783 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624865	3,477,831 - 3,503,783 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Trib2
84 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	571
Count of miRNA genes:	286
Interacting mature miRNAs:	358
Transcripts:	ENSRNOT00000005774
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	32074428	72227641	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	33309549	57730294	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	33309549	81132889	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34434137	77102317	Rat
1354632	Scl29	Serum cholesterol level QTL 29	3.74		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	6	35098709	71636405	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	35230417	80230417	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	35691618	57730540	Rat

Markers in Region

D6Rat96

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	38,552,053 - 38,552,278 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	41,022,805 - 41,023,027	NCBI	Rnor6.0
Rnor_5.0	6	49,780,811 - 49,781,033	UniSTS	Rnor5.0
RGSC_v3.4	6	39,480,326 - 39,480,549	RGD	RGSC3.4
RGSC_v3.4	6	39,480,327 - 39,480,549	UniSTS	RGSC3.4
RGSC_v3.1	6	39,483,280 - 39,483,502	RGD
Celera	6	37,866,615 - 37,866,811	UniSTS
RH 3.4 Map	6	164.1	RGD
RH 3.4 Map	6	164.1	UniSTS
RH 2.0 Map	6	323.8	RGD
SHRSP x BN Map	6	33.0298	RGD
Cytogenetic Map	6	q15	UniSTS

AW319517

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	38,546,107 - 38,546,223 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	41,016,859 - 41,016,974	NCBI	Rnor6.0
Rnor_5.0	6	49,774,865 - 49,774,980	UniSTS	Rnor5.0
RGSC_v3.4	6	39,474,380 - 39,474,495	UniSTS	RGSC3.4
Celera	6	37,860,677 - 37,860,792	UniSTS
Cytogenetic Map	6	q15	UniSTS

RH132990

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	38,546,027 - 38,546,225 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	41,016,779 - 41,016,976	NCBI	Rnor6.0
Rnor_5.0	6	49,774,785 - 49,774,982	UniSTS	Rnor5.0
RGSC_v3.4	6	39,474,300 - 39,474,497	UniSTS	RGSC3.4
Celera	6	37,860,597 - 37,860,794	UniSTS
RH 3.4 Map	6	163.8	UniSTS
Cytogenetic Map	6	q15	UniSTS

Trib2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	38,546,106 - 38,546,387 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	41,016,858 - 41,017,138	NCBI	Rnor6.0
Rnor_5.0	6	49,774,864 - 49,775,144	UniSTS	Rnor5.0
RGSC_v3.4	6	39,474,379 - 39,474,659	UniSTS	RGSC3.4
Celera	6	37,860,676 - 37,860,956	UniSTS
Cytogenetic Map	6	q15	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	42	22	10	19	10	8	10	74	35	34	11	8
Low	1	1	35	31		31		1			7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112194	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005774 ⟹ ENSRNOP00000005774

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	38,545,975 - 38,569,370 (-)	Ensembl
Rnor_6.0 Ensembl	6	41,016,730 - 41,039,437 (-)	Ensembl

RefSeq Acc Id:

NM_001108015 ⟹ NP_001101485

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	44,274,762 - 44,299,094 (-)	NCBI
mRatBN7.2	6	38,545,971 - 38,570,305 (-)	NCBI
Rnor_6.0	6	41,016,722 - 41,039,437 (-)	NCBI
Rnor_5.0	6	49,774,728 - 49,799,035 (-)	NCBI
RGSC_v3.4	6	39,474,243 - 39,496,718 (-)	RGD
Celera	6	37,860,540 - 37,883,149 (-)	RGD

Sequence:

show sequence

CCGCGCTGTGCATCTGCACAGCGGAGAGGAGCTGGTGTGCAAGGTGTTTGAGATCAGCTGCTAC
CAGGAGTCCCTGGCCCCCTGCTTCTGCCTGTCTGCCCATAGCAACATCAACCAAATCACAGAAA
TCCTCCTGGGAGAGACCAAAGCCTATGTGTTCTTCGAGCGGAGCTATGGAGACATGCATTCCTT
TGTCCGCACTTGCAAGAAGCTGAGGGAGGAGGAGGCAGCCCGACTGTTCTACCAGATTGCCTCG
GCGGTGGCCCACTGCCATGATGGGGGGCTGGTGCTGCGTGACCTCAAGCTGCGGAAATTTATCT
TCAAGGATGAAGAGAGGACTCGTGTCAAGCTGGAGAGTTTGGAAGACGCTTACATTCTCCGGGG
TGATGACGACTCCCTCTCTGACAAGCATGGCTGCCCAGCATATGTCAGCCCAGAGATCTTGAAC
ACCAACGGCAGTTATTCGGGCAAGGCAGCGGACGTGTGGAGCCTGGGGGTAATGCTGTACACCA
TGTTGGTGGGGCGTTACCCTTTCCATGACATTGAGCCTAGTTCCCTCTTCAGTAAGATCCGCAG
GGGCCAATTCAACATTCCAGAAACTCTGTCTCCCAAGGCCAAGTGCCTCATCCGAAGCATCCTG
CGACGGGAGCCCTCAGAGCGGCTGACCTCACAGGAAATTCTGGACCATCCTTGGTTTTCTACAG
ATTTTAGTGTCTCAAATTCGGGATTTGGTGCTAAAGAGGCATGTGACCAGCTGGTGCCAGACGT
CAACATGGAGGAGAACTTGGACCCTTTCTTTAACTGAGCTTAAGGCCCAGGGACACATAGCAGG
TACCAGGAGCGAGAGAGAGCTCCAGAAAGGAGTTCTGGGACACAGGTGGCCTGGCTGAGAAGCA
AGACGGACCCATCATATTTACACATTTCTTGGTTCAGAGAAGGAATATGTTCTAGGAAATGATG
GAACATGTAGCATGGGAACAAGATGTGTGGGATGGGGGTTGGGTTCAGATGGACGGGAGCCCTT
CCCCTAAACTTCTCTTCCCTTGGGTAGCCTGAGAGTCCCCCTTACCAGTAGGGCTATCTGGTCT
ACCCCACTTTTCATTTTGTTCAGAAATAGTTGCAGATCTCGATAGAATCGAAACTCTTCTGCCT
CAAACACATACCTTGGCATTGCACTGTTAGCATTTAACTTCTTGTTACGATTCAGGGAAGGGAC
AATTGATCGAAGATTTTTTTTTTCGAACAGGCCAACCACCTATGTAATAATTAATAGGATTCAC
CTAAAAAATAATAATAATTCGGTGCACACAGACTGACCTGAAACCTGGGTGCTAAACTAAAAGA
AAACAAAAGTTCCAGTTGTCGTCTCTCATCCACACTTTCCAATTCATTTCTTCTAAATAAACAA
TTTCCTATTCTGGTTAGGAAGTGACATGTTAATGCTTTGCTCCCTGAAGGGGGAAGGGAAGTCT
ATTCCTTCACAGACATTTCTGTTTTGTATCAGCTGGTTTTTGTAGCAAGAAACTATATGAAGTC
AAACTTCCAGATACATTATCACAGTCCAGGGGATGAAGAAAGGAAAAGAGAAAAATACAACTCC
TTTCTGGTTTTTGTTCTTTTGAAGGAAGAGGGTTCACATTGTAGACATTGCTCTCTGCTCCAAA
TACGGTGAGGGGGTCCCAGAGGGCAGGCGCCTCCTGGAGTCAGATCTTTTTGATGATGCTGATC
TCAACATTTTGTTTTTGCTTTATGGGAAACTAGTAAAACAAGACAGGTTGTCCCATGTGTATAA
AATACAGGGCAGCTATTTCCTTTTCTTTGCTAAGAATGATCCTTTGGGCTTGGAAAGGCCCTCT
GGTTTGAACAGAAGGAGTAAATGGGCAATAAGCCAAAAGCCAGGATGATATACATACAAACAGC
TCTCTGTCCCAATACGCACCTTGTATTTATTAAGGAAAATGTCACATTGTGATGTATCAAGCCA
GTACTTCAATTACGGGTCAATGGGATGACATGTTACATGCTGTAGTTTAACATTTATAATTTTA
TTCCCCTGTTTTGAGTATATCTGTCCCTGGAATAACCTTTTATTTGGCTCTCTCTAGATAGCCT
TATTTGATTTCGAGTGGCAAAATGTTTTCCTTTTGTATTCTGGCTTTTTTATTGCTGTATGATA
CAGAACTCTTTTGGCATAAATATTTGTGTTCCCAGTACCTCAGTCATTTGGGTTTTACTGCTTG
CATATGTTTTGTGAAATGGTCCTGTTTTTGGGTAGGTAACACGTGGACTCTAGTATGTAAATGT
TACTTGAATCTGTGCTTCACTCTCGTATGTGGCATGTGTGTGCGGACTCTTGGATGCTTCACGC
CTACTCCACTGGAGCCCCTGTCCCCAGGAGGGCAGCTTCCCCATTGATAATCAGGGGACAAAGC
TGCCATGGATTTACCCTTGATTCTATTTTGATAATGGAAGATACAGAGAAAGGGTTTTTACATT
CAGAAGATGGTGCTGTGGCAAGAAGGACCTTTTATCTTCCCTCTCCCCTGTTTTTAAAGTCCTG
GGTGGGAGGAAAGATTGGTAACATGCATGATGGGGACTAATGGCCTCTGGTGCTTTGTCCTGTA
TTTGGTTTAATGTTTTTGTCCTAATCTCTTCAATCAATAAAATTGTGCGTATTTAACTAAAAAA
AAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039112192 ⟹ XP_038968120

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	44,274,762 - 44,299,139 (-)	NCBI
mRatBN7.2	6	38,545,971 - 38,570,349 (-)	NCBI

RefSeq Acc Id:

XM_039112193 ⟹ XP_038968121

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	44,277,015 - 44,299,111 (-)	NCBI
mRatBN7.2	6	38,548,183 - 38,570,318 (-)	NCBI

RefSeq Acc Id:

XM_039112194 ⟹ XP_038968122

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	44,280,915 - 44,299,111 (-)	NCBI
mRatBN7.2	6	38,552,129 - 38,570,318 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101485	(Get FASTA)	NCBI Sequence Viewer
	XP_038968120	(Get FASTA)	NCBI Sequence Viewer
	XP_038968121	(Get FASTA)	NCBI Sequence Viewer
	XP_038968122	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68939	(Get FASTA)	NCBI Sequence Viewer
	EDM03126	(Get FASTA)	NCBI Sequence Viewer
	EDM03127	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005774
	ENSRNOP00000005774.6

RefSeq Acc Id:

NP_001101485 ⟸ NM_001108015

- UniProtKB:

A0A8J8XB91 (UniProtKB/TrEMBL), A6HAS1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAY
ILRGDDDSLSDKHGCPAYVSPEILNTNGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFS
KIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSGFGAKEACDQL
VPDVNMEENLDPFFN

hide sequence

RefSeq Acc Id:

ENSRNOP00000005774 ⟸ ENSRNOT00000005774

RefSeq Acc Id:	XP_038968120 ⟸ XM_039112192
- Peptide Label:	isoform X1
- UniProtKB:	A0A8J8XB91 (UniProtKB/TrEMBL), A6HAS1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968121 ⟸ XM_039112193
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038968122 ⟸ XM_039112194
- Peptide Label:	isoform X2

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DF61-F1-model_v2	AlphaFold	B5DF61	1-207	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564451	AgrOrtholog
BioCyc Gene	G2FUF-38080	BioCyc
Ensembl Genes	ENSRNOG00000004110	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005774	ENTREZGENE
	ENSRNOT00000005774.8	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Tribbles/Ser_Thr_kinase_40	UniProtKB/TrEMBL
KEGG Report	rno:313974	UniProtKB/TrEMBL
NCBI Gene	313974	ENTREZGENE
PANTHER	PTHR22961	UniProtKB/TrEMBL
	TRIBBLES HOMOLOG 2	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Trib2	PhenoGen
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004110	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8J8XB91	ENTREZGENE, UniProtKB/TrEMBL
	A6HAS1	ENTREZGENE, UniProtKB/TrEMBL
	B5DF61_RAT	UniProtKB/TrEMBL
UniProt Secondary	G3V6J6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Trib2	tribbles pseudokinase 2	LOC108351208	uncharacterized LOC108351208	Data merged from RGD:11402704	737654	PROVISIONAL
2016-08-02	LOC108351208	uncharacterized LOC108351208			Symbol and Name status set to provisional	70820	PROVISIONAL
2015-07-29	Trib2	tribbles pseudokinase 2	LOC690207	hypothetical protein LOC690207	Data merged from RGD:1582901	737654	PROVISIONAL
2013-11-11	Trib2	tribbles pseudokinase 2	Trib2	tribbles homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Trib2	tribbles homolog 2 (Drosophila)	RGD1564451_predicted	similar to Tribbles homolog 2 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC690207	hypothetical protein LOC690207	LOC686423	hypothetical protein LOC686423	Data merged from RGD:1597661	1643240	APPROVED
2006-11-20	LOC686423	hypothetical protein LOC686423			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC690207	hypothetical protein LOC690207			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-07	RGD1564451_predicted	similar to Tribbles homolog 2 (predicted)	LOC313974	similar to Tribbles homolog 2	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC313974	similar to Tribbles homolog 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar