Trib2 (tribbles pseudokinase 2) - Rat Genome Database

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Gene: Trib2 (tribbles pseudokinase 2) Chinchilla lanigera
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Symbol: Trib2
Name: tribbles pseudokinase 2
RGD ID: 9058565
Description: ENCODES a protein that exhibits nucleotide binding (ortholog); protein kinase activity (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN negative regulation of fat cell differentiation (ortholog); negative regulation of interleukin-10 production (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tribbles homolog 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554876,890,246 - 6,915,135 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554876,889,571 - 6,915,068 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Trib2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554876,890,246 - 6,915,135 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554876,889,571 - 6,915,068 (+)NCBIChiLan1.0ChiLan1.0
TRIB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38212,716,936 - 12,742,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl212,716,910 - 12,742,734 (+)EnsemblGRCh38hg38GRCh38
GRCh37212,857,062 - 12,882,860 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36212,774,659 - 12,800,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 34212,807,805 - 12,833,454NCBI
Celera212,773,761 - 12,799,625 (+)NCBICelera
Cytogenetic Map2p24.3NCBI
HuRef212,706,690 - 12,732,553 (+)NCBIHuRef
CHM1_1212,786,401 - 12,812,238 (+)NCBICHM1_1
T2T-CHM13v2.0212,746,001 - 12,771,799 (+)NCBIT2T-CHM13v2.0
Trib2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391215,841,726 - 15,866,963 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1215,841,728 - 15,866,923 (-)EnsemblGRCm39 Ensembl
GRCm381215,791,725 - 15,816,962 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1215,791,727 - 15,816,922 (-)EnsemblGRCm38mm10GRCm38
MGSCv371215,798,533 - 15,823,591 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361215,817,277 - 15,842,335 (-)NCBIMGSCv36mm8
Celera1216,119,723 - 16,144,805 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map127.25NCBI
Trib2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8644,274,762 - 44,299,139 (-)NCBIGRCr8
mRatBN7.2638,545,971 - 38,570,349 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl638,545,975 - 38,569,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx638,866,451 - 38,890,817 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0639,181,120 - 39,205,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0638,614,428 - 38,638,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0641,016,722 - 41,040,972 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl641,016,730 - 41,039,437 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0649,774,728 - 49,799,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4639,474,243 - 39,496,718 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera637,860,540 - 37,883,149 (-)NCBICelera
Cytogenetic Map6q16NCBI
TRIB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212113,781,541 - 113,807,406 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A113,786,011 - 113,811,364 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A12,705,043 - 12,730,932 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A12,847,631 - 12,873,499 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A12,847,631 - 12,873,499 (+)Ensemblpanpan1.1panPan2
TRIB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1179,225,598 - 9,251,826 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl179,226,017 - 9,249,821 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha179,159,625 - 9,182,294 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0179,331,314 - 9,357,639 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl179,331,347 - 9,420,050 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1179,221,427 - 9,244,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0179,220,767 - 9,243,473 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0179,240,169 - 9,263,855 (+)NCBIUU_Cfam_GSD_1.0
Trib2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629253,599,159 - 53,622,876 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365328,354,205 - 8,377,924 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3124,172,098 - 124,196,210 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13124,170,677 - 124,196,253 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23132,790,605 - 132,816,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRIB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11494,887,152 - 94,913,219 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604517,401,176 - 17,427,297 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trib2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248653,475,141 - 3,503,783 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248653,477,831 - 3,503,783 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000003286   ⟹   ENSCLAP00000003222
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554876,890,246 - 6,915,135 (+)Ensembl
RefSeq Acc Id: XM_005404436   ⟹   XP_005404493
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554876,890,235 - 6,915,068 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504382   ⟹   XP_013359836
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554876,890,202 - 6,915,068 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504383   ⟹   XP_013359837
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554876,889,571 - 6,915,068 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005404493 (Get FASTA)   NCBI Sequence Viewer  
  XP_013359836 (Get FASTA)   NCBI Sequence Viewer  
  XP_013359837 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000003222
  ENSCLAP00000003222.1
RefSeq Acc Id: XP_005404493   ⟸   XM_005404436
- UniProtKB: A0A8C2UST7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359837   ⟸   XM_013504383
- UniProtKB: A0A8C2UST7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359836   ⟸   XM_013504382
- UniProtKB: A0A8C2UST7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000003222   ⟸   ENSCLAT00000003286
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002309 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000003286 ENTREZGENE
  ENSCLAT00000003286.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Tribbles/Ser_Thr_kinase_40 UniProtKB/TrEMBL
NCBI Gene Trib2 ENTREZGENE
PANTHER PTHR22961 UniProtKB/TrEMBL
  TRIBBLES HOMOLOG 2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2UST7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Trib2  tribbles pseudokinase 2    tribbles homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED