Mt-co1 (mitochondrially encoded cytochrome c oxidase I) - Rat Genome Database

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Gene: Mt-co1 (mitochondrially encoded cytochrome c oxidase I) Rattus norvegicus
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Symbol: Mt-co1
Name: mitochondrially encoded cytochrome c oxidase I
RGD ID: 621871
Description: Predicted to enable heme binding activity and metal ion binding activity. Predicted to contribute to cytochrome-c oxidase activity. Involved in several processes, including response to copper ion; response to electrical stimulus; and response to hypoxia. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex III and mitochondrial respiratory chain complex IV. Predicted to be active in mitochondrion. Used to study hepatocellular carcinoma. Biomarker of Parkinsonism. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I); PARTICIPATES IN electron transport chain pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Co1; COI; Cox1; cytochrome c oxidase 1 mitochondrial; cytochrome c oxidase I, mitochondrial; cytochrome c oxidase subunit 1; cytochrome c oxidase subunit I; mitochondrially encoded cytochrome c oxidase 1; Mt-coi; mt_Co1
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT5,323 - 6,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT5,323 - 6,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT5,323 - 6,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT5,323 - 6,867 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT5,323 - 6,867 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT5,323 - 6,867 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT5,323 - 6,867 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT5,323 - 6,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-carnitine  (ISO)
(S)-nicotine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamiprid  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
Aflatoxin G2  (ISO)
aldehydo-D-glucose  (EXP)
Allylamine  (EXP)
alpha-D-galactose  (EXP)
alpha-hexachlorocyclohexane  (EXP)
aminoguanidine  (EXP)
aristolochic acid A  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
beauvericin  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
chalcones  (ISO)
chloramphenicol  (ISO)
chlorogenic acid  (ISO)
clofibrate  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crotonaldehyde  (EXP)
D-glucose  (EXP)
dehydroepiandrosterone  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
dichloromethane  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
disulfiram  (EXP)
doxorubicin  (EXP,ISO)
enniatin  (ISO)
ethidium  (ISO)
folic acid  (ISO)
galactose  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP)
glyphosate  (ISO)
herbicide  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
hydroxytyrosol  (EXP)
ivermectin  (ISO)
kojic acid  (ISO)
lamivudine  (ISO)
lead nitrate  (EXP)
lenvatinib  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (EXP)
malathion  (ISO)
Mesaconitine  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
N-acetyl-L-cysteine  (EXP)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nicotinamide  (ISO)
nicotine  (EXP)
nitric oxide  (EXP)
O-acetyl-L-carnitine  (EXP)
ochratoxin A  (ISO)
Osajin  (ISO)
ozone  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
PhIP  (EXP)
picloram  (ISO)
pirinixic acid  (EXP)
Pomiferin  (ISO)
puerarin  (EXP,ISO)
pyrroloquinoline quinone  (ISO)
pyruvic acid  (EXP)
quercetin  (EXP)
rac-1,2-dichloropropane  (ISO)
resveratrol  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
sodium hydrogensulfite  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
tofacitinib  (ISO)
trichlopyr  (ISO)
trilobatin  (EXP)
tunicamycin  (ISO)
uridine  (ISO)
valproic acid  (EXP,ISO)
zalcitabine  (ISO)
zearalenone  (ISO)
zidovudine  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. RNAs containing mitochondrial ND6 and COI sequences present an abnormal structure in chemically induced rat hepatomas. Corral M, etal., Nucleic Acids Res. 1989 Jul 11;17(13):5191-206.
2. The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates. Gadaleta G, etal., J Mol Evol 1989 Jun;28(6):497-516.
3. Mitochondrial DNA fragments released through the permeability transition pore correspond to specific gene size. Garcia N and Chavez E, Life Sci. 2007 Sep 15;81(14):1160-6. Epub 2007 Aug 28.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Age-associated changes in mitochondrial mRNA expression and translation in the Wistar rat heart. Hudson EK, etal., Mech Ageing Dev. 1998 Jun 15;103(2):179-93.
6. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. Huttemann M, etal., Gene 2003 Jul 17;312:95-102.
7. Cardiac cytochrome C oxidase activity and contents of subunits 1 and 4 are altered in offspring by low prenatal copper intake by rat dams. Johnson WT and Anderson CM, J Nutr. 2008 Jul;138(7):1269-73.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Non-random patterns of nucleotide substitutions and codon strategy in the mammalian mitochondrial genes coding for identified and unidentified reading frames. Pepe G, etal., Biochem Int 1983 Apr;6(4):553-63.
12. Content of mitochondrial DNA and of three mitochondrial RNAs in developing and adult rat cerebellum. Renis M, etal., J Neurochem. 1989 Mar;52(3):750-4.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Metabolic activity of cerebellar and basal ganglia-thalamic neurons is reduced in parkinsonism. Rolland AS, etal., Brain. 2007 Jan;130(Pt 1):265-75.
18. Tissue-specific regulation of cytochrome c oxidase subunit expression by thyroid hormone. Sheehan TE, etal., Am J Physiol Endocrinol Metab 2004 Jun;286(6):E968-74. Epub 2004 Feb 17.
19. Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata. Tai CH, etal., FASEB J. 2003 Oct;17(13):1820-30.
20. Up-regulation of cytochrome oxidase in the retina following optic nerve injury. Wang AG, etal., Exp Eye Res. 2002 May;74(5):651-9.
21. WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARĪ± pathway. Yan J, etal., Life Sci. 2021 Feb 1;266:118888. doi: 10.1016/j.lfs.2020.118888. Epub 2020 Dec 10.
Additional References at PubMed
PMID:12506326   PMID:17429720   PMID:18198996   PMID:18456673   PMID:19087623   PMID:24058566   PMID:25107896   PMID:26316108   PMID:35326380  


Genomics

Comparative Map Data
Mt-co1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT5,323 - 6,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT5,323 - 6,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT5,323 - 6,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT5,323 - 6,867 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT5,323 - 6,867 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT5,323 - 6,867 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT5,323 - 6,867 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT5,323 - 6,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI
MT-CO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38MT5,904 - 7,445 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblMT5,904 - 7,445 (+)EnsemblGRCh38hg38GRCh38
GRCh37MT5,904 - 7,445 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36MT5,905 - 7,446 (+)NCBINCBI36Build 36hg18NCBI36
mt-Co1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39MT5,328 - 6,872 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblMT5,328 - 6,872 (+)EnsemblGRCm39 Ensembl
GRCm38MT5,328 - 6,872 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblMT5,328 - 6,872 (+)EnsemblGRCm38mm10GRCm38
MGSCv37MT5,328 - 6,872 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MT-CO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1MT5,349 - 6,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblMT5,349 - 6,893 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaMT5,349 - 6,893 (+)NCBIDog10K_Boxer_Tasha
MT-CO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblMT6,511 - 8,055 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1MT6,511 - 8,055 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2MT6,511 - 8,055 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mt-co1
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:9
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000050156
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3 43 57 41 19 41 8 11 74 35 41 11 8
Medium
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000050156   ⟹   ENSRNOP00000039048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblMT5,323 - 6,867 (+)Ensembl
Rnor_6.0 EnsemblMT5,323 - 6,867 (+)Ensembl
RefSeq Acc Id: ENSRNOP00000039048   ⟸   ENSRNOT00000050156
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05503-F1-model_v2 AlphaFold P05503 1-514 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621871 AgrOrtholog
BioCyc Gene G2FUF-22 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000034234 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050156.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.210.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_c_oxase-like_su1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxase-like_su1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_C_Oxase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_Oxase_su1_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxase_su1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26195 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26195 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10422 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mt-co1 PhenoGen
PRINTS CYCOXIDASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE COX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COX1_CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034234 RatGTEx
Superfamily-SCOP SSF81442 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt COX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q06QA9 ENTREZGENE, UniProtKB/TrEMBL
  Q06QK0 ENTREZGENE, UniProtKB/TrEMBL
  Q8HIC9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Mt-co1  mitochondrially encoded cytochrome c oxidase I  Mt-co1  mitochondrially encoded cytochrome c oxidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-12-02 Mt-co1  mitochondrially encoded cytochrome c oxidase 1  Mt-co1  mitochondrially encoded cytochrome c oxidase I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-09-05 Mt-co1  mitochondrially encoded cytochrome c oxidase I  Mt-coi  mitochondrially encoded cytochrome c oxidase I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-27 Mt-coi  mitochondrially encoded cytochrome c oxidase I  Mt-co1  mitochondrially encoded cytochrome c oxidase I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Mt-co1  mitochondrially encoded cytochrome c oxidase I  mt-Co1  cytochrome c oxidase I, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Krt1-9  cytochrome c oxidase I, mitochondrial  mt-Co1  cytochrome c oxidase subunit 1  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 mt-Co1  cytochrome c oxidase subunit 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein one of the three mitochondrial coded subunits, among the 13 subunits of each COX monomer 724423