Enables protein kinase binding activity. Involved in positive regulation of endothelial cell proliferation and regulation of phosphorylation. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1); PARTICIPATES IN mTOR signaling pathway; insulin signaling pathway; INTERACTS WITH bafilomycin A1; bisphenol A; carbon disulfide.
Diamide inhibits the reaction [MTOR protein binds to RPTOR protein] and RPTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of RPTOR mRNA
[bisphenol S co-treated with Fulvestrant] results in increased methylation of RPTOR gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of RPTOR mRNA
[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of RPTOR mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of RPTOR mRNA
[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of RPTOR mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of RPTOR mRNA
bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
[Resveratrol results in increased abundance of Calcium] which results in increased activity of RPTOR protein modified form and dorsomorphin inhibits the reaction [[Resveratrol results in increased abundance of Calcium] which results in increased activity of RPTOR protein modified form]
[Resveratrol results in increased abundance of Calcium] which results in increased activity of RPTOR protein modified form and dorsomorphin inhibits the reaction [[Resveratrol results in increased abundance of Calcium] which results in increased activity of RPTOR protein modified form]
cobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein] and ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein]]
[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased phosphorylation of RPTOR protein and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of RPTOR mRNA
dorsomorphin inhibits the reaction [[Resveratrol results in increased abundance of Calcium] which results in increased activity of RPTOR protein modified form]
dorsomorphin inhibits the reaction [[14-deoxy-11 and 12-didehydroandrographolide co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RPTOR protein]
dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
[bisphenol A co-treated with Fulvestrant] results in increased methylation of RPTOR gene and [bisphenol S co-treated with Fulvestrant] results in increased methylation of RPTOR gene
ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein]] and ginsenoside Rg1 results in increased activity of [MTOR protein binds to RAPTOR protein]
[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased phosphorylation of RPTOR protein
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of RPTOR mRNA
[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased phosphorylation of RPTOR protein
[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of RPTOR protein and PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of RPTOR protein]
[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of RPTOR protein and PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of RPTOR protein]
bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]] more ...
Orotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein] and Sirolimus inhibits the reaction [Orotic Acid results in decreased phosphorylation of RPTOR protein]
[Resveratrol results in increased abundance of Calcium] which results in increased activity of RPTOR protein modified form and dorsomorphin inhibits the reaction [[Resveratrol results in increased abundance of Calcium] which results in increased activity of RPTOR protein modified form]
[Sirolimus inhibits the reaction [MTOR protein binds to RPTOR protein]] which results in increased expression of MAP1LC3A protein alternative form more ...
1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1 and 6)naphthyridin-2(1H)-one inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein]
Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer.
Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites.
