Sftpc (surfactant protein C) - Rat Genome Database

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Gene: Sftpc (surfactant protein C) Rattus norvegicus
Symbol: Sftpc
Name: surfactant protein C
RGD ID: 3666
Description: Enables identical protein binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in alveolar lamellar body; extracellular space; and multivesicular body. Biomarker of bacterial pneumonia and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C); INTERACTS WITH 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil; all-trans-retinol.
Type: protein-coding
Previously known as: pulmonary surfactant-associated protein C; pulmonary surfactant-associated proteolipid SPL(Val); SP-C; surfactant associated protein C; Surfactant pulmonary-associated protein C; Surfactant, pulmonary-associated protein C
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81552,006,274 - 52,009,324 (-)NCBIGRCr8
mRatBN7.21545,596,565 - 45,599,615 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,596,574 - 45,610,777 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,714,437 - 49,717,379 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,825,943 - 50,828,885 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,685,234 - 47,688,176 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,211,538 - 52,214,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,211,544 - 52,214,616 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,935,055 - 55,937,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,923,105 - 50,926,047 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,938,884 - 50,941,827 (-)NCBI
Celera1545,274,971 - 45,277,913 (-)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bleomycin A2  (EXP)
bosentan  (EXP)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
colforsin daropate hydrochloride  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
fonofos  (ISO)
ionomycin  (EXP,ISO)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
mercaptopurine  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-5'-carboxamidoadenosine  (EXP,ISO)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP,ISO)
ozone  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
protein kinase inhibitor  (EXP)
purine-6-thiol  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
resveratrol  (ISO)
Ro 31-8220  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
silicon carbide  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium chlorate  (EXP)
terbufos  (ISO)
terbutaline  (EXP,ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
tubocurarine  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
vitamin D  (ISO)
wortmannin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Surfactant protein deficiency in familial interstitial lung disease. Amin RS, etal., J Pediatr. 2001 Jul;139(1):85-92.
2. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. Atochina EN, etal., J Lab Clin Med. 2001 Jun;137(6):429-39.
3. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. Atochina EN, etal., Respir Res. 2003 Dec 8;4:15. Print 2003.
4. Two novel mutations in surfactant protein-C, lung function and obstructive lung disease. Baekvad-Hansen M, etal., Respir Med. 2010 Mar;104(3):418-25. Epub 2009 Nov 11.
5. Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes. Brasch F, etal., Am J Respir Cell Mol Biol 2002 Jun;26(6):659-70.
6. A common mutation in the surfactant protein C gene associated with lung disease. Cameron HS, etal., J Pediatr. 2005 Mar;146(3):370-5.
7. Mild vitamin A deficiency delays fetal lung maturation in the rat. Chailley-Heu B, etal., Am J Respir Cell Mol Biol. 1999 Jul;21(1):89-96.
8. Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma. Erpenbeck VJ, etal., Allergy. 2006 May;61(5):598-604.
9. Dynamic investigation of alveolar type II cell function in a long-term survival model of rat lung ischemia-reperfusion injury. Feng D, etal., Scand J Clin Lab Invest. 2010 Sep;70(5):364-73.
10. Nucleotide and deduced amino acid sequence of the hydrophobic surfactant protein SP-C from rat: expression in alveolar type II cells and homology with SP-C from other species. Fisher JH, etal., Biochim Biophys Acta 1989 May 1;995(3):225-30.
11. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Fujita M, etal., Cytokine. 2005 Jul 7;31(1):25-33.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Glasser SW, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72. Epub 2009 Mar 20.
14. Pneumonitis and emphysema in sp-C gene targeted mice. Glasser SW, etal., J Biol Chem. 2003 Apr 18;278(16):14291-8. Epub 2003 Jan 7.
15. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. Glasser SW, etal., J Immunol. 2008 Jul 1;181(1):621-8.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Regulation of SP-B and SP-C secretion in rat type II cells in primary culture. Gobran LI and Rooney SA, Am J Physiol Lung Cell Mol Physiol 2001 Dec;281(6):L1413-9.
18. Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Griese M, etal., Am J Respir Crit Care Med. 2004 Nov 1;170(9):1000-5. Epub 2004 Jul 21.
19. New surfactant protein C gene mutations associated with diffuse lung disease. Guillot L, etal., J Med Genet. 2009 Jul;46(7):490-4. Epub 2009 May 13.
20. Continuous mechanical contraction modulates expression of alveolar epithelial cell phenotype. Gutierrez JA, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):81-7. Epub 2003 Jan 31.
21. Defective surfactant secretion in a mouse model of Hermansky-Pudlak syndrome. Guttentag SH, etal., Am J Respir Cell Mol Biol. 2005 Jul;33(1):14-21. Epub 2005 Mar 24.
22. Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice. Haczku A, etal., Am J Respir Cell Mol Biol. 2001 Jul;25(1):45-50.
23. Effects of rSP-C surfactant on oxygenation and histology in a rat-lung-lavage model of acute lung injury. Hafner D, etal., Am J Respir Crit Care Med. 1998 Jul;158(1):270-8.
24. Comparison of rSP-C surfactant with natural and synthetic surfactants after late treatment in a rat model of the acute respiratory distress syndrome. Hafner D, etal., Br J Pharmacol. 1998 Jul;124(6):1083-90.
25. Lung epithelium is the major source of IL-33 and is regulated by IL-33-dependent and IL-33-independent mechanisms in pulmonary cryptococcosis. Heyen L, etal., Pathog Dis. 2016 Oct;74(7). pii: ftw086. doi: 10.1093/femspd/ftw086. Epub 2016 Sep 4.
26. Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury. Ikegami M, etal., J Appl Physiol. 2002 Feb;92(2):519-26.
27. Effects of intrauterine IL-6 and IL-8 on the expression of surfactant apoprotein mRNAs in the fetal rat lung. Ikegami T, etal., Eur J Obstet Gynecol Reprod Biol. 2000 Nov;93(1):97-103.
28. Circadian rhythm of surfactant protein A, B and C mRNA in rats. Kim CM, etal., Korean J Intern Med. 2003 Jun;18(2):76-82.
29. Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Lawson WE, etal., Am J Pathol. 2005 Nov;167(5):1267-77.
30. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. Lee JW, etal., Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L950-7. Epub 2005 Jan 7.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residues. Mulugeta S and Beers MF, J Biol Chem. 2003 Nov 28;278(48):47979-86. Epub 2003 Aug 21.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. A mutation in the surfactant protein C gene associated with familial interstitial lung disease. Nogee LM, etal., N Engl J Med. 2001 Feb 22;344(8):573-9.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Surfactant protein composition of lamellar bodies isolated from rat lung. Oosterlaken-Dijksterhuis MA, etal., Biochem J. 1991 Feb 15;274 ( Pt 1):115-9.
37. Antagonistic effects of dexamethasone and retinoic acid on rat lung morphogenesis. Oshika E, etal., Pediatr Res. 1998 Mar;43(3):315-24.
38. Differential effects of halothane and thiopental on surfactant protein C messenger RNA in vivo and in vitro in rats. Paugam-Burtz C, etal., Anesthesiology. 2000 Sep;93(3):805-10.
39. Haplotypes of surfactant protein C are associated with common paediatric lung diseases. Puthothu B, etal., Pediatr Allergy Immunol. 2006 Dec;17(8):572-7.
40. Differential effects in vivo of thyroid hormone on the expression of surfactant phospholipid, surfactant protein mRNA and antioxidant enzyme mRNA in fetal rat lung. Ramadurai SM, etal., Exp Lung Res. 1998 Sep-Oct;24(5):641-57.
41. Glucose decreases steady state mRNA content of hydrophobic surfactant proteins B and C in fetal rat lung explants. Rayani HH, etal., Exp Lung Res. 1999 Jan-Feb;25(1):69-79.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Comprehensive gene review and curation RGD comprehensive gene curation
46. Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia. Russo TA, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L655-63.
47. Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C. Savani RC, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L685-96.
48. Measles immunity. Report of countywide school survey. Schell HB and Abruzzo TC, N Y State J Med 1977 Nov;77(13):2095-6.
49. Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration. Schmidt R, etal., Respir Res. 2007 Jul 27;8:55.
50. Distribution of surfactant proteins in type II pneumocytes of newborn, 14-day old, and adult rats: an immunoelectron microscopic and stereological study. Schmiedl A, etal., Histochem Cell Biol. 2005 Dec;124(6):465-76. Epub 2005 Sep 27.
51. Clinical features and genetic analysis of surfactant protein C in adult-onset familial interstitial pneumonia. Setoguchi Y, etal., Respirology. 2006 Jan;11 Suppl:S41-5.
52. [Genetic basis in chronic interstitial familial pneumopathy. Familial study of SFTPC] Somaschini M, etal., Pediatr Med Chir. 2005 May-Aug;27(3-4):103-7.
53. Overexpression of surfactant protein SP-A, SP-B, and SP-C mRNA in rat lungs with lipopolysaccharide-induced injury. Sugahara K, etal., Lab Invest. 1996 Jan;74(1):209-20.
54. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
55. [Polymorphic variants of a surfactant protein C gene in patients with chronic obstructive pulmonary disease]. Tsvetkova OA and Veselovskaia MV, Ter Arkh. 2007;79(9):65-9.
56. SFTPC Mutations are the Basis of a Significant Portion of Adult Familial Pulmonary Fibrosis in a Dutch Cohort. van Moorsel CH, etal., Am J Respir Crit Care Med. 2010 Jul 23.
57. Surfactant protein C: hormonal control of SP-C mRNA levels in vitro. Veletza SV, etal., Am J Physiol. 1992 Jun;262(6 Pt 1):L684-7.
58. Aberrant processing of surfactant protein C in hereditary SP-B deficiency. Vorbroker DK, etal., Am J Physiol. 1995 Apr;268(4 Pt 1):L647-56.
59. Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain. Wang WJ, etal., J Biol Chem. 2002 May 31;277(22):19929-37. Epub 2002 Mar 20.
60. Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia. White CW, etal., Am J Respir Cell Mol Biol. 2001 Jul;25(1):51-9.
61. KGF regulates pulmonary epithelial proliferation and surfactant protein gene expression in adult rat lung. Yano T, etal., Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1146-58.
Additional References at PubMed
PMID:8813084   PMID:9006067   PMID:12477932   PMID:12904592   PMID:16794256   PMID:18239190   PMID:21169555   PMID:24191021   PMID:25416956   PMID:25910212   PMID:27155084   PMID:30341519  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81552,006,274 - 52,009,324 (-)NCBIGRCr8
mRatBN7.21545,596,565 - 45,599,615 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,596,574 - 45,610,777 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,714,437 - 49,717,379 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,825,943 - 50,828,885 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,685,234 - 47,688,176 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,211,538 - 52,214,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,211,544 - 52,214,616 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,935,055 - 55,937,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,923,105 - 50,926,047 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,938,884 - 50,941,827 (-)NCBI
Celera1545,274,971 - 45,277,913 (-)NCBICelera
Cytogenetic Map15p11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38822,157,383 - 22,164,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,156,913 - 22,164,479 (+)EnsemblGRCh38hg38GRCh38
GRCh37822,014,896 - 22,021,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,075,129 - 22,077,937 (+)NCBINCBI36Build 36hg18NCBI36
Build 34822,075,112 - 22,077,928NCBI
Celera820,981,168 - 20,983,976 (+)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,561,488 - 20,564,296 (+)NCBIHuRef
CHM1_1822,220,843 - 22,223,651 (+)NCBICHM1_1
T2T-CHM13v2.0822,431,328 - 22,438,424 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391470,758,381 - 70,761,521 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,758,389 - 70,761,521 (-)EnsemblGRCm39 Ensembl
GRCm381470,520,941 - 70,524,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,520,949 - 70,524,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv371470,920,748 - 70,923,888 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,256,020 - 69,259,150 (-)NCBIMGSCv36mm8
Celera1468,062,491 - 68,065,631 (-)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540345,649,122 - 45,651,837 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,649,149 - 45,651,421 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2740,658,965 - 40,666,346 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,384,149 - 16,391,532 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,402,060 - 21,409,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,343,007 - 18,348,764 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,345,940 - 18,348,764 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12535,088,295 - 35,090,995 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,088,279 - 35,091,457 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,677,864 - 35,680,614 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,299,616 - 35,302,366 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,299,694 - 35,302,250 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,245,093 - 35,247,843 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02535,099,613 - 35,102,363 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,255,134 - 35,257,884 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494312,588,481 - 12,596,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,979,417 - 5,982,011 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365555,966,610 - 5,982,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl146,440,309 - 6,443,095 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,440,309 - 6,443,104 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,868,096 - 6,880,564 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1820,229,756 - 20,233,568 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,230,870 - 20,234,020 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605222,002,517 - 22,009,591 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475817,742,415 - 17,744,655 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,742,439 - 17,744,664 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Sftpc
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:80
Interacting mature miRNAs:84
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,596,780 - 45,596,906 (+)MAPPERmRatBN7.2
Rnor_6.01552,211,751 - 52,211,876NCBIRnor6.0
Rnor_5.01555,935,268 - 55,935,393UniSTSRnor5.0
RGSC_v3.41550,923,318 - 50,923,443UniSTSRGSC3.4
Celera1545,275,184 - 45,275,309UniSTS
Cytogenetic Map15p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,597,955 - 45,598,125 (+)MAPPERmRatBN7.2
Rnor_6.01552,212,926 - 52,213,095NCBIRnor6.0
Rnor_5.01555,936,443 - 55,936,612UniSTSRnor5.0
RGSC_v3.41550,924,493 - 50,924,662UniSTSRGSC3.4
Celera1545,276,359 - 45,276,528UniSTS
Cytogenetic Map15p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,598,632 - 45,598,824 (+)MAPPERmRatBN7.2
Rnor_6.01552,213,603 - 52,213,794NCBIRnor6.0
Rnor_5.01555,937,120 - 55,937,311UniSTSRnor5.0
RGSC_v3.41550,925,170 - 50,925,361UniSTSRGSC3.4
Celera1545,277,036 - 45,277,227UniSTS
Cytogenetic Map15p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,596,682 - 45,596,873 (+)MAPPERmRatBN7.2
Rnor_6.01552,211,653 - 52,211,843NCBIRnor6.0
Rnor_5.01555,935,170 - 55,935,360UniSTSRnor5.0
RGSC_v3.41550,923,220 - 50,923,410UniSTSRGSC3.4
Celera1545,275,086 - 45,275,276UniSTS
Cytogenetic Map15p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,597,866 - 45,598,233 (+)MAPPERmRatBN7.2
Rnor_6.01552,212,837 - 52,213,203NCBIRnor6.0
Rnor_5.01555,936,354 - 55,936,720UniSTSRnor5.0
RGSC_v3.41550,924,404 - 50,924,770UniSTSRGSC3.4
Celera1545,276,270 - 45,276,636UniSTS
Cytogenetic Map15p11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 11
Medium 1 1 1 1 3 4 2 5 3
Low 1 8 24 8 15 8 5 5 13 9 21 5
Below cutoff 2 7 1 1 3 1 6 1 6


RefSeq Acc Id: ENSRNOT00000015035   ⟹   ENSRNOP00000015032
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,596,574 - 45,599,692 (-)Ensembl
Rnor_6.0 Ensembl1552,211,544 - 52,214,616 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099545   ⟹   ENSRNOP00000086489
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,596,574 - 45,598,662 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119173   ⟹   ENSRNOP00000093629
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,596,574 - 45,610,777 (-)Ensembl
RefSeq Acc Id: NM_017342   ⟹   NP_059038
Rat AssemblyChrPosition (strand)Source
GRCr81552,006,277 - 52,009,219 (-)NCBI
mRatBN7.21545,596,568 - 45,599,512 (-)NCBI
Rnor_6.01552,211,538 - 52,214,480 (-)NCBI
Rnor_5.01555,935,055 - 55,937,997 (-)NCBI
RGSC_v3.41550,923,105 - 50,926,047 (-)RGD
Celera1545,274,971 - 45,277,913 (-)RGD
RefSeq Acc Id: XM_039093609   ⟹   XP_038949537
Rat AssemblyChrPosition (strand)Source
GRCr81552,006,274 - 52,009,324 (-)NCBI
mRatBN7.21545,596,565 - 45,599,615 (-)NCBI
RefSeq Acc Id: NP_059038   ⟸   NM_017342
- UniProtKB: Q52MA6 (UniProtKB/Swiss-Prot),   P11685 (UniProtKB/Swiss-Prot),   A0A8I6A637 (UniProtKB/TrEMBL),   A6HTK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015032   ⟸   ENSRNOT00000015035
RefSeq Acc Id: XP_038949537   ⟸   XM_039093609
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093629   ⟸   ENSRNOT00000119173
RefSeq Acc Id: ENSRNOP00000086489   ⟸   ENSRNOT00000099545
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11685-F1-model_v2 AlphaFold P11685 1-194 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3666 AgrOrtholog
BioCyc Gene G2FUF-13213 BioCyc
Ensembl Genes ENSRNOG00000011177 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015035 ENTREZGENE
  ENSRNOT00000015035.5 UniProtKB/TrEMBL
  ENSRNOT00000099545.1 UniProtKB/TrEMBL
  ENSRNOT00000119173.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BRICHOS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SP-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SP-C_palmitoylation_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Surfactant_protein_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50683 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SP_C-Propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sftpc PhenoGen
RatGTEx ENSRNOG00000011177 RatGTEx
  SF_P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204886
  P11685 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q52MA6 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Sftpc  surfactant protein C  Sftpc  surfactant associated protein C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sftpc  Surfactant, pulmonary-associated protein C      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mediates biophysical functions of surfactant 628506
gene_regulation secretion is stimulated by b-adrenergic, adenosine A2B, and purinergic P2Y2 receptor agonists, and by TPA and ionomycin in isolated type II cells 628506
gene_regulation precursor protein undergoes N-terminal processing by cathepsin H 727636