Mmp7 (matrix metallopeptidase 7) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mmp7 (matrix metallopeptidase 7) Rattus norvegicus
Analyze
Symbol: Mmp7
Name: matrix metallopeptidase 7
RGD ID: 3100
Description: Enables heparin binding activity. Involved in several processes, including cellular response to mechanical stimulus; estrous cycle; and maternal process involved in female pregnancy. Located in cell surface and extracellular space. Used to study hypertension and prostate carcinoma. Biomarker of bladder neck obstruction; coronary restenosis; hypertension; prostate cancer; and renal hypertension. Orthologous to human MMP7 (matrix metallopeptidase 7); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: matrilysin; matrin; matrix metalloproteinase 7; Matrix metalloproteinase 7 (matrilysin); matrix metalloproteinase-7; MMP-7; MPMM; pump-1 protease; uterine metalloproteinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,133,043 - 13,140,761 (+)NCBIGRCr8
mRatBN7.284,848,186 - 4,855,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,848,186 - 4,855,902 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,808,955 - 8,816,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,106,740 - 7,114,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,107,859 - 5,115,573 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,893,253 - 5,900,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,893,249 - 5,901,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,895,393 - 5,903,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,526,018 - 4,533,730 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,526,033 - 4,533,729 (+)NCBI
Celera86,407,543 - 6,415,255 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 28 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp7RatAcute Lung Injury  IEP 9685338associated with SepsisRGD 
Mmp7Ratbladder neck obstruction treatmentIEP 7257549 RGD 
Mmp7RatBurns  IEP 9685358mRNA:increased expression:ileumRGD 
Mmp7RatCardiac Fibrosis  IEP 9685341associated with Heart FailureRGD 
Mmp7RatChronic Allograft Nephropathy treatmentIDA 9685339 RGD 
Mmp7Ratcoronary restenosis treatmentIEP 9685362 RGD 
Mmp7Ratendometrial cancer disease_progressionISOMMP7 (Homo sapiens)2298522protein:increased expression:endometriumRGD 
Mmp7Ratendometrial hyperplasia  ISOMMP7 (Homo sapiens)2298522protein:increased expression:endometriumRGD 
Mmp7RatExperimental Autoimmune Encephalomyelitis  IEP 8547909 RGD 
Mmp7RatExperimental Autoimmune Neuritis  IEP 9685357 RGD 
Mmp7RatExperimental Mammary Neoplasms onsetISOMmp7 (Mus musculus)9685350 RGD 
Mmp7Ratglioblastoma severityISOMMP7 (Homo sapiens)7207145protein:increased expression:brain (human)RGD 
Mmp7RatHearing Loss, Noise-Induced  ISOMmp7 (Mus musculus)9685340 RGD 
Mmp7Rathypertension  IEP 9685347 RGD 
Mmp7Rathypertension treatmentIMP 9685347 RGD 
Mmp7RatIntimal Hyperplasia  IEP 9685369 RGD 
Mmp7RatLung Neoplasms  ISOMMP7 (Homo sapiens)5129528mRNA:increased expression:lungRGD 
Mmp7Ratlung non-small cell carcinoma  ISOMMP7 (Homo sapiens)5129528mRNA:increased expression:lungRGD 
Mmp7Ratmyocardial infarction  ISOMmp7 (Mus musculus)1582373 RGD 
Mmp7RatOsteolysis  ISOMmp7 (Mus musculus)9685352associated with Prostatic NeoplasmsRGD 
1 to 20 of 28 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp7Ratasphyxiating thoracic dystrophy  ISOMMP7 (Homo sapiens)8554872ClinVar Annotator: match by term: Jeune thoracic dystrophyClinVarPMID:23339108 more ...
Mmp7Ratataxia telangiectasia  ISOMMP7 (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia syndromeClinVarPMID:23807571 more ...
Mmp7Ratintellectual disability  ISOMMP7 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp7RatColonic Neoplasms  ISOMMP7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15059925
Mmp7Ratpulmonary tuberculosis  ISOMMP7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24890593
Mmp7RatRecurrence  ISOMMP7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25596746
Mmp7RatSpontaneous Abortions  ISOMMP7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18539642
Mmp7RatStomach Neoplasms  ISOMMP7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25847246
Mmp7Ratureteral obstruction  ISOMMP7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28318631

1 to 20 of 217 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp7Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMMP7 (Homo sapiens)6480464Acetylcysteine inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein] more ...CTDPMID:17928719
Mmp7Rat(-)-epigallocatechin 3-gallate increases expressionISOMMP7 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of MMP7 proteinCTDPMID:17928719
Mmp7Rat(E)-thiamethoxam increases expressionISOMmp7 (Mus musculus)6480464Thiamethoxam results in increased expression of MMP7 mRNACTDPMID:33533595
Mmp7Rat(S)-nicotine multiple interactionsISOMmp7 (Mus musculus)6480464[Nicotine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Mmp7Rat(S)-nicotine increases expressionISOMMP7 (Homo sapiens)6480464Nicotine results in increased expression of MMP7 mRNA and Nicotine results in increased expression of MMP7 proteinCTDPMID:20061081 and PMID:25847246
Mmp7Rat(S)-nicotine affects response to substanceISOMMP7 (Homo sapiens)6480464MMP7 promoter SNP affects the susceptibility to NicotineCTDPMID:25847246
Mmp7Rat(S)-nicotine multiple interactionsISOMMP7 (Homo sapiens)6480464CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA] more ...CTDPMID:20061081 and PMID:25847246
Mmp7Rat1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of MMP7 mRNACTDPMID:27840820
Mmp7Rat1,2-dimethylhydrazine increases expressionISOMmp7 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of MMP7 mRNACTDPMID:22206623
Mmp7Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISOMmp7 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Mmp7Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOMmp7 (Mus musculus)6480464[Caffeine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Mmp7Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of MMP7 mRNACTDPMID:30723492
Mmp7Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of MMP7 mRNACTDPMID:17351261
Mmp7Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of MMP7 mRNACTDPMID:12655037 more ...
Mmp7Rat17alpha-ethynylestradiol increases expressionISOMMP7 (Homo sapiens)6480464Ethinyl Estradiol results in increased expression of MMP7 mRNACTDPMID:18936297
Mmp7Rat17beta-estradiol multiple interactionsISOMMP7 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in decreased expression of MMP7 mRNA and [Estradiol co-treated with Progesterone] results in decreased secretion of MMP7 proteinCTDPMID:16009159 and PMID:20660070
Mmp7Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of MMP7 mRNACTDPMID:26945725
Mmp7Rat17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with Plant Preparations] results in increased expression of MMP7 mRNA more ...CTDPMID:11375906 and PMID:26945725
Mmp7Rat17beta-estradiol increases expressionISOMmp7 (Mus musculus)6480464Estradiol results in increased expression of MMP7 mRNACTDPMID:15289156
Mmp7Rat17beta-estradiol increases secretionISOMMP7 (Homo sapiens)6480464Estradiol results in increased secretion of MMP7 proteinCTDPMID:16009159

1 to 20 of 217 rows

Biological Process
1 to 20 of 33 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp7Ratantibacterial peptide biosynthetic process acts_upstream_of_or_withinIEAUniProtKB:Q10738 and ensembl:ENSMUSP000000187671600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp7Ratantibacterial peptide biosynthetic process acts_upstream_of_or_withinISOMmp7 (Mus musculus)1624291 PMID:20056603RGDPMID:20056603
Mmp7Ratantibacterial peptide secretion acts_upstream_of_or_withinISOMmp7 (Mus musculus)1624291 PMID:11248802RGDPMID:11248802
Mmp7Ratantibacterial peptide secretion acts_upstream_of_or_withinIEAUniProtKB:Q10738 and ensembl:ENSMUSP000000187671600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp7Ratcellular response to mechanical stimulus  IEP 8547898 RGD 
Mmp7Ratcollagen catabolic process involved_inIBAMGI:101900 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mmp7Ratcollagen catabolic process involved_inIEAUniProtKB-KW:KW-01771600115GO_REF:0000043UniProtGO_REF:0000043
Mmp7Ratdefense response to bacterium acts_upstream_of_or_withinISOMmp7 (Mus musculus)1624291 PMID:11248802RGDPMID:11248802
Mmp7Ratdefense response to bacterium acts_upstream_of_or_withinIEAUniProtKB:Q10738 and ensembl:ENSMUSP000000187671600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp7Ratdefense response to Gram-negative bacterium acts_upstream_of_or_withinIEAUniProtKB:Q10738 and ensembl:ENSMUSP000000187671600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp7Ratdefense response to Gram-negative bacterium acts_upstream_of_or_withinISOMmp7 (Mus musculus)1624291 PMID:11248802RGDPMID:11248802
Mmp7Ratdefense response to Gram-positive bacterium acts_upstream_of_or_withinISOMmp7 (Mus musculus)1624291 PMID:11248802RGDPMID:11248802
Mmp7Ratdefense response to Gram-positive bacterium acts_upstream_of_or_withinIEAUniProtKB:Q10738 and ensembl:ENSMUSP000000187671600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp7Ratestrous cycle  IEP 9685349 RGD 
Mmp7Ratextracellular matrix organization involved_inIBAFB:FBgn0033438 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mmp7Ratmaternal process involved in female pregnancy  IEP 9685360 RGD 
Mmp7Ratmembrane protein ectodomain proteolysis acts_upstream_of_or_withinISOMMP7 (Homo sapiens)1624291 PMID:23437250RGDPMID:23437250
Mmp7Ratmembrane protein ectodomain proteolysis acts_upstream_of_or_withinIEAUniProtKB:P09237 and ensembl:ENSP000002602271600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp7Ratmembrane protein intracellular domain proteolysis acts_upstream_of_or_withinISOMMP7 (Homo sapiens)1624291 PMID:23437250RGDPMID:23437250
Mmp7Ratmembrane protein intracellular domain proteolysis acts_upstream_of_or_withinIEAUniProtKB:P09237 and ensembl:ENSP000002602271600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 33 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp7Ratcell surface  IDA 9685351 RGD 
Mmp7Ratextracellular matrix located_inIEAInterPro:IPR001818 and InterPro:IPR0211581600115GO_REF:0000002InterProGO_REF:0000002
Mmp7Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Mmp7Ratextracellular space  IDA 9685354 RGD 
Mmp7Ratextracellular space is_active_inIBAPANTHER:PTN002565758 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp7Ratendopeptidase activity enablesISSUniProtKB:P092371600115GO_REF:0000024UniProtGO_REF:0000024
Mmp7Ratendopeptidase activity enablesIEAUniProtKB:P09237 and ensembl:ENSP000002602271600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp7Ratendopeptidase activity enablesISOMMP7 (Homo sapiens)1624291 PMID:23845380RGDPMID:23845380
Mmp7Ratheparin binding  IDA 9685351 RGD 
Mmp7Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Mmp7Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Mmp7Ratmetalloendopeptidase activity enablesIBAFB:FBgn0033438 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mmp7Ratmetalloendopeptidase activity enablesIEAEC:3.4.24.231600115GO_REF:0000003UniProtGO_REF:0000003
Mmp7Ratmetalloendopeptidase activity enablesIEAInterPro:IPR001818 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mmp7Ratmetallopeptidase activity enablesISOMMP7 (Homo sapiens)1624291 PMID:15297466 and PMID:26482249RGDPMID:15297466 and PMID:26482249
Mmp7Ratmetallopeptidase activity enablesIEAUniProtKB:P09237 and ensembl:ENSP000002602271600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp7Ratmetallopeptidase activity enablesIEAUniProtKB-KW:KW-04821600115GO_REF:0000043UniProtGO_REF:0000043
Mmp7Ratmetallopeptidase activity enablesIEAInterPro:IPR006026 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mmp7Ratpeptidase activity enablesIEAUniProtKB:Q10738 and ensembl:ENSMUSP000000187671600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp7Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Mmp7Ratpeptidase activity enablesISOMmp7 (Mus musculus)1624291MGI:1857932 PMID:20056603RGDPMID:20056603
Mmp7Ratprotein binding enablesISOMMP7 (Homo sapiens)1624291UniProtKB:P17931 and PMID:20812334RGDPMID:20812334
Mmp7Ratzinc ion binding enablesIEAInterPro:IPR001818 more ...1600115GO_REF:0000002InterProGO_REF:0000002
1 to 18 of 18 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp7RatWnt signaling pathway  IEA 6907045 KEGGrno:04310

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp7Ratsyndecan signaling pathway  ISOMMP7 (Homo sapiens)6484113 PIDPID:200156

1 to 20 of 46 rows
#
Reference Title
Reference Citation
1. Characterization of rat uterine matrilysin and its cDNA. Relationship to human pump-1 and activation of procollagenases. Abramson SR, etal., J Biol Chem 1995 Jul 7;270(27):16016-22.
2. Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department setting. Anwaruddin S, etal., Am J Clin Pathol. 2005 Jan;123(1):140-5.
3. Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent. Asamoto M, etal., Cancer Res. 2001 Jun 15;61(12):4693-700.
4. Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat. Boixel C, etal., J Am Coll Cardiol. 2003 Jul 16;42(2):336-44.
5. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
6. Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction. Chen G, etal., Am J Physiol Renal Physiol. 2007 Oct;293(4):F1272-81. Epub 2007 Aug 1.
7. Protease-activated receptor-1 antagonist F 16618 reduces arterial restenosis by down-regulation of tumor necrosis factor alpha and matrix metalloproteinase 7 expression, migration, and proliferation of vascular smooth muscle cells. Chieng-Yane P, etal., J Pharmacol Exp Ther. 2011 Mar;336(3):643-51. doi: 10.1124/jpet.110.175182. Epub 2010 Dec 7.
8. Matrilysin activity in the rat uterus during the oestrous cycle and implantation. Feng J, etal., J Reprod Fertil. 1998 Nov;114(2):347-50.
9. Role of myoglobin in the antioxidant defense of the heart. Flogel U, etal., FASEB J. 2004 Jul;18(10):1156-8. Epub 2004 May 7.
10. Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve. Gantus MA, etal., Brain Res. 2006 Nov 29;1122(1):36-46. Epub 2006 Oct 6.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Thyroid hormone stimulates myoglobin gene expression in rat cardiac muscle. Giannocco G, etal., Mol Cell Endocrinol. 2004 Oct 29;226(1-2):19-26.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Metalloproteinases and their associated genes contribute to the functional integrity and noise-induced damage in the cochlear sensory epithelium. Hu BH, etal., J Neurosci. 2012 Oct 24;32(43):14927-41. doi: 10.1523/JNEUROSCI.1588-12.2012.
15. Activation of adventitial fibroblasts in the early stage of the aortic transplant vasculopathy in rat. Ji J, etal., Transplantation. 2010 Apr 27;89(8):945-53. doi: 10.1097/TP.0b013e3181d05aa7.
16. Implication of matrix metalloproteinase 7 and the noncanonical wingless-type signaling pathway in a model of kidney allograft tolerance induced by the administration of anti-donor class II antibodies. Jovanovic V, etal., J Immunol. 2008 Feb 1;180(3):1317-25.
17. Matrix metalloproteinases MMP-9 and MMP-7 are expressed in experimental autoimmune neuritis and the Guillain-Barre syndrome. Kieseier BC, etal., Ann Neurol. 1998 Apr;43(4):427-34.
18. Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis. Kieseier BC, etal., Brain. 1998 Jan;121 ( Pt 1):159-66.
19. Myoglobin Translational Diffusion in Myocardium and Its Implication on Intracellular Oxygen Transport. Lin PC, etal., J Physiol. 2006 Oct 12;.
20. Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction. Lindsey ML, etal., Circulation. 2006 Jun 27;113(25):2919-28. Epub 2006 Jun 12.
1 to 20 of 46 rows
PMID:9037065   PMID:11248802   PMID:14656925   PMID:15297466   PMID:15489334   PMID:17554258   PMID:18644839   PMID:20056603   PMID:20655064   PMID:22238106   PMID:23376485   PMID:23533145  
PMID:23845380   PMID:23870463   PMID:26482249   PMID:28626073   PMID:31493243   PMID:31791378   PMID:38643908  



Mmp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,133,043 - 13,140,761 (+)NCBIGRCr8
mRatBN7.284,848,186 - 4,855,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,848,186 - 4,855,902 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,808,955 - 8,816,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,106,740 - 7,114,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,107,859 - 5,115,573 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,893,253 - 5,900,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,893,249 - 5,901,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,895,393 - 5,903,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,526,018 - 4,533,730 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,526,033 - 4,533,729 (+)NCBI
Celera86,407,543 - 6,415,255 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,520,508 - 102,530,747 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,520,508 - 102,530,750 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,391,239 - 102,401,478 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,896,449 - 101,906,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411101,896,448 - 101,906,688NCBI
Celera1199,552,782 - 99,563,021 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,318,241 - 98,328,480 (-)NCBIHuRef
CHM1_111102,274,287 - 102,284,528 (-)NCBICHM1_1
T2T-CHM13v2.011102,522,678 - 102,532,920 (-)NCBIT2T-CHM13v2.0
Mmp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,692,095 - 7,699,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,692,091 - 7,699,587 (+)EnsemblGRCm39 Ensembl
GRCm3897,692,090 - 7,699,585 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,692,090 - 7,699,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,692,111 - 7,699,416 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,692,097 - 7,699,255 (+)NCBIMGSCv36mm8
Celera95,082,790 - 5,090,191 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,778,502 - 5,792,445 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,780,772 - 5,792,485 (-)NCBIChiLan1.0ChiLan1.0
MMP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,319,695 - 103,329,920 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,408,059 - 104,418,283 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,467,037 - 97,477,305 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,960,107 - 100,970,355 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,960,032 - 100,971,099 (-)Ensemblpanpan1.1panPan2
MMP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,187,902 - 29,196,157 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,187,851 - 29,196,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,135,576 - 29,143,842 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,239,121 - 29,247,375 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,238,932 - 29,247,371 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,273,927 - 29,282,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,153,310 - 29,161,571 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,328,802 - 29,337,062 (+)NCBIUU_Cfam_GSD_1.0
Mmp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,138,756 - 86,148,072 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,388,459 - 5,395,071 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,388,456 - 5,395,071 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,214,594 - 33,225,080 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,214,590 - 33,225,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,133,037 - 37,143,432 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,889,189 - 93,901,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl193,889,198 - 93,899,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,959,442 - 31,969,839 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878345,038 - 361,652 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878345,038 - 364,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Mmp7
48 total Variants

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:30
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000014041
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 9 of 9 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat

1 to 9 of 9 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 5 28 61 60 32 25 32 6 105 44 9 15 45 28



Ensembl Acc Id: ENSRNOT00000014041   ⟹   ENSRNOP00000014041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,848,186 - 4,855,902 (+)Ensembl
Rnor_6.0 Ensembl85,893,249 - 5,901,049 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100430   ⟹   ENSRNOP00000079054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,848,186 - 4,854,256 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109262   ⟹   ENSRNOP00000091123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,848,186 - 4,854,275 (+)Ensembl
RefSeq Acc Id: NM_012864   ⟹   NP_036996
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,133,043 - 13,140,761 (+)NCBI
mRatBN7.284,848,186 - 4,855,908 (+)NCBI
Rnor_6.085,893,253 - 5,900,965 (+)NCBI
Rnor_5.085,895,393 - 5,903,105 (+)NCBI
RGSC_v3.484,526,018 - 4,533,730 (+)RGD
Celera86,407,543 - 6,415,255 (+)RGD
Sequence:
Protein RefSeqs NP_036996 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA99432 (Get FASTA)   NCBI Sequence Viewer  
  AAH64657 (Get FASTA)   NCBI Sequence Viewer  
  EDL78525 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014041
  ENSRNOP00000014041.4
GenBank Protein P50280 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036996   ⟸   NM_012864
- Peptide Label: precursor
- UniProtKB: P50280 (UniProtKB/Swiss-Prot),   A6JN40 (UniProtKB/TrEMBL),   A0A8I5ZMN5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014041   ⟸   ENSRNOT00000014041
Ensembl Acc Id: ENSRNOP00000091123   ⟸   ENSRNOT00000109262
Ensembl Acc Id: ENSRNOP00000079054   ⟸   ENSRNOT00000100430
Peptidase metallopeptidase

Name Modeler Protein Id AA Range Protein Structure
AF-P50280-F1-model_v2 AlphaFold P50280 1-267 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695735
Promoter ID:EPDNEW_R6260
Type:single initiation site
Name:Mmp7_1
Description:matrix metallopeptidase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.085,893,240 - 5,893,300EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31782 BioCyc
Ensembl Genes ENSRNOG00000010507 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014041 ENTREZGENE
  ENSRNOT00000014041.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623517 IMAGE-MGC_LOAD
InterPro M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot
  PGBD-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:25335 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72527 IMAGE-MGC_LOAD
NCBI Gene 25335 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
  PTHR10201:SF143 UniProtKB/Swiss-Prot
Pfam Peptidase_M10 UniProtKB/Swiss-Prot
  PG_binding_1 UniProtKB/Swiss-Prot
PhenoGen Mmp7 PhenoGen
PRINTS MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010507 RatGTEx
SMART ZnMc UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF47090 UniProtKB/Swiss-Prot
TIGR TC209815
UniProt A0A8I5ZMN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFJ9_RAT UniProtKB/TrEMBL
  A6JN40 ENTREZGENE, UniProtKB/TrEMBL
  MMP7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mmp7  matrix metallopeptidase 7    matrix metalloproteinase 7  Name updated 1299863 APPROVED
2002-06-10 Mmp7  Matrix metalloproteinase 7 (matrilysin)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_function cleaves and activates latent human interstitial collagenase 1 728999