Mmp7 (matrix metallopeptidase 7) - Rat Genome Database

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Gene: Mmp7 (matrix metallopeptidase 7) Rattus norvegicus
Analyze
Symbol: Mmp7
Name: matrix metallopeptidase 7
RGD ID: 3100
Description: Enables heparin binding activity. Involved in several processes, including cellular response to mechanical stimulus; estrous cycle; and maternal process involved in female pregnancy. Located in cell surface and extracellular space. Used to study hypertension and prostate carcinoma. Biomarker of bladder neck obstruction; coronary restenosis; hypertension; prostate cancer; and renal hypertension. Orthologous to human MMP7 (matrix metallopeptidase 7); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: matrilysin; matrin; matrix metalloproteinase 7; Matrix metalloproteinase 7 (matrilysin); matrix metalloproteinase-7; MMP-7; MPMM; pump-1 protease; uterine metalloproteinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,133,043 - 13,140,761 (+)NCBIGRCr8
mRatBN7.284,848,186 - 4,855,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,848,186 - 4,855,902 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,808,955 - 8,816,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,106,740 - 7,114,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,107,859 - 5,115,573 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,893,253 - 5,900,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,893,249 - 5,901,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,895,393 - 5,903,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,526,018 - 4,533,730 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,526,033 - 4,533,729 (+)NCBI
Celera86,407,543 - 6,415,255 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(E)-thiamethoxam  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
antimonite  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzyl isothiocyanate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
BQ 123  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
celastrol  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
delta-tocotrienol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
folic acid  (EXP,ISO)
fructose  (ISO)
furan  (EXP)
gallic acid  (ISO)
Garcinol  (ISO)
genistein  (ISO)
glucose  (ISO)
graphite  (EXP)
GW 4064  (ISO)
Honokiol  (ISO)
isoorientin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
losartan  (ISO)
mangiferin  (ISO)
mercaptopurine  (EXP)
methotrexate  (ISO)
mibolerone  (ISO)
mifepristone  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
niclosamide  (EXP,ISO)
nicotine  (ISO)
nitroglycerin  (ISO)
nobiletin  (ISO)
Pachymic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
procymidone  (ISO)
progesterone  (ISO)
propofol  (ISO)
Prothioconazole-desthio  (ISO)
pterostilbene  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
riddelliine  (EXP)
salicylates  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
sulindac sulfone  (ISO)
Tanshinone I  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thiamethoxam  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
trans-pinosylvin  (ISO)
trichloroacetaldehyde  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
zearalenone  (EXP)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of rat uterine matrilysin and its cDNA. Relationship to human pump-1 and activation of procollagenases. Abramson SR, etal., J Biol Chem 1995 Jul 7;270(27):16016-22.
2. Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department setting. Anwaruddin S, etal., Am J Clin Pathol. 2005 Jan;123(1):140-5.
3. Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent. Asamoto M, etal., Cancer Res. 2001 Jun 15;61(12):4693-700.
4. Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat. Boixel C, etal., J Am Coll Cardiol. 2003 Jul 16;42(2):336-44.
5. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
6. Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction. Chen G, etal., Am J Physiol Renal Physiol. 2007 Oct;293(4):F1272-81. Epub 2007 Aug 1.
7. Protease-activated receptor-1 antagonist F 16618 reduces arterial restenosis by down-regulation of tumor necrosis factor alpha and matrix metalloproteinase 7 expression, migration, and proliferation of vascular smooth muscle cells. Chieng-Yane P, etal., J Pharmacol Exp Ther. 2011 Mar;336(3):643-51. doi: 10.1124/jpet.110.175182. Epub 2010 Dec 7.
8. Matrilysin activity in the rat uterus during the oestrous cycle and implantation. Feng J, etal., J Reprod Fertil. 1998 Nov;114(2):347-50.
9. Role of myoglobin in the antioxidant defense of the heart. Flogel U, etal., FASEB J. 2004 Jul;18(10):1156-8. Epub 2004 May 7.
10. Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve. Gantus MA, etal., Brain Res. 2006 Nov 29;1122(1):36-46. Epub 2006 Oct 6.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Thyroid hormone stimulates myoglobin gene expression in rat cardiac muscle. Giannocco G, etal., Mol Cell Endocrinol. 2004 Oct 29;226(1-2):19-26.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Metalloproteinases and their associated genes contribute to the functional integrity and noise-induced damage in the cochlear sensory epithelium. Hu BH, etal., J Neurosci. 2012 Oct 24;32(43):14927-41. doi: 10.1523/JNEUROSCI.1588-12.2012.
15. Activation of adventitial fibroblasts in the early stage of the aortic transplant vasculopathy in rat. Ji J, etal., Transplantation. 2010 Apr 27;89(8):945-53. doi: 10.1097/TP.0b013e3181d05aa7.
16. Implication of matrix metalloproteinase 7 and the noncanonical wingless-type signaling pathway in a model of kidney allograft tolerance induced by the administration of anti-donor class II antibodies. Jovanovic V, etal., J Immunol. 2008 Feb 1;180(3):1317-25.
17. Matrix metalloproteinases MMP-9 and MMP-7 are expressed in experimental autoimmune neuritis and the Guillain-Barre syndrome. Kieseier BC, etal., Ann Neurol. 1998 Apr;43(4):427-34.
18. Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis. Kieseier BC, etal., Brain. 1998 Jan;121 ( Pt 1):159-66.
19. Myoglobin Translational Diffusion in Myocardium and Its Implication on Intracellular Oxygen Transport. Lin PC, etal., J Physiol. 2006 Oct 12;.
20. Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction. Lindsey ML, etal., Circulation. 2006 Jun 27;113(25):2919-28. Epub 2006 Jun 12.
21. Immunolocalization and gene expression of matrilysin during corneal wound healing. Lu PC, etal., Invest Ophthalmol Vis Sci. 1999 Jan;40(1):20-7.
22. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Lynch CC, etal., Cancer Cell. 2005 May;7(5):485-96.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. Nakano A, etal., J Neurosurg. 1995 Aug;83(2):298-307.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Significance of matrix metalloproteinase-7 [correction of matrix metalloproteinase-2], -11 and tissue inhibitor of metalloproteinase-1 expression in normal, hyperplastic and neoplastic endometrium. Obokata A, etal., Anticancer Res. 2007 Jan-Feb;27(1A):95-105.
27. Proteomic analysis of slow- and fast-twitch skeletal muscles. Okumura N, etal., Proteomics. 2005 Jul;5(11):2896-906.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. Effect of inhibition of matrix metalloproteinases on endometrial decidualization and implantation in mated rats. Rechtman MP, etal., J Reprod Fertil. 1999 Sep;117(1):169-77.
31. GOA pipeline RGD automated data pipeline
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis. Rudolph-Owen LA, etal., Cancer Res. 1998 Dec 1;58(23):5500-6.
34. Expression of MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease. Safranek J, etal., Anticancer Res. 2009 Jul;29(7):2513-7.
35. Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. Schroder A, etal., J Urol. 2013 Jun;189(6):2377-84. doi: 10.1016/j.juro.2012.12.110. Epub 2013 Jan 9.
36. Virtual cooperativity in myoglobin oxygen saturation curve in skeletal muscle in vivo. Seiyama A Dyn Med. 2006 Jan 24;5:3.
37. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
38. Evaluation of coronary artery patency using cardiac markers. Tanasijevic MJ J Thromb Thrombolysis. 2005 Feb;19(1):21-4.
39. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
40. WNT/beta-catenin signaling is modulated by mechanical ventilation in an experimental model of acute lung injury. Villar J, etal., Intensive Care Med. 2011 Jul;37(7):1201-9. doi: 10.1007/s00134-011-2234-0. Epub 2011 May 13.
41. Activation of the Wnt/beta-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. Villar J, etal., PLoS One. 2011;6(9):e23914. doi: 10.1371/journal.pone.0023914. Epub 2011 Sep 15.
42. Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy. Wang X, etal., Circulation. 2009 May 12;119(18):2480-9. doi: 10.1161/CIRCULATIONAHA.108.835488. Epub 2009 Apr 27.
43. [Defensin-5 and Matrilysin mRNA expression in the intestine of scalded rats and its relation to bacterial translocation]. Yang HM, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Jun;16(6):345-7.
44. Cyclic stretch magnitude and duration affect rat alveolar epithelial gene expression. Yerrapureddy A, etal., Cell Physiol Biochem. 2010;25(1):113-22. doi: 10.1159/000272056. Epub 2009 Dec 22.
45. Heparan sulfate proteoglycans as extracellular docking molecules for matrilysin (matrix metalloproteinase 7). Yu WH and Woessner JF Jr, J Biol Chem. 2000 Feb 11;275(6):4183-91.
46. [Influence of Bushen Huoxue decoction on beta-catenin, MMP-7 of synoviocytes in rats with knee osteoarthritis]. Yuan Q, etal., Zhongguo Gu Shang. 2012 Sep;25(9):761-5.
Additional References at PubMed
PMID:9037065   PMID:11248802   PMID:14656925   PMID:15297466   PMID:15489334   PMID:17554258   PMID:18644839   PMID:20056603   PMID:20655064   PMID:22238106   PMID:23376485   PMID:23533145  
PMID:23845380   PMID:23870463   PMID:26482249   PMID:28626073   PMID:31493243   PMID:31791378  


Genomics

Comparative Map Data
Mmp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,133,043 - 13,140,761 (+)NCBIGRCr8
mRatBN7.284,848,186 - 4,855,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,848,186 - 4,855,902 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,808,955 - 8,816,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,106,740 - 7,114,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,107,859 - 5,115,573 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,893,253 - 5,900,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,893,249 - 5,901,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,895,393 - 5,903,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,526,018 - 4,533,730 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,526,033 - 4,533,729 (+)NCBI
Celera86,407,543 - 6,415,255 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,520,508 - 102,530,747 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,520,508 - 102,530,750 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,391,239 - 102,401,478 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,896,449 - 101,906,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411101,896,448 - 101,906,688NCBI
Celera1199,552,782 - 99,563,021 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,318,241 - 98,328,480 (-)NCBIHuRef
CHM1_111102,274,287 - 102,284,528 (-)NCBICHM1_1
T2T-CHM13v2.011102,522,678 - 102,532,920 (-)NCBIT2T-CHM13v2.0
Mmp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,692,095 - 7,699,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,692,091 - 7,699,586 (+)EnsemblGRCm39 Ensembl
GRCm3897,692,090 - 7,699,585 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,692,090 - 7,699,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,692,111 - 7,699,416 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,692,097 - 7,699,255 (+)NCBIMGSCv36mm8
Celera95,082,790 - 5,090,191 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,778,502 - 5,792,445 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,780,772 - 5,792,485 (-)NCBIChiLan1.0ChiLan1.0
MMP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,319,695 - 103,329,920 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,408,059 - 104,418,283 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,467,037 - 97,477,305 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,960,107 - 100,970,355 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,960,032 - 100,971,099 (-)Ensemblpanpan1.1panPan2
MMP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,187,902 - 29,196,157 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,187,851 - 29,196,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,135,576 - 29,143,842 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,239,121 - 29,247,375 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,238,932 - 29,247,371 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,273,927 - 29,282,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,153,310 - 29,161,571 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,328,802 - 29,337,062 (+)NCBIUU_Cfam_GSD_1.0
Mmp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,138,756 - 86,148,072 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,388,459 - 5,395,071 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,388,456 - 5,395,071 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,214,594 - 33,225,080 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,214,590 - 33,225,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,133,037 - 37,143,432 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,889,189 - 93,901,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl193,889,198 - 93,899,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,959,442 - 31,969,839 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878345,038 - 361,652 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878345,038 - 364,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp7
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:30
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000014041
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 1 4 1
Low 1 11 14 1 1 1 13 3 1
Below cutoff 1 5 28 24 5 24 4 4 6 10 15 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014041   ⟹   ENSRNOP00000014041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,848,186 - 4,855,902 (+)Ensembl
Rnor_6.0 Ensembl85,893,249 - 5,901,049 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100430   ⟹   ENSRNOP00000079054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,848,186 - 4,854,256 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109262   ⟹   ENSRNOP00000091123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,848,186 - 4,854,275 (+)Ensembl
RefSeq Acc Id: NM_012864   ⟹   NP_036996
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,133,043 - 13,140,761 (+)NCBI
mRatBN7.284,848,186 - 4,855,908 (+)NCBI
Rnor_6.085,893,253 - 5,900,965 (+)NCBI
Rnor_5.085,895,393 - 5,903,105 (+)NCBI
RGSC_v3.484,526,018 - 4,533,730 (+)RGD
Celera86,407,543 - 6,415,255 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036996   ⟸   NM_012864
- Peptide Label: precursor
- UniProtKB: P50280 (UniProtKB/Swiss-Prot),   A6JN40 (UniProtKB/TrEMBL),   A0A8I5ZMN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014041   ⟸   ENSRNOT00000014041
RefSeq Acc Id: ENSRNOP00000091123   ⟸   ENSRNOT00000109262
RefSeq Acc Id: ENSRNOP00000079054   ⟸   ENSRNOT00000100430
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50280-F1-model_v2 AlphaFold P50280 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695735
Promoter ID:EPDNEW_R6260
Type:single initiation site
Name:Mmp7_1
Description:matrix metallopeptidase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.085,893,240 - 5,893,300EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3100 AgrOrtholog
BioCyc Gene G2FUF-31782 BioCyc
Ensembl Genes ENSRNOG00000010507 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005894 UniProtKB/Swiss-Prot
  ENSRNOG00060015558 UniProtKB/Swiss-Prot
  ENSRNOG00065002624 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014041 ENTREZGENE
  ENSRNOT00000014041.6 UniProtKB/Swiss-Prot
  ENSRNOT00000100430.1 UniProtKB/TrEMBL
  ENSRNOT00000109262.1 UniProtKB/TrEMBL
  ENSRNOT00055009540 UniProtKB/Swiss-Prot
  ENSRNOT00060026619 UniProtKB/Swiss-Prot
  ENSRNOT00065003503 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623517 IMAGE-MGC_LOAD
InterPro M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72527 IMAGE-MGC_LOAD
NCBI Gene 25335 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10201:SF143 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmp7 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010507 RatGTEx
  ENSRNOG00055005894 RatGTEx
  ENSRNOG00060015558 RatGTEx
  ENSRNOG00065002624 RatGTEx
SMART ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209815
UniProt A0A8I5ZMN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFJ9_RAT UniProtKB/TrEMBL
  A6JN40 ENTREZGENE, UniProtKB/TrEMBL
  MMP7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mmp7  matrix metallopeptidase 7    matrix metalloproteinase 7  Name updated 1299863 APPROVED
2002-06-10 Mmp7  Matrix metalloproteinase 7 (matrilysin)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function cleaves and activates latent human interstitial collagenase 1 728999