Mmp7 (matrix metallopeptidase 7) - Rat Genome Database

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Gene: Mmp7 (matrix metallopeptidase 7) Mus musculus
Analyze
Symbol: Mmp7
Name: matrix metallopeptidase 7
RGD ID: 10906
MGI Page MGI
Description: Enables peptidase activity. Acts upstream of or within several processes, including defense response to bacterium; proteolysis; and response to xenobiotic stimulus. Predicted to be located in cell surface. Predicted to be active in extracellular space. Is expressed in several structures, including exocrine gland; genitourinary system; hemolymphoid system gland; intestine; and liver and biliary system. Orthologous to human MMP7 (matrix metallopeptidase 7).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MA; MAT; matrilysin; matrilysin, uterine; matrin; matrix metalloproteinase 7; matrix metalloproteinase-7; MMP-7; pump-1 protease; uterine metalloproteinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,692,095 - 7,699,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,692,091 - 7,699,587 (+)EnsemblGRCm39 Ensembl
GRCm3897,692,090 - 7,699,585 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,692,090 - 7,699,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,692,111 - 7,699,416 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,692,097 - 7,699,255 (+)NCBIMGSCv36mm8
Celera95,082,790 - 5,090,191 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(E)-thiamethoxam  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
andrographolide  (ISO)
antimonite  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzyl isothiocyanate  (ISO)
bisphenol A  (ISO)
bleomycin A2  (EXP)
BQ 123  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
celastrol  (EXP)
chlordecone  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
deguelin  (ISO)
delta-tocotrienol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
ethanol  (EXP)
fenofibrate  (ISO)
ferric oxide  (ISO)
folic acid  (EXP,ISO)
fructose  (EXP)
furan  (ISO)
gallic acid  (ISO)
Garcinol  (ISO)
genistein  (EXP,ISO)
glucose  (EXP)
graphite  (ISO)
GW 4064  (EXP)
Honokiol  (EXP)
isoorientin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
losartan  (EXP,ISO)
mangiferin  (ISO)
mercaptopurine  (ISO)
methotrexate  (ISO)
mibolerone  (ISO)
mifepristone  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
nitroglycerin  (ISO)
nobiletin  (ISO)
Pachymic acid  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl isothiocyanate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pinosylvin  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propofol  (ISO)
Prothioconazole-desthio  (EXP)
pterostilbene  (EXP)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
salicylates  (ISO)
serpentine asbestos  (EXP,ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP,ISO)
sulindac  (EXP)
sulindac sulfone  (ISO)
Tanshinone I  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thiamethoxam  (EXP)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
trans-pinosylvin  (ISO)
trichloroacetaldehyde  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department setting. Anwaruddin S, etal., Am J Clin Pathol. 2005 Jan;123(1):140-5.
2. Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent. Asamoto M, etal., Cancer Res. 2001 Jun 15;61(12):4693-700.
3. Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat. Boixel C, etal., J Am Coll Cardiol. 2003 Jul 16;42(2):336-44.
4. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
5. Protease-activated receptor-1 antagonist F 16618 reduces arterial restenosis by down-regulation of tumor necrosis factor alpha and matrix metalloproteinase 7 expression, migration, and proliferation of vascular smooth muscle cells. Chieng-Yane P, etal., J Pharmacol Exp Ther. 2011 Mar;336(3):643-51. doi: 10.1124/jpet.110.175182. Epub 2010 Dec 7.
6. Role of myoglobin in the antioxidant defense of the heart. Flogel U, etal., FASEB J. 2004 Jul;18(10):1156-8. Epub 2004 May 7.
7. Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve. Gantus MA, etal., Brain Res. 2006 Nov 29;1122(1):36-46. Epub 2006 Oct 6.
8. Thyroid hormone stimulates myoglobin gene expression in rat cardiac muscle. Giannocco G, etal., Mol Cell Endocrinol. 2004 Oct 29;226(1-2):19-26.
9. Metalloproteinases and their associated genes contribute to the functional integrity and noise-induced damage in the cochlear sensory epithelium. Hu BH, etal., J Neurosci. 2012 Oct 24;32(43):14927-41. doi: 10.1523/JNEUROSCI.1588-12.2012.
10. Activation of adventitial fibroblasts in the early stage of the aortic transplant vasculopathy in rat. Ji J, etal., Transplantation. 2010 Apr 27;89(8):945-53. doi: 10.1097/TP.0b013e3181d05aa7.
11. Implication of matrix metalloproteinase 7 and the noncanonical wingless-type signaling pathway in a model of kidney allograft tolerance induced by the administration of anti-donor class II antibodies. Jovanovic V, etal., J Immunol. 2008 Feb 1;180(3):1317-25.
12. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
13. Matrix metalloproteinases MMP-9 and MMP-7 are expressed in experimental autoimmune neuritis and the Guillain-Barre syndrome. Kieseier BC, etal., Ann Neurol. 1998 Apr;43(4):427-34.
14. Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis. Kieseier BC, etal., Brain. 1998 Jan;121 ( Pt 1):159-66.
15. Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction. Lindsey ML, etal., Circulation. 2006 Jun 27;113(25):2919-28. Epub 2006 Jun 12.
16. Immunolocalization and gene expression of matrilysin during corneal wound healing. Lu PC, etal., Invest Ophthalmol Vis Sci. 1999 Jan;40(1):20-7.
17. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Lynch CC, etal., Cancer Cell. 2005 May;7(5):485-96.
18. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
19. MGDs mouse GO annotations MGD data from the GO Consortium
20. MGD IEA MGD IEA
21. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. Nakano A, etal., J Neurosurg. 1995 Aug;83(2):298-307.
22. Significance of matrix metalloproteinase-7 [correction of matrix metalloproteinase-2], -11 and tissue inhibitor of metalloproteinase-1 expression in normal, hyperplastic and neoplastic endometrium. Obokata A, etal., Anticancer Res. 2007 Jan-Feb;27(1A):95-105.
23. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis. Rudolph-Owen LA, etal., Cancer Res. 1998 Dec 1;58(23):5500-6.
29. Expression of MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease. Safranek J, etal., Anticancer Res. 2009 Jul;29(7):2513-7.
30. Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. Schroder A, etal., J Urol. 2013 Jun;189(6):2377-84. doi: 10.1016/j.juro.2012.12.110. Epub 2013 Jan 9.
31. Evaluation of coronary artery patency using cardiac markers. Tanasijevic MJ J Thromb Thrombolysis. 2005 Feb;19(1):21-4.
32. WNT/beta-catenin signaling is modulated by mechanical ventilation in an experimental model of acute lung injury. Villar J, etal., Intensive Care Med. 2011 Jul;37(7):1201-9. doi: 10.1007/s00134-011-2234-0. Epub 2011 May 13.
33. Activation of the Wnt/beta-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. Villar J, etal., PLoS One. 2011;6(9):e23914. doi: 10.1371/journal.pone.0023914. Epub 2011 Sep 15.
34. Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy. Wang X, etal., Circulation. 2009 May 12;119(18):2480-9. doi: 10.1161/CIRCULATIONAHA.108.835488. Epub 2009 Apr 27.
35. [Defensin-5 and Matrilysin mRNA expression in the intestine of scalded rats and its relation to bacterial translocation]. Yang HM, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Jun;16(6):345-7.
Additional References at PubMed
PMID:7579699   PMID:9037065   PMID:9348221   PMID:9722956   PMID:9769324   PMID:10204802   PMID:10337617   PMID:10349636   PMID:10359808   PMID:10419448   PMID:10433819   PMID:10607586  
PMID:10642592   PMID:10731089   PMID:10922068   PMID:10934155   PMID:10949577   PMID:10987280   PMID:11042159   PMID:11076861   PMID:11248802   PMID:11359935   PMID:11733520   PMID:11752298  
PMID:11825873   PMID:11983918   PMID:12045257   PMID:12359768   PMID:12464176   PMID:12477932   PMID:12482850   PMID:12506066   PMID:12815621   PMID:15149334   PMID:15186480   PMID:15201952  
PMID:15543138   PMID:15618213   PMID:15734845   PMID:15748811   PMID:15778706   PMID:15843578   PMID:15921521   PMID:15964556   PMID:16141072   PMID:16141073   PMID:16230531   PMID:16397239  
PMID:16423057   PMID:16515559   PMID:16822871   PMID:17017992   PMID:17101148   PMID:17203242   PMID:17218472   PMID:17219436   PMID:17617617   PMID:17638887   PMID:17681175   PMID:17923522  
PMID:18334539   PMID:18385523   PMID:18499699   PMID:18606667   PMID:18639653   PMID:18644839   PMID:18663129   PMID:18676849   PMID:18713744   PMID:19002110   PMID:19181662   PMID:19267908  
PMID:19329997   PMID:19394326   PMID:19429912   PMID:19549527   PMID:19608871   PMID:19668337   PMID:19679556   PMID:19766716   PMID:19795413   PMID:19855381   PMID:19893044   PMID:20048070  
PMID:20056603   PMID:20139113   PMID:20215503   PMID:20332116   PMID:20488791   PMID:20616008   PMID:20691176   PMID:20809186   PMID:20864640   PMID:21079048   PMID:21481787   PMID:21873635  
PMID:21991388   PMID:22095947   PMID:22957090   PMID:23258229   PMID:23421805   PMID:23554135   PMID:24095877   PMID:24129163   PMID:24624896   PMID:24837365   PMID:25118165   PMID:25352026  
PMID:25636537   PMID:25770908   PMID:26015543   PMID:26163370   PMID:26933888   PMID:26934381   PMID:26934670   PMID:27398409   PMID:27510977   PMID:27732661   PMID:28622386   PMID:29229950  
PMID:29600597   PMID:30878215   PMID:30967475   PMID:31053533   PMID:31743113   PMID:32053892   PMID:32270301   PMID:32468660   PMID:35204783   PMID:35493520   PMID:36275703   PMID:37312734  
PMID:37701782   PMID:37982452  


Genomics

Comparative Map Data
Mmp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,692,095 - 7,699,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,692,091 - 7,699,587 (+)EnsemblGRCm39 Ensembl
GRCm3897,692,090 - 7,699,585 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,692,090 - 7,699,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,692,111 - 7,699,416 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,692,097 - 7,699,255 (+)NCBIMGSCv36mm8
Celera95,082,790 - 5,090,191 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
MMP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,520,508 - 102,530,747 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,520,508 - 102,530,750 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,391,239 - 102,401,478 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,896,449 - 101,906,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411101,896,448 - 101,906,688NCBI
Celera1199,552,782 - 99,563,021 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,318,241 - 98,328,480 (-)NCBIHuRef
CHM1_111102,274,287 - 102,284,528 (-)NCBICHM1_1
T2T-CHM13v2.011102,522,678 - 102,532,920 (-)NCBIT2T-CHM13v2.0
Mmp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,133,043 - 13,140,761 (+)NCBIGRCr8
mRatBN7.284,848,186 - 4,855,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,848,186 - 4,855,902 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,808,955 - 8,816,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,106,740 - 7,114,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,107,859 - 5,115,573 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,893,253 - 5,900,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,893,249 - 5,901,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,895,393 - 5,903,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,526,018 - 4,533,730 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,526,033 - 4,533,729 (+)NCBI
Celera86,407,543 - 6,415,255 (+)NCBICelera
Cytogenetic Map8q11NCBI
Mmp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,778,502 - 5,792,445 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,780,772 - 5,792,485 (-)NCBIChiLan1.0ChiLan1.0
MMP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,319,695 - 103,329,920 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,408,059 - 104,418,283 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,467,037 - 97,477,305 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,960,107 - 100,970,355 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,960,032 - 100,971,099 (-)Ensemblpanpan1.1panPan2
MMP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,187,902 - 29,196,157 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,187,851 - 29,196,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,135,576 - 29,143,842 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,239,121 - 29,247,375 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,238,932 - 29,247,371 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,273,927 - 29,282,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,153,310 - 29,161,571 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,328,802 - 29,337,062 (+)NCBIUU_Cfam_GSD_1.0
Mmp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,138,756 - 86,148,072 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,388,459 - 5,395,071 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,388,456 - 5,395,071 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,214,594 - 33,225,080 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,214,590 - 33,225,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,133,037 - 37,143,432 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,889,189 - 93,901,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl193,889,198 - 93,899,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,959,442 - 31,969,839 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878345,038 - 361,652 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878345,038 - 364,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Mmp7
259 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:105
Interacting mature miRNAs:115
Transcripts:ENSMUST00000018767
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse

Markers in Region
D9Mit57  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3897,694,215 - 7,694,379UniSTSGRCm38
MGSCv3797,694,215 - 7,694,379UniSTSGRCm37
Celera95,084,894 - 5,085,058UniSTS
Cytogenetic Map9A1UniSTS
cM Map94.0UniSTS
Whitehead Genetic92.2UniSTS
Whitehead/MRC_RH993.75UniSTS
Whitehead_YAC9 UniSTS
Mmp7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3797,699,388 - 7,699,519UniSTSGRCm37
Celera95,090,163 - 5,090,294UniSTS
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
cM Map91.0UniSTS
cM Map91.0UniSTS
Mmp7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A1UniSTS
Mmp7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A1UniSTS
Mmp7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
Mmp7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3897,699,388 - 7,699,519UniSTSGRCm38
MGSCv3797,699,388 - 7,699,519UniSTSGRCm37
Celera95,090,163 - 5,090,294UniSTS
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000018767   ⟹   ENSMUSP00000018767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,692,091 - 7,699,586 (+)Ensembl
GRCm38.p6 Ensembl97,692,090 - 7,699,585 (+)Ensembl
Ensembl Acc Id: ENSMUST00000249869
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,692,222 - 7,699,587 (+)Ensembl
RefSeq Acc Id: NM_001319986   ⟹   NP_001306915
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,692,342 - 7,699,587 (+)NCBI
GRCm3897,692,341 - 7,699,585 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010810   ⟹   NP_034940
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,692,095 - 7,699,587 (+)NCBI
GRCm3897,692,090 - 7,699,585 (+)NCBI
MGSCv3797,692,111 - 7,699,416 (+)RGD
Celera95,082,790 - 5,090,191 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034940   ⟸   NM_010810
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q10738 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001306915   ⟸   NM_001319986
- Peptide Label: isoform 2
- UniProtKB: Q3UN27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000018767   ⟸   ENSMUST00000018767
Protein Domains
Peptidase M10 metallopeptidase   Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q10738-F1-model_v2 AlphaFold Q10738 1-264 view protein structure

Promoters
RGD ID:8668760
Promoter ID:EPDNEW_M12411
Type:multiple initiation site
Name:Mmp7_1
Description:Mus musculus matrix metallopeptidase 7 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3897,692,094 - 7,692,154EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103189 AgrOrtholog
Ensembl Genes ENSMUSG00000018623 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018767 ENTREZGENE
  ENSMUST00000018767.9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUST00000249869 ENTREZGENE
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17393 UniProtKB/TrEMBL
MGD MGI:103189 ENTREZGENE
NCBI Gene 17393 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10201:SF143 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmp7 PhenoGen
PRINTS MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MMP7_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UN27 ENTREZGENE, UniProtKB/TrEMBL
  Q6GXA3_MOUSE UniProtKB/TrEMBL