Cdk2 (cyclin dependent kinase 2) - Rat Genome Database

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Gene: Cdk2 (cyclin dependent kinase 2) Rattus norvegicus
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Symbol: Cdk2
Name: cyclin dependent kinase 2
RGD ID: 70486
Description: Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including DNA synthesis involved in mitotic DNA replication; cellular response to insulin stimulus; and liver regeneration. Located in nucleus. Used to study membranoproliferative glomerulonephritis. Biomarker of interstitial cystitis. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2); PARTICIPATES IN G1/S transition pathway; interleukin-2 signaling pathway; mTOR signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (S)-colchicine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell division protein kinase 2; cyclin dependent kinase 2-alpha; cyclin-dependent kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,714,392 - 1,721,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,714,392 - 1,721,878 (-)EnsemblGRCr8
mRatBN7.271,129,878 - 1,137,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,129,811 - 1,137,403 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,893,030 - 3,900,519 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,768,702 - 5,776,191 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,065,517 - 6,073,007 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd76,845,726 - 6,853,216 (-)NCBI
Lyon_Normotensive76,265,547 - 6,273,037 (-)NCBI
Lyon_Hypertensive77,084,094 - 7,091,584 (-)NCBI
F344_StmMcwi75,438,106 - 5,445,596 (-)NCBI
Rnor_6.073,124,953 - 3,132,533 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,124,954 - 3,132,457 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.073,097,653 - 3,105,210 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.472,000,196 - 2,007,682 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera71,000,083 - 1,007,560 (-)NCBICelera
RGSC_v3.172,000,196 - 2,007,682 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-methoxy-17beta-estradiol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxypsoralen  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
ABT-100  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (ISO)
acteoside  (ISO)
afimoxifene  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (ISO)
alsterpaullone  (ISO)
alvocidib  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
Antrocin  (ISO)
antroquinonol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
artesunate  (EXP)
Aspidin  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
baicalein  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
berberine  (ISO)
beta-ionone  (ISO)
Betulonic acid  (ISO)
bexarotene  (EXP)
biotin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bohemine  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
BQ 123  (ISO)
brassinolide  (ISO)
Bruceantinol  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calix[6]arene  (ISO)
camptothecin  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamate ester  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
Cardanol  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
Cinobufagin  (ISO)
ciprofloxacin  (ISO)
Cirsimarin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
citric acid  (ISO)
clobenpropit  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corticosterone  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
DDT  (ISO)
deferasirox  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydrourocanic acid  (ISO)
dimethyl sulfoxide  (ISO)
dinaciclib  (ISO)
dinophysistoxin 2  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
Echimidine  (ISO)
elemental selenium  (ISO)
embelin  (ISO)
erythrosin B  (ISO)
esculetin  (EXP)
ethanol  (EXP)
ethyl trans-caffeate  (ISO)
etoposide  (ISO)
farnesol  (ISO)
fenthion  (ISO)
fenvalerate  (ISO)
fipronil  (EXP)
fisetin  (ISO)
fluvalinate  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fraxetin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
gedunin  (ISO)
genistein  (ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hesperetin  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
indirubin  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
Isoangustone A  (ISO)
isopimaric acid  (ISO)
isosilybin A  (ISO)
isovitexin  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
kainic acid  (EXP)
kenpaullone  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactucin  (ISO)
lapatinib  (ISO)
Lasiocarpine  (ISO)
LDN-193189  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP,ISO)
Liensinine  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
malathion  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mechlorethamine  (ISO)
melatonin  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mevalonic acid  (EXP)
mifepristone  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
nelfinavir  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olomoucine  (EXP,ISO)
omacetaxine mepesuccinate  (ISO)
orientin  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
palmatine  (ISO)
Panduratin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentachlorophenol  (EXP)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perillyl alcohol  (ISO)
Phellopterin  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium atom  (EXP)
potassium dichromate  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
pterostilbene  (EXP)
Pulsatilla saponin D  (ISO)
pyrene  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
rubitecan  (ISO)
ruxolitinib  (ISO)
Sanggenon C  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
seliciclib  (EXP)
selumetinib  (ISO)
semilicoisoflavone B  (ISO)
silibinin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sorafenib  (ISO)
spiromesifen  (ISO)
sterigmatocystin  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tartrazine  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetracaine  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (ISO)
Tomentosin  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
Tryptanthrine  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
wogonin  (EXP,ISO)
wortmannin  (ISO)
zebularine  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons. Alvira D, etal., Neuroscience. 2007 Apr 25;146(1):350-65. Epub 2007 Mar 7.
2. The map kinase ERK regulates renal activity of cyclin-dependent kinase 2 in experimental glomerulonephritis. Bokemeyer D, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3431-41. Epub 2007 Sep 24.
3. Molecular characterisation of breast cancer patients at high and low recurrence risk. Bonin S, etal., Virchows Arch. 2008 Jan 31;.
4. Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization. Bora PS, etal., FEBS J. 2006 Apr;273(7):1403-14.
5. D-type cyclins and G1 progression during liver development in the rat. Boylan JM and Gruppuso PA, Biochem Biophys Res Commun. 2005 May 13;330(3):722-30.
6. Microsomal localization of cyclin A and cdk2 in proliferating rat liver cells. Castro A, etal., Biochem Biophys Res Commun. 1994 Jun 30;201(3):1072-8.
7. Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. Choi KS, etal., J Biol Chem. 1999 Nov 5;274(45):31775-83. doi: 10.1074/jbc.274.45.31775.
8. p38 mitogen-activated protein kinase contributes to cell cycle regulation by cAMP in FRTL-5 thyroid cells. Correze C, etal., Eur J Endocrinol. 2005 Jul;153(1):123-33.
9. Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation. Gao CY, etal., Exp Eye Res 1999 Dec;69(6):695-703.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. Geisen C and Moroy T, J Biol Chem 2002 Oct 18;277(42):39909-18. Epub 2002 Jul 30.
12. Progressive derailment of cell cycle regulators in endometrial carcinogenesis. Horree N, etal., J Clin Pathol. 2008 Jan;61(1):36-42. Epub 2007 May 4.
13. Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extracellular matrix. Inamoto T, etal., Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3470-7.
14. Immunohistochemical study of cyclins D and E and cyclin dependent kinase (cdk) 2 and 4 in human endometrial carcinoma. Ito K, etal., Anticancer Res. 1998 May-Jun;18(3A):1661-4.
15. Elucidation of the pathophysiology of interstitial cystitis/bladder pain syndrome via experimental autoimmune cystitis rat model. Kadekawa K, etal., Am J Physiol Regul Integr Comp Physiol. 2024 Aug 1;327(2):R250-R260. doi: 10.1152/ajpregu.00269.2023. Epub 2024 Jun 6.
16. Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins. Kim TJ, etal., Vascul Pharmacol. 2007 Oct;47(4):229-37. Epub 2007 Jul 5.
17. Activation of Cdk2-pRB-E2F1 cell cycle pathway by repeated electroconvulsive shock in the rat frontal cortex. Kim Y, etal., Biol Psychiatry. 2005 Jan 1;57(1):107-9.
18. Long-term 17alpha-ethinyl estradiol treatment decreases cyclin E and cdk2 expression, reduces cdk2 kinase activity and inhibits S phase entry in regenerating rat liver. Koroxenidou L, etal., J Hepatol. 2005 Sep;43(3):478-84.
19. A variant form of cyclin-dependent kinase 2 (Cdk2) in a malignantly transformed rat thyroid (FRTL-Tc) cell line. Kotani S, etal., Oncogene 1995 Feb 16;10(4):663-9.
20. Experimental glaucoma and optic nerve transection induce simultaneous upregulation of proapoptotic and prosurvival genes. Levkovitch-Verbin H, etal., Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2491-7.
21. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
22. Analysis of cyclin E and CDK2 in ovarian cancer: gene amplification and RNA overexpression. Marone M, etal., Int J Cancer. 1998 Jan 5;75(1):34-9.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Morishita R, etal., Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8474-8.
25. [Changes in the activity of cyclin-kinase complexes governing cell transition from G1 phase to DNA replication phase in E1A + c-Ha-ras transformants transfected with the bcl-2 gene] Neliudova AM, etal., Tsitologiia 2003;45(2):149-57.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Differential association of p21Cip1 and p27Kip1 with cyclin E-CDK2 during rat liver regeneration. Pujol MJ, etal., J Hepatol. 2000 Aug;33(2):266-74.
29. Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. Ren S, etal., Int J Biochem Cell Biol. 2020 Aug;125:105777. doi: 10.1016/j.biocel.2020.105777. Epub 2020 Jun 3.
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
33. Apoptosis and tumor inhibition induced by human chorionic gonadotropin beta in mouse breast carcinoma. Shi SQ, etal., J Mol Med. 2006 Nov;84(11):933-41. Epub 2006 Aug 5.
34. Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. Shukla S and Gupta S, Mol Cancer Ther. 2006 Apr;5(4):843-52.
35. Blunted DNA synthesis and delayed S-phase entry following inhibition of Cdk2 activity in the regenerating rat liver. Starkel P, etal., Lab Invest. 2005 Apr;85(4):562-71.
36. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
37. Implication of malignancy and prognosis of p27(kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors. Sui L, etal., Gynecol Oncol. 2001 Oct;83(1):56-63.
38. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Tian B, etal., Nat Cell Biol. 2009 Feb;11(2):211-8. doi: 10.1038/ncb1829. Epub 2009 Jan 18.
39. Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat. Wang F, etal., J Cereb Blood Flow Metab 2002 Feb;22(2):171-82.
40. Cadmium induces cell cycle arrest in rat kidney epithelial cells in G2/M phase. Xie J and Shaikh ZA, Toxicology. 2006 Jul 5;224(1-2):56-65. Epub 2006 Apr 27.
41. Expression patterns of cytokine, growth factor and cell cycle-related genes after partial hepatectomy in rats with thioacetamide-induced cirrhosis. Yang S, etal., World J Gastroenterol. 2006 Feb 21;12(7):1063-70.
42. Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128. Zempolich K, etal., Gynecol Oncol. 2008 May;109(2):275-9. Epub 2008 Mar 4.
Additional References at PubMed
PMID:1312467   PMID:1653904   PMID:7739547   PMID:7797074   PMID:8245034   PMID:8673024   PMID:8684460   PMID:8692841   PMID:8876165   PMID:9054499   PMID:9344597   PMID:10082561  
PMID:10767298   PMID:10995387   PMID:11340163   PMID:11384971   PMID:11746698   PMID:11981756   PMID:12124778   PMID:12816757   PMID:12944431   PMID:12970171   PMID:12970760   PMID:14985333  
PMID:15024385   PMID:15063782   PMID:15158336   PMID:15514162   PMID:15564458   PMID:15631990   PMID:15750306   PMID:15975997   PMID:16137671   PMID:16393152   PMID:17635516   PMID:17784788  
PMID:18356301   PMID:18667424   PMID:18692063   PMID:18721488   PMID:19306950   PMID:19773423   PMID:19961935   PMID:19966300   PMID:20215406   PMID:20935635   PMID:21262353   PMID:21508411  
PMID:21596315   PMID:21761349   PMID:22045811   PMID:22223646   PMID:22258892   PMID:22584582   PMID:22713240   PMID:23168795   PMID:23184662   PMID:23599433   PMID:23781148   PMID:23904268  
PMID:24119616   PMID:24380855   PMID:24531709   PMID:24891606   PMID:26058566   PMID:26297806   PMID:26996940   PMID:28666995   PMID:29203878   PMID:29567075   PMID:31223614   PMID:33300064  
PMID:33671248  


Genomics

Comparative Map Data
Cdk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,714,392 - 1,721,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,714,392 - 1,721,878 (-)EnsemblGRCr8
mRatBN7.271,129,878 - 1,137,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,129,811 - 1,137,403 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,893,030 - 3,900,519 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,768,702 - 5,776,191 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,065,517 - 6,073,007 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd76,845,726 - 6,853,216 (-)NCBI
Lyon_Normotensive76,265,547 - 6,273,037 (-)NCBI
Lyon_Hypertensive77,084,094 - 7,091,584 (-)NCBI
F344_StmMcwi75,438,106 - 5,445,596 (-)NCBI
Rnor_6.073,124,953 - 3,132,533 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,124,954 - 3,132,457 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.073,097,653 - 3,105,210 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.472,000,196 - 2,007,682 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera71,000,083 - 1,007,560 (-)NCBICelera
RGSC_v3.172,000,196 - 2,007,682 (-)NCBI
Cytogenetic Map7q11NCBI
CDK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,966,830 - 55,972,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,966,781 - 55,972,789 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371256,360,614 - 56,366,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,646,826 - 54,652,835 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341254,646,825 - 54,652,834NCBI
Celera1256,013,264 - 56,019,276 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,399,466 - 53,405,479 (+)NCBIHuRef
CHM1_11256,327,689 - 56,333,679 (+)NCBICHM1_1
T2T-CHM13v2.01255,933,893 - 55,939,852 (+)NCBIT2T-CHM13v2.0
Cdk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,533,807 - 128,540,920 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,533,796 - 128,540,963 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810128,697,938 - 128,705,051 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,697,939 - 128,705,031 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv3710128,134,995 - 128,142,107 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610128,100,888 - 128,107,961 (-)NCBIMGSCv36mm8
Celera10131,090,071 - 131,097,183 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.13NCBI
Cdk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,555,603 - 3,562,120 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554583,555,603 - 3,561,063 (+)NCBIChiLan1.0ChiLan1.0
CDK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,356,902 - 38,362,969 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,353,674 - 38,359,695 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,940,225 - 32,946,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,189,934 - 33,195,945 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,189,934 - 33,195,945 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
CDK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110300,863 - 306,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10300,903 - 305,438 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha10362,779 - 368,479 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.010307,657 - 313,366 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10307,694 - 312,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110285,465 - 291,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010528,243 - 533,942 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010652,514 - 658,220 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1657,323,227 - 57,329,166 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440494558,484,370 - 58,490,389 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646379,842 - 385,877 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936646379,849 - 385,648 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,365,764 - 21,372,168 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1521,365,723 - 21,372,170 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,941,174 - 22,947,591 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11153,495,945 - 53,501,985 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666037194,076,082 - 194,082,105 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11151,905,085 - 51,910,209 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1151,905,115 - 51,909,907 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Cdk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480212,076,443 - 12,082,608 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462480212,076,443 - 12,082,630 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl1728,335,037 - 28,341,007 (-)Ensembl
Cdk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11156,174,352 - 156,182,293 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Cdk2
68 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:124
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000031963
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH132933  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,129,935 - 1,130,155 (+)MAPPERmRatBN7.2
Rnor_6.073,125,011 - 3,125,230NCBIRnor6.0
Rnor_5.073,097,711 - 3,097,930UniSTSRnor5.0
RGSC_v3.472,000,254 - 2,000,473UniSTSRGSC3.4
Celera71,000,141 - 1,000,360UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
264 156 726 1590 4003 1004 1720 133 867 490 849 156 5368 2591 447 3916 38 1381 741 908 159 157

Sequence


Ensembl Acc Id: ENSRNOT00000031963   ⟹   ENSRNOP00000032191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,714,392 - 1,721,878 (-)Ensembl
mRatBN7.2 Ensembl71,129,811 - 1,137,385 (-)Ensembl
Rnor_6.0 Ensembl73,124,954 - 3,132,457 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101553   ⟹   ENSRNOP00000094402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,714,392 - 1,721,878 (-)Ensembl
mRatBN7.2 Ensembl71,129,879 - 1,137,403 (-)Ensembl
RefSeq Acc Id: NM_199501   ⟹   NP_955795
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,714,392 - 1,721,878 (-)NCBI
mRatBN7.271,129,878 - 1,137,365 (-)NCBI
Dahl_SR_JrHsd76,845,726 - 6,853,216 (-)NCBI
Lyon_Normotensive76,265,547 - 6,273,037 (-)NCBI
Lyon_Hypertensive77,084,094 - 7,091,584 (-)NCBI
F344_StmMcwi75,438,106 - 5,445,596 (-)NCBI
Rnor_6.073,124,953 - 3,132,457 (-)NCBI
Rnor_5.073,097,653 - 3,105,210 (-)NCBI
RGSC_v3.472,000,196 - 2,007,682 (-)RGD
Celera71,000,083 - 1,007,560 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240778   ⟹   XP_006240840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,714,392 - 1,721,964 (-)NCBI
mRatBN7.271,129,878 - 1,137,431 (-)NCBI
Rnor_6.073,124,953 - 3,132,533 (-)NCBI
Rnor_5.073,097,653 - 3,105,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079378   ⟹   XP_038935306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,714,392 - 1,721,550 (-)NCBI
mRatBN7.271,129,878 - 1,137,093 (-)NCBI
RefSeq Acc Id: XM_039079379   ⟹   XP_038935307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,714,392 - 1,721,529 (-)NCBI
mRatBN7.271,129,878 - 1,137,091 (-)NCBI
RefSeq Acc Id: XR_010052990
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,714,392 - 1,721,964 (-)NCBI
RefSeq Acc Id: NP_955795   ⟸   NM_199501
- UniProtKB: Q63699 (UniProtKB/Swiss-Prot),   O09136 (UniProtKB/Swiss-Prot),   F6PTK8 (UniProtKB/TrEMBL),   Q6P751 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240840   ⟸   XM_006240778
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000032191   ⟸   ENSRNOT00000031963
RefSeq Acc Id: XP_038935306   ⟸   XM_039079378
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935307   ⟸   XM_039079379
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000094402   ⟸   ENSRNOT00000101553
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63699-F1-model_v2 AlphaFold Q63699 1-298 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694948
Promoter ID:EPDNEW_R5473
Type:initiation region
Name:Cdk2_1
Description:cyclin dependent kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,132,509 - 3,132,569EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70486 AgrOrtholog
BioCyc Gene G2FUF-35337 BioCyc
Ensembl Genes ENSRNOG00000006469 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000031963 ENTREZGENE
  ENSRNOT00000101553 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599608 IMAGE-MGC_LOAD
InterPro CDK UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
MGC_CLONE MGC:72609 IMAGE-MGC_LOAD
NCBI Gene Cdk2 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/Swiss-Prot
  CYCLIN-DEPENDENT KINASE 2 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Cdk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006469 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6AHN8 ENTREZGENE, UniProtKB/TrEMBL
  CDK2_RAT UniProtKB/Swiss-Prot
  F6PTK8 ENTREZGENE, UniProtKB/TrEMBL
  O09136 ENTREZGENE
  Q63699 ENTREZGENE
  Q6P751 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O09136 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Cdk2  cyclin dependent kinase 2      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Cdk2  cyclin dependent kinase 2      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease involved in global and local ischemia 70277
gene_disease involved in global and local ischemia 70293
gene_process inhibition provides neuroprotection 70277
gene_process inhibition provides neuroprotection 70293
gene_process controls transition from G1 to S phase in the cell cycle 70277
gene_process controls transition from G1 to S phase in the cell cycle 70293
gene_transcript gene encodes two mRNA isoforms of 2.5 kb and 3.0 kb 70293