Cdk2 (cyclin dependent kinase 2) - Rat Genome Database
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Gene: Cdk2 (cyclin dependent kinase 2) Rattus norvegicus
Analyze
Symbol: Cdk2
Name: cyclin dependent kinase 2
RGD ID: 70486
Description: Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Is predicted to contribute to histone kinase activity. Involved in several processes, including cellular response to insulin stimulus; response to cAMP; and response to estradiol. Localizes to cytosol and nucleus. Used to study membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2); PARTICIPATES IN G1/S transition pathway; interleukin-2 signaling pathway; mTOR signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cell division protein kinase 2; cyclin dependent kinase 2-alpha; cyclin-dependent kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.271,129,878 - 1,137,431 (-)NCBI
Rnor_6.0 Ensembl73,124,954 - 3,132,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.073,124,953 - 3,132,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.073,097,653 - 3,105,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,000,196 - 2,007,682 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.172,000,196 - 2,007,682 (-)NCBI
Celera71,000,083 - 1,007,560 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-mevalonic acid  (EXP)
(S)-(-)-perillyl alcohol  (ISO)
(S)-colchicine  (EXP)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-methoxy-17beta-estradiol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxypsoralen  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
acteoside  (ISO)
afimoxifene  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (ISO)
alsterpaullone  (ISO)
alvocidib  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene  (ISO)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Aspidin  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
berberine  (ISO)
beta-ionone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bohemine  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
BQ 123  (ISO)
brassinolide  (ISO)
busulfan  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calix[6]arene  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
carbamate ester  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
Cinobufagin  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
citric acid  (ISO)
clobenpropit  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coptisine  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
DDT  (ISO)
deferasirox  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl sulfate  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 2  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
elemental selenium  (ISO)
embelin  (ISO)
erythrosin B  (ISO)
esculetin  (EXP)
ethanol  (EXP)
ethyl trans-caffeate  (ISO)
etoposide  (ISO)
farnesol  (ISO)
fenvalerate  (ISO)
fisetin  (ISO)
fluvalinate  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
gedunin  (ISO)
genistein  (ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hesperetin  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
kainic acid  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lapatinib  (ISO)
lidocaine  (ISO)
linuron  (EXP)
lovastatin  (ISO)
luteolin  (ISO)
malathion  (ISO)
maneb  (ISO)
mechlorethamine  (ISO)
melatonin  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (EXP)
monoethyl phthalate  (ISO)
motexafin gadolinium  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
nelfinavir  (ISO)
Nicardipine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olomoucine  (EXP,ISO)
omacetaxine mepesuccinate  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
Panduratin A  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
pentachlorophenol  (EXP)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perillyl alcohol  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
Piplartine  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium atom  (EXP)
potassium dichromate  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
pterostilbene  (EXP)
pyrene  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
rotenone  (EXP)
rubitecan  (ISO)
SB 203580  (EXP,ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
silibinin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sorafenib  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
wogonin  (EXP,ISO)
wortmannin  (ISO)
zebularine  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Alvira D, etal., Neuroscience. 2007 Apr 25;146(1):350-65. Epub 2007 Mar 7.
2. Bokemeyer D, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3431-41. Epub 2007 Sep 24.
3. Bonin S, etal., Virchows Arch. 2008 Jan 31;.
4. Bora PS, etal., FEBS J. 2006 Apr;273(7):1403-14.
5. Boylan JM and Gruppuso PA, Biochem Biophys Res Commun. 2005 May 13;330(3):722-30.
6. Castro A, etal., Biochem Biophys Res Commun. 1994 Jun 30;201(3):1072-8.
7. Correze C, etal., Eur J Endocrinol. 2005 Jul;153(1):123-33.
8. Gao CY, etal., Exp Eye Res 1999 Dec;69(6):695-703.
9. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Geisen C and Moroy T, J Biol Chem 2002 Oct 18;277(42):39909-18. Epub 2002 Jul 30.
11. Horree N, etal., J Clin Pathol. 2008 Jan;61(1):36-42. Epub 2007 May 4.
12. Inamoto T, etal., Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3470-7.
13. Ito K, etal., Anticancer Res. 1998 May-Jun;18(3A):1661-4.
14. Kim TJ, etal., Vascul Pharmacol. 2007 Oct;47(4):229-37. Epub 2007 Jul 5.
15. Kim Y, etal., Biol Psychiatry. 2005 Jan 1;57(1):107-9.
16. Koroxenidou L, etal., J Hepatol. 2005 Sep;43(3):478-84.
17. Kotani S, etal., Oncogene 1995 Feb 16;10(4):663-9.
18. Levkovitch-Verbin H, etal., Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2491-7.
19. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
20. Marone M, etal., Int J Cancer. 1998 Jan 5;75(1):34-9.
21. MGD data from the GO Consortium
22. Morishita R, etal., Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8474-8.
23. Neliudova AM, etal., Tsitologiia 2003;45(2):149-57.
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Pujol MJ, etal., J Hepatol. 2000 Aug;33(2):266-74.
27. RGD automated data pipeline
28. RGD automated import pipeline for gene-chemical interactions
29. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
30. Shi SQ, etal., J Mol Med. 2006 Nov;84(11):933-41. Epub 2006 Aug 5.
31. Shukla S and Gupta S, Mol Cancer Ther. 2006 Apr;5(4):843-52.
32. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
33. Sui L, etal., Gynecol Oncol. 2001 Oct;83(1):56-63.
34. Wang F, etal., J Cereb Blood Flow Metab 2002 Feb;22(2):171-82.
35. Xie J and Shaikh ZA, Toxicology. 2006 Jul 5;224(1-2):56-65. Epub 2006 Apr 27.
36. Yang S, etal., World J Gastroenterol. 2006 Feb 21;12(7):1063-70.
37. Zempolich K, etal., Gynecol Oncol. 2008 May;109(2):275-9. Epub 2008 Mar 4.
Additional References at PubMed
PMID:1312467   PMID:1653904   PMID:7739547   PMID:7797074   PMID:8245034   PMID:8673024   PMID:8684460   PMID:8692841   PMID:8876165   PMID:9054499   PMID:9344597   PMID:10082561  
PMID:10767298   PMID:10995387   PMID:11340163   PMID:11384971   PMID:11746698   PMID:11981756   PMID:12124778   PMID:12816757   PMID:12944431   PMID:12970171   PMID:12970760   PMID:14985333  
PMID:15024385   PMID:15063782   PMID:15158336   PMID:15514162   PMID:15564458   PMID:15631990   PMID:15750306   PMID:15975997   PMID:16137671   PMID:16393152   PMID:17635516   PMID:17784788  
PMID:18305109   PMID:18356301   PMID:18667424   PMID:18692063   PMID:18721488   PMID:19306950   PMID:19773423   PMID:19961935   PMID:19966300   PMID:20215406   PMID:20935635   PMID:21262353  
PMID:21508411   PMID:21596315   PMID:21761349   PMID:22045811   PMID:22223646   PMID:22258892   PMID:22584582   PMID:22713240   PMID:23168795   PMID:23184662   PMID:23599433   PMID:23781148  
PMID:23904268   PMID:24119616   PMID:24380855   PMID:24531709   PMID:24891606   PMID:26058566   PMID:26297806   PMID:26996940   PMID:28666995   PMID:29203878   PMID:29567075   PMID:31223614  


Genomics

Comparative Map Data
Cdk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.271,129,878 - 1,137,431 (-)NCBI
Rnor_6.0 Ensembl73,124,954 - 3,132,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.073,124,953 - 3,132,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.073,097,653 - 3,105,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,000,196 - 2,007,682 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.172,000,196 - 2,007,682 (-)NCBI
Celera71,000,083 - 1,007,560 (-)NCBICelera
Cytogenetic Map7q11NCBI
CDK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1255,966,781 - 55,972,789 (+)EnsemblGRCh38hg38GRCh38
GRCh381255,966,830 - 55,972,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,360,614 - 56,366,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,646,826 - 54,652,835 (+)NCBINCBI36hg18NCBI36
Build 341254,646,825 - 54,652,834NCBI
Celera1256,013,264 - 56,019,276 (+)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1253,399,466 - 53,405,479 (+)NCBIHuRef
CHM1_11256,327,686 - 56,333,684 (+)NCBICHM1_1
Cdk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,533,807 - 128,540,920 (-)NCBIGRCm39mm39
GRCm39 Ensembl10128,533,808 - 128,540,900 (-)Ensembl
GRCm3810128,697,938 - 128,705,051 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,697,939 - 128,705,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,134,995 - 128,142,107 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610128,100,888 - 128,107,961 (-)NCBImm8
Celera10131,090,071 - 131,097,183 (-)NCBICelera
Cytogenetic Map10D3NCBI
Cdk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,555,603 - 3,562,120 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,555,603 - 3,561,063 (+)NCBIChiLan1.0ChiLan1.0
CDK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11233,189,934 - 33,195,945 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,189,934 - 33,195,945 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,940,225 - 32,946,236 (-)NCBIMhudiblu_PPA_v0panPan3
CDK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl10300,903 - 305,438 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.110300,863 - 306,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cdk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936646379,849 - 385,648 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,365,763 - 21,392,726 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,365,723 - 21,372,170 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,941,174 - 22,947,591 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,905,085 - 51,910,209 (+)NCBI
ChlSab1.1 Ensembl1151,905,115 - 51,909,907 (+)Ensembl
Cdk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480212,076,443 - 12,082,608 (-)NCBI

Position Markers
RH132933  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.073,125,011 - 3,125,230NCBIRnor6.0
Rnor_5.073,097,711 - 3,097,930UniSTSRnor5.0
RGSC_v3.472,000,254 - 2,000,473UniSTSRGSC3.4
Celera71,000,141 - 1,000,360UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:124
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000031963
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 40 29 19 29 55 29 40 11
Low 15 17 12 12 8 11 19 6 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031963   ⟹   ENSRNOP00000032191
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl73,124,954 - 3,132,457 (-)Ensembl
RefSeq Acc Id: NM_199501   ⟹   NP_955795
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.271,129,878 - 1,137,365 (-)NCBI
Rnor_6.073,124,953 - 3,132,457 (-)NCBI
Rnor_5.073,097,653 - 3,105,210 (-)NCBI
RGSC_v3.472,000,196 - 2,007,682 (-)RGD
Celera71,000,083 - 1,007,560 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240778   ⟹   XP_006240840
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.271,129,878 - 1,137,431 (-)NCBI
Rnor_6.073,124,953 - 3,132,533 (-)NCBI
Rnor_5.073,097,653 - 3,105,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079378   ⟹   XP_038935306
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.271,129,878 - 1,137,093 (-)NCBI
RefSeq Acc Id: XM_039079379   ⟹   XP_038935307
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.271,129,878 - 1,137,091 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_955795   ⟸   NM_199501
- UniProtKB: Q6P751 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240840   ⟸   XM_006240778
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000032191   ⟸   ENSRNOT00000031963
RefSeq Acc Id: XP_038935306   ⟸   XM_039079378
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935307   ⟸   XM_039079379
- Peptide Label: isoform X3
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694948
Promoter ID:EPDNEW_R5473
Type:initiation region
Name:Cdk2_1
Description:cyclin dependent kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,132,509 - 3,132,569EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 3126597 3126598 G T snv WKY/N (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 2001840 2001841 G T snv WKY/N (KNAW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70486 AgrOrtholog
Ensembl Genes ENSRNOG00000006469 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000032191 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031963 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599608 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362817 UniProtKB/TrEMBL
MGC_CLONE MGC:72609 IMAGE-MGC_LOAD
NCBI Gene 362817 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CDK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P751 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O09136 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Cdk2  cyclin dependent kinase 2      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Cdk2  cyclin dependent kinase 2      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease involved in global and local ischemia 70277
gene_disease involved in global and local ischemia 70293
gene_process inhibition provides neuroprotection 70277
gene_process inhibition provides neuroprotection 70293
gene_process controls transition from G1 to S phase in the cell cycle 70277
gene_process controls transition from G1 to S phase in the cell cycle 70293
gene_transcript gene encodes two mRNA isoforms of 2.5 kb and 3.0 kb 70293