GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13520106480464CTDCisplatin results in increased expression of CDK2 mRNA

PMID:27594783
increases phosphorylationISORGD:13520106480464CTDCisplatin results in increased phosphorylation of CDK2 protein

PMID:21592546
multiple interactionsISORGD:13520106480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of CDK2 mRNA

Cisplatin affects the reaction [Piroxicam results in decreased expression of CDK2 mRNA]

Cisplatin promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased expression of CDK2 mRNA]

Cisplatin results in decreased activity of [CCNA2 protein binds to CDK2 protein]

Cisplatin results in decreased activity of [CCNE1 protein binds to CDK2 protein]

Cisplatin results in increased activity of [CDK2 protein binds to CCNA2 protein]

Tretinoin affects the reaction [Cisplatin results in increased activity of [CDK2 protein binds to CCNA2 protein]]

PMID:12012012, PMID:20195699, PMID:21592546, PMID:21858171, PMID:27514524
multiple interactionsISORGD:705016480464CTDCisplatin promotes the reaction [CDK2 protein binds to and results in increased phosphorylation of CDKN1A protein]

PMID:21325496
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.