GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:705016480464CTDwortmannin results in decreased activity of CDK2 protein

PMID:17129604
decreases expressionISORGD:705016480464CTDwortmannin results in decreased expression of CDK2 protein

PMID:17129604
multiple interactionsISORGD:13520106480464CTD[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]

[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein]

PMID:26385184
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.