Cdk2 (cyclin-dependent kinase 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cdk2 (cyclin-dependent kinase 2) Mus musculus
Analyze
Symbol: Cdk2
Name: cyclin-dependent kinase 2
RGD ID: 70501
MGI Page MGI
Description: Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and magnesium ion binding activity. Involved in peptidyl-serine phosphorylation and positive regulation of cell population proliferation. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; potassium ion transport; and regulation of cellular macromolecule biosynthetic process. Located in chromosome and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; ear; gut gland; and integumental system. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2); PARTICIPATES IN G1/S transition pathway; interleukin-2 signaling pathway; mTOR signaling pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 14-Deoxy-11,12-didehydroandrographolide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A630093N05Rik; cell division protein kinase 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,533,807 - 128,540,920 (-)NCBIGRCm39mm39
GRCm39 Ensembl10128,533,808 - 128,540,900 (-)Ensembl
GRCm3810128,697,938 - 128,705,051 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,697,939 - 128,705,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,134,995 - 128,142,107 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610128,100,888 - 128,107,961 (-)NCBImm8
Celera10131,090,071 - 131,097,183 (-)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-mevalonic acid  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-colchicine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxypsoralen  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
acteoside  (ISO)
afimoxifene  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (EXP)
alsterpaullone  (ISO)
alvocidib  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
andrographolide  (EXP,ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene  (ISO)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Aspidin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-ionone  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bohemine  (EXP)
bortezomib  (ISO)
bosutinib  (EXP)
BQ 123  (ISO)
brassinolide  (ISO)
busulfan  (EXP)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calix[6]arene  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamate ester  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
Cinobufagin  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citric acid  (ISO)
clobenpropit  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coptisine  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
daidzein  (ISO)
DDT  (ISO)
deferasirox  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP)
dinophysistoxin 2  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
Echimidine  (ISO)
elemental selenium  (ISO)
embelin  (ISO)
erythrosin B  (ISO)
esculetin  (ISO)
ethanol  (ISO)
ethyl trans-caffeate  (ISO)
etoposide  (ISO)
farnesol  (ISO)
fenvalerate  (ISO)
fipronil  (ISO)
fisetin  (ISO)
fluvalinate  (ISO)
folic acid  (EXP,ISO)
fraxetin  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-tocopherol  (ISO)
gedunin  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
Isoangustone A  (EXP,ISO)
ivermectin  (ISO)
kainic acid  (ISO)
kenpaullone  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lapatinib  (ISO)
Lasiocarpine  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
linuron  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
malathion  (ISO)
maneb  (EXP)
mechlorethamine  (ISO)
melatonin  (EXP)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (EXP,ISO)
methylparaben  (EXP,ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (EXP)
motexafin gadolinium  (ISO)
N-(6-acetamidohexyl)acetamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
naringin  (ISO)
nelfinavir  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olomoucine  (EXP,ISO)
omacetaxine mepesuccinate  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
Panduratin A  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (EXP,ISO)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perillyl alcohol  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
Piplartine  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium atom  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propiconazole  (EXP)
propylparaben  (EXP,ISO)
pterostilbene  (ISO)
pyrene  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
rubitecan  (ISO)
ruxolitinib  (ISO)
SB 203580  (EXP,ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (ISO)
selumetinib  (EXP)
silibinin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
sorafenib  (ISO)
sterigmatocystin  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trans-caffeic acid  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP,ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
zebularine  (ISO)
zinc acetate  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiac output  (IAGP)
abnormal cell cycle  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryo development  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal gametogenesis  (IAGP)
abnormal heart valve morphology  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal male germ cell apoptosis  (IAGP)
abnormal male meiosis  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal meiosis  (IAGP)
abnormal oocyte morphology  (IAGP)
abnormal oogenesis  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spermiogenesis  (IAGP)
absent corpus luteum  (IAGP)
absent oocytes  (IAGP)
absent ovarian follicles  (IAGP)
azoospermia  (IAGP)
congestive heart failure  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cell proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased myocardial fiber number  (IAGP)
decreased tumor incidence  (IAGP)
edema  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged heart atrium  (IAGP)
enlarged myocardial fiber  (IAGP)
female infertility  (IAGP)
hemorrhage  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
infertility  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hypoplasia  (IAGP)
male infertility  (IAGP)
myocardial fiber disarray  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
ovary atrophy  (IAGP)
pallor  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
reduced male fertility  (IAGP)
small heart  (IAGP)
small ovary  (IAGP)
small seminiferous tubules  (IAGP)
small testis  (IAGP)
testicular atrophy  (IAGP)
thin ventricular wall  (IAGP)
uterus atrophy  (IAGP)
ventricular septal defect  (IAGP)
References

Additional References at PubMed
PMID:1653904   PMID:7593274   PMID:7604037   PMID:7728962   PMID:7739547   PMID:7797074   PMID:7811275   PMID:8033213   PMID:8157956   PMID:8226784   PMID:8413252   PMID:8534916  
PMID:8547220   PMID:8552401   PMID:8601034   PMID:8730099   PMID:8769642   PMID:8822197   PMID:8916036   PMID:8995365   PMID:9078394   PMID:9126296   PMID:9126324   PMID:9281369  
PMID:9371520   PMID:9372237   PMID:9438340   PMID:9457065   PMID:9488036   PMID:9584157   PMID:9639506   PMID:9664690   PMID:9666304   PMID:9841865   PMID:9843212   PMID:9856457  
PMID:9925645   PMID:10068472   PMID:10075979   PMID:10082561   PMID:10349636   PMID:10457012   PMID:10875923   PMID:10915795   PMID:11042159   PMID:11076861   PMID:11134518   PMID:11172011  
PMID:11217851   PMID:11328857   PMID:11463824   PMID:11506705   PMID:11585773   PMID:11726663   PMID:11809759   PMID:11940659   PMID:11981756   PMID:12007403   PMID:12097586   PMID:12121977  
PMID:12124778   PMID:12149264   PMID:12420317   PMID:12429912   PMID:12447695   PMID:12466960   PMID:12477932   PMID:12520002   PMID:12729791   PMID:12923533   PMID:12970171   PMID:12970760  
PMID:14536078   PMID:14561402   PMID:14610273   PMID:14627988   PMID:14672936   PMID:14681479   PMID:14691545   PMID:14695906   PMID:14699150   PMID:14707069   PMID:15003506   PMID:15028671  
PMID:15107404   PMID:15155733   PMID:15158336   PMID:15159393   PMID:15214576   PMID:15247247   PMID:15302592   PMID:15315760   PMID:15315761   PMID:15355984   PMID:15368294   PMID:15456866  
PMID:15489334   PMID:15531365   PMID:15664192   PMID:15707957   PMID:15730892   PMID:15749021   PMID:15782199   PMID:15800025   PMID:15824106   PMID:15950907   PMID:16007079   PMID:16081423  
PMID:16102793   PMID:16109376   PMID:16120603   PMID:16137671   PMID:16141072   PMID:16141073   PMID:16166639   PMID:16183859   PMID:16331279   PMID:16376875   PMID:16393152   PMID:16428455  
PMID:16537903   PMID:16627785   PMID:16672052   PMID:16678773   PMID:16760655   PMID:16869759   PMID:16925590   PMID:16969133   PMID:17000767   PMID:17038621   PMID:17256742   PMID:17274640  
PMID:17276355   PMID:17371838   PMID:17485443   PMID:17601773   PMID:17631145   PMID:17699765   PMID:17700700   PMID:17784788   PMID:17942597   PMID:17942901   PMID:18073538   PMID:18086919  
PMID:18191580   PMID:18199752   PMID:18321928   PMID:18354084   PMID:18356301   PMID:18462697   PMID:18599613   PMID:18635963   PMID:18667424   PMID:18692063   PMID:18729080   PMID:18787066  
PMID:18799693   PMID:18981479   PMID:19103742   PMID:19117947   PMID:19129496   PMID:19150984   PMID:19213844   PMID:19224635   PMID:19233286   PMID:19237534   PMID:19239702   PMID:19265663  
PMID:19302146   PMID:19307310   PMID:19383288   PMID:19494131   PMID:19590016   PMID:19592082   PMID:19644667   PMID:19652536   PMID:19737069   PMID:19773423   PMID:19933848   PMID:20010815  
PMID:20059953   PMID:20068041   PMID:20104581   PMID:20150892   PMID:20215406   PMID:20347762   PMID:20444741   PMID:20516642   PMID:20609353   PMID:20863901   PMID:20926513   PMID:21194568  
PMID:21242972   PMID:21267068   PMID:21325496   PMID:21357749   PMID:21385896   PMID:21398609   PMID:21440680   PMID:21502361   PMID:21508411   PMID:21532884   PMID:21536883   PMID:21660953  
PMID:21690373   PMID:21737879   PMID:21844184   PMID:21873635   PMID:21944720   PMID:22286767   PMID:22331465   PMID:22355113   PMID:22367880   PMID:22474407   PMID:22505032   PMID:22532528  
PMID:22560297   PMID:22802651   PMID:22898775   PMID:22898779   PMID:22957921   PMID:23055394   PMID:23071090   PMID:23077062   PMID:23136201   PMID:23166296   PMID:23316279   PMID:23321641  
PMID:23322385   PMID:23342106   PMID:23396135   PMID:23479742   PMID:23506836   PMID:23599433   PMID:23787781   PMID:23839966   PMID:23853094   PMID:23888052   PMID:23904268   PMID:24075009  
PMID:24184637   PMID:24269842   PMID:24380855   PMID:24453338   PMID:24515438   PMID:24531709   PMID:24569637   PMID:24586195   PMID:24759790   PMID:24797635   PMID:24802190   PMID:24820417  
PMID:24858909   PMID:24876127   PMID:24886500   PMID:24891606   PMID:24990151   PMID:25071185   PMID:25218637   PMID:25380821   PMID:25616574   PMID:25625205   PMID:26023099   PMID:26139602  
PMID:26148348   PMID:26240362   PMID:26241389   PMID:26303530   PMID:26449752   PMID:26574916   PMID:26581405   PMID:26681189   PMID:26861625   PMID:27025256   PMID:27034005   PMID:27122033  
PMID:27141870   PMID:27349859   PMID:27371320   PMID:27657745   PMID:27798144   PMID:27828963   PMID:28003546   PMID:28031483   PMID:28100774   PMID:28340616   PMID:28712289   PMID:29215012  
PMID:29453456   PMID:29551768   PMID:29570951   PMID:29720484   PMID:30150405   PMID:30152757   PMID:30457570   PMID:31286143   PMID:31350280   PMID:31503005   PMID:31582414   PMID:31915367  
PMID:32575562   PMID:32703236   PMID:32731332   PMID:32819570   PMID:32845237   PMID:33075054   PMID:33147210   PMID:33230114   PMID:33503433   PMID:33634103  


Genomics

Comparative Map Data
Cdk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,533,807 - 128,540,920 (-)NCBIGRCm39mm39
GRCm39 Ensembl10128,533,808 - 128,540,900 (-)Ensembl
GRCm3810128,697,938 - 128,705,051 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,697,939 - 128,705,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,134,995 - 128,142,107 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610128,100,888 - 128,107,961 (-)NCBImm8
Celera10131,090,071 - 131,097,183 (-)NCBICelera
Cytogenetic Map10D3NCBI
CDK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1255,966,781 - 55,972,789 (+)EnsemblGRCh38hg38GRCh38
GRCh381255,966,830 - 55,972,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,360,614 - 56,366,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,646,826 - 54,652,835 (+)NCBINCBI36hg18NCBI36
Build 341254,646,825 - 54,652,834NCBI
Celera1256,013,264 - 56,019,276 (+)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1253,399,466 - 53,405,479 (+)NCBIHuRef
CHM1_11256,327,689 - 56,333,679 (+)NCBICHM1_1
Cdk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.271,129,878 - 1,137,431 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl71,129,811 - 1,137,403 (-)Ensembl
Rnor_6.073,124,953 - 3,132,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,124,954 - 3,132,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,097,653 - 3,105,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,000,196 - 2,007,682 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.172,000,196 - 2,007,682 (-)NCBI
Celera71,000,083 - 1,007,560 (-)NCBICelera
Cytogenetic Map7q11NCBI
Cdk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,555,603 - 3,562,120 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,555,603 - 3,561,063 (+)NCBIChiLan1.0ChiLan1.0
CDK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11233,189,934 - 33,195,945 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,189,934 - 33,195,945 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,940,225 - 32,946,236 (-)NCBIMhudiblu_PPA_v0panPan3
CDK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110300,863 - 306,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10300,903 - 305,438 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10362,779 - 368,479 (+)NCBI
ROS_Cfam_1.010307,657 - 313,366 (+)NCBI
UMICH_Zoey_3.110285,465 - 291,170 (+)NCBI
UNSW_CanFamBas_1.010528,243 - 533,942 (+)NCBI
UU_Cfam_GSD_1.010652,514 - 658,220 (+)NCBI
Cdk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,484,370 - 58,490,389 (-)NCBI
SpeTri2.0NW_004936646379,849 - 385,648 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,365,763 - 21,392,726 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,365,723 - 21,372,170 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,941,174 - 22,947,591 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,905,085 - 51,910,209 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1151,905,115 - 51,909,907 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037194,076,082 - 194,082,105 (-)NCBIVero_WHO_p1.0
Cdk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480212,076,443 - 12,082,608 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
UniSTS:236489  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,698,391 - 128,698,657UniSTSGRCm38
MGSCv3710128,135,447 - 128,135,713UniSTSGRCm37
Celera10131,090,523 - 131,090,789UniSTS
Cytogenetic Map10D3UniSTS
Cdk2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10D3UniSTS
cM Map10 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097381196130694993Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097381196130694993Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397381196130694993Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097381196130694993Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097700000130694993Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97922739130694993Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099384730130694993Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099384730130694993Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099384730130694993Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10101150611130694993Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10101150611130694993Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101661259130694993Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101661259130694993Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102671003130694993Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10103011947130694993Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10103066603130694993Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103407822130694993Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104274116130694993Mouse
14746996Manh69_mmandible shape 69 (mouse)10104927733130694993Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105205399130694993Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105205399130694993Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105205399130694993Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105343808130694993Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105343808130694993Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105343808130694993Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108680038130694993Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108680038130694993Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108739225130694993Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108739225130694993Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108739225130694993Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108739225130694993Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122950065129631127Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122950065129631127Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122950065129631127Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125797802129630506Mouse
12911219Frct3b_mfear conditioning traits 3b (mouse)10127839705129631127Mouse
12911221Frct3d_mfear conditioning traits 3d (mouse)10127839705129631127Mouse
12904000Opfaq7_mopen field activity QTL 7 (mouse)10127910449129630506Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:994
Count of miRNA genes:318
Interacting mature miRNAs:375
Transcripts:ENSMUST00000026415, ENSMUST00000026416
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_183417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ223732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ223733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN705407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000026415   ⟹   ENSMUSP00000026415
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,533,808 - 128,540,872 (-)Ensembl
GRCm38.p6 Ensembl10128,697,939 - 128,705,003 (-)Ensembl
RefSeq Acc Id: ENSMUST00000026416   ⟹   ENSMUSP00000026416
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,533,813 - 128,540,899 (-)Ensembl
GRCm38.p6 Ensembl10128,697,944 - 128,705,030 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219047
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,537,609 - 128,540,872 (-)Ensembl
GRCm38.p6 Ensembl10128,701,740 - 128,705,003 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219099
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,533,813 - 128,540,900 (-)Ensembl
GRCm38.p6 Ensembl10128,697,944 - 128,705,031 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219601
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,536,007 - 128,540,868 (-)Ensembl
GRCm38.p6 Ensembl10128,700,138 - 128,704,999 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219983
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,533,815 - 128,540,848 (-)Ensembl
GRCm38.p6 Ensembl10128,697,946 - 128,704,979 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220407
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,537,229 - 128,540,450 (-)Ensembl
GRCm38.p6 Ensembl10128,701,360 - 128,704,581 (-)Ensembl
RefSeq Acc Id: NM_016756   ⟹   NP_058036
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,533,808 - 128,540,920 (-)NCBI
GRCm3810128,697,939 - 128,705,051 (-)NCBI
MGSCv3710128,134,995 - 128,142,107 (-)RGD
Celera10131,090,071 - 131,097,183 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_183417   ⟹   NP_904326
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,533,808 - 128,540,920 (-)NCBI
GRCm3810128,697,939 - 128,705,051 (-)NCBI
MGSCv3710128,134,995 - 128,142,107 (-)RGD
Celera10131,090,071 - 131,097,183 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513162   ⟹   XP_006513225
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,533,807 - 128,540,484 (-)NCBI
GRCm3810128,697,938 - 128,704,615 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011243321   ⟹   XP_011241623
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,533,807 - 128,540,897 (-)NCBI
GRCm3810128,697,938 - 128,704,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244853   ⟹   XP_030100713
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,533,807 - 128,540,894 (-)NCBI
GRCm3810128,697,938 - 128,704,995 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244854   ⟹   XP_030100714
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,533,807 - 128,540,484 (-)NCBI
GRCm3810128,697,938 - 128,704,615 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058036   ⟸   NM_016756
- Peptide Label: isoform 2
- UniProtKB: P97377 (UniProtKB/Swiss-Prot),   Q3U6X7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_904326   ⟸   NM_183417
- Peptide Label: isoform 1
- UniProtKB: P97377 (UniProtKB/Swiss-Prot),   Q3U6X7 (UniProtKB/TrEMBL),   Q3UGB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513225   ⟸   XM_006513162
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011241623   ⟸   XM_011243321
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030100713   ⟸   XM_030244853
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030100714   ⟸   XM_030244854
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000026415   ⟸   ENSMUST00000026415
RefSeq Acc Id: ENSMUSP00000026416   ⟸   ENSMUST00000026416
Protein Domains
Protein kinase

Promoters
RGD ID:6819099
Promoter ID:MM_KWN:6018
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_016756,   NM_183417,   UC007HOA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610128,141,506 - 128,142,302 (-)MPROMDB
RGD ID:8673650
Promoter ID:EPDNEW_M14856
Type:initiation region
Name:Cdk2_1
Description:Mus musculus cyclin-dependent kinase 2 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810128,705,000 - 128,705,060EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104772 AgrOrtholog
Ensembl Genes ENSMUSG00000025358 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000026415 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000026416 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026415 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000026416 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104772 ENTREZGENE
NCBI Gene 12566 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CDK2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U307_MOUSE UniProtKB/TrEMBL
  Q3U6X7 ENTREZGENE, UniProtKB/TrEMBL
  Q3UGB9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O55105 UniProtKB/Swiss-Prot