Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cdk2 (cyclin-dependent kinase 2) Mus musculus
Analyze
Symbol: Cdk2
Name: cyclin-dependent kinase 2
Description: Exhibits cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and magnesium ion binding activity. Predicted to contribute to histone kinase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; peptidyl-serine phosphorylation; and regulation of cellular macromolecule biosynthetic process. Localizes to several cellular components, including chromosome; cyclin-dependent protein kinase holoenzyme complex; and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; ear; gut gland; and integumental system. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2); PARTICIPATES IN G1/S transition pathway; interleukin-2 signaling pathway; mTOR signaling pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 14-Deoxy-11,12-didehydroandrographolide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A630093N05Rik; cell division protein kinase 2
Orthologs:
Homo sapiens (human) : CDK2 (cyclin dependent kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cdk2 (cyclin dependent kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk2 (cyclin dependent kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK2 (cyclin dependent kinase 2)
Canis lupus familiaris (dog) : CDK2 (cyclin dependent kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk2 (cyclin dependent kinase 2)
Sus scrofa (pig) : CDK2 (cyclin dependent kinase 2)
Chlorocebus sabaeus (African green monkey) : CDK2 (cyclin dependent kinase 2)
Heterocephalus glaber (naked mole-rat) : Cdk2 (cyclin dependent kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl10128,697,939 - 128,705,031 (-)EnsemblGRCm38mm10GRCm38
GRCm3810128,697,938 - 128,705,051 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710128,134,995 - 128,142,107 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610128,100,888 - 128,107,961 (-)NCBImm8
Celera10131,090,071 - 131,097,183 (-)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cdk2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70501
Created: 2002-05-02
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.