GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDCorticosterone results in decreased activity of CDK2 protein

PMID:12807724
decreases expressionEXP 6480464CTDCorticosterone results in decreased expression of CDK2 protein

PMID:12807724
multiple interactionsEXP 6480464CTDCorticosterone promotes the reaction [CDKN1A protein binds to CDK2 protein]

PMID:12807724
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.