GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of CDK2 mRNA

PMID:29111458
multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [CDK2 protein results in increased phosphorylation of RB1 protein]

PMID:9442036
decreases activityISORGD:13520106480464CTDDexamethasone results in decreased activity of CDK2 protein

PMID:12800980
decreases expressionISORGD:13520106480464CTDDexamethasone results in decreased expression of CDK2 mRNA

Dexamethasone results in decreased expression of CDK2 protein

Dexamethasone results in decreased expression of CDK2 protein modified form

PMID:12800980, PMID:19428934
decreases expressionISORGD:705016480464CTDDexamethasone results in decreased expression of CDK2 mRNA

PMID:21041162
increases expressionISORGD:13520106480464CTDDexamethasone results in increased expression of CDK2 mRNA

PMID:23137833
multiple interactionsISORGD:13520106480464CTDCycloheximide inhibits the reaction [Dexamethasone results in decreased expression of CDK2 mRNA]

Dexamethasone inhibits the reaction [CDK2 protein binds to CDKN1A protein]

PMID:12800980
multiple interactionsISORGD:705016480464CTD14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]

5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CDK2 protein]

[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein

[Acrylamide co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein

[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CDK2 protein

andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]

dorsomorphin inhibits the reaction [14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of CDK2 protein]]

PMID:24646949, PMID:27475717, PMID:30248417, PMID:30409764
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.