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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CDK2 mRNAPMID:20458559
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTD[ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CDK2 mRNA; Arsenic Trioxide inhibits the reaction [PDGFB protein results in increased expression of CDK2 protein]; Arsenic Trioxide promotes the reaction [CDK2 protein binds to CDKN1A protein]; Arsenic Trioxide results in decreased expression of and results in decreased activity of CDK2 proteinPMID:12480548 PMID:30012499 PMID:35276128
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