GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:90225
Term: rubitecan
Definition: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
Chemical ID: MESH:C079905
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13520106480464CTD[rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CDK2 protein

PMID:21695227
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.