GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases phosphorylationISORGD:13520106480464CTDTetradecanoylphorbol Acetate results in decreased phosphorylation of CDK2 protein

PMID:15978937
increases activityISORGD:13520106480464CTDTetradecanoylphorbol Acetate results in increased activity of CDK2 protein

PMID:12421932
increases expressionISORGD:13520106480464CTDTetradecanoylphorbol Acetate results in increased expression of CDK2 protein

PMID:24073338
multiple interactionsISORGD:13520106480464CTDTretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of CDK2 protein]

PMID:12421932
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.