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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases expressionEXP 6480464CTDTretinoin results in decreased expression of CDK2 proteinPMID:11675954
Cdk2multiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [FGF2 protein results in increased expression of CDK2 mRNA]PMID:11675954
Cdk2decreases degradationISOCDK2 (Homo sapiens)6480464CTDTretinoin results in decreased degradation of CDK2 proteinPMID:20935519
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDTretinoin results in decreased expression of CDK2 proteinPMID:16517207 PMID:17960384
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTD[Tretinoin co-treated with caffeic acid phenethyl ester] inhibits the reaction [CDK2 protein binds to CCNE1 protein]; [Tretinoin co-treated with IFNG protein] results in decreased expression of CDK2 protein; Tretinoin affects the reaction [Cisplatin results in increased activity of [CDK2 protein binds to CCNA2 protein]]; Tretinoin inhibits the reaction [CDK2 protein binds to CCNE1 protein]; Tretinoin promotes the reaction [CDK2 protein binds to CCNE1 protein]; Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of CDK2 protein]PMID:12012012 PMID:12421932 PMID:16765349 PMID:16766008 PMID:17960384
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