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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases expressionEXP 6480464CTDchromium hexavalent ion results in decreased expression of CDK2 proteinPMID:21621607
Cdk2multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CDK2 protein]PMID:21621607
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDchromium hexavalent ion results in decreased expression of CDK2 proteinPMID:22886373
Cdk2multiple interactionsISOCdk2 (Mus musculus)6480464CTD[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of CDK2 protein; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in decreased expression of CDK2 protein]PMID:35643323
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