CDK2 (cyclin dependent kinase 2) - Rat Genome Database
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Gene: CDK2 (cyclin dependent kinase 2) Homo sapiens
Analyze
Symbol: CDK2
Name: cyclin dependent kinase 2
RGD ID: 1352010
HGNC Page HGNC
Description: Exhibits cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and protein domain specific binding activity. Contributes to histone kinase activity. Involved in several processes, including Ras protein signal transduction; centriole replication; and protein phosphorylation. Localizes to several cellular components, including Cajal body; centrosome; and cyclin-dependent protein kinase holoenzyme complex. Implicated in prostate cancer and renal cell carcinoma. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cdc2-related protein kinase; CDKN2; cell devision kinase 2; cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1255,966,781 - 55,972,789 (+)EnsemblGRCh38hg38GRCh38
GRCh381255,966,830 - 55,972,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,360,614 - 56,366,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,646,826 - 54,652,835 (+)NCBINCBI36hg18NCBI36
Build 341254,646,825 - 54,652,834NCBI
Celera1256,013,264 - 56,019,276 (+)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1253,399,466 - 53,405,479 (+)NCBIHuRef
CHM1_11256,327,686 - 56,333,684 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(-)-demecolcine  (EXP)
(20R)-protopanaxadiol  (EXP)
(R)-mevalonic acid  (ISO)
(S)-(-)-perillyl alcohol  (EXP)
(S)-colchicine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-diindolylmethane  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
5-formyltetrahydrofolic acid  (EXP)
5-methoxypsoralen  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
acteoside  (EXP)
afimoxifene  (EXP)
albuterol  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
alsterpaullone  (EXP)
alvocidib  (EXP)
amlodipine  (EXP)
ammonium chloride  (ISO)
andrographolide  (EXP,ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
anthracene  (EXP)
antirheumatic drug  (EXP)
antroquinonol  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
Aspidin  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
berberine  (EXP)
beta-ionone  (EXP)
biphenyl-4-amine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bohemine  (ISO)
bortezomib  (EXP)
bosutinib  (ISO)
BQ 123  (EXP)
brassinolide  (EXP)
busulfan  (ISO)
Butylparaben  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (EXP)
calcitriol  (EXP)
calix[6]arene  (EXP)
camptothecin  (EXP)
capsaicin  (EXP)
carbamate ester  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
casticin  (EXP)
celastrol  (EXP)
celecoxib  (EXP)
choline  (ISO)
chromium(6+)  (EXP,ISO)
Cinobufagin  (EXP)
ciprofloxacin  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citric acid  (EXP)
clobenpropit  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coptisine  (EXP)
corticosterone  (ISO)
coumarin  (EXP)
coumestrol  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
daidzein  (EXP)
DDT  (EXP)
deferasirox  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
diclofenac  (EXP)
dieldrin  (ISO)
diethyl sulfate  (EXP)
diethylstilbestrol  (ISO)
dinophysistoxin 2  (EXP)
dioscin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (EXP)
elemental selenium  (EXP)
embelin  (EXP)
erythrosin B  (EXP)
esculetin  (ISO)
ethanol  (ISO)
ethyl trans-caffeate  (EXP)
etoposide  (EXP)
farnesol  (EXP)
fenvalerate  (EXP)
fisetin  (EXP)
fluvalinate  (EXP)
folic acid  (EXP,ISO)
fulvestrant  (EXP)
furan  (ISO)
gamma-tocopherol  (EXP)
gedunin  (EXP)
genistein  (EXP,ISO)
geraniol  (EXP)
ginsenoside Rg1  (EXP)
glyphosate  (EXP)
GW 3965  (EXP)
GW 4064  (EXP)
hesperetin  (EXP)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
histamine  (EXP)
hydrogen peroxide  (EXP)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
kainic acid  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lapatinib  (EXP)
lidocaine  (ISO)
linuron  (ISO)
lovastatin  (EXP)
luteolin  (EXP)
malathion  (EXP)
maneb  (ISO)
mechlorethamine  (EXP)
melatonin  (ISO)
metformin  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl isocyanate  (EXP,ISO)
methylparaben  (EXP,ISO)
methylseleninic acid  (EXP)
mifepristone  (EXP)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
motexafin gadolinium  (EXP)
N-(6-acetamidohexyl)acetamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (EXP)
naringin  (EXP,ISO)
nelfinavir  (EXP)
Nicardipine  (EXP)
nickel atom  (EXP)
niclosamide  (EXP)
Nonylphenol  (EXP)
NS-398  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
olomoucine  (EXP,ISO)
omacetaxine mepesuccinate  (EXP)
orlistat  (EXP)
ouabain  (EXP)
oxaliplatin  (EXP,ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
Panduratin A  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP,ISO)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (EXP)
perfluorononanoic acid  (EXP)
perillyl alcohol  (EXP)
phenanthrene  (EXP)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidylcholine  (EXP)
pinosylvin  (EXP)
pioglitazone  (EXP)
Piplartine  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
potassium atom  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propiconazole  (ISO)
propylparaben  (EXP,ISO)
pterostilbene  (ISO)
pyrene  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
ritonavir  (EXP)
rotenone  (ISO)
rubitecan  (EXP)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP)
selumetinib  (ISO)
silibinin  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sorafenib  (EXP)
sulindac  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thymoquinone  (EXP)
Tiron  (EXP)
titanium dioxide  (EXP)
tocopherol  (EXP)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trans-caffeic acid  (EXP)
trans-pinosylvin  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (EXP)
usnic acid  (EXP)
valproic acid  (EXP)
vincaleukoblastine  (EXP)
vincristine  (EXP)
wogonin  (EXP,ISO)
wortmannin  (EXP,ISO)
zebularine  (EXP)
zinc acetate  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anaphase-promoting complex-dependent catabolic process  (TAS)
animal organ regeneration  (ISO)
cell division  (IEA)
cellular response to insulin stimulus  (ISO)
cellular response to nitric oxide  (TAS)
centriole replication  (IMP)
centrosome duplication  (TAS)
DNA repair  (IEA)
DNA replication  (TAS)
DNA replication initiation  (TAS)
G1/S transition of mitotic cell cycle  (IBA,IEA,ISO,TAS)
G2/M transition of mitotic cell cycle  (NAS,TAS)
granulocyte differentiation  (TAS)
histone phosphorylation  (IDA)
lens development in camera-type eye  (ISO)
meiotic cell cycle  (TAS)
mitotic G1 DNA damage checkpoint signaling  (TAS)
negative regulation of cellular protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
peptidyl-serine phosphorylation  (IDA,IEA)
positive regulation of cell population proliferation  (IBA,IDA,IEA)
positive regulation of DNA-dependent DNA replication initiation  (IEA,ISO)
positive regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
positive regulation of transcription, DNA-templated  (IEA,ISO)
potassium ion transport  (IEA,ISO)
protein phosphorylation  (IBA,IDA,IEA,IMP,ISO)
Ras protein signal transduction  (IEP)
regulation of cell cycle  (IEA)
regulation of G2/M transition of mitotic cell cycle  (IBA)
regulation of gene expression  (IBA)
regulation of gene silencing  (IDA)
regulation of signal transduction by p53 class mediator  (TAS)
response to cadmium ion  (ISO)
response to cAMP  (ISO)
response to drug  (ISO)
response to electrical stimulus  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to toxic substance  (ISO)
signal transduction  (IBA)
telomere maintenance via telomerase  (TAS)

Cellular Component

References

Additional References at PubMed
PMID:1312467   PMID:1388288   PMID:1396589   PMID:1530885   PMID:1653904   PMID:1714386   PMID:1717994   PMID:2227411   PMID:7553852   PMID:7569954   PMID:7629134   PMID:7630397  
PMID:7644510   PMID:7716549   PMID:7743995   PMID:7780738   PMID:7799941   PMID:7903056   PMID:7969176   PMID:8033213   PMID:8101826   PMID:8127873   PMID:8230483   PMID:8242750  
PMID:8242751   PMID:8245034   PMID:8259214   PMID:8275715   PMID:8393783   PMID:8397206   PMID:8397207   PMID:8458319   PMID:8463339   PMID:8475101   PMID:8491188   PMID:8510751  
PMID:8521818   PMID:8565853   PMID:8601310   PMID:8606778   PMID:8610110   PMID:8617791   PMID:8622677   PMID:8626527   PMID:8641969   PMID:8647086   PMID:8647814   PMID:8662825  
PMID:8684460   PMID:8692841   PMID:8692842   PMID:8756328   PMID:8756624   PMID:8764100   PMID:8806683   PMID:8867812   PMID:8876165   PMID:8917641   PMID:8943373   PMID:8978686  
PMID:9019396   PMID:9029153   PMID:9030781   PMID:9041194   PMID:9053846   PMID:9054499   PMID:9139732   PMID:9150368   PMID:9178893   PMID:9188854   PMID:9190208   PMID:9192873  
PMID:9199321   PMID:9218599   PMID:9223324   PMID:9244350   PMID:9258347   PMID:9284049   PMID:9311822   PMID:9311993   PMID:9315635   PMID:9334743   PMID:9372912   PMID:9380407  
PMID:9380698   PMID:9464540   PMID:9467962   PMID:9472014   PMID:9525916   PMID:9545286   PMID:9546435   PMID:9566895   PMID:9632134   PMID:9632813   PMID:9636170   PMID:9658399  
PMID:9660939   PMID:9677190   PMID:9710583   PMID:9716181   PMID:9724724   PMID:9731206   PMID:9811456   PMID:9840927   PMID:9840932   PMID:9840943   PMID:9858585   PMID:9858587  
PMID:9885575   PMID:9886493   PMID:9889196   PMID:9891079   PMID:9933170   PMID:10022118   PMID:10082561   PMID:10095772   PMID:10198259   PMID:10202152   PMID:10207050   PMID:10323868  
PMID:10330164   PMID:10339564   PMID:10348343   PMID:10359664   PMID:10373465   PMID:10373534   PMID:10386600   PMID:10393546   PMID:10432313   PMID:10447003   PMID:10454565   PMID:10486249  
PMID:10499802   PMID:10548110   PMID:10559858   PMID:10559988   PMID:10574912   PMID:10585280   PMID:10593981   PMID:10602502   PMID:10639311   PMID:10652300   PMID:10747897   PMID:10748114  
PMID:10748174   PMID:10767298   PMID:10783242   PMID:10825149   PMID:10827081   PMID:10846177   PMID:10874474   PMID:10877824   PMID:10878006   PMID:10884347   PMID:10908655   PMID:10918595  
PMID:10924145   PMID:10930425   PMID:10934208   PMID:10938080   PMID:10938106   PMID:10995386   PMID:10995387   PMID:10995390   PMID:11042687   PMID:11063125   PMID:11069302   PMID:11076863  
PMID:11102515   PMID:11113184   PMID:11132966   PMID:11160398   PMID:11175348   PMID:11231585   PMID:11238922   PMID:11245432   PMID:11259605   PMID:11264176   PMID:11278991   PMID:11302688  
PMID:11306463   PMID:11310559   PMID:11340163   PMID:11377199   PMID:11395479   PMID:11433299   PMID:11463386   PMID:11463845   PMID:11477082   PMID:11532001   PMID:11598016   PMID:11684017  
PMID:11698641   PMID:11746698   PMID:11781350   PMID:11781834   PMID:11850621   PMID:11884610   PMID:11907280   PMID:11931757   PMID:11940657   PMID:11953320   PMID:11980914   PMID:11983168  
PMID:12036888   PMID:12044161   PMID:12049628   PMID:12064478   PMID:12081504   PMID:12096339   PMID:12114499   PMID:12140288   PMID:12149264   PMID:12185076   PMID:12190313   PMID:12191604  
PMID:12239611   PMID:12244298   PMID:12361598   PMID:12383116   PMID:12388094   PMID:12417722   PMID:12477932   PMID:12529437   PMID:12531694   PMID:12560341   PMID:12676582   PMID:12676926  
PMID:12684681   PMID:12729791   PMID:12732645   PMID:12745075   PMID:12757710   PMID:12800980   PMID:12801928   PMID:12810668   PMID:12839962   PMID:12839982   PMID:12853968   PMID:12857729  
PMID:12912980   PMID:12915577   PMID:12923533   PMID:12941338   PMID:12944431   PMID:12947099   PMID:12949733   PMID:12954644   PMID:12963725   PMID:12970441   PMID:12972555   PMID:13678583  
PMID:14506259   PMID:14530271   PMID:14536078   PMID:14550307   PMID:14551212   PMID:14562046   PMID:14597612   PMID:14612403   PMID:14612406   PMID:14645251   PMID:14646596   PMID:14656438  
PMID:14681231   PMID:14691455   PMID:14694185   PMID:14701826   PMID:14985333   PMID:14993212   PMID:15003538   PMID:15004009   PMID:15004027   PMID:15024056   PMID:15024385   PMID:15030318  
PMID:15050687   PMID:15063782   PMID:15107404   PMID:15144186   PMID:15147269   PMID:15159402   PMID:15169570   PMID:15173007   PMID:15178429   PMID:15189033   PMID:15199159   PMID:15226429  
PMID:15232106   PMID:15239650   PMID:15241418   PMID:15282296   PMID:15302935   PMID:15309028   PMID:15355984   PMID:15355997   PMID:15455144   PMID:15456866   PMID:15469821   PMID:15489334  
PMID:15489336   PMID:15514162   PMID:15530371   PMID:15557281   PMID:15572662   PMID:15583032   PMID:15601848   PMID:15607961   PMID:15611077   PMID:15611625   PMID:15619620   PMID:15632290  
PMID:15635413   PMID:15647383   PMID:15649889   PMID:15652749   PMID:15660127   PMID:15665273   PMID:15670215   PMID:15671017   PMID:15695403   PMID:15695825   PMID:15707957   PMID:15753125  
PMID:15772084   PMID:15800615   PMID:15800651   PMID:15811853   PMID:15828833   PMID:15855168   PMID:15890360   PMID:15922732   PMID:15944161   PMID:15964852   PMID:15980415   PMID:15998794  
PMID:16009130   PMID:16027724   PMID:16036217   PMID:16061792   PMID:16082200   PMID:16082227   PMID:16085226   PMID:16150942   PMID:16159883   PMID:16174846   PMID:16191191   PMID:16205633  
PMID:16209941   PMID:16223725   PMID:16226712   PMID:16258277   PMID:16262700   PMID:16289656   PMID:16290148   PMID:16326706   PMID:16327805   PMID:16343435   PMID:16344560   PMID:16365885  
PMID:16376875   PMID:16381901   PMID:16407256   PMID:16431923   PMID:16446360   PMID:16458891   PMID:16479163   PMID:16504183   PMID:16517729   PMID:16519687   PMID:16540140   PMID:16575928  
PMID:16582606   PMID:16707497   PMID:16762841   PMID:16765349   PMID:16777603   PMID:16782892   PMID:16824683   PMID:16826239   PMID:16878158   PMID:16912045   PMID:16912201   PMID:16951407  
PMID:16962592   PMID:16979657   PMID:16985050   PMID:17001081   PMID:17013093   PMID:17038621   PMID:17053782   PMID:17083724   PMID:17095507   PMID:17192257   PMID:17207508   PMID:17224799  
PMID:17254966   PMID:17254967   PMID:17255359   PMID:17274640   PMID:17293600   PMID:17353931   PMID:17361108   PMID:17371838   PMID:17386261   PMID:17409098   PMID:17409409   PMID:17418410  
PMID:17431037   PMID:17495531   PMID:17631934   PMID:17638878   PMID:17661632   PMID:17671428   PMID:17698606   PMID:17713927   PMID:17927916   PMID:17970072   PMID:18042686   PMID:18156799  
PMID:18174243   PMID:18177895   PMID:18198356   PMID:18199752   PMID:18202766   PMID:18208561   PMID:18243139   PMID:18276582   PMID:18281541   PMID:18285702   PMID:18305109   PMID:18345036  
PMID:18372919   PMID:18400748   PMID:18408738   PMID:18455747   PMID:18470542   PMID:18471975   PMID:18507837   PMID:18559665   PMID:18604603   PMID:18615582   PMID:18617527   PMID:18632610  
PMID:18635963   PMID:18667424   PMID:18784074   PMID:18806832   PMID:18838553   PMID:18850315   PMID:18941885   PMID:19014373   PMID:19061641   PMID:19066288   PMID:19091404   PMID:19101503  
PMID:19103742   PMID:19124506   PMID:19150984   PMID:19166026   PMID:19197163   PMID:19201832   PMID:19225156   PMID:19238148   PMID:19258477   PMID:19270695   PMID:19321444   PMID:19423708  
PMID:19440053   PMID:19470470   PMID:19483727   PMID:19556892   PMID:19594747   PMID:19596857   PMID:19603446   PMID:19609547   PMID:19622356   PMID:19631451   PMID:19686743   PMID:19703905  
PMID:19706521   PMID:19723060   PMID:19724860   PMID:19732026   PMID:19738611   PMID:19773423   PMID:19786724   PMID:19797611   PMID:19822658   PMID:19829063   PMID:19838212   PMID:19838216  
PMID:19854217   PMID:19858290   PMID:19885547   PMID:19960406   PMID:19966300   PMID:20017906   PMID:20062077   PMID:20068231   PMID:20079829   PMID:20098747   PMID:20102411   PMID:20147522  
PMID:20160477   PMID:20195506   PMID:20399812   PMID:20422243   PMID:20444741   PMID:20465575   PMID:20508983   PMID:20512928   PMID:20587660   PMID:20679368   PMID:20694007   PMID:20711190  
PMID:20733051   PMID:20837141   PMID:20844047   PMID:20871633   PMID:20935635   PMID:20956357   PMID:21048031   PMID:21062975   PMID:21088490   PMID:21092281   PMID:21099355   PMID:21145461  
PMID:21148318   PMID:21233845   PMID:21241890   PMID:21262353   PMID:21264535   PMID:21319273   PMID:21325496   PMID:21372285   PMID:21423803   PMID:21439954   PMID:21447625   PMID:21454540  
PMID:21515670   PMID:21565702   PMID:21596315   PMID:21646351   PMID:21651489   PMID:21654808   PMID:21658603   PMID:21697511   PMID:21699904   PMID:21704044   PMID:21769424   PMID:21804548  
PMID:21840486   PMID:21871181   PMID:21873635   PMID:21918011   PMID:21941773   PMID:21952639   PMID:21965652   PMID:21988832   PMID:22084169   PMID:22158041   PMID:22231403   PMID:22370481  
PMID:22467868   PMID:22474407   PMID:22479189   PMID:22539978   PMID:22623531   PMID:22654103   PMID:22673765   PMID:22718829   PMID:22768111   PMID:22770219   PMID:22810586   PMID:22819841  
PMID:22927831   PMID:22940584   PMID:22951725   PMID:22951823   PMID:23007395   PMID:23028682   PMID:23064645   PMID:23065011   PMID:23082202   PMID:23140174   PMID:23184662   PMID:23185313  
PMID:23230143   PMID:23300027   PMID:23321641   PMID:23390492   PMID:23390529   PMID:23421998   PMID:23443559   PMID:23446853   PMID:23455922   PMID:23479742   PMID:23532886   PMID:23602568  
PMID:23643165   PMID:23670162   PMID:23671119   PMID:23678366   PMID:23720738   PMID:23727278   PMID:23737759   PMID:23770852   PMID:23776131   PMID:23776205   PMID:23781148   PMID:23787073  
PMID:23853094   PMID:23926101   PMID:23972993   PMID:24075009   PMID:24186063   PMID:24204256   PMID:24216307   PMID:24218572   PMID:24240190   PMID:24302728   PMID:24358021   PMID:24386425  
PMID:24390342   PMID:24407240   PMID:24444383   PMID:24520316   PMID:24623419   PMID:24632684   PMID:24671051   PMID:24700371   PMID:24705021   PMID:24771265   PMID:24820417   PMID:24835992  
PMID:24911186   PMID:24922574   PMID:24935000   PMID:24947816   PMID:25015816   PMID:25071185   PMID:25136960   PMID:25149358   PMID:25154617   PMID:25218592   PMID:25218637   PMID:25220500  
PMID:25241761   PMID:25265349   PMID:25271736   PMID:25303791   PMID:25410660   PMID:25416956   PMID:25443276   PMID:25451924   PMID:25463638   PMID:25483090   PMID:25495526   PMID:25501982  
PMID:25541464   PMID:25544563   PMID:25669885   PMID:25691663   PMID:25728284   PMID:25744732   PMID:25754137   PMID:25808870   PMID:25832654   PMID:25852190   PMID:25860957   PMID:25918937  
PMID:25921289   PMID:25959826   PMID:26026083   PMID:26028036   PMID:26083744   PMID:26124340   PMID:26139602   PMID:26147897   PMID:26151768   PMID:26186194   PMID:26204491   PMID:26248649  
PMID:26297806   PMID:26299517   PMID:26303530   PMID:26304236   PMID:26344197   PMID:26373553   PMID:26387543   PMID:26450989   PMID:26464264   PMID:26496610   PMID:26555773   PMID:26595527  
PMID:26638075   PMID:26644182   PMID:26652902   PMID:26677902   PMID:26678539   PMID:26714749   PMID:26730572   PMID:26774155   PMID:26811472   PMID:26828990   PMID:26857166   PMID:26861625  
PMID:26876672   PMID:26890070   PMID:26960431   PMID:26972000   PMID:26996940   PMID:27065328   PMID:27100206   PMID:27107012   PMID:27109354   PMID:27163259   PMID:27166195   PMID:27175940  
PMID:27215384   PMID:27259234   PMID:27285764   PMID:27378523   PMID:27402161   PMID:27432908   PMID:27465546   PMID:27475256   PMID:27629878   PMID:27663592   PMID:27773672   PMID:27819669  
PMID:27831832   PMID:27998760   PMID:28003546   PMID:28030798   PMID:28100774   PMID:28137908   PMID:28162934   PMID:28319085   PMID:28345297   PMID:28350121   PMID:28430399   PMID:28446751  
PMID:28514442   PMID:28515276   PMID:28581483   PMID:28655764   PMID:28666995   PMID:28675297   PMID:28712289   PMID:28760857   PMID:28842430   PMID:29044141   PMID:29118189   PMID:29157894  
PMID:29203878   PMID:29229926   PMID:29253178   PMID:29254517   PMID:29323532   PMID:29328425   PMID:29363574   PMID:29372687   PMID:29373224   PMID:29424068   PMID:29439025   PMID:29445034  
PMID:29507054   PMID:29510343   PMID:29570358   PMID:29666278   PMID:29687635   PMID:29720484   PMID:29750532   PMID:29764937   PMID:29782647   PMID:29845934   PMID:29896817   PMID:29997244  
PMID:30057196   PMID:30145203   PMID:30184107   PMID:30286765   PMID:30300385   PMID:30463901   PMID:30516105   PMID:30570821   PMID:30573684   PMID:30833792   PMID:30842588   PMID:30947664  
PMID:30948266   PMID:31067491   PMID:31073040   PMID:31091453   PMID:31112565   PMID:31160578   PMID:31270457   PMID:31309634   PMID:31431461   PMID:31451657   PMID:31467278   PMID:31649026  
PMID:31731257   PMID:31804459   PMID:31822694   PMID:31964753   PMID:32045367   PMID:32075913   PMID:32088186   PMID:32120135   PMID:32373965   PMID:32416067   PMID:32423798   PMID:32538752  
PMID:32694731   PMID:32786267   PMID:32814053   PMID:32992673   PMID:33016930   PMID:33152268  


Genomics

Comparative Map Data
CDK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1255,966,781 - 55,972,789 (+)EnsemblGRCh38hg38GRCh38
GRCh381255,966,830 - 55,972,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,360,614 - 56,366,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,646,826 - 54,652,835 (+)NCBINCBI36hg18NCBI36
Build 341254,646,825 - 54,652,834NCBI
Celera1256,013,264 - 56,019,276 (+)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1253,399,466 - 53,405,479 (+)NCBIHuRef
CHM1_11256,327,686 - 56,333,684 (+)NCBICHM1_1
Cdk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,533,807 - 128,540,920 (-)NCBIGRCm39mm39
GRCm39 Ensembl10128,533,808 - 128,540,900 (-)Ensembl
GRCm3810128,697,938 - 128,705,051 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,697,939 - 128,705,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,134,995 - 128,142,107 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610128,100,888 - 128,107,961 (-)NCBImm8
Celera10131,090,071 - 131,097,183 (-)NCBICelera
Cytogenetic Map10D3NCBI
Cdk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.271,129,878 - 1,137,431 (-)NCBI
Rnor_6.0 Ensembl73,124,954 - 3,132,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.073,124,953 - 3,132,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.073,097,653 - 3,105,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,000,196 - 2,007,682 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.172,000,196 - 2,007,682 (-)NCBI
Celera71,000,083 - 1,007,560 (-)NCBICelera
Cytogenetic Map7q11NCBI
Cdk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,555,603 - 3,562,120 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,555,603 - 3,561,063 (+)NCBIChiLan1.0ChiLan1.0
CDK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11233,189,934 - 33,195,945 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,189,934 - 33,195,945 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,940,225 - 32,946,236 (-)NCBIMhudiblu_PPA_v0panPan3
CDK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110300,863 - 306,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10300,903 - 305,438 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10362,779 - 368,479 (+)NCBI
ROS_Cfam_1.010307,657 - 313,366 (+)NCBI
UMICH_Zoey_3.110285,465 - 291,170 (+)NCBI
UNSW_CanFamBas_1.010528,243 - 533,942 (+)NCBI
UU_Cfam_GSD_1.010652,514 - 658,220 (+)NCBI
Cdk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,484,370 - 58,490,389 (-)NCBI
SpeTri2.0NW_004936646379,849 - 385,648 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,365,763 - 21,392,726 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,365,723 - 21,372,170 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,941,174 - 22,947,591 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,905,085 - 51,910,209 (+)NCBI
ChlSab1.1 Ensembl1151,905,115 - 51,909,907 (+)Ensembl
Cdk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480212,076,443 - 12,082,608 (-)NCBI

Position Markers
RH70858  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,365,415 - 56,365,566UniSTSGRCh37
Build 361254,651,682 - 54,651,833RGDNCBI36
Celera1256,018,123 - 56,018,274RGD
Cytogenetic Map12q13UniSTS
HuRef1253,404,325 - 53,404,476UniSTS
GeneMap99-GB4 RH Map12245.84UniSTS
NCBI RH Map12455.8UniSTS
RH118926  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,362,356 - 56,362,641UniSTSGRCh37
Build 361254,648,623 - 54,648,908RGDNCBI36
Celera1256,015,064 - 56,015,349RGD
Cytogenetic Map12q13UniSTS
HuRef1253,401,266 - 53,401,551UniSTS
TNG Radiation Hybrid Map1226226.0UniSTS
RH45696  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,358,619 - 56,358,719UniSTSGRCh37
Build 361254,644,886 - 54,644,986RGDNCBI36
Cytogenetic Map12q13-q14UniSTS
Cytogenetic Map12q13UniSTS
HuRef1253,397,528 - 53,397,628UniSTS
GeneMap99-GB4 RH Map12246.49UniSTS
csnpcdk2-pcr1-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,360,518 - 56,361,022UniSTSGRCh37
Build 361254,646,785 - 54,647,289RGDNCBI36
Celera1256,013,226 - 56,013,730RGD
Cytogenetic Map12q13UniSTS
Cytogenetic Map12q13-q14UniSTS
HuRef1253,399,428 - 53,399,932UniSTS
csnpcdk2-pcr5-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,363,186 - 56,363,518UniSTSGRCh37
Build 361254,649,453 - 54,649,785RGDNCBI36
Celera1256,015,894 - 56,016,226RGD
Cytogenetic Map12q13UniSTS
HuRef1253,402,096 - 53,402,428UniSTS
csnpcdk2-pcr7-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,365,227 - 56,365,741UniSTSGRCh37
Build 361254,651,494 - 54,652,008RGDNCBI36
Celera1256,017,935 - 56,018,449RGD
Cytogenetic Map12q13UniSTS
HuRef1253,404,137 - 53,404,651UniSTS
PMC85407P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,365,356 - 56,365,726UniSTSGRCh37
Build 361254,651,623 - 54,651,993RGDNCBI36
Celera1256,018,064 - 56,018,434RGD
Cytogenetic Map12q13UniSTS
HuRef1253,404,266 - 53,404,636UniSTS
CDK2_529  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,365,909 - 56,366,573UniSTSGRCh37
Build 361254,652,176 - 54,652,840RGDNCBI36
Celera1256,018,617 - 56,019,281RGD
HuRef1253,404,819 - 53,405,484UniSTS
SHGC-12640  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,365,703 - 56,366,034UniSTSGRCh37
Build 361254,651,970 - 54,652,301RGDNCBI36
Celera1256,018,411 - 56,018,742RGD
Cytogenetic Map12q13UniSTS
HuRef1253,404,613 - 53,404,944UniSTS
Stanford-G3 RH Map122323.0UniSTS
GeneMap99-G3 RH Map122269.0UniSTS
MARC_16937-16938:1017082126:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,361,903 - 56,362,706UniSTSGRCh37
Build 361254,648,170 - 54,648,973RGDNCBI36
Celera1256,014,611 - 56,015,414RGD
HuRef1253,400,813 - 53,401,616UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR885hsa-miR-885-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI21233845
MIR885hsa-miR-885-5pOncomiRDBexternal_infoNANA21233845
MIR124-2hsa-miR-124-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19404929
MIR376A2hsa-miR-376a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21556037
MIR372hsa-miR-372-3pOncomiRDBexternal_infoNANA21646351
MIR376A1hsa-miR-376a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21556037
MIR302Dhsa-miR-302d-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI21062975
MIR302Dhsa-miR-302d-5pMirecordsexternal_infoNANA21062975

Predicted Target Of
Summary Value
Count of predictions:4419
Count of miRNA genes:973
Interacting mature miRNAs:1152
Transcripts:ENST00000266970, ENST00000354056, ENST00000440311, ENST00000553376, ENST00000554545, ENST00000554619, ENST00000555357, ENST00000555408, ENST00000556146, ENST00000556276, ENST00000556464, ENST00000556656
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3
Medium 2122 1587 1044 276 1272 151 3539 990 863 258 1269 1587 139 1158 1998 4
Low 316 1399 681 348 675 314 814 1206 2832 161 187 25 35 1 46 790 1 2
Below cutoff 1 3 4 35 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_034014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_052827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA789250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA810989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB012305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC025162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC034102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF512553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ223951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BJ991087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA814453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M68520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000266970   ⟹   ENSP00000266970
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,966,830 - 55,972,789 (+)Ensembl
RefSeq Acc Id: ENST00000354056   ⟹   ENSP00000243067
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,966,831 - 55,971,912 (+)Ensembl
RefSeq Acc Id: ENST00000440311   ⟹   ENSP00000393605
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,966,830 - 55,971,760 (+)Ensembl
RefSeq Acc Id: ENST00000553376   ⟹   ENSP00000452514
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,966,821 - 55,972,121 (+)Ensembl
RefSeq Acc Id: ENST00000554545
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,971,120 - 55,971,837 (+)Ensembl
RefSeq Acc Id: ENST00000554619
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,966,834 - 55,969,883 (+)Ensembl
RefSeq Acc Id: ENST00000555357   ⟹   ENSP00000452138
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,966,831 - 55,968,311 (+)Ensembl
RefSeq Acc Id: ENST00000555408   ⟹   ENSP00000450983
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,966,800 - 55,972,385 (+)Ensembl
RefSeq Acc Id: ENST00000556146
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,967,462 - 55,971,087 (+)Ensembl
RefSeq Acc Id: ENST00000556276
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,967,280 - 55,971,099 (+)Ensembl
RefSeq Acc Id: ENST00000556464
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,966,781 - 55,971,099 (+)Ensembl
RefSeq Acc Id: ENST00000556656
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,967,321 - 55,971,625 (+)Ensembl
RefSeq Acc Id: NM_001290230   ⟹   NP_001277159
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381255,966,830 - 55,972,789 (+)NCBI
CHM1_11256,327,686 - 56,333,684 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001798   ⟹   NP_001789
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381255,966,830 - 55,972,789 (+)NCBI
GRCh371256,360,556 - 56,366,573 (+)NCBI
Build 361254,646,826 - 54,652,835 (+)NCBI Archive
HuRef1253,399,466 - 53,405,479 (+)ENTREZGENE
CHM1_11256,327,686 - 56,333,684 (+)NCBI
Sequence:
RefSeq Acc Id: NM_052827   ⟹   NP_439892
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381255,966,830 - 55,972,789 (+)NCBI
GRCh371256,360,556 - 56,366,573 (+)NCBI
Build 361254,646,826 - 54,652,835 (+)NCBI Archive
HuRef1253,399,466 - 53,405,479 (+)ENTREZGENE
CHM1_11256,327,686 - 56,333,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011537732   ⟹   XP_011536034
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381255,966,830 - 55,972,789 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001789   ⟸   NM_001798
- Peptide Label: isoform 1
- UniProtKB: P24941 (UniProtKB/Swiss-Prot),   A0A024RB77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_439892   ⟸   NM_052827
- Peptide Label: isoform 2
- UniProtKB: P24941 (UniProtKB/Swiss-Prot),   A0A024RB10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277159   ⟸   NM_001290230
- Peptide Label: isoform 3
- UniProtKB: P24941 (UniProtKB/Swiss-Prot),   B4DDL9 (UniProtKB/TrEMBL),   E7ESI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011536034   ⟸   XM_011537732
- Peptide Label: isoform X1
- UniProtKB: G3V5T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000266970   ⟸   ENST00000266970
RefSeq Acc Id: ENSP00000450983   ⟸   ENST00000555408
RefSeq Acc Id: ENSP00000452138   ⟸   ENST00000555357
RefSeq Acc Id: ENSP00000393605   ⟸   ENST00000440311
RefSeq Acc Id: ENSP00000243067   ⟸   ENST00000354056
RefSeq Acc Id: ENSP00000452514   ⟸   ENST00000553376
Protein Domains
Protein kinase

Promoters
RGD ID:6790494
Promoter ID:HG_KWN:15869
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001798,   NM_052827,   UC001SIQ.1,   UC001SIR.1,   UC001SIS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361254,646,586 - 54,647,086 (-)MPROMDB
RGD ID:7224343
Promoter ID:EPDNEW_H17917
Type:single initiation site
Name:CDK2_2
Description:cyclin dependent kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17919  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381255,966,291 - 55,966,351EPDNEW
RGD ID:7224347
Promoter ID:EPDNEW_H17919
Type:initiation region
Name:CDK2_1
Description:cyclin dependent kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17917  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381255,966,830 - 55,966,890EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q13.13-13.3(chr12:53420606-56202942)x3 copy number gain See cases [RCV000141435] Chr12:53420606..56202942 [GRCh38]
Chr12:53814390..56596726 [GRCh37]
Chr12:52100657..54882993 [NCBI36]
Chr12:12q13.13-13.3
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q13.2(chr12:55975308-56593032)x3 copy number gain See cases [RCV000446219] Chr12:55975308..56593032 [GRCh37]
Chr12:12q13.2
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_001798.5(CDK2):c.825T>A (p.Ile275=) single nucleotide variant not provided [RCV000917994] Chr12:55971553 [GRCh38]
Chr12:56365337 [GRCh37]
Chr12:12q13.2
likely benign
GRCh37/hg19 12q13.2-14.1(chr12:55552371-62126304)x3 copy number gain not provided [RCV001006505] Chr12:55552371..62126304 [GRCh37]
Chr12:12q13.2-14.1
pathogenic
GRCh37/hg19 12q13.2(chr12:56333246-56558418)x3 copy number gain not provided [RCV001259615] Chr12:56333246..56558418 [GRCh37]
Chr12:12q13.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1771 AgrOrtholog
COSMIC CDK2 COSMIC
Ensembl Genes ENSG00000123374 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000243067 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000266970 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000393605 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000450983 UniProtKB/TrEMBL
  ENSP00000452138 UniProtKB/TrEMBL
  ENSP00000452514 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000266970 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000354056 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000440311 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000553376 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000555357 UniProtKB/TrEMBL
  ENST00000555408 UniProtKB/TrEMBL
GTEx ENSG00000123374 GTEx
HGNC ID HGNC:1771 ENTREZGENE
Human Proteome Map CDK2 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1017 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1017 ENTREZGENE
OMIM 116953 OMIM
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA101 PharmGKB
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RB10 ENTREZGENE, UniProtKB/TrEMBL
  A0A024RB77 ENTREZGENE, UniProtKB/TrEMBL
  B4DDL9 ENTREZGENE, UniProtKB/TrEMBL
  CDK2_HUMAN UniProtKB/Swiss-Prot
  E7ESI2 ENTREZGENE, UniProtKB/TrEMBL
  G3V317_HUMAN UniProtKB/TrEMBL
  G3V5T9 ENTREZGENE, UniProtKB/TrEMBL
  P24941 ENTREZGENE
UniProt Secondary A8K7C6 UniProtKB/Swiss-Prot
  O75100 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-21 CDK2  cyclin dependent kinase 2    cyclin-dependent kinase 2  Symbol and/or name change 5135510 APPROVED
2011-08-16 CDK2  cyclin-dependent kinase 2  CDK2  cyclin-dependent kinase 2  Symbol and/or name change 5135510 APPROVED