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Gene: CDK2 (cyclin dependent kinase 2) Homo sapiens
Symbol: CDK2
Name: cyclin dependent kinase 2
Description: This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cdc2-related protein kinase; CDKN2; cell devision kinase 2; cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2)
Mus musculus (house mouse) : Cdk2 (cyclin-dependent kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdk2 (cyclin dependent kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk2 (cyclin dependent kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK2 (cyclin dependent kinase 2)
Canis lupus familiaris (dog) : CDK2 (cyclin dependent kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk2 (cyclin dependent kinase 2)
Sus scrofa (pig) : CDK2 (cyclin dependent kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381255,966,769 - 55,972,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,360,556 - 56,366,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,646,826 - 54,652,835 (+)NCBINCBI36hg18NCBI36
Build 341254,646,825 - 54,652,834NCBI
Celera1256,013,264 - 56,019,276 (+)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1253,399,466 - 53,405,479 (+)NCBIHuRef
CHM1_11256,327,686 - 56,333,684 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CDK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352010
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.