GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[oxaliplatin co-treated with Topotecan] results in decreased expression of CDK2 mRNA

PMID:25729387
increases expressionISORGD:13520106480464CTDoxaliplatin results in increased expression of CDK2 protein

PMID:15204521
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.