GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:50692
Term: mifepristone
Definition: A 3-oxo steroid that has formula 429.59374.
Chemical ID: MESH:D015735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13520106480464CTDMifepristone inhibits the reaction [CDK2 protein binds to CCNE1 protein]

Mifepristone promotes the reaction [CDK2 protein binds to CDKN1B protein]

Mifepristone promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]

Mifepristone promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]

Mifepristone results in decreased localization of and results in decreased expression of CDK2 protein

PMID:17545545
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.