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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:17447
Term: geraniol
Definition: A monoterpenoid consisting of two prenyl units linked head-to-tail and functionalised with a hydroxy group at its tail end.
Chemical ID: MESH:C007836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDgeraniol results in decreased expression of CDK2 mRNA; geraniol results in decreased expression of CDK2 proteinPMID:15450939 PMID:17138864 PMID:27683099
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTDgeraniol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; geraniol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]PMID:17138864
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