Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CDK2 mRNAPMID:30816183 PMID:34947998
Cdk2increases expressionEXP 6480464CTDbisphenol A analog results in increased expression of CDK2 mRNA; bisphenol A analog results in increased expression of CDK2 protein; bisphenol A results in increased expression of CDK2 mRNAPMID:25181051 PMID:36214340
Cdk2affects expressionISOCDK2 (Homo sapiens)6480464CTDbisphenol A affects the expression of CDK2 mRNAPMID:30903817
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CDK2 mRNAPMID:29275510
Cdk2decreases expressionISOCdk2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of CDK2 mRNAPMID:23798566
Cdk2decreases phosphorylationISOCDK2 (Homo sapiens)6480464CTDbisphenol A results in decreased phosphorylation of CDK2 proteinPMID:29275510
Cdk2increases expressionISOCDK2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of CDK2 mRNA; bisphenol A results in increased expression of CDK2 proteinPMID:16474171 PMID:22552626 PMID:23222814 PMID:25130739
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTD[bisphenol A co-treated with resveratrol] results in decreased expression of CDK2 mRNA; Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein]PMID:22552626 PMID:23222814
Go Back to source page   Continue to Ontology report