GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDbisphenol A results in increased expression of CDK2 mRNA

PMID:25181051
decreases expressionISORGD:13520106480464CTDbisphenol A results in decreased expression of CDK2 mRNA

PMID:29275510
decreases expressionISORGD:705016480464CTDbisphenol A results in decreased expression of CDK2 mRNA

PMID:23798566
decreases phosphorylationISORGD:13520106480464CTDbisphenol A results in decreased phosphorylation of CDK2 protein

PMID:29275510
increases expressionISORGD:13520106480464CTDbisphenol A results in increased expression of CDK2 mRNA

bisphenol A results in increased expression of CDK2 protein

PMID:16474171, PMID:22552626, PMID:23222814, PMID:25130739
multiple interactionsISORGD:13520106480464CTD[bisphenol A co-treated with resveratrol] results in decreased expression of CDK2 mRNA

Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein]

PMID:22552626, PMID:23222814
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.