GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdk2 | decreases activity | ISO | CDK2 (Homo sapiens) | 6480464 | CTD | troglitazone results in decreased activity of CDK2 protein | PMID:11343236 PMID:12717389 | Cdk2 | decreases expression | ISO | CDK2 (Homo sapiens) | 6480464 | CTD | troglitazone results in decreased expression of CDK2 mRNA; troglitazone results in decreased expression of CDK2 protein | PMID:12595159 PMID:15729575 PMID:19140230 PMID:20540935 | Cdk2 | decreases expression | ISO | Cdk2 (Mus musculus) | 6480464 | CTD | troglitazone results in decreased expression of CDK2 protein | PMID:15610522 | Cdk2 | increases activity | ISO | CDK2 (Homo sapiens) | 6480464 | CTD | troglitazone results in increased activity of CDK2 protein | PMID:11741176 | Cdk2 | multiple interactions | ISO | CDK2 (Homo sapiens) | 6480464 | CTD | [N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CDK2 protein]; GSK3B protein affects the susceptibility to [troglitazone results in decreased expression of CDK2 protein]; troglitazone promotes the reaction [Aspirin results in decreased expression of CDK2 protein]; troglitazone promotes the reaction [CDKN1A protein binds to CDK2 protein]; troglitazone promotes the reaction [CDKN1B protein binds to CDK2 protein] | PMID:12717389 PMID:19908241 PMID:20540935 | Cdk2 | multiple interactions | ISO | Cdk2 (Mus musculus) | 6480464 | CTD | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [troglitazone results in decreased expression of CDK2 protein]; troglitazone results in increased degradation of and results in increased ubiquitination of CDK2 protein | PMID:15610522 | |
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