GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:13520106480464CTDtroglitazone results in decreased activity of CDK2 protein

PMID:11343236, PMID:12717389
decreases expressionISORGD:13520106480464CTDtroglitazone results in decreased expression of CDK2 mRNA

troglitazone results in decreased expression of CDK2 protein

PMID:12595159, PMID:15729575, PMID:19140230, PMID:20540935
decreases expressionISORGD:705016480464CTDtroglitazone results in decreased expression of CDK2 protein

PMID:15610522
increases activityISORGD:13520106480464CTDtroglitazone results in increased activity of CDK2 protein

PMID:11741176
multiple interactionsISORGD:13520106480464CTD[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CDK2 protein]

GSK3B protein affects the susceptibility to [troglitazone results in decreased expression of CDK2 protein]

troglitazone promotes the reaction [Aspirin results in decreased expression of CDK2 protein]

troglitazone promotes the reaction [CDKN1A protein binds to CDK2 protein]

troglitazone promotes the reaction [CDKN1B protein binds to CDK2 protein]

PMID:12717389, PMID:19908241, PMID:20540935
multiple interactionsISORGD:705016480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [troglitazone results in decreased expression of CDK2 protein]

troglitazone results in increased degradation of and results in increased ubiquitination of CDK2 protein

PMID:15610522
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.