GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:24814
Term: indole-3-methanol
Definition: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Chemical ID: MESH:C016517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationISORGD:13520106480464CTDindole-3-carbinol affects the localization of CDK2 protein

PMID:15611077
decreases activityISORGD:13520106480464CTDindole-3-carbinol analog results in decreased activity of CDK2 protein

indole-3-carbinol results in decreased activity of CDK2 protein

PMID:15611077, PMID:18023427, PMID:20570586
decreases expressionISORGD:13520106480464CTDindole-3-carbinol results in decreased expression of CDK2

PMID:16082211
multiple interactionsISORGD:13520106480464CTDindole-3-carbinol affects the localization of [CDK2 protein binds to CCNE1 protein alternative form]

indole-3-carbinol promotes the reaction [CDK2 protein binds to CCNE1 protein alternative form]

PMID:15611077
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.