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Gene: Sgk1 (serum/glucocorticoid regulated kinase 1) Rattus norvegicus
Symbol: Sgk1
Name: serum/glucocorticoid regulated kinase 1
RGD ID: 3668
Description: Exhibits 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and tau protein binding activity. Involved in several processes, including cellular response to hormone stimulus; generation of neurons; and learning or memory. Localizes to neuron projection; nucleus; and perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1); PARTICIPATES IN corticosteroid signaling pathway; insulin signaling pathway; mTOR signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 11-dehydrocorticosterone; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: serine/threonine protein kinase SGK; serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase; serum/glucocorticoid-regulated kinase 1; Sgk
Homo sapiens (human) : SGK1 (serum/glucocorticoid regulated kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Sgk1 (serum/glucocorticoid regulated kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sgk1 (serum/glucocorticoid regulated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SGK1 (serum/glucocorticoid regulated kinase 1)
Canis lupus familiaris (dog) : SGK1 (serum/glucocorticoid regulated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sgk1 (serum/glucocorticoid regulated kinase 1)
Sus scrofa (pig) : SGK1 (serum/glucocorticoid regulated kinase 1)
Chlorocebus sabaeus (African green monkey) : SGK1 (serum/glucocorticoid regulated kinase 1)
Heterocephalus glaber (naked mole-rat) : Sgk1 (serum/glucocorticoid regulated kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0124,185,451 - 24,302,309 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl124,185,435 - 24,302,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0125,652,750 - 25,769,448 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,501,257 - 23,506,651 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1123,504,206 - 23,509,647 (-)NCBI
Celera121,704,048 - 21,711,886 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sgk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3668
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.