Sgk1 (serum/glucocorticoid regulated kinase 1) - Rat Genome Database

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Gene: Sgk1 (serum/glucocorticoid regulated kinase 1) Rattus norvegicus
Analyze
Symbol: Sgk1
Name: serum/glucocorticoid regulated kinase 1
RGD ID: 3668
Description: Enables 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and tau protein binding activity. Involved in several processes, including learning or memory; negative regulation of microtubule polymerization; and positive regulation of dendrite morphogenesis. Acts upstream of or within cellular response to insulin stimulus; positive regulation of sodium ion transport; and regulation of protein localization. Located in perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1); PARTICIPATES IN glucocorticoid signaling pathway; insulin signaling pathway; mTOR signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 11-dehydrocorticosterone; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: serine/threonine protein kinase SGK; serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase; serum/glucocorticoid-regulated kinase 1; Sgk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,799,391 - 24,916,886 (-)NCBIGRCr8
mRatBN7.2122,980,257 - 23,098,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,980,261 - 23,098,283 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,760,448 - 22,768,284 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.011,465,432 - 1,473,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,957,500 - 22,965,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0124,185,451 - 24,302,309 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl124,185,435 - 24,302,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0125,652,750 - 25,769,448 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,501,257 - 23,506,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1123,504,206 - 23,509,647 (-)NCBI
Celera121,704,048 - 21,711,886 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
11-dehydrocorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
CARBENOXOLONE  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clomiphene  (ISO)
clotrimazole  (EXP)
clozapine  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
cortisone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyproterone  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
estrone  (ISO)
ethanol  (ISO)
ethisterone  (ISO)
ethyl methanesulfonate  (ISO)
farglitazar  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
fluvastatin  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
haloperidol  (EXP)
hexestrol  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxyurea  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin-3'-monoxime  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
mestranol  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl carbamate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
metyrapone  (EXP)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-methylformamide  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
norethisterone  (ISO)
ochratoxin A  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
ouabain  (ISO)
oxybenzone  (ISO)
ozone  (EXP)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
Primycin  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP)
spironolactone  (EXP,ISO)
starch  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response. Aoyama T, etal., Circulation. 2005 Apr 5;111(13):1652-9. Epub 2005 Mar 28.
2. The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. Bhargava A, etal., Endocrinology 2001 Apr;142(4):1587-94.
3. Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways. Buse P, etal., J Biol Chem. 1999 Mar 12;274(11):7253-63.
4. Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Busjahn A, etal., Hypertension. 2002 Sep;40(3):256-60.
5. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
6. Expression of serum- and glucocorticoid-inducible kinase is regulated in an experience-dependent manner and can cause dendrite growth. David S, etal., J Neurosci. 2005 Jul 27;25(30):7048-53.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Enrichment enhances the expression of sgk, a glucocorticoid-induced gene, and facilitates spatial learning through glutamate AMPA receptor mediation. Lee EH, etal., Eur J Neurosci. 2003 Nov;18(10):2842-52.
10. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Lee IH, etal., J Biol Chem. 2007 Oct 12;282(41):29866-73. Epub 2007 Aug 22.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Mineralocorticoid effects in the kidney: correlation between alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+. Muller OG, etal., J Am Soc Nephrol 2003 May;14(5):1107-15.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. Nishida Y, etal., Brain Res Mol Brain Res. 2004 Apr 7;123(1-2):121-5.
15. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. Park J, etal., EMBO J. 1999 Jun 1;18(11):3024-33.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. 11Beta-hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart. Sheppard KE and Autelitano DJ, Endocrinology 2002 Jan;143(1):198-204.
22. SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. Tai DJ, etal., J Biol Chem. 2009 Feb 13;284(7):4073-89. Epub 2008 Dec 16.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Low prevalence of nonconservative mutations of serum and glucocorticoid-regulated kinase (SGK1) gene in hypertensive and renal patients. Trochen N, etal., Nephrol Dial Transplant. 2004 Oct;19(10):2499-504. Epub 2004 Aug 10.
25. sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Tsai KJ, etal., Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3990-5.
26. Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. von Wowern F, etal., Kidney Int. 2005 Nov;68(5):2164-72.
27. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Webster MK, etal., Mol Cell Biol 1993 Apr;13(4):2031-40.
28. Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Yang YC, etal., Mol Cell Biol. 2006 Nov;26(22):8357-70. Epub 2006 Sep 18.
Additional References at PubMed
PMID:7740159   PMID:7854047   PMID:8647846   PMID:9058378   PMID:12477932   PMID:12631736   PMID:12642512   PMID:12734207   PMID:15007040   PMID:15234985   PMID:15383658   PMID:15838307  
PMID:15958725   PMID:16426574   PMID:16495212   PMID:16553792   PMID:16756948   PMID:17157265   PMID:17568772   PMID:17692313   PMID:18088355   PMID:18184857   PMID:18586672   PMID:18615584  
PMID:19051070   PMID:19468237   PMID:19521108   PMID:19609277   PMID:19910698   PMID:20051515   PMID:20664544   PMID:20738430   PMID:20933037   PMID:21224398   PMID:21849984   PMID:22327331  
PMID:22797923   PMID:22980744   PMID:23516288   PMID:23589291   PMID:23650397   PMID:23826409   PMID:24429675   PMID:24825325   PMID:25515054   PMID:26506154   PMID:27592201   PMID:27655894  
PMID:28376115   PMID:28980287   PMID:29497029   PMID:32139897   PMID:32645929   PMID:32946263   PMID:33063281   PMID:34898378   PMID:36781297   PMID:37371111  


Genomics

Comparative Map Data
Sgk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,799,391 - 24,916,886 (-)NCBIGRCr8
mRatBN7.2122,980,257 - 23,098,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,980,261 - 23,098,283 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,760,448 - 22,768,284 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.011,465,432 - 1,473,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,957,500 - 22,965,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0124,185,451 - 24,302,309 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl124,185,435 - 24,302,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0125,652,750 - 25,769,448 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,501,257 - 23,506,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1123,504,206 - 23,509,647 (-)NCBI
Celera121,704,048 - 21,711,886 (-)NCBICelera
Cytogenetic Map1p12NCBI
SGK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386134,169,256 - 134,318,112 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6134,169,248 - 134,318,112 (-)EnsemblGRCh38hg38GRCh38
GRCh376134,490,394 - 134,639,250 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366134,532,081 - 134,537,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 346134,532,081 - 134,537,695NCBI
Celera6135,231,367 - 135,380,168 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6132,059,144 - 132,203,585 (-)NCBIHuRef
CHM1_16134,752,625 - 134,901,421 (-)NCBICHM1_1
T2T-CHM13v2.06135,357,191 - 135,506,235 (-)NCBIT2T-CHM13v2.0
Sgk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391021,758,083 - 21,875,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1021,758,083 - 21,875,802 (+)EnsemblGRCm39 Ensembl
GRCm381021,882,184 - 21,999,903 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1021,882,184 - 21,999,903 (+)EnsemblGRCm38mm10GRCm38
MGSCv371021,601,990 - 21,719,709 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361021,684,112 - 21,689,308 (+)NCBIMGSCv36mm8
Celera1021,774,459 - 21,893,673 (+)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.83NCBI
Sgk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554392,290,035 - 2,406,587 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554392,399,992 - 2,406,587 (+)NCBIChiLan1.0ChiLan1.0
SGK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25154,142,635 - 154,288,380 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16152,048,314 - 152,194,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06131,936,397 - 132,082,670 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16136,033,851 - 136,180,121 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6136,033,851 - 136,180,121 (-)Ensemblpanpan1.1panPan2
SGK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,086,431 - 27,196,601 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,087,361 - 27,196,521 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha127,967,769 - 28,077,630 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0127,245,018 - 27,354,617 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl127,245,018 - 27,354,852 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1127,128,500 - 27,238,272 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0127,008,812 - 27,118,227 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0127,318,579 - 27,428,323 (-)NCBIUU_Cfam_GSD_1.0
Sgk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946122,200,588 - 122,229,971 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365601,979,808 - 2,088,329 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365601,979,804 - 2,009,167 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SGK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl129,745,114 - 29,753,602 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1129,625,786 - 29,753,619 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2133,226,672 - 33,256,205 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SGK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11339,152,289 - 39,306,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1339,300,567 - 39,306,183 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604011,341,622 - 11,492,670 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sgk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624942507,605 - 641,585 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624942508,035 - 641,349 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sgk1
743 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:93
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000016121, ENSRNOT00000040736, ENSRNOT00000061157
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat

Markers in Region
D1Got27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,982,440 - 22,982,586 (+)MAPPERmRatBN7.2
Rnor_6.0124,187,635 - 24,187,780NCBIRnor6.0
Rnor_5.0125,654,934 - 25,655,079UniSTSRnor5.0
RGSC_v3.4123,503,440 - 23,503,586RGDRGSC3.4
RGSC_v3.4123,503,441 - 23,503,586UniSTSRGSC3.4
RGSC_v3.1123,506,386 - 23,506,531RGD
Celera121,706,232 - 21,706,377UniSTS
RH 3.4 Map1229.3UniSTS
RH 3.4 Map1229.3RGD
RH 2.0 Map1156.8RGD
Cytogenetic Map1p12UniSTS
RH129312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,980,317 - 22,980,472 (+)MAPPERmRatBN7.2
Rnor_6.0124,185,512 - 24,185,666NCBIRnor6.0
Rnor_5.0125,652,811 - 25,652,965UniSTSRnor5.0
RGSC_v3.4123,501,318 - 23,501,472UniSTSRGSC3.4
Celera121,704,109 - 21,704,263UniSTS
RH 3.4 Map1232.5UniSTS
Cytogenetic Map1p12UniSTS
AU048783  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,982,308 - 22,982,576 (+)MAPPERmRatBN7.2
Rnor_6.0124,187,503 - 24,187,770NCBIRnor6.0
Rnor_5.0125,654,802 - 25,655,069UniSTSRnor5.0
RGSC_v3.4123,503,309 - 23,503,576UniSTSRGSC3.4
Celera121,706,100 - 21,706,367UniSTS
Cytogenetic Map1p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 48 34 19 34 8 10 62 35 34 11 8
Low 35 9 7 7 1 12 7
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000016121   ⟹   ENSRNOP00000016121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,980,261 - 22,985,702 (-)Ensembl
Rnor_6.0 Ensembl124,185,456 - 24,190,896 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000040736   ⟹   ENSRNOP00000046277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,980,262 - 22,988,097 (-)Ensembl
Rnor_6.0 Ensembl124,185,456 - 24,193,567 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000061157   ⟹   ENSRNOP00000057871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,980,262 - 22,986,436 (-)Ensembl
Rnor_6.0 Ensembl124,185,456 - 24,191,908 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083452   ⟹   ENSRNOP00000069545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,980,262 - 23,098,283 (-)Ensembl
Rnor_6.0 Ensembl124,185,435 - 24,302,298 (-)Ensembl
RefSeq Acc Id: NM_001193568   ⟹   NP_001180497
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,805,570 (-)NCBI
mRatBN7.2122,980,257 - 22,986,436 (-)NCBI
Rnor_6.0124,185,451 - 24,191,630 (-)NCBI
Rnor_5.0125,652,750 - 25,769,448 (-)NCBI
Celera121,704,048 - 21,710,227 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001193569   ⟹   NP_001180498
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,807,231 (-)NCBI
mRatBN7.2122,980,257 - 22,988,097 (-)NCBI
Rnor_6.0124,185,451 - 24,193,567 (-)NCBI
Rnor_5.0125,652,750 - 25,769,448 (-)NCBI
Celera121,704,048 - 21,711,886 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019232   ⟹   NP_062105
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,804,831 (-)NCBI
mRatBN7.2122,980,257 - 22,985,697 (-)NCBI
Rnor_6.0124,185,451 - 24,190,891 (-)NCBI
Rnor_5.0125,652,750 - 25,769,448 (-)NCBI
RGSC_v3.4123,501,257 - 23,506,651 (-)RGD
Celera121,704,048 - 21,709,488 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227723   ⟹   XP_006227785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,916,886 (-)NCBI
mRatBN7.2122,980,257 - 23,098,122 (-)NCBI
Rnor_6.0124,185,451 - 24,302,309 (-)NCBI
Rnor_5.0125,652,750 - 25,769,448 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109489   ⟹   XP_038965417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,869,119 (-)NCBI
mRatBN7.2122,980,257 - 23,050,000 (-)NCBI
RefSeq Acc Id: NP_062105   ⟸   NM_019232
- Peptide Label: isoform 3
- UniProtKB: Q06226 (UniProtKB/Swiss-Prot),   Q68G05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001180498   ⟸   NM_001193569
- Peptide Label: isoform 2
- UniProtKB: Q06226 (UniProtKB/Swiss-Prot),   F1LXA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001180497   ⟸   NM_001193568
- Peptide Label: isoform 1
- UniProtKB: Q06226 (UniProtKB/Swiss-Prot),   D4A128 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227785   ⟸   XM_006227723
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016121   ⟸   ENSRNOT00000016121
Ensembl Acc Id: ENSRNOP00000057871   ⟸   ENSRNOT00000061157
Ensembl Acc Id: ENSRNOP00000069545   ⟸   ENSRNOT00000083452
Ensembl Acc Id: ENSRNOP00000046277   ⟸   ENSRNOT00000040736
RefSeq Acc Id: XP_038965417   ⟸   XM_039109489
- Peptide Label: isoform X2
Protein Domains
AGC-kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06226-F1-model_v2 AlphaFold Q06226 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689538
Promoter ID:EPDNEW_R62
Type:single initiation site
Name:Sgk1_1
Description:serum/glucocorticoid regulated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R63  EPDNEW_R64  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0124,190,896 - 24,190,956EPDNEW
RGD ID:13689539
Promoter ID:EPDNEW_R63
Type:multiple initiation site
Name:Sgk1_2
Description:serum/glucocorticoid regulated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R62  EPDNEW_R64  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0124,191,852 - 24,191,912EPDNEW
RGD ID:13689540
Promoter ID:EPDNEW_R64
Type:single initiation site
Name:Sgk1_3
Description:serum/glucocorticoid regulated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R62  EPDNEW_R63  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0124,193,594 - 24,193,654EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3668 AgrOrtholog
BioCyc Gene G2FUF-62032 BioCyc
Ensembl Genes ENSRNOG00000011815 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016121.6 UniProtKB/TrEMBL
  ENSRNOT00000040736.4 UniProtKB/TrEMBL
  ENSRNOT00000061157.4 UniProtKB/TrEMBL
  ENSRNOT00000083452.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1520.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130800 IMAGE-MGC_LOAD
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29517 UniProtKB/TrEMBL
MGC_CLONE MGC:93480 IMAGE-MGC_LOAD
NCBI Gene 29517 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE SGK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sgk1 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011815 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF64268 UniProtKB/TrEMBL
TIGR TC217781
UniProt A0A0G2JVM7 ENTREZGENE, UniProtKB/TrEMBL
  D4A128 ENTREZGENE, UniProtKB/TrEMBL
  F1LXA3 ENTREZGENE, UniProtKB/TrEMBL
  F7FJ32_RAT UniProtKB/TrEMBL
  Q06226 ENTREZGENE
  Q68G05 ENTREZGENE, UniProtKB/TrEMBL
  SGK1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-02 Sgk1  serum/glucocorticoid regulated kinase 1  Sgk  serum/glucocorticoid regulated kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sgk  serum/glucocorticoid regulated kinase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a GRE in the promoter region 69995
gene_process in the heart acts as a converging point between steroid signalling and other ligands that activate phosphoinositide 3-kinase 69995
gene_process in the heart acts as a converging point between steroid signalling and other ligands that activate phosphoinositide 3-kinase 70436
gene_process may mediate early aldosterone effects by stimulating epitherlial sodium channel (ENaC)-mediated sodium transport in kidneys 628514
gene_process may mediate effects of aldosterone on Na homeostasis 628514
gene_regulation aldosterone induces expression in kidney collecting duct and distal colon 628514