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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3668
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sgk1
Name: serum/glucocorticoid regulated kinase 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sgk1affects expressionISOSgk1 (Mus musculus)6480464CTDEthanol affects the expression of SGK1 mRNAPMID:30319688
Sgk1affects splicingISOSgk1 (Mus musculus)6480464CTDEthanol affects the splicing of SGK1 mRNAPMID:30319688
Sgk1decreases expressionISOSgk1 (Mus musculus)6480464CTDEthanol results in decreased expression of SGK1 proteinPMID:23991167
Sgk1increases expressionISOSgk1 (Mus musculus)6480464CTDEthanol results in increased expression of SGK1 mRNAPMID:21955143 PMID:23991167
Sgk1multiple interactionsISOSGK1 (Homo sapiens)6480464CTD[[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of SGK1 mRNAPMID:29432896
Sgk1multiple interactionsISOSgk1 (Mus musculus)6480464CTD[Ethanol results in increased phosphorylation of and results in increased activity of SGK1 protein] which results in increased phosphorylation of NDRG1 protein; Ethanol promotes the reaction [NR3C1 protein binds to SGK1 promoter]; Ethanol results in increased phosphorylation of and results in increased activity of SGK1 proteinPMID:23991167
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