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Gene: PDPK1 (3-phosphoinositide dependent protein kinase 1) Homo sapiens
Symbol: PDPK1
Name: 3-phosphoinositide dependent protein kinase 1
Description: Exhibits 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of protein kinase activity; and regulation of signal transduction. Localizes to cell projection; cytoplasm; and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma; PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2-methylcholine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; hPDK1; MGC20087; MGC35290; PDK1; PDPK2; PDPK2P; PkB kinase like gene 1; PkB-like 1; PRO0461
Mus musculus (house mouse) : Pdpk1 (3-phosphoinositide dependent protein kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdpk1 (3-phosphoinositide dependent protein kinase-1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdpk1 (3-phosphoinositide dependent protein kinase 1)
Canis lupus familiaris (dog) : PDPK1 (3-phosphoinositide dependent protein kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdpk1 (3-phosphoinositide dependent protein kinase 1)
Sus scrofa (pig) : PDPK1 (3-phosphoinositide dependent protein kinase 1)
Chlorocebus sabaeus (African green monkey) : PDPK1 (3-phosphoinositide dependent protein kinase 1)
Heterocephalus glaber (naked mole-rat) : Pdpk1 (3-phosphoinositide dependent protein kinase 1)
more info ...
Related Pseudogenes: PDPK2P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: PDK1 (Gene ID: 5163) and PDPK1 (Gene ID: 5170) share the PDK1 symbol/alias in common. PDK1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (PDPK1). [01 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl162,537,979 - 2,603,188 (+)EnsemblGRCh38hg38GRCh38
GRCh38162,538,014 - 2,603,190 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37162,587,965 - 2,653,191 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,527,971 - 2,593,190 (+)NCBINCBI36hg18NCBI36
Build 34162,527,970 - 2,593,189NCBI
Cytogenetic Map16p13.3NCBI
HuRef162,533,939 - 2,579,217 (+)NCBIHuRef
CHM1_1162,587,908 - 2,653,167 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDPK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732664
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.