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Gene: SGK1 (serum/glucocorticoid regulated kinase 1) Homo sapiens
Symbol: SGK1
Name: serum/glucocorticoid regulated kinase 1
Description: Exhibits protein serine/threonine/tyrosine kinase activity. Predicted to be involved in intracellular signal transduction; neuron projection morphogenesis; and peptidyl-serine phosphorylation. Localizes to the cytosol and nuclear speck. Implicated in hypertension. Biomarker of granulosa cell tumor; mucinous cystadenocarcinoma; and serous cystadenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: serine/threonine protein kinase SGK; serine/threonine-protein kinase Sgk1; serum/glucocorticoid-regulated kinase 1; SGK; Sgk1 variant i3
Mus musculus (house mouse) : Sgk1 (serum/glucocorticoid regulated kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sgk1 (serum/glucocorticoid regulated kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sgk1 (serum/glucocorticoid regulated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SGK1 (serum/glucocorticoid regulated kinase 1)
Canis lupus familiaris (dog) : SGK1 (serum/glucocorticoid regulated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sgk1 (serum/glucocorticoid regulated kinase 1)
Sus scrofa (pig) : SGK1 (serum/glucocorticoid regulated kinase 1)
Chlorocebus sabaeus (green monkey) : SGK1 (serum/glucocorticoid regulated kinase 1)
Heterocephalus glaber (naked mole-rat) : Sgk1 (serum/glucocorticoid regulated kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl6134,169,246 - 134,318,112 (-)Ensembl
GRCh386134,169,246 - 134,318,112 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376134,490,384 - 134,639,196 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366134,532,081 - 134,537,695 (-)NCBINCBI36hg18NCBI36
Build 346134,532,081 - 134,537,695NCBI
Celera6135,231,367 - 135,380,168 (-)NCBI
Cytogenetic Map6q23.2NCBI
HuRef6132,059,144 - 132,203,585 (-)NCBIHuRef
CHM1_16134,752,625 - 134,901,421 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SGK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731028
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.