SGK1 (serum/glucocorticoid regulated kinase 1) - Rat Genome Database

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Gene: SGK1 (serum/glucocorticoid regulated kinase 1) Homo sapiens
Analyze
Symbol: SGK1
Name: serum/glucocorticoid regulated kinase 1
RGD ID: 731028
HGNC Page HGNC:10810
Description: Enables protein serine/threonine/tyrosine kinase activity. Predicted to be involved in intracellular signal transduction and neuron projection morphogenesis. Predicted to act upstream of or within several processes, including DNA damage response; cellular response to hormone stimulus; and positive regulation of sodium ion transport. Located in cytosol and nuclear speck. Implicated in hypertension. Biomarker of granulosa cell tumor; mucinous cystadenocarcinoma; and serous cystadenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: serine/threonine protein kinase SGK; serine/threonine-protein kinase Sgk1; serum/glucocorticoid-regulated kinase 1; SGK; Sgk1 variant i3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386134,169,256 - 134,318,112 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6134,169,248 - 134,318,112 (-)EnsemblGRCh38hg38GRCh38
GRCh376134,490,394 - 134,639,250 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366134,532,081 - 134,537,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 346134,532,081 - 134,537,695NCBI
Celera6135,231,367 - 135,380,168 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6132,059,144 - 132,203,585 (-)NCBIHuRef
CHM1_16134,752,625 - 134,901,421 (-)NCBICHM1_1
T2T-CHM13v2.06135,357,191 - 135,506,235 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
11-dehydrocorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetamide  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
adenine  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amosite asbestos  (EXP)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
azathioprine  (EXP)
barium(0)  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[e]pyrene  (EXP)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A5  (EXP)
bortezomib  (EXP)
bromobenzene  (ISO)
buspirone  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
calcitriol  (EXP)
cannabidiol  (EXP)
carbamazepine  (EXP)
CARBENOXOLONE  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
CGP 52608  (EXP)
chloropicrin  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP,ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clomiphene  (EXP)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
cortisone  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
cyproterone  (EXP)
D-glucose  (ISO)
daidzein  (EXP)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichromium trioxide  (EXP)
diclofenac  (ISO)
dicrotophos  (EXP)
dieldrin  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
estrone  (EXP)
ethanol  (EXP,ISO)
ethisterone  (EXP)
ethyl methanesulfonate  (EXP)
farglitazar  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
fluvastatin  (ISO)
formaldehyde  (EXP)
FR900359  (EXP)
fructose  (ISO)
fulvestrant  (EXP)
furan  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
haloperidol  (ISO)
hexestrol  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxyurea  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
indirubin-3'-monoxime  (EXP)
irinotecan  (EXP)
ivermectin  (EXP)
ketoconazole  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (EXP)
megestrol acetate  (EXP)
melphalan  (EXP)
mercury dibromide  (EXP)
mestranol  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
methyl carbamate  (EXP)
methyl methanesulfonate  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methylseleninic acid  (EXP)
metyrapone  (ISO)
mifepristone  (EXP,ISO)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
naphthalene  (ISO)
nefazodone  (ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nimesulide  (ISO)
norethisterone  (EXP)
ochratoxin A  (EXP)
organoselenium compound  (EXP)
orphenadrine  (ISO)
ouabain  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
p-toluidine  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium chromate  (EXP)
potassium cyanide  (ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
Primycin  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
sarin  (EXP)
SB 431542  (EXP)
SCH 23390  (ISO)
serpentine asbestos  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
spironolactone  (EXP,ISO)
starch  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
T-2 toxin  (EXP)
tamoxifen  (EXP)
temozolomide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (EXP)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Busjahn A, etal., Hypertension. 2002 Sep;40(3):256-60.
2. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. Nishida Y, etal., Brain Res Mol Brain Res. 2004 Apr 7;123(1-2):121-5.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Low prevalence of nonconservative mutations of serum and glucocorticoid-regulated kinase (SGK1) gene in hypertensive and renal patients. Trochen N, etal., Nephrol Dial Transplant. 2004 Oct;19(10):2499-504. Epub 2004 Aug 10.
10. Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. von Wowern F, etal., Kidney Int. 2005 Nov;68(5):2164-72.
11. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Wen W, etal., Cell Discov. 2020 May 4;6:31. doi: 10.1038/s41421-020-0168-9. eCollection 2020.
Additional References at PubMed
PMID:9114008   PMID:9722955   PMID:10191262   PMID:10357815   PMID:10548550   PMID:10869359   PMID:10884438   PMID:11154281   PMID:11254654   PMID:11410590   PMID:11696533   PMID:11707620  
PMID:11742982   PMID:11751930   PMID:12023960   PMID:12077559   PMID:12218062   PMID:12376324   PMID:12387817   PMID:12397388   PMID:12417559   PMID:12435876   PMID:12444200   PMID:12477932  
PMID:12590200   PMID:12628440   PMID:12631736   PMID:12634932   PMID:12684516   PMID:12729930   PMID:12788082   PMID:12823993   PMID:12911626   PMID:12923071   PMID:14499622   PMID:14574404  
PMID:14623317   PMID:14702039   PMID:14725621   PMID:15040001   PMID:15044175   PMID:15166308   PMID:15167446   PMID:15208094   PMID:15328345   PMID:15342340   PMID:15461589   PMID:15489334  
PMID:15496163   PMID:15576372   PMID:15578212   PMID:15650334   PMID:15665527   PMID:15695387   PMID:15721303   PMID:15733869   PMID:15735679   PMID:15737648   PMID:15910284   PMID:16006511  
PMID:16036218   PMID:16105029   PMID:16125969   PMID:16301823   PMID:16301825   PMID:16344560   PMID:16443776   PMID:16460280   PMID:16543730   PMID:16716084   PMID:16817852   PMID:16847254  
PMID:16895519   PMID:16971495   PMID:16982696   PMID:17170520   PMID:17314099   PMID:17317952   PMID:17332896   PMID:17353931   PMID:17360471   PMID:17382906   PMID:17442044   PMID:17512525  
PMID:17568772   PMID:17570343   PMID:17571248   PMID:17595519   PMID:17640988   PMID:17916563   PMID:17932503   PMID:17965184   PMID:17982254   PMID:17982255   PMID:17985234   PMID:18209482  
PMID:18239069   PMID:18319604   PMID:18456663   PMID:18487207   PMID:18570873   PMID:18753299   PMID:18801914   PMID:18985156   PMID:19068477   PMID:19088076   PMID:19088452   PMID:19232516  
PMID:19322201   PMID:19380724   PMID:19402821   PMID:19447520   PMID:19461886   PMID:19584721   PMID:19617352   PMID:19619128   PMID:19706464   PMID:19756449   PMID:19913121   PMID:19917253  
PMID:19953087   PMID:19961832   PMID:20041238   PMID:20098747   PMID:20174665   PMID:20237237   PMID:20338997   PMID:20368287   PMID:20433920   PMID:20438709   PMID:20466724   PMID:20511718  
PMID:20516150   PMID:20525693   PMID:20530112   PMID:20628086   PMID:20631247   PMID:20730100   PMID:20832730   PMID:20884880   PMID:20919962   PMID:20933037   PMID:20947508   PMID:21063096  
PMID:21079778   PMID:21147854   PMID:21224398   PMID:21355052   PMID:21430556   PMID:21478911   PMID:21563193   PMID:21691090   PMID:21757730   PMID:21784856   PMID:21873635   PMID:21900244  
PMID:21988832   PMID:22001908   PMID:22240294   PMID:22250980   PMID:22309306   PMID:22590650   PMID:22610502   PMID:22648267   PMID:22704443   PMID:22797923   PMID:22809514   PMID:22832853  
PMID:22939624   PMID:23012321   PMID:23019294   PMID:23034940   PMID:23055545   PMID:23108393   PMID:23192594   PMID:23314748   PMID:23339546   PMID:23363009   PMID:23392695   PMID:23487453  
PMID:23509962   PMID:23581296   PMID:23589291   PMID:23650397   PMID:23933686   PMID:24043625   PMID:24043696   PMID:24214981   PMID:24431232   PMID:24586903   PMID:24602173   PMID:24685888  
PMID:24811177   PMID:24864229   PMID:24878720   PMID:24961472   PMID:25152363   PMID:25384981   PMID:25422956   PMID:25614279   PMID:25667458   PMID:25705664   PMID:25825522   PMID:25849655  
PMID:25993992   PMID:26034353   PMID:26038830   PMID:26186194   PMID:26188042   PMID:26230157   PMID:26277930   PMID:26359301   PMID:26429539   PMID:26491696   PMID:26506154   PMID:26548813  
PMID:26658840   PMID:26827666   PMID:26840046   PMID:26869290   PMID:26942879   PMID:27020669   PMID:27251632   PMID:27331901   PMID:27451907   PMID:27488665   PMID:27606670   PMID:27664953  
PMID:27771704   PMID:28177128   PMID:28264193   PMID:28336914   PMID:28338770   PMID:28389565   PMID:28504714   PMID:28514442   PMID:28608480   PMID:28634071   PMID:28733463   PMID:28993509  
PMID:29055016   PMID:29117863   PMID:29328462   PMID:29346764   PMID:29352074   PMID:29412164   PMID:29604467   PMID:29889103   PMID:29976632   PMID:30021884   PMID:30257988   PMID:30337371  
PMID:30655532   PMID:30706178   PMID:30837283   PMID:30920175   PMID:30966771   PMID:31203134   PMID:31641423   PMID:31694887   PMID:31725056   PMID:32036218   PMID:32106831   PMID:32296183  
PMID:32323833   PMID:32597300   PMID:32707033   PMID:32767771   PMID:33003561   PMID:33093458   PMID:33517828   PMID:33730592   PMID:33961781   PMID:33988691   PMID:34669124   PMID:34715204  
PMID:34741867   PMID:34826606   PMID:34857952   PMID:34860160   PMID:35106936   PMID:35202674   PMID:35222400   PMID:35799024   PMID:35861941   PMID:35998035   PMID:36611927   PMID:36696461  
PMID:36736316   PMID:36857592   PMID:37079269   PMID:37099628   PMID:37276417   PMID:37280474   PMID:37286891   PMID:37340653   PMID:37343701   PMID:37353719   PMID:37854018   PMID:38250161  


Genomics

Comparative Map Data
SGK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386134,169,256 - 134,318,112 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6134,169,248 - 134,318,112 (-)EnsemblGRCh38hg38GRCh38
GRCh376134,490,394 - 134,639,250 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366134,532,081 - 134,537,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 346134,532,081 - 134,537,695NCBI
Celera6135,231,367 - 135,380,168 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6132,059,144 - 132,203,585 (-)NCBIHuRef
CHM1_16134,752,625 - 134,901,421 (-)NCBICHM1_1
T2T-CHM13v2.06135,357,191 - 135,506,235 (-)NCBIT2T-CHM13v2.0
Sgk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391021,758,083 - 21,875,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1021,758,083 - 21,875,802 (+)EnsemblGRCm39 Ensembl
GRCm381021,882,184 - 21,999,903 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1021,882,184 - 21,999,903 (+)EnsemblGRCm38mm10GRCm38
MGSCv371021,601,990 - 21,719,709 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361021,684,112 - 21,689,308 (+)NCBIMGSCv36mm8
Celera1021,774,459 - 21,893,673 (+)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.83NCBI
Sgk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,799,391 - 24,916,886 (-)NCBIGRCr8
mRatBN7.2122,980,257 - 23,098,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,980,261 - 23,098,283 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,760,448 - 22,768,284 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.011,465,432 - 1,473,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,957,500 - 22,965,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0124,185,451 - 24,302,309 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl124,185,435 - 24,302,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0125,652,750 - 25,769,448 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,501,257 - 23,506,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1123,504,206 - 23,509,647 (-)NCBI
Celera121,704,048 - 21,711,886 (-)NCBICelera
Cytogenetic Map1p12NCBI
Sgk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554392,290,035 - 2,406,587 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554392,399,992 - 2,406,587 (+)NCBIChiLan1.0ChiLan1.0
SGK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25154,142,635 - 154,288,380 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16152,048,314 - 152,194,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06131,936,397 - 132,082,670 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16136,033,851 - 136,180,121 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6136,033,851 - 136,180,121 (-)Ensemblpanpan1.1panPan2
SGK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,086,431 - 27,196,601 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,087,361 - 27,196,521 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha127,967,769 - 28,077,630 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0127,245,018 - 27,354,617 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl127,245,018 - 27,354,852 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1127,128,500 - 27,238,272 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0127,008,812 - 27,118,227 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0127,318,579 - 27,428,323 (-)NCBIUU_Cfam_GSD_1.0
Sgk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946122,200,588 - 122,229,971 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365601,979,808 - 2,088,329 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365601,979,804 - 2,009,167 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SGK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl129,745,114 - 29,753,602 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1129,625,786 - 29,753,619 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2133,226,672 - 33,256,205 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SGK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11339,152,289 - 39,306,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1339,300,567 - 39,306,183 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604011,341,622 - 11,492,670 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sgk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624942507,605 - 641,585 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624942508,035 - 641,349 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SGK1
30 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001143676.1(SGK1):c.336A>G (p.Arg112=) single nucleotide variant Malignant melanoma [RCV000067132] Chr6:134207381 [GRCh38]
Chr6:134528519 [GRCh37]
Chr6:134570212 [NCBI36]
Chr6:6q23.2
not provided
NM_001143676.1(SGK1):c.1333A>G (p.Lys445Glu) single nucleotide variant Malignant melanoma [RCV000061318] Chr6:134170906 [GRCh38]
Chr6:134492044 [GRCh37]
Chr6:134533737 [NCBI36]
Chr6:6q23.2
not provided
NM_001143676.1(SGK1):c.1251T>C (p.Asn417=) single nucleotide variant Malignant melanoma [RCV000061319] Chr6:134171095 [GRCh38]
Chr6:134492233 [GRCh37]
Chr6:134533926 [NCBI36]
Chr6:6q23.2
not provided
NM_001143676.1(SGK1):c.1241_1242delAT (p.Ile415Tyrfs) deletion Malignant melanoma [RCV000061320] Chr6:134171104..134171105 [GRCh38]
Chr6:134492242..134492243 [GRCh37]
Chr6:134533935..134533936 [NCBI36]
Chr6:6q23.2
not provided
GRCh38/hg38 6q23.2-23.3(chr6:134143117-134707402)x3 copy number gain See cases [RCV000134171] Chr6:134143117..134707402 [GRCh38]
Chr6:134464255..135028540 [GRCh37]
Chr6:134505948..135070233 [NCBI36]
Chr6:6q23.2-23.3
uncertain significance
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1
pathogenic
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27
pathogenic
GRCh37/hg19 6q23.2(chr6:133665622-134502227)x1 copy number loss See cases [RCV000446135] Chr6:133665622..134502227 [GRCh37]
Chr6:6q23.2
uncertain significance
GRCh37/hg19 6q23.2(chr6:134582400-134736595)x1 copy number loss See cases [RCV000448255] Chr6:134582400..134736595 [GRCh37]
Chr6:6q23.2
likely benign
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q23.2-24.2(chr6:133077239-143761582)x1 copy number loss See cases [RCV000510451] Chr6:133077239..143761582 [GRCh37]
Chr6:6q23.2-24.2
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_001143676.3(SGK1):c.772C>T (p.His258Tyr) single nucleotide variant Inborn genetic diseases [RCV003299744] Chr6:134173085 [GRCh38]
Chr6:134494223 [GRCh37]
Chr6:6q23.2
uncertain significance
GRCh37/hg19 6q23.2-23.3(chr6:131388023-137469640)x1 copy number loss not provided [RCV000682724] Chr6:131388023..137469640 [GRCh37]
Chr6:6q23.2-23.3
pathogenic
GRCh37/hg19 6q23.2-23.3(chr6:132002460-137160850)x1 copy number loss not provided [RCV000682725] Chr6:132002460..137160850 [GRCh37]
Chr6:6q23.2-23.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q23.2(chr6:134581016-134594393)x0 copy number loss not provided [RCV000746044] Chr6:134581016..134594393 [GRCh37]
Chr6:6q23.2
benign
GRCh37/hg19 6q23.2(chr6:134581118-134594393)x1 copy number loss not provided [RCV000746045] Chr6:134581118..134594393 [GRCh37]
Chr6:6q23.2
benign
GRCh37/hg19 6q23.2(chr6:134582426-134594393)x0 copy number loss not provided [RCV000746046] Chr6:134582426..134594393 [GRCh37]
Chr6:6q23.2
benign
NM_001143676.3(SGK1):c.1530C>T (p.Ala510=) single nucleotide variant not provided [RCV000948747] Chr6:134170319 [GRCh38]
Chr6:134491457 [GRCh37]
Chr6:6q23.2
benign
NM_001143676.3(SGK1):c.362-10T>C single nucleotide variant not provided [RCV000973130] Chr6:134174596 [GRCh38]
Chr6:134495734 [GRCh37]
Chr6:6q23.2
likely benign
NM_001143676.3(SGK1):c.1379A>G (p.Asn460Ser) single nucleotide variant Multiple myeloma [RCV000984130] Chr6:134170860 [GRCh38]
Chr6:134491998 [GRCh37]
Chr6:6q23.2
likely pathogenic
GRCh37/hg19 6q23.2-24.1(chr6:133817341-140038401)x1 copy number loss not provided [RCV001005848] Chr6:133817341..140038401 [GRCh37]
Chr6:6q23.2-24.1
pathogenic
GRCh37/hg19 6q23.2-24.1(chr6:133810210-140046615)x1 copy number loss not provided [RCV001537931] Chr6:133810210..140046615 [GRCh37]
Chr6:6q23.2-24.1
pathogenic
GRCh37/hg19 6q23.1-23.3(chr6:130769034-136009217)x1 copy number loss not provided [RCV001829086] Chr6:130769034..136009217 [GRCh37]
Chr6:6q23.1-23.3
pathogenic
GRCh37/hg19 6q23.2(chr6:134516112-134737470)x3 copy number gain not provided [RCV001834349] Chr6:134516112..134737470 [GRCh37]
Chr6:6q23.2
uncertain significance
GRCh37/hg19 6q23.2(chr6:133522860-134541311)x1 copy number loss not provided [RCV002474801] Chr6:133522860..134541311 [GRCh37]
Chr6:6q23.2
pathogenic
NM_001143676.3(SGK1):c.249C>G (p.Asn83Lys) single nucleotide variant Inborn genetic diseases [RCV002752429] Chr6:134261969 [GRCh38]
Chr6:134583107 [GRCh37]
Chr6:6q23.2
likely benign
NM_001143676.3(SGK1):c.1447G>A (p.Glu483Lys) single nucleotide variant Inborn genetic diseases [RCV002821137] Chr6:134170402 [GRCh38]
Chr6:134491540 [GRCh37]
Chr6:6q23.2
uncertain significance
NM_001143676.3(SGK1):c.978T>G (p.Asp326Glu) single nucleotide variant Inborn genetic diseases [RCV002893106] Chr6:134172286 [GRCh38]
Chr6:134493424 [GRCh37]
Chr6:6q23.2
uncertain significance
NM_001143676.3(SGK1):c.1516G>A (p.Val506Ile) single nucleotide variant Inborn genetic diseases [RCV002802403] Chr6:134170333 [GRCh38]
Chr6:134491471 [GRCh37]
Chr6:6q23.2
uncertain significance
NM_001143676.3(SGK1):c.1498G>A (p.Val500Ile) single nucleotide variant Inborn genetic diseases [RCV002670553] Chr6:134170351 [GRCh38]
Chr6:134491489 [GRCh37]
Chr6:6q23.2
likely benign
NM_001143676.3(SGK1):c.890A>G (p.Tyr297Cys) single nucleotide variant Inborn genetic diseases [RCV002672318] Chr6:134172719 [GRCh38]
Chr6:134493857 [GRCh37]
Chr6:6q23.2
uncertain significance
NM_001143676.3(SGK1):c.1306G>A (p.Gly436Arg) single nucleotide variant Inborn genetic diseases [RCV003209163] Chr6:134171040 [GRCh38]
Chr6:134492178 [GRCh37]
Chr6:6q23.2
uncertain significance
NM_001143676.3(SGK1):c.1459G>C (p.Glu487Gln) single nucleotide variant Inborn genetic diseases [RCV003213059] Chr6:134170390 [GRCh38]
Chr6:134491528 [GRCh37]
Chr6:6q23.2
uncertain significance
NM_001143676.3(SGK1):c.557C>T (p.Pro186Leu) single nucleotide variant Inborn genetic diseases [RCV003175462] Chr6:134173523 [GRCh38]
Chr6:134494661 [GRCh37]
Chr6:6q23.2
uncertain significance
GRCh37/hg19 6q22.31-23.3(chr6:120218852-137160850)x1 copy number loss not provided [RCV003482930] Chr6:120218852..137160850 [GRCh37]
Chr6:6q22.31-23.3
pathogenic
GRCh37/hg19 6q23.2-24.2(chr6:131569837-145572239)x3 copy number gain not specified [RCV003986663] Chr6:131569837..145572239 [GRCh37]
Chr6:6q23.2-24.2
pathogenic
GRCh37/hg19 6q22.31-25.3(chr6:119840686-156623091)x3 copy number gain not specified [RCV003986631] Chr6:119840686..156623091 [GRCh37]
Chr6:6q22.31-25.3
pathogenic
NM_001143676.3(SGK1):c.362-998G>A single nucleotide variant not provided [RCV003885258] Chr6:134175584 [GRCh38]
Chr6:134496722 [GRCh37]
Chr6:6q23.2
likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6490
Count of miRNA genes:1318
Interacting mature miRNAs:1706
Transcripts:ENST00000237305, ENST00000367855, ENST00000367857, ENST00000367858, ENST00000413996, ENST00000460769, ENST00000461976, ENST00000472859, ENST00000473704, ENST00000474427, ENST00000475719, ENST00000475882, ENST00000477460, ENST00000484353, ENST00000485771, ENST00000489458, ENST00000490149, ENST00000524387, ENST00000524764, ENST00000524929, ENST00000525700, ENST00000525877, ENST00000528577, ENST00000530421, ENST00000531575, ENST00000531782, ENST00000532021, ENST00000532856, ENST00000533224, ENST00000534658
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH102  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,490,663 - 134,490,792UniSTSGRCh37
Build 366134,532,356 - 134,532,485RGDNCBI36
Celera6135,231,646 - 135,231,775RGD
Cytogenetic Map6q23UniSTS
HuRef6132,059,423 - 132,059,552UniSTS
GeneMap99-GB4 RH Map6541.18UniSTS
NCBI RH Map61538.9UniSTS
RH80261  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,554,997 - 134,555,171UniSTSGRCh37
Build 366134,596,690 - 134,596,864RGDNCBI36
Celera6135,295,996 - 135,296,170RGD
Cytogenetic Map6q23UniSTS
HuRef6132,123,900 - 132,124,074UniSTS
GeneMap99-GB4 RH Map6540.79UniSTS
AL008757  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,631,338 - 134,631,497UniSTSGRCh37
Build 366134,673,031 - 134,673,190RGDNCBI36
Celera6135,372,312 - 135,372,471RGD
Cytogenetic Map6q23UniSTS
HuRef6132,195,732 - 132,195,891UniSTS
RH16308  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,491,438 - 134,491,560UniSTSGRCh37
Build 366134,533,131 - 134,533,253RGDNCBI36
Celera6135,232,421 - 135,232,543RGD
Cytogenetic Map6q23UniSTS
HuRef6132,060,198 - 132,060,320UniSTS
GeneMap99-GB4 RH Map6541.28UniSTS
PMC86685P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,490,694 - 134,490,983UniSTSGRCh37
Build 366134,532,387 - 134,532,676RGDNCBI36
Celera6135,231,677 - 135,231,966RGD
Cytogenetic Map6q23UniSTS
HuRef6132,059,454 - 132,059,743UniSTS
STS-H95353  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,491,807 - 134,491,972UniSTSGRCh37
Build 366134,533,500 - 134,533,665RGDNCBI36
Celera6135,232,790 - 135,232,955RGD
Cytogenetic Map6q23UniSTS
HuRef6132,060,567 - 132,060,732UniSTS
GeneMap99-GB4 RH Map6541.18UniSTS
NCBI RH Map61538.9UniSTS
AL022528  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,624,963 - 134,625,115UniSTSGRCh37
Build 366134,666,656 - 134,666,808RGDNCBI36
Celera6135,365,937 - 135,366,089RGD
Cytogenetic Map6q23UniSTS
HuRef6132,189,356 - 132,189,508UniSTS
STS-H74007  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,492,054 - 134,492,174UniSTSGRCh37
Build 366134,533,747 - 134,533,867RGDNCBI36
Celera6135,233,037 - 135,233,157RGD
Cytogenetic Map6q23UniSTS
HuRef6132,060,814 - 132,060,934UniSTS
GeneMap99-GB4 RH Map6541.18UniSTS
NCBI RH Map61538.9UniSTS
D9S233  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,525,968 - 134,526,219UniSTSGRCh37
Build 366134,567,661 - 134,567,912RGDNCBI36
Celera6135,266,965 - 135,267,216RGD
Cytogenetic Map6q23UniSTS
HuRef6132,094,538 - 132,094,789UniSTS
STS-T33566  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,490,513 - 134,490,687UniSTSGRCh37
Build 366134,532,206 - 134,532,380RGDNCBI36
Celera6135,231,496 - 135,231,670RGD
Cytogenetic Map6q23UniSTS
HuRef6132,059,273 - 132,059,447UniSTS
GeneMap99-GB4 RH Map6541.28UniSTS
NCBI RH Map61538.9UniSTS
WI-13202  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,490,412 - 134,490,536UniSTSGRCh37
Build 366134,532,105 - 134,532,229RGDNCBI36
Celera6135,231,395 - 135,231,519RGD
Cytogenetic Map6q23UniSTS
HuRef6132,059,172 - 132,059,296UniSTS
GeneMap99-GB4 RH Map6541.28UniSTS
Whitehead-RH Map6761.0UniSTS
ha3097  
Human AssemblyChrPosition (strand)SourceJBrowse
HuRef6132,184,507 - 132,184,557UniSTS
MARC_12229-12230:1007996328:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376134,492,259 - 134,493,394UniSTSGRCh37
Celera6135,233,242 - 135,234,377UniSTS
HuRef6132,061,019 - 132,062,154UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 1443 1561 1411 474 777 316 3177 836 2521 335 1245 1458 166 1196 1787 3
Low 977 1413 312 148 1090 148 1178 1352 1197 81 196 144 6 1 8 1001 1
Below cutoff 12 10 1 75 1 4 12 3 13 6 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001143676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001143677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001143678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF153609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF460178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ000512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX925976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY651831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP384292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ183142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX649005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA309338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB450096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC428953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU518415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM205707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM205708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM205709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM205710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ836654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF458297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT585135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y10032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z84486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000237305   ⟹   ENSP00000237305
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,169,256 - 134,174,866 (-)Ensembl
RefSeq Acc Id: ENST00000367855
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,169,284 - 134,174,842 (-)Ensembl
RefSeq Acc Id: ENST00000367857   ⟹   ENSP00000356831
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,169,353 - 134,174,865 (-)Ensembl
RefSeq Acc Id: ENST00000367858   ⟹   ENSP00000356832
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,169,256 - 134,318,112 (-)Ensembl
RefSeq Acc Id: ENST00000413996   ⟹   ENSP00000396242
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,169,250 - 134,175,991 (-)Ensembl
RefSeq Acc Id: ENST00000460769   ⟹   ENSP00000431705
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,214,954 - 134,262,059 (-)Ensembl
RefSeq Acc Id: ENST00000461976   ⟹   ENSP00000435577
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,173,555 - 134,317,911 (-)Ensembl
RefSeq Acc Id: ENST00000472859
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,173,909 - 134,174,861 (-)Ensembl
RefSeq Acc Id: ENST00000473704
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,171,105 - 134,172,134 (-)Ensembl
RefSeq Acc Id: ENST00000474427
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,169,248 - 134,174,866 (-)Ensembl
RefSeq Acc Id: ENST00000475719   ⟹   ENSP00000434302
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,170,106 - 134,174,864 (-)Ensembl
RefSeq Acc Id: ENST00000475882
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,172,724 - 134,174,247 (-)Ensembl
RefSeq Acc Id: ENST00000477460
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,169,252 - 134,172,907 (-)Ensembl
RefSeq Acc Id: ENST00000484353
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,180,255 - 134,262,017 (-)Ensembl
RefSeq Acc Id: ENST00000485771
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,214,945 - 134,230,481 (-)Ensembl
RefSeq Acc Id: ENST00000489458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,171,651 - 134,174,379 (-)Ensembl
RefSeq Acc Id: ENST00000490149
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,172,777 - 134,174,191 (-)Ensembl
RefSeq Acc Id: ENST00000524387
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,173,064 - 134,230,467 (-)Ensembl
RefSeq Acc Id: ENST00000524764
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,172,600 - 134,173,345 (-)Ensembl
RefSeq Acc Id: ENST00000524929   ⟹   ENSP00000435724
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,259,793 - 134,317,629 (-)Ensembl
RefSeq Acc Id: ENST00000525700
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,173,801 - 134,177,847 (-)Ensembl
RefSeq Acc Id: ENST00000525877
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,171,365 - 134,172,739 (-)Ensembl
RefSeq Acc Id: ENST00000528577   ⟹   ENSP00000434450
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,169,881 - 134,177,905 (-)Ensembl
RefSeq Acc Id: ENST00000530421
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,173,700 - 134,174,866 (-)Ensembl
RefSeq Acc Id: ENST00000531575
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,173,081 - 134,249,540 (-)Ensembl
RefSeq Acc Id: ENST00000531782
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,170,800 - 134,172,297 (-)Ensembl
RefSeq Acc Id: ENST00000532021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,173,117 - 134,177,860 (-)Ensembl
RefSeq Acc Id: ENST00000532856
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,173,172 - 134,174,861 (-)Ensembl
RefSeq Acc Id: ENST00000533224   ⟹   ENSP00000436470
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,262,038 - 134,318,112 (-)Ensembl
RefSeq Acc Id: ENST00000534658
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6134,172,726 - 134,174,868 (-)Ensembl
RefSeq Acc Id: NM_001143676   ⟹   NP_001137148
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386134,169,256 - 134,318,112 (-)NCBI
GRCh376134,490,384 - 134,639,196 (-)NCBI
HuRef6132,059,144 - 132,203,585 (-)ENTREZGENE
CHM1_16134,752,625 - 134,901,421 (-)NCBI
T2T-CHM13v2.06135,357,191 - 135,506,235 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001143677   ⟹   NP_001137149
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386134,169,256 - 134,177,861 (-)NCBI
GRCh376134,490,384 - 134,639,196 (-)ENTREZGENE
HuRef6132,059,144 - 132,203,585 (-)ENTREZGENE
CHM1_16134,752,625 - 134,761,251 (-)NCBI
T2T-CHM13v2.06135,357,191 - 135,365,795 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001143678   ⟹   NP_001137150
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386134,169,256 - 134,175,714 (-)NCBI
GRCh376134,490,384 - 134,639,196 (-)ENTREZGENE
HuRef6132,059,144 - 132,203,585 (-)ENTREZGENE
CHM1_16134,752,625 - 134,759,311 (-)NCBI
T2T-CHM13v2.06135,357,191 - 135,363,649 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291995   ⟹   NP_001278924
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386134,169,256 - 134,174,866 (-)NCBI
CHM1_16134,752,625 - 134,758,275 (-)NCBI
T2T-CHM13v2.06135,357,191 - 135,362,801 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005627   ⟹   NP_005618
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386134,169,256 - 134,174,866 (-)NCBI
GRCh376134,490,384 - 134,639,196 (-)ENTREZGENE
Build 366134,532,081 - 134,537,695 (-)NCBI Archive
HuRef6132,059,144 - 132,203,585 (-)ENTREZGENE
CHM1_16134,752,625 - 134,758,275 (-)NCBI
T2T-CHM13v2.06135,357,191 - 135,362,801 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001137148 (Get FASTA)   NCBI Sequence Viewer  
  NP_001137149 (Get FASTA)   NCBI Sequence Viewer  
  NP_001137150 (Get FASTA)   NCBI Sequence Viewer  
  NP_001278924 (Get FASTA)   NCBI Sequence Viewer  
  NP_005618 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD41091 (Get FASTA)   NCBI Sequence Viewer  
  AAH01263 (Get FASTA)   NCBI Sequence Viewer  
  AAN40971 (Get FASTA)   NCBI Sequence Viewer  
  ACD35864 (Get FASTA)   NCBI Sequence Viewer  
  AFJ04414 (Get FASTA)   NCBI Sequence Viewer  
  BAG51463 (Get FASTA)   NCBI Sequence Viewer  
  BAH11497 (Get FASTA)   NCBI Sequence Viewer  
  BAH12061 (Get FASTA)   NCBI Sequence Viewer  
  BAH12848 (Get FASTA)   NCBI Sequence Viewer  
  CAA04146 (Get FASTA)   NCBI Sequence Viewer  
  CAA71138 (Get FASTA)   NCBI Sequence Viewer  
  CAD97879 (Get FASTA)   NCBI Sequence Viewer  
  CAF02380 (Get FASTA)   NCBI Sequence Viewer  
  CAH10381 (Get FASTA)   NCBI Sequence Viewer  
  CAR58095 (Get FASTA)   NCBI Sequence Viewer  
  CAR58096 (Get FASTA)   NCBI Sequence Viewer  
  CAR58097 (Get FASTA)   NCBI Sequence Viewer  
  CAR58098 (Get FASTA)   NCBI Sequence Viewer  
  EAW47991 (Get FASTA)   NCBI Sequence Viewer  
  EAW47992 (Get FASTA)   NCBI Sequence Viewer  
  EAW47993 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000237305
  ENSP00000237305.7
  ENSP00000356831.5
  ENSP00000356832
  ENSP00000356832.5
  ENSP00000396242
  ENSP00000396242.3
  ENSP00000431705.1
  ENSP00000434302
  ENSP00000434302.1
  ENSP00000434450
  ENSP00000434450.1
  ENSP00000435577.1
  ENSP00000435724.1
  ENSP00000436470.1
GenBank Protein O00141 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001137148   ⟸   NM_001143676
- Peptide Label: isoform 2
- UniProtKB: O00141 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001137149   ⟸   NM_001143677
- Peptide Label: isoform 3
- UniProtKB: O00141 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001137150   ⟸   NM_001143678
- Peptide Label: isoform 4
- UniProtKB: B7Z325 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_005618   ⟸   NM_005627
- Peptide Label: isoform 1
- UniProtKB: Q5VY65 (UniProtKB/Swiss-Prot),   Q5TCN4 (UniProtKB/Swiss-Prot),   Q5TCN3 (UniProtKB/Swiss-Prot),   Q5TCN2 (UniProtKB/Swiss-Prot),   E1P583 (UniProtKB/Swiss-Prot),   B7Z5B2 (UniProtKB/Swiss-Prot),   B7UUP9 (UniProtKB/Swiss-Prot),   B7UUP8 (UniProtKB/Swiss-Prot),   B7UUP7 (UniProtKB/Swiss-Prot),   Q9UN56 (UniProtKB/Swiss-Prot),   O00141 (UniProtKB/Swiss-Prot),   B7Z325 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278924   ⟸   NM_001291995
- Peptide Label: isoform 5
- UniProtKB: B7Z325 (UniProtKB/TrEMBL),   E9PR89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000396242   ⟸   ENST00000413996
RefSeq Acc Id: ENSP00000436470   ⟸   ENST00000533224
RefSeq Acc Id: ENSP00000435724   ⟸   ENST00000524929
RefSeq Acc Id: ENSP00000356832   ⟸   ENST00000367858
RefSeq Acc Id: ENSP00000356831   ⟸   ENST00000367857
RefSeq Acc Id: ENSP00000237305   ⟸   ENST00000237305
RefSeq Acc Id: ENSP00000434450   ⟸   ENST00000528577
RefSeq Acc Id: ENSP00000431705   ⟸   ENST00000460769
RefSeq Acc Id: ENSP00000434302   ⟸   ENST00000475719
RefSeq Acc Id: ENSP00000435577   ⟸   ENST00000461976
Protein Domains
AGC-kinase C-terminal   Protein kinase   PX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O00141-F1-model_v2 AlphaFold O00141 1-431 view protein structure

Promoters
RGD ID:7209199
Promoter ID:EPDNEW_H10345
Type:initiation region
Name:SGK1_1
Description:serum/glucocorticoid regulated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10346  EPDNEW_H10347  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386134,174,864 - 134,174,924EPDNEW
RGD ID:7209201
Promoter ID:EPDNEW_H10346
Type:initiation region
Name:SGK1_2
Description:serum/glucocorticoid regulated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10345  EPDNEW_H10347  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386134,177,861 - 134,177,921EPDNEW
RGD ID:7209203
Promoter ID:EPDNEW_H10347
Type:initiation region
Name:SGK1_3
Description:serum/glucocorticoid regulated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10345  EPDNEW_H10346  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386134,318,058 - 134,318,118EPDNEW
RGD ID:6815577
Promoter ID:HG_MRA:14113
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:BC013832,   CU674631
Position:
Human AssemblyChrPosition (strand)Source
Build 366134,533,016 - 134,533,516 (-)MPROMDB
RGD ID:6804787
Promoter ID:HG_KWN:55079
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000042308
Position:
Human AssemblyChrPosition (strand)Source
Build 366134,534,516 - 134,535,467 (-)MPROMDB
RGD ID:6804786
Promoter ID:HG_KWN:55080
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000042317,   OTTHUMT00000042318
Position:
Human AssemblyChrPosition (strand)Source
Build 366134,535,716 - 134,536,216 (-)MPROMDB
RGD ID:6804788
Promoter ID:HG_KWN:55081
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000367855,   NM_005627,   OTTHUMT00000042309,   OTTHUMT00000042310,   OTTHUMT00000042315,   OTTHUMT00000042316,   OTTHUMT00000042319
Position:
Human AssemblyChrPosition (strand)Source
Build 366134,536,986 - 134,537,787 (-)MPROMDB
RGD ID:6851354
Promoter ID:EP73475
Type:multiple initiation site
Name:HS_SGK
Description:Serum/glucocorticoid regulated kinase.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 366134,537,692 - 134,537,752EPD
RGD ID:6804785
Promoter ID:HG_KWN:55082
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:NM_001143678
Position:
Human AssemblyChrPosition (strand)Source
Build 366134,538,386 - 134,539,317 (-)MPROMDB
RGD ID:6804784
Promoter ID:HG_KWN:55083
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   NB4
Transcripts:NM_001143677
Position:
Human AssemblyChrPosition (strand)Source
Build 366134,540,666 - 134,541,437 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10810 AgrOrtholog
COSMIC SGK1 COSMIC
Ensembl Genes ENSG00000118515 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000237305 ENTREZGENE
  ENST00000237305.12 UniProtKB/Swiss-Prot
  ENST00000367857.9 UniProtKB/Swiss-Prot
  ENST00000367858 ENTREZGENE
  ENST00000367858.10 UniProtKB/Swiss-Prot
  ENST00000413996 ENTREZGENE
  ENST00000413996.7 UniProtKB/Swiss-Prot
  ENST00000460769.1 UniProtKB/TrEMBL
  ENST00000461976.2 UniProtKB/TrEMBL
  ENST00000475719 ENTREZGENE
  ENST00000475719.6 UniProtKB/TrEMBL
  ENST00000524929.1 UniProtKB/TrEMBL
  ENST00000528577 ENTREZGENE
  ENST00000528577.5 UniProtKB/Swiss-Prot
  ENST00000533224.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1520.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000118515 GTEx
HGNC ID HGNC:10810 ENTREZGENE
Human Proteome Map SGK1 Human Proteome Map
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PX_dom UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6446 UniProtKB/Swiss-Prot
NCBI Gene 6446 ENTREZGENE
OMIM 602958 OMIM
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE SGK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00787 UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162403013 PharmGKB
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF64268 UniProtKB/TrEMBL
UniProt B7UUP7 ENTREZGENE
  B7UUP8 ENTREZGENE
  B7UUP9 ENTREZGENE
  B7Z325 ENTREZGENE, UniProtKB/TrEMBL
  B7Z5B2 ENTREZGENE
  E1P583 ENTREZGENE
  E9PJN2_HUMAN UniProtKB/TrEMBL
  E9PP33_HUMAN UniProtKB/TrEMBL
  E9PR89 ENTREZGENE, UniProtKB/TrEMBL
  H0YCJ3_HUMAN UniProtKB/TrEMBL
  O00141 ENTREZGENE
  Q5TCN2 ENTREZGENE
  Q5TCN3 ENTREZGENE
  Q5TCN4 ENTREZGENE
  Q5VY65 ENTREZGENE
  Q7Z3I4_HUMAN UniProtKB/TrEMBL
  Q9UN56 ENTREZGENE
  R4I3I2_HUMAN UniProtKB/TrEMBL
  SGK1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B7UUP7 UniProtKB/Swiss-Prot
  B7UUP8 UniProtKB/Swiss-Prot
  B7UUP9 UniProtKB/Swiss-Prot
  B7Z5B2 UniProtKB/Swiss-Prot
  E1P583 UniProtKB/Swiss-Prot
  Q5TCN2 UniProtKB/Swiss-Prot
  Q5TCN3 UniProtKB/Swiss-Prot
  Q5TCN4 UniProtKB/Swiss-Prot
  Q5VY65 UniProtKB/Swiss-Prot
  Q9UN56 UniProtKB/Swiss-Prot