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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3668
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sgk1
Name: serum/glucocorticoid regulated kinase 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sgk1increases expressionISOSGK1 (Homo sapiens)6480464CTDAtrazine results in increased expression of SGK1 mRNAPMID:18461179 PMID:22378314
Sgk1multiple interactionsISOSGK1 (Homo sapiens)6480464CTDSGK1 protein affects the reaction [Atrazine results in increased expression of CYP11A1 mRNA]; SGK1 protein affects the reaction [Atrazine results in increased expression of CYP19A1 mRNA]; SGK1 protein affects the reaction [Atrazine results in increased expression of HSD11B2 mRNA]; SGK1 protein affects the reaction [Atrazine results in increased expression of LHB mRNA]PMID:18461179
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