C3ar1 (complement C3a receptor 1) - Rat Genome Database

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Gene: C3ar1 (complement C3a receptor 1) Rattus norvegicus
Analyze
Symbol: C3ar1
Name: complement C3a receptor 1
RGD ID: 620537
Description: Enables complement component C3a binding activity and complement component C3a receptor activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of cell population proliferation; and tolerance induction to nonself antigen. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study adult respiratory distress syndrome. Biomarker of asthma and lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C3a anaphylatoxin chemotactic receptor; C3a-R; C3AR; complement component 3a receptor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Oia7
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,747,419 - 157,756,609 (-)NCBIGRCr8
mRatBN7.24156,074,747 - 156,084,680 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4156,075,389 - 156,084,701 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,347,387 - 162,354,238 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04158,130,613 - 158,137,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,775,694 - 156,782,545 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,681,767 - 155,691,240 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,684,029 - 155,690,869 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,702,646 - 222,711,738 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,326,402 - 159,333,433 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,571,333 - 159,578,369 (-)NCBI
Celera4144,898,053 - 144,904,840 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
Echimidine  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
Heliotrine  (EXP)
indinavir  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methylmercury chloride  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
Octicizer  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
saquinavir  (ISO)
SB 290157  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributyl phosphate  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death. Benard M, etal., J Biol Chem. 2004 Oct 15;279(42):43487-96. Epub 2004 Aug 2.
2. Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum. Benard M, etal., Mol Immunol. 2008 Aug;45(14):3767-74. Epub 2008 Jul 16.
3. Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma. Fregonese L, etal., J Allergy Clin Immunol. 2005 Jun;115(6):1148-54.
4. Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation. Fukuoka Y, etal., Biochem Biophys Res Commun 1998 Jan 26;242(3):663-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Role of complement 3a in the synthetic phenotype and angiotensin II-production in vascular smooth muscle cells from spontaneously hypertensive rats. Han Y, etal., Am J Hypertens. 2012 Mar;25(3):284-9. doi: 10.1038/ajh.2011.214. Epub 2011 Nov 17.
7. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301.
8. Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats. Ikeda K, etal., Clin Exp Hypertens. 2013 May 28.
9. Overexpression of the anaphylatoxin receptors, complement anaphylatoxin 3a receptor and complement anaphylatoxin 5a receptor, in the nasal mucosa of patients with mild and severe persistent allergic rhinitis. Jun SW, etal., J Allergy Clin Immunol. 2008 Jul;122(1):119-25. Epub 2008 Jun 5.
10. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29.
11. C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. Melendi GA, etal., J Virol. 2007 Jan;81(2):991-9. Epub 2006 Nov 1.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Ablation of the complement C3a anaphylatoxin receptor causes enhanced killing of Pseudomonas aeruginosa in a mouse model of pneumonia. Mueller-Ortiz SL, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L157-65. Epub 2006 Feb 3.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. Proctor LM, etal., Br J Pharmacol. 2004 Jun;142(4):756-64. Epub 2004 May 24.
17. Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. Proctor LM, etal., Int Immunopharmacol. 2006 Aug;6(8):1224-32. Epub 2006 Apr 3.
18. Complement factors C3a and C5a have distinct hemodynamic effects in the rat. Proctor LM, etal., Int Immunopharmacol. 2009 Jun;9(6):800-6. Epub 2009 Mar 12.
19. Biomarkers of acute respiratory allergen exposure: screening for sensitization potential. Pucheu-Haston CM, etal., Toxicol Appl Pharmacol. 2010 Apr 15;244(2):144-55. Epub 2010 Jan 4.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Sohn JH, etal., Nat Med. 2003 Feb;9(2):206-12. Epub 2003 Jan 6.
24. Complement Inhibition Alleviates Paraquat-Induced Acute Lung Injury. Sun S, etal., Am J Respir Cell Mol Biol. 2011 Mar 18.
25. Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation. Tschernig T, etal., Exp Toxicol Pathol. 2007 Aug;58(6):419-25. Epub 2007 Jun 1.
Additional References at PubMed
PMID:10571060   PMID:16452172   PMID:22099750   PMID:23940034   PMID:25422985   PMID:32617860   PMID:36871753  


Genomics

Comparative Map Data
C3ar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,747,419 - 157,756,609 (-)NCBIGRCr8
mRatBN7.24156,074,747 - 156,084,680 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4156,075,389 - 156,084,701 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,347,387 - 162,354,238 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04158,130,613 - 158,137,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,775,694 - 156,782,545 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,681,767 - 155,691,240 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,684,029 - 155,690,869 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,702,646 - 222,711,738 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,326,402 - 159,333,433 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,571,333 - 159,578,369 (-)NCBI
Celera4144,898,053 - 144,904,840 (-)NCBICelera
Cytogenetic Map4q42NCBI
C3AR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,056,844 - 8,066,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,056,844 - 8,066,359 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,209,440 - 8,218,955 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,102,186 - 8,110,222 (-)NCBINCBI36Build 36hg18NCBI36
Build 34128,102,185 - 8,110,222NCBI
Celera129,787,991 - 9,796,026 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef128,022,647 - 8,030,683 (-)NCBIHuRef
CHM1_1128,210,143 - 8,218,179 (-)NCBICHM1_1
T2T-CHM13v2.0128,070,449 - 8,079,963 (-)NCBIT2T-CHM13v2.0
C3ar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,824,099 - 122,833,116 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6122,824,097 - 122,833,120 (-)EnsemblGRCm39 Ensembl
GRCm386122,847,140 - 122,856,157 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,847,138 - 122,856,161 (-)EnsemblGRCm38mm10GRCm38
MGSCv376122,797,158 - 122,806,175 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366122,813,577 - 122,821,624 (-)NCBIMGSCv36mm8
Celera6124,649,306 - 124,658,328 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map657.93NCBI
C3ar1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554136,707,689 - 6,715,689 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554136,707,003 - 6,715,689 (-)NCBIChiLan1.0ChiLan1.0
C3AR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21013,614,735 - 13,622,861 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11213,611,497 - 13,619,623 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,178,064 - 8,186,206 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,220,505 - 8,228,480 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,220,933 - 8,222,381 (-)Ensemblpanpan1.1panPan2
C3AR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,431,745 - 37,439,858 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,433,792 - 37,435,246 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,176,099 - 9,184,204 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,785,758 - 37,793,862 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,785,991 - 37,793,787 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,660,414 - 37,668,519 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,701,675 - 37,709,781 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,662,656 - 8,670,749 (+)NCBIUU_Cfam_GSD_1.0
C3ar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494599,162,915 - 99,170,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936892347,842 - 349,296 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936892347,547 - 355,143 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3AR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1563,088,778 - 63,098,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
C3AR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,128,192 - 8,135,517 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,128,620 - 8,130,062 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666089222,592 - 230,801 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C3ar1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248605,197,619 - 5,199,043 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248605,196,621 - 5,204,686 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C3ar1
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:50
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000012216
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
731178Oia7Oil induced arthritis QTL 70.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4156050654157232313Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
D4Got128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24156,085,418 - 156,085,563 (+)MAPPERmRatBN7.2
Rnor_6.04155,691,688 - 155,691,830NCBIRnor6.0
Rnor_5.04222,712,454 - 222,712,596UniSTSRnor5.0
RGSC_v3.44159,334,251 - 159,334,394RGDRGSC3.4
RGSC_v3.44159,334,252 - 159,334,394UniSTSRGSC3.4
RGSC_v3.14159,579,188 - 159,579,330RGD
Celera4144,905,659 - 144,905,801UniSTS
RH 3.4 Map4998.8RGD
RH 3.4 Map4998.8UniSTS
Cytogenetic Map4q42UniSTS
RH138462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24156,077,849 - 156,077,978 (+)MAPPERmRatBN7.2
Rnor_6.04155,684,124 - 155,684,252NCBIRnor6.0
Rnor_5.04222,705,003 - 222,705,131UniSTSRnor5.0
RGSC_v3.44159,326,499 - 159,326,627UniSTSRGSC3.4
Celera4144,898,150 - 144,898,278UniSTS
RH 3.4 Map41001.5UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3
Low 3 43 54 41 16 41 8 11 72 35 35 11 8
Below cutoff 3 3 2 3

Sequence


Ensembl Acc Id: ENSRNOT00000012216   ⟹   ENSRNOP00000012216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4156,075,389 - 156,084,701 (-)Ensembl
Rnor_6.0 Ensembl4155,684,029 - 155,690,869 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106930   ⟹   ENSRNOP00000094051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4156,075,389 - 156,084,701 (-)Ensembl
RefSeq Acc Id: NM_032060   ⟹   NP_114449
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,749,684 - 157,756,530 (-)NCBI
mRatBN7.24156,077,753 - 156,084,600 (-)NCBI
Rnor_6.04155,684,027 - 155,690,869 (-)NCBI
Rnor_5.04222,702,646 - 222,711,738 (-)NCBI
RGSC_v3.44159,326,402 - 159,333,433 (-)RGD
Celera4144,898,053 - 144,904,840 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237314   ⟹   XP_006237376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,747,419 - 157,756,609 (-)NCBI
mRatBN7.24156,074,747 - 156,084,680 (-)NCBI
Rnor_6.04155,681,767 - 155,691,240 (-)NCBI
Rnor_5.04222,702,646 - 222,711,738 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_114449 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237376 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40071 (Get FASTA)   NCBI Sequence Viewer  
  EDM01978 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012216.2
  ENSRNOP00000094051.1
GenBank Protein O55197 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114449   ⟸   NM_032060
- UniProtKB: O55197 (UniProtKB/Swiss-Prot),   G3V759 (UniProtKB/TrEMBL),   A6ILG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237376   ⟸   XM_006237314
- Peptide Label: isoform X1
- UniProtKB: O55197 (UniProtKB/Swiss-Prot),   G3V759 (UniProtKB/TrEMBL),   A6ILG1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012216   ⟸   ENSRNOT00000012216
Ensembl Acc Id: ENSRNOP00000094051   ⟸   ENSRNOT00000106930
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55197-F1-model_v2 AlphaFold O55197 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693372
Promoter ID:EPDNEW_R3897
Type:single initiation site
Name:C3ar1_1
Description:complement C3a receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04155,690,918 - 155,690,978EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620537 AgrOrtholog
BioCyc Gene G2FUF-43141 BioCyc
Ensembl Genes ENSRNOG00000009211 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012216.4 UniProtKB/TrEMBL
  ENSRNOT00000106930.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Anaphtx_C3AR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anphylx_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl_rcpt-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84007 UniProtKB/Swiss-Prot
NCBI Gene 84007 ENTREZGENE
PANTHER PTHR24225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24225:SF28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C3ar1 PhenoGen
PRINTS ANPHYLATOXNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C3ANPHYLTXNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009211 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6ILG1 ENTREZGENE, UniProtKB/TrEMBL
  C3AR_RAT UniProtKB/Swiss-Prot
  G3V759 ENTREZGENE, UniProtKB/TrEMBL
  O55197 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C3ar1  complement C3a receptor 1  C3ar1  complement component 3a receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 C3ar1  complement component 3a receptor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 C3ar1  complement component 3a receptor 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression ubiquitously expressed 724614
gene_process important mediator of inflammation and potent chemotactic factor for eosinophils and mast cells 724614
gene_product member of the G-protein coupled receptor family 724614