RGD Reference Report - Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. - Rat Genome Database

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Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells.

Authors: Sohn, JH  Bora, PS  Suk, HJ  Molina, H  Kaplan, HJ  Bora, NS 
Citation: Sohn JH, etal., Nat Med. 2003 Feb;9(2):206-12. Epub 2003 Jan 6.
RGD ID: 5129547
Pubmed: (View Article at PubMed) PMID:12514742
DOI: Full-text: DOI:10.1038/nm814

Systemic tolerance can be induced by the introduction of antigen into an immune-privileged site. Here we investigated the role of complement in the induction of tolerance after intraocular injection. We found that the development of antigen-specific tolerance is dependent on a complement activation product. The ligation of the complement C3 activation product iC3b to complement receptor type 3 (the iC3b receptor) on antigen-presenting cells resulted in the sequential production of transforming growth factor-beta2 and interleukin-10, which is essential for the induction of tolerance. These observations may extend to the development of both neonatal tolerance and other forms of acquired tolerance.



Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
C3ar1  (complement C3a receptor 1)


Additional Information