Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | age related macular degeneration 9 | | ISO | RGD:735504 | 8554872 | ClinVar more ... | ClinVar | PMID:12462331 more ... | atypical hemolytic-uremic syndrome | | ISO | RGD:735504 | 8554872 | ClinVar more ... | ClinVar | PMID:14639503 more ... | atypical hemolytic-uremic syndrome | | ISO | RGD:735504 | 8554872 | ClinVar more ... | ClinVar | PMID:14639503 more ... | atypical hemolytic-uremic syndrome | | ISO | RGD:735504 | 8554872 | ClinVar more ... | ClinVar | PMID:14639503 more ... | complement component 3 deficiency | | ISO | RGD:735504 | 8554872 | ClinVar more ... | ClinVar | PMID:1350678 more ... | congenital hemolytic anemia | | ISO | RGD:735504 | 8554872 | ClinVar Annotator: match by term: Congenital hemolytic anemia | ClinVar | PMID:25741868 | focal segmental glomerulosclerosis | | ISO | RGD:735504 | 8554872 | ClinVar Annotator: match by term: Focal segmental glomerulosclerosis | ClinVar | PMID:16687714 more ... | focal segmental glomerulosclerosis 1 | | ISO | RGD:735504 | 8554872 | ClinVar Annotator: match by term: Focal sclerosis with hyalinosis | ClinVar | PMID:17634448 more ... | genetic disease | | ISO | RGD:735504 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:16687714 more ... | kidney disease | | ISO | RGD:735504 | 8554872 | ClinVar more ... | ClinVar | PMID:25741868 more ... | macular degeneration | | ISO | RGD:735504 | 8554872 | ClinVar Annotator: match by term: Macular degeneration | ClinVar | PMID:25741868, PMID:28492532 | membranoproliferative glomerulonephritis | | ISO | RGD:735504 | 8554872 | ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis | ClinVar | PMID:32581362 | mucolipidosis type IV | | ISO | RGD:735504 | 8554872 | ClinVar Annotator: match by term: Mucolipidosis type IV | ClinVar | PMID:11030752 more ... | primary ovarian insufficiency | | ISO | RGD:735504 | 8554872 | ClinVar Annotator: match by term: Premature ovarian failure | ClinVar | PMID:25741868 more ... | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Complement components (C3, C4) as inflammatory markers in asthma. | Abdel Fattah M, etal., Indian J Pediatr. 2010 Jul;77(7):771-3. Epub 2010 Jun 29. |
| 2. | Intraglomerular synthesis of complement C3 and its activation products in IgA nephropathy. | Abe K, etal., Nephron. 2001 Mar;87(3):231-9. |
| 3. | C-reactive protein and complement components but not other acute-phase reactants discriminate between clinical subsets and organ damage in systemic lupus erythematosus. | Amezcua-Guerra LM, etal., Clin Lab. 2011;57(7-8):607-13. |
| 4. | Treatment with captopril abrogates the altered expression of alpha1 macroglobulin and alpha1 antiproteinase in sera of spontaneously hypertensive rats. | Aminudin N, etal., Proteome Sci. 2012 Mar 15;10(1):17. doi: 10.1186/1477-5956-10-17. |
| 5. | Cathepsin B and complement C3 are major comigrants in the estrogen-induced peroxidase fraction of rat uterine fluid. | Balan KV, etal., J Submicrosc Cytol Pathol. 2001 Jul;33(3):221-30. |
| 6. | Complement proteins and C3 anaphylatoxin in the tears of patients with conjunctivitis. | Ballow M, etal., J Allergy Clin Immunol. 1985 Sep;76(3):473-6. |
| 7. | Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. | Barnes KC, etal., Genes Immun. 2006 Jan;7(1):27-35. |
| 8. | Complement abnormalities during an epidemic of group B meningococcal infection in children. | Beatty DW, etal., Clin Exp Immunol. 1986 Jun;64(3):465-70. |
| 9. | Up-regulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus. The Shwartzman phenomenon revisited. | Belmont HM, etal., Arthritis Rheum. 1994 Mar;37(3):376-83. |
| 10. | Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration. | Ben-David I, etal., Am J Respir Cell Mol Biol. 2005 Nov;33(5):476-82. Epub 2005 Jul 13. |
| 11. | Molecular basis of hereditary C3 deficiency. | Botto M, etal., J Clin Invest. 1990 Oct;86(4):1158-63. |
| 12. | Increase in complement component C3 is an early response to experimental magnesium deficiency in rats. | Bussiere FI, etal., Life Sci. 2003 Jun 13;73(4):499-507. |
| 13. | Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. | Cai XW, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):867-76. |
| 14. | Proteomic analysis of rat plasma following transient focal cerebral ischemia. | Chen R, etal., Biomark Med. 2011 Dec;5(6):837-46. |
| 15. | Beneficial effect of the polysaccharides from Bupleurum smithii var. parvifolium on "two-hit" acute lung injury in rats. | Cheng XQ, etal., Inflammation. 2012 Oct;35(5):1715-22. doi: 10.1007/s10753-012-9489-7. |
| 16. | Increased activation of the alternative complement pathway in sickle cell disease. | Chudwin DS, etal., Clin Immunol Immunopathol. 1985 Oct;37(1):93-7. |
| 17. | Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. | Collier RJ, etal., Invest Ophthalmol Vis Sci. 2011 Oct 11;52(11):8108-16. doi: 10.1167/iovs.10-6418. |
| 18. | Complement levels in pneumococcal pneumonia. | Coonrod JD and Rylko-Bauer B, Infect Immun. 1977 Oct;18(1):14-22. |
| 19. | Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1/IRF-1 pathway during tolerance induction. | Cordoba SP, etal., Liver Transpl. 2006 Apr;12(4):636-43. |
| 20. | Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats. | Cowell RM, etal., J Neurosci. 2003 Oct 15;23(28):9459-68. |
| 21. | Increased serum complement component 3 and mannose-binding lectin levels in adult Chinese patients with chronic rhinosinusitis. | Cui YH, etal., Rhinology. 2009 Jun;47(2):187-91. |
| 22. | Intravenous immunoglobulin (IVIG) attenuates antibody binding in acute haemorrhagic immunopneumonitis in a rat model of complement-dependent lung injury. | Dantas M, etal., Clin Exp Immunol. 2000 Jul;121(1):139-45. |
| 23. | Rat C-reactive protein activates the autologous complement system. | Diaz Padilla N, etal., Immunology. 2003 Aug;109(4):564-71. |
| 24. | Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy. | Drouin SM, etal., J Immunol. 2001 Oct 15;167(8):4141-5. |
| 25. | Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction. | Emmens RW, etal., Cardiovasc Pathol. 2016 Jan-Feb;25(1):33-9. doi: 10.1016/j.carpath.2015.09.006. Epub 2015 Sep 25. |
| 26. | CD36-mediated hematoma absorption following intracerebral hemorrhage: negative regulation by TLR4 signaling. | Fang H, etal., J Immunol. 2014 Jun 15;192(12):5984-92. doi: 10.4049/jimmunol.1400054. Epub 2014 May 7. |
| 27. | Autoantibodies in patients with chronic obstructive pulmonary disease. | Feghali-Bostwick CA, etal., Am J Respir Crit Care Med. 2008 Jan 15;177(2):156-63. Epub 2007 Nov 1. |
| 28. | Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. | Fischetti F, etal., Blood. 2005 Oct 1;106(7):2340-6. Epub 2005 Jun 14. |
| 29. | The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. | Flierl MA, etal., PLoS One. 2008 Jul 2;3(7):e2560. |
| 30. | Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. | Fu J, etal., Biochem Biophys Res Commun. 2006 Nov 10;350(1):162-8. Epub 2006 Sep 15. |
| 31. | Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation. | Fukuoka Y, etal., Biochem Biophys Res Commun 1998 Jan 26;242(3):663-8. |
| 32. | Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci | Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50 |
| 33. | A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft. | Gajanayake T, etal., Sci Transl Med. 2014 Aug 13;6(249):249ra110. doi: 10.1126/scitranslmed.3008778. |
| 34. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 35. | Vaccinia virus complement control protein (VCP) improves kidney structure and function following ischemia/reperfusion injury in rats. | Ghebremariam YT, etal., J Surg Res. 2010 Apr;159(2):747-54. doi: 10.1016/j.jss.2009.04.049. Epub 2009 Jun 6. |
| 36. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 37. | CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. | Goudriaan JR, etal., J Lipid Res. 2003 Dec;44(12):2270-7. Epub 2003 Aug 16. |
| 38. | Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. | Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89 |
| 39. | A murine model for the study of mycotic mastitis. | Guhad FA, etal., J Comp Pathol. 1995 Nov;113(4):315-25. |
| 40. | Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. | Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301. |
| 41. | Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. | Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23. |
| 42. | Responsiveness of endometrial genes Connexin26, Connexin43, C3 and clusterin to primary estrogen, selective estrogen receptor modulators, phyto- and xenoestrogens. | Heikaus S, etal., J Mol Endocrinol. 2002 Oct;29(2):239-49. |
| 43. | The complement system in Mediterranean spotted fever. | Herrero-Herrero JI, etal., J Infect Dis. 1988 May;157(5):1093-5. |
| 44. | Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration. | Hoh Kam J, etal., Am J Pathol. 2013 Aug;183(2):480-92. doi: 10.1016/j.ajpath.2013.04.008. Epub 2013 Jun 6. |
| 45. | Species difference in correlation between in vivo/in vitro liposome-complement interactions. | Huong TM, etal., Biol Pharm Bull. 2001 Apr;24(4):439-41. |
| 46. | Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonal antibody-induced arthritis. | Hutamekalin P, etal., J Pharmacol Sci. 2010;112(1):56-63. Epub 2010 Jan 6. |
| 47. | Association study of the C3 gene with adult and childhood asthma. | Inoue H, etal., J Hum Genet. 2008;53(8):728-38. Epub 2008 Jun 20. |
| 48. | Genetic-biochemical criteria for individual sensitivity in development of occupational bronchopulmonary diseases. | Izmerov NF, etal., Cent Eur J Public Health. 2002 Jun;10(1-2):35-41. |
| 49. | Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection. | Jacobs T, etal., Med Microbiol Immunol. 2005 May;194(3):143-9. Epub 2004 Sep 17. |
| 50. | Intravenous immunoglobulin protects against experimental thrombotic microangiopathy. | Jefferson JA, etal., Kidney Int. 2001 Sep;60(3):1018-25. |
| 51. | Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). | Jha P, etal., J Immunol. 2006 Jun 15;176(12):7221-31. |
| 52. | Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury. | Jordan JE, etal., Circulation. 2001 Sep 18;104(12):1413-8. |
| 53. | Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection. | Kapadia SB, etal., Immunity. 2002 Aug;17(2):143-55. |
| 54. | Involvement of complement in atopic dermatitis. | Kapp A and Schopf E, Acta Derm Venereol Suppl (Stockh). 1985;114:152-4. |
| 55. | Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin. | Kellermann W, etal., Klin Wochenschr. 1989 Feb 1;67(3):190-5. |
| 56. | Renal C3 complement component: feed forward to diabetic kidney disease. | Kelly KJ, etal., Am J Nephrol. 2015;41(1):48-56. doi: 10.1159/000371426. Epub 2015 Jan 30. |
| 57. | Innate immune defense against pneumococcal pneumonia requires pulmonary complement component C3. | Kerr AR, etal., Infect Immun. 2005 Jul;73(7):4245-52. |
| 58. | Studies on type II collagen induced polyarthritis in rats. Effect of complement depletion. | Kerwar SS, etal., J Immunopharmacol. 1981-1982;3(3-4):323-37. |
| 59. | Serum complement C3 predicts renal arteriolosclerosis in non-diabetic chronic kidney disease. | Kojima C, etal., J Atheroscler Thromb. 2012;19(9):854-61. Epub 2012 Aug 1. |
| 60. | Potentiation of photodynamic therapy of cancer by complement: the effect of gamma-inulin. | Korbelik M and Cooper PD, Br J Cancer. 2007 Jan 15;96(1):67-72. Epub 2006 Dec 5. |
| 61. | Complement component 3 (C 3) and diabetes mellitus. | Krantz S, etal., Exp Clin Endocrinol. 1988 Mar;92(3):287-96. |
| 62. | Retinal synthesis and deposition of complement components induced by ocular hypertension. | Kuehn MH, etal., Exp Eye Res. 2006 Sep;83(3):620-8. Epub 2006 May 4. |
| 63. | Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. | Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29. |
| 64. | [MRNA expression of complement C3 and C4 in rat nasal mucosa with allergic rhinitis]. | Lang JT, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006 Dec;41(12):928-31. |
| 65. | Expression and activation of complement protein and alveolar damage during Pneumocystis pneumonia. | Lasbury ME, etal., J Eukaryot Microbiol. 2006;53 Suppl 1:S136-7. |
| 66. | Photodynamic therapy boosts anti-glioma immunity in mice: a dependence on the activities of T cells and complement C3. | Li F, etal., J Cell Biochem. 2011 Oct;112(10):3035-43. doi: 10.1002/jcb.23228. |
| 67. | Regulation of complement C3 expression by the bile acid receptor FXR. | Li J, etal., J Biol Chem. 2005 Mar 4;280(9):7427-34. Epub 2004 Dec 7. |
| 68. | Complement activation contributes to leukocyte recruitment and neuropathic pain following peripheral nerve injury in rats. | Li M, etal., Eur J Neurosci. 2007 Dec;26(12):3486-500. Epub 2007 Dec 4. |
| 69. | Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice. | Li Q, etal., Infect Immun. 2011 Jul;79(7):2578-85. doi: 10.1128/IAI.00168-11. Epub 2011 Apr 18. |
| 70. | The protective effect of SCR(15-18) on cerebral ischemia-reperfusion injury. | Li S, etal., Neurol Res. 2011 Oct;33(8):866-74. doi: 10.1179/1743132811Y.0000000016. |
| 71. | Complement activation is critical for placental ischemia-induced hypertension in the rat. | Lillegard KE, etal., Mol Immunol. 2013 Nov;56(1-2):91-7. doi: 10.1016/j.molimm.2013.04.009. Epub 2013 May 15. |
| 72. | C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. | Lim J, etal., FASEB J. 2013 Feb;27(2):822-31. doi: 10.1096/fj.12-220582. Epub 2012 Nov 1. |
| 73. | Treatment with mycophenolate mofetil attenuates the development of Heymann nephritis. | Luca ME, etal., Exp Nephrol. 2000 Mar-Apr;8(2):77-83. |
| 74. | Rat uterine complement C3 expression as a model for progesterone receptor modulators: characterization of the new progestin trimegestone. | Lundeen SG, etal., J Steroid Biochem Mol Biol. 2001 Aug;78(2):137-43. |
| 75. | Ethanol preconditioning reduces hepatic I/R injury by inhibiting the complement system activation. | Ma ZW, etal., J Surg Res. 2011 Apr;166(2):314-23. doi: 10.1016/j.jss.2009.05.037. Epub 2009 Jun 18. |
| 76. | Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. | Maga TK, etal., Hum Mutat. 2010 Jun;31(6):E1445-60. doi: 10.1002/humu.21256. |
| 77. | Elevated expression of complement C3 protein in chemically induced hepatotumorogenesis in Wistar rats: a correlative proteomics and histopathological study. | Malik S, etal., Exp Toxicol Pathol. 2013 Sep;65(6):767-73. doi: 10.1016/j.etp.2012.11.003. Epub 2012 Dec 12. |
| 78. | Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort. | McKay GJ, etal., Mol Vis. 2010 Feb 10;16:194-9. |
| 79. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 80. | Nucleotide and deduced amino acid sequence of rat complement C3. | Misumi Y, etal., Nucleic Acids Res 1990 Apr 25;18(8):2178. |
| 81. | Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. | Mizuno M, etal., Biol Reprod. 2004 Oct;71(4):1374-83. Epub 2004 Jun 23. |
| 82. | Complement activation during painful crisis in sickle cell anemia. | Mold C, etal., Clin Immunol Immunopathol. 1995 Sep;76(3 Pt 1):314-20. |
| 83. | Activated complement in inflamed aqueous humor. | Mondino BJ, etal., Invest Ophthalmol Vis Sci. 1984 Jul;25(7):871-3. |
| 84. | Overexpression of innate immune response genes in a model of recessive polycystic kidney disease. | Mrug M, etal., Kidney Int. 2008 Jan;73(1):63-76. Epub 2007 Oct 24. |
| 85. | Complement components (C3, C4) in childhood asthma. | Najam FI, etal., Indian J Pediatr. 2005 Sep;72(9):745-9. |
| 86. | Complement C3 cleavage and cytokines interleukin-1beta and tumor necrosis factor-alpha in otitis media with effusion. | Narkio-Makela M, etal., Laryngoscope. 2000 Oct;110(10 Pt 1):1745-9. |
| 87. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 88. | Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3. | Nguyen CQ, etal., J Immunol. 2007 Aug 15;179(4):2318-29. |
| 89. | Abnormal activation of complement C3 in the spinal dorsal horn is closely associated with progression of neuropathic pain. | Nie F, etal., Int J Mol Med. 2013 Jun;31(6):1333-42. doi: 10.3892/ijmm.2013.1344. Epub 2013 Apr 11. |
| 90. | A Protective Role for Complement C3 Protein during Pandemic 2009 H1N1 and H5N1 Influenza A Virus Infection. | O'Brien KB, etal., PLoS One. 2011 Mar 9;6(3):e17377. |
| 91. | Complement activation following optic nerve crush in the adult rat. | Ohlsson M, etal., J Neurotrauma. 2003 Sep;20(9):895-904. |
| 92. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 93. | C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion. | Padilla ND, etal., Surgery. 2007 Nov;142(5):722-33. |
| 94. | Increased enzymatic activity of the alternative pathway convertase when bound to the erythrocytes of paroxysmal nocturnal hemoglobinuria. | Parker CJ, etal., J Clin Invest. 1982 Feb;69(2):337-46. |
| 95. | Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population. | Pei XT, etal., Curr Eye Res. 2009 Aug;34(8):615-22. |
| 96. | Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. | Pickering MC, etal., J Exp Med. 2007 Jun 11;204(6):1249-56. Epub 2007 May 21. |
| 97. | Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. | Pierangeli SS, etal., Arthritis Rheum. 2005 Jul;52(7):2120-4. |
| 98. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 99. | A role for immune complexes in enhanced respiratory syncytial virus disease. | Polack FP, etal., J Exp Med. 2002 Sep 16;196(6):859-65. |
| 100. | Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. | Proitsi P, etal., Neurobiol Aging. 2012 Aug;33(8):1843.e9-17. doi: 10.1016/j.neurobiolaging.2011.12.036. Epub 2012 Feb 1. |
| 101. | Cirrhosis-induced defects in innate pulmonary defenses against Streptococcus pneumoniae. | Propst-Graham KL, etal., BMC Microbiol. 2007 Oct 23;7:94. |
| 102. | Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. | Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2. |
| 103. | Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis. | Read RW, etal., Exp Eye Res. 2006 Mar;82(3):389-94. Epub 2005 Sep 6. |
| 104. | GOA pipeline | RGD automated data pipeline |
| 105. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 106. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 107. | Comprehensive gene review and curation | RGD comprehensive gene curation |
| 108. | Alterations in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy. | Richardson MR, etal., Mol Vis. 2010 Nov 11;16:2376-83. |
| 109. | Activation of the complement system in the adult respiratory distress syndrome. | Robbins RA, etal., Am Rev Respir Dis. 1987 Mar;135(3):651-8. |
| 110. | Profiling and identification of cerebrospinal fluid proteins in a rat EAE model of multiple sclerosis. | Rosenling T, etal., J Proteome Res. 2012 Apr 6;11(4):2048-60. Epub 2012 Feb 23. |
| 111. | The terminal pathway of the complement system is activated in focal penetrating but not in mild diffuse traumatic brain injury. | Rostami E, etal., J Neurotrauma. 2013 Dec 1;30(23):1954-65. doi: 10.1089/neu.2012.2583. Epub 2013 Oct 30. |
| 112. | Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation. | Roy RM, etal., MBio. 2013 Apr 2;4(2). pii: e00162-13. doi: 10.1128/mBio.00162-13. |
| 113. | Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration. | Rutar M, etal., Invest Ophthalmol Vis Sci. 2011 Jul 18;52(8):5347-58. doi: 10.1167/iovs.10-7119. |
| 114. | Elevated levels of iC3b and C4d, but not Bb, complement fragments from plasma of persons infected with human T cell leukemia virus (HTLV) with HTLV-I-associated myelopathy/tropical spastic paraparesis. | Saarloos MN, etal., J Infect Dis. 1995 Oct;172(4):1095-7. |
| 115. | Breakdown product of factor B as an index of complement activation in lepromatous leprosy and its relation with bacillary load. | Saha K, etal., Scand J Immunol. 1983 Jan;17(1):37-43. |
| 116. | Ultrastructural localization of immune complexes (IgG and C3) at the end-plate in experimental autoimmune myasthenia gravis. | Sahashi K, etal., J Neuropathol Exp Neurol. 1978 Mar-Apr;37(2):212-23. |
| 117. | Down-regulation of complement receptor 3 and major histocompatibility complex I and II antigen-like immunoreactivity accompanies ramification in isolated rat microglia. | Salimi K and Humpel C, Brain Res 2002 Aug 16;946(2):283-9. |
| 118. | Increased synthesis of secreted hepatic proteins during abdominal sepsis. | Sax HC, etal., J Surg Res. 1988 Feb;44(2):109-16. |
| 119. | Alterations in gene expression of complement components in chronic rhinosinusitis. | Schlosser RJ, etal., Am J Rhinol Allergy. 2010 Jan-Feb;24(1):21-5. |
| 120. | Comprehensive evaluation of complement components in the course of type I (Lepra) and type II (ENL) reactions. | Sehgal VN, etal., Int J Dermatol. 1989 Jan-Feb;28(1):32-5. |
| 121. | Activation of the complement system in systemic sclerosis. Relationship to clinical severity. | Senaldi G, etal., Arthritis Rheum. 1989 Oct;32(10):1262-7. |
| 122. | Defective solubilization of immune complexes and activation of the complement system in patients with pulmonary tuberculosis. | Senbagavalli P, etal., J Clin Immunol. 2009 Sep;29(5):674-80. Epub 2009 May 27. |
| 123. | Vascular C3 deposits on renal biopsy in pediatric patients with hematuria. | Sheth RD, etal., Pediatr Nephrol. 2000 Aug;14(8-9):797-801. |
| 124. | Involvement of dipeptidyl peptidase IV in immune complex-mediated glomerulonephritis. | Shinosaki T, etal., Lab Invest. 2002 Apr;82(4):505-13. |
| 125. | Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. | Siezen CL, etal., Pediatr Infect Dis J. 2009 Apr;28(4):333-5. |
| 126. | A quantitative proteomic analysis of soluble bronchoalveolar fluid proteins from patients with sarcoidosis and chronic beryllium disease. | Silva E, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2007 Mar;24(1):24-32. |
| 127. | Topical application of complement C3 in collagen formulation increases early wound healing. | Sinno H, etal., J Dermatolog Treat. 2013 Apr;24(2):141-7. doi: 10.3109/09546634.2011.631977. Epub 2011 Nov 21. |
| 128. | C3 R102G polymorphism increases risk of age-related macular degeneration. | Spencer KL, etal., Hum Mol Genet. 2008 Jun 15;17(12):1821-4. doi: 10.1093/hmg/ddn075. Epub 2008 Mar 6. |
| 129. | Activation of complement C3, C5, and C9 genes in tumors treated by photodynamic therapy. | Stott B and Korbelik M, Cancer Immunol Immunother. 2007 May;56(5):649-58. Epub 2006 Sep 1. |
| 130. | Complement Inhibition Alleviates Paraquat-Induced Acute Lung Injury. | Sun S, etal., Am J Respir Cell Mol Biol. 2011 Mar 18. |
| 131. | Estrogen regulation of tissue-specific expression of complement C3. | Sundstrom SA, etal., J Biol Chem 1989 Oct 5;264(28):16941-7. |
| 132. | Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo. | Trcka J, etal., Immunity. 2002 Jun;16(6):861-8. |
| 133. | Replication of genetic association studies in asthma and related phenotypes. | Undarmaa S, etal., J Hum Genet. 2010 Jun;55(6):342-9. Epub 2010 Apr 16. |
| 134. | Complement component C3 functions as an embryotrophic factor in early postimplantation rat embryos. | Usami M, etal., Int J Dev Biol. 2010;54(8-9):1277-85. |
| 135. | The metabolic syndrome in relation to complement component 3 and postprandial lipemia in patients from an outpatient lipid clinic and healthy volunteers. | van Oostrom AJ, etal., Atherosclerosis. 2007 Jan;190(1):167-73. Epub 2006 Feb 20. |
| 136. | Circulating immune complexes and complement levels in hemophilic children. | Verroust F, etal., J Clin Lab Immunol. 1981 Sep;6(2):127-30. |
| 137. | Cutting edge: myeloid complement C3 enhances the humoral response to peripheral viral infection. | Verschoor A, etal., J Immunol. 2001 Sep 1;167(5):2446-51. |
| 138. | [Changes of the complement system in myelodysplastic syndromes]. | Villaescusa Blanco R, etal., Sangre (Barc). 1998 Jun;43(3):210-2. |
| 139. | The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. | Woodruff TM, etal., J Immunol. 2008 Dec 15;181(12):8727-34. |
| 140. | Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. | Xiao X, etal., J Autoimmun. 2009 Mar;32(2):85-93. doi: 10.1016/j.jaut.2008.12.003. Epub 2009 Feb 5. |
| 141. | Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy. | Xu J, etal., J Immunol. 2018 Jun 15;200(12):4094-4101. doi: 10.4049/jimmunol.1701716. Epub 2018 Apr 25. |
| 142. | A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population. | Yanagisawa S, etal., PLoS One. 2011;6(12):e28847. doi: 10.1371/journal.pone.0028847. Epub 2011 Dec 12. |
| 143. | A new mouse model of autoimmune ocular myasthenia gravis. | Yang H, etal., Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5101-11. |
| 144. | CD36 deficiency rescues lipotoxic cardiomyopathy. | Yang J, etal., Circ Res. 2007 Apr 27;100(8):1208-17. Epub 2007 Mar 15. |
| 145. | Complement 3 activates the KLF5 gene in rat vascular smooth muscle cells. | Yao EH, etal., Biochem Biophys Res Commun. 2008 Mar 7;367(2):468-73. Epub 2008 Jan 4. |
| 146. | Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy. | Yuhki K, etal., J Pharmacol Exp Ther. 2008 May;325(2):601-9. Epub 2008 Feb 6. |
| 147. | A complex role for complement in allergic asthma. | Zhang X and Kohl J, Expert Rev Clin Immunol. 2010 Mar;6(2):269-77. |
| 148. | Viral and host factors related to the clinical outcome of COVID-19. | Zhang X, etal., Nature. 2020 May 20. pii: 10.1038/s41586-020-2355-0. doi: 10.1038/s41586-020-2355-0. |
| 149. | Brain edema after intracerebral hemorrhage in rats: the role of inflammation. | Zhang X, etal., Neurol India. 2006 Dec;54(4):402-7. |
| 150. | Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice. | Zhang Y, etal., Cardiovasc Diabetol. 2015 Jun 3;14:69. doi: 10.1186/s12933-015-0234-z. |
| 151. | Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. | Zou L, etal., J Immunol. 2013 Dec 1;191(11):5625-35. doi: 10.4049/jimmunol.1301903. Epub 2013 Oct 23. |
| 152. | Protective effects of Ephedra sinica extract on blood-brain barrier integrity and neurological function correlate with complement C3 reduction after subarachnoid hemorrhage in rats. | Zuo S, etal., Neurosci Lett. 2015 Nov 16;609:216-22. doi: 10.1016/j.neulet.2015.10.056. Epub 2015 Oct 27. |
Additional References at PubMed
| PMID:309768 | PMID:8889548 | PMID:9059512 | PMID:9555951 | PMID:9688553 | PMID:10432298 | PMID:10825534 | PMID:11901193 | PMID:15611275 | PMID:15833747 | PMID:16034134 | PMID:16452172 |
| PMID:16502470 | PMID:18083105 | PMID:18292556 | PMID:18947875 | PMID:19285573 | PMID:19302245 | PMID:19411110 | PMID:19710459 | PMID:20199584 | PMID:20864665 | PMID:21362503 | PMID:22183312 |
| PMID:22438044 | PMID:22516433 | PMID:22537900 | PMID:22632727 | PMID:22768796 | PMID:23012479 | PMID:23181358 | PMID:23376485 | PMID:23487775 | PMID:23533145 | PMID:23580065 | PMID:23613499 |
| PMID:23713944 | PMID:24006456 | PMID:24705166 | PMID:25284781 | PMID:25645918 | PMID:26316108 | PMID:26687560 | PMID:28057640 | PMID:28582497 | PMID:29476059 | PMID:30256128 | PMID:31070083 |
| PMID:31654641 | PMID:32617860 |
Genomics
Comparative Map Data
| C3 (Rattus norvegicus - Norway rat) |
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| C3 (Homo sapiens - human) |
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| C3 (Mus musculus - house mouse) |
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| C3 (Chinchilla lanigera - long-tailed chinchilla) |
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| C3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| C3 (Canis lupus familiaris - dog) |
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| C3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| C3 (Sus scrofa - pig) |
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| C3 (Chlorocebus sabaeus - green monkey) |
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| C3 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in C3
147 total Variants 
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