C3 (complement C3) - Rat Genome Database

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Gene: C3 (complement C3) Rattus norvegicus
Analyze
Symbol: C3
Name: complement C3
RGD ID: 2232
Description: Exhibits lipid binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; response to estradiol; and response to steroid hormone. Localizes to extracellular space. Used to study glomerulonephritis; membranous glomerulonephritis; obesity; pneumonia; and pre-eclampsia. Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); pneumocystosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; and sickle cell anemia. Orthologous to human C3 (complement C3); PARTICIPATES IN classical complement pathway; Chagas disease pathway; coagulation cascade pathway; INTERACTS WITH (S)-colchicine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: complement component 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: C3em1Linf  
Genetic Models: F344;SD-C3em1Linf
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.292,087,437 - 2,114,366 (-)NCBI
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.099,721,137 - 9,747,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.098,728,465 - 8,754,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,407,133 - 6,432,968 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (IEP)
acute myocardial infarction  (ISO)
adult respiratory distress syndrome  (ISO)
age related macular degeneration 7  (ISO)
age related macular degeneration 9  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (IEP)
Anemia, Refractory, with Excess of Blasts  (ISO)
anterior uveitis  (IEP,ISO)
arteriolosclerosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
bacterial pneumonia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (IEP)
brain ischemia  (IEP)
Carcinoma, Lewis Lung  (ISO)
Cerebral Hemorrhage  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Dysfunction  (IDA)
chronic obstructive pulmonary disease  (ISO)
complement component 3 deficiency  (ISO)
congenital hemolytic anemia  (ISO)
conjunctivitis  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (IEP,ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
erythema nodosum  (ISO)
Experimental Arthritis  (IDA,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Myasthenia Gravis  (IEP,ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
factor VIII deficiency  (ISO)
Fuchs' endothelial dystrophy  (ISO)
glomerulonephritis  (IDA)
Hematuria  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (IEP)
herpes simplex  (ISO)
Herpesviridae Infections  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IEP)
hypertension  (IEP)
IgA glomerulonephritis  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (IEP)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (ISO)
lepromatous leprosy  (ISO)
Liver Reperfusion Injury  (IEP)
lung disease  (ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
mastitis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (IDA,ISO)
Meningococcal Infections  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IEP,ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (IEP)
obesity  (IDA)
ocular hypertension  (IEP)
Optic Nerve Injuries  (IEP)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Paratuberculosis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
pleurisy  (ISO)
Pneumococcal Pneumonia  (IEP,ISO)
pneumocystosis  (IEP)
pneumonia  (IDA)
pre-eclampsia  (IDA)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (IEP)
retinal degeneration  (IEP)
rheumatoid arthritis  (ISO)
rhinitis  (IEP,ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IEP)
Sepsis  (IEP,ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Subarachnoid Hemorrhage  (IEP)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombophilia  (ISO)
Thrombotic Microangiopathies  (IDA)
transient cerebral ischemia  (IEP,ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Viral Bronchiolitis  (ISO)
vitiligo  (ISO)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-colchicine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9-phenanthrol  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
carbon nanotube  (EXP,ISO)
chlorpromazine  (ISO)
chondroitin sulfate  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
daidzein  (EXP)
danazol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diethyl malate  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenvalerate  (ISO)
ferulic acid  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (EXP)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
heparin  (ISO)
hydrazine  (ISO)
ibuprofen  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (EXP)
lipopolysaccharide  (ISO)
magnesium atom  (ISO)
mangiferin  (ISO)
medroxyprogesterone acetate  (EXP)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methacholine chloride  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methyltestosterone  (ISO)
mifepristone  (EXP)
Mizoribine  (EXP)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (EXP)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
nilotinib  (ISO)
nitroglycerin  (ISO)
Nonylphenol  (EXP,ISO)
olanzapine  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
poly(styrene)  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (EXP)
progesterone  (EXP,ISO)
propofol  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
rofecoxib  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sophoraflavanone B  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
trichloroethene  (ISO)
triclosan  (EXP,ISO)
trimegestone  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zearalenone  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IEA,ISO)
blood coagulation  (IMP)
cell surface receptor signaling pathway involved in cell-cell signaling  (IEA,ISO)
chemotaxis  (IEA)
complement activation  (IBA,IDA,ISO)
complement activation, alternative pathway  (IEA)
complement activation, classical pathway  (IEA,TAS)
complement-dependent cytotoxicity  (IEA,ISO)
complement-mediated synapse pruning  (IEA,ISO)
fatty acid metabolic process  (IEA)
inflammatory response  (IEA)
innate immune response  (ISO)
negative regulation of endopeptidase activity  (IEA)
neuron remodeling  (IEA,ISO)
oviduct epithelium development  (IEA,ISO)
positive regulation of activation of membrane attack complex  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic cell clearance  (IEA,ISO)
positive regulation of developmental growth  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of G protein-coupled receptor signaling pathway  (IEA,ISO,ISS)
positive regulation of glucose transmembrane transport  (IEA,ISO,ISS)
positive regulation of lipid storage  (IEA,ISO,ISS)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (IEA,ISO)
positive regulation of protein phosphorylation  (IEA,ISO,ISS)
positive regulation of receptor-mediated endocytosis  (IEA,ISO)
positive regulation of type IIa hypersensitivity  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
regulation of triglyceride biosynthetic process  (IEA,ISO,ISS)
response to bacterium  (IEA,ISO)
response to estradiol  (IEP)
response to estrogen  (IEP)
response to glucocorticoid  (IEP)
response to magnesium ion  (IEP)
response to paclitaxel  (IEP)
response to progesterone  (IEP)
retina development in camera-type eye  (ISO)
tolerance induction  (IEP)
vascular associated smooth muscle cell differentiation  (ISO)
vertebrate eye-specific patterning  (IEA,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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Additional References at PubMed
PMID:309768   PMID:8889548   PMID:9059512   PMID:9555951   PMID:9688553   PMID:10432298   PMID:10825534   PMID:11901193   PMID:15611275   PMID:15833747   PMID:16034134   PMID:16452172  
PMID:16502470   PMID:18083105   PMID:18292556   PMID:18947875   PMID:19285573   PMID:19302245   PMID:19411110   PMID:19710459   PMID:20199584   PMID:20864665   PMID:21362503   PMID:22183312  
PMID:22438044   PMID:22516433   PMID:22537900   PMID:22632727   PMID:22768796   PMID:23012479   PMID:23181358   PMID:23376485   PMID:23487775   PMID:23533145   PMID:23580065   PMID:23613499  
PMID:23713944   PMID:24006456   PMID:24705166   PMID:25284781   PMID:25645918   PMID:26316108   PMID:26687560   PMID:28057640   PMID:28582497   PMID:29476059   PMID:30256128   PMID:31070083  
PMID:31654641  


Genomics

Candidate Gene Status
C3 is a candidate Gene for QTL Ciaa3
Comparative Map Data
C3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.292,087,437 - 2,114,366 (-)NCBI
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.099,721,137 - 9,747,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.098,728,465 - 8,754,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,407,133 - 6,432,968 (+)NCBICelera
Cytogenetic Map9q12NCBI
C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl196,677,704 - 6,730,562 (-)EnsemblGRCh38hg38GRCh38
GRCh38196,677,704 - 6,720,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37196,677,715 - 6,720,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,628,846 - 6,671,662 (-)NCBINCBI36hg18NCBI36
Build 34196,628,877 - 6,671,660NCBI
Celera196,619,402 - 6,662,926 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef196,440,030 - 6,483,146 (-)NCBIHuRef
CHM1_1196,678,095 - 6,720,552 (-)NCBICHM1_1
C3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBImm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
C3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,796,663 - 2,824,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,796,601 - 2,824,233 (+)NCBIChiLan1.0ChiLan1.0
C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1196,629,240 - 6,674,786 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,629,287 - 6,674,699 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,708,211 - 5,753,178 (-)NCBIMhudiblu_PPA_v0panPan3
C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,566,226 - 53,598,365 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,566,261 - 53,598,761 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,314,550 - 53,347,112 (+)NCBI
ROS_Cfam_1.02054,220,548 - 54,253,547 (+)NCBI
UMICH_Zoey_3.12053,287,896 - 53,320,436 (+)NCBI
UNSW_CanFamBas_1.02053,735,894 - 53,768,908 (+)NCBI
UU_Cfam_GSD_1.02053,965,350 - 53,997,908 (+)NCBI
C3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,824,886 - 213,849,048 (+)NCBI
SpeTri2.0NW_0049365883,985,732 - 4,023,221 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,431,499 - 72,528,112 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,431,470 - 72,471,622 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,762,013 - 72,820,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2272,950,572 - 72,957,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2qNCBI
C3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,250,422 - 6,289,264 (-)NCBI
Vero_WHO_p1.0NW_0236660811,706,107 - 1,746,127 (+)NCBI
C3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248283,773,816 - 3,798,077 (-)NCBI

Position Markers
D17Mit88  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.292,115,495 - 2,115,641 (-)MAPPER
Rnor_6.099,719,862 - 9,720,007NCBIRnor6.0
Rnor_5.098,727,190 - 8,727,335UniSTSRnor5.0
Celera96,405,858 - 6,406,003UniSTS
Cytogenetic Map9q11UniSTS
RH130704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.292,087,529 - 2,087,831 (-)MAPPER
Rnor_6.099,746,690 - 9,746,991NCBIRnor6.0
Rnor_5.098,754,018 - 8,754,319UniSTSRnor5.0
Celera96,432,574 - 6,432,875UniSTS
Cytogenetic Map9q11UniSTS
AU049381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.292,087,244 - 2,087,522 (-)MAPPER
Rnor_6.099,746,999 - 9,747,276NCBIRnor6.0
Rnor_5.098,754,327 - 8,754,604UniSTSRnor5.0
Celera96,432,883 - 6,433,160UniSTS
Cytogenetic Map9q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9116520166Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9129467098Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9140383872Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9140383872Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9140383872Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9145029794Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9190783415555026Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9235572247355722Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9235572247355722Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9288097747375681Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9288097747880977Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9498609549986095Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9498609549986095Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9572425425692342Rat


Genetic Models
This gene C3 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:210
Count of miRNA genes:87
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000073042, ENSRNOT00000075494
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 33 33 27 1
Medium 1 22 14 13 14 2 2 5 2 7 11 2
Low 2 26 8 6 6 7 26 29 26 6
Below cutoff 17 2 41 4 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073042   ⟹   ENSRNOP00000066885
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075494   ⟹   ENSRNOP00000066934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl99,721,137 - 9,747,077 (+)Ensembl
RefSeq Acc Id: NM_016994   ⟹   NP_058690
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.292,087,437 - 2,114,366 (-)NCBI
Rnor_6.099,721,137 - 9,747,084 (+)NCBI
Rnor_5.098,728,465 - 8,754,412 (+)NCBI
Celera96,407,133 - 6,432,968 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058690 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40837 (Get FASTA)   NCBI Sequence Viewer  
  AAG00532 (Get FASTA)   NCBI Sequence Viewer  
  CAA36716 (Get FASTA)   NCBI Sequence Viewer  
  EDL83571 (Get FASTA)   NCBI Sequence Viewer  
  P01026 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058690   ⟸   NM_016994
- Peptide Label: precursor
- UniProtKB: P01026 (UniProtKB/Swiss-Prot),   M0RBF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066885   ⟸   ENSRNOT00000073042
RefSeq Acc Id: ENSRNOP00000066934   ⟸   ENSRNOT00000075494
Protein Domains
Anaphylatoxin-like   NTR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696435
Promoter ID:EPDNEW_R6959
Type:multiple initiation site
Name:C3_1
Description:complement C3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.099,721,123 - 9,721,183EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2232 AgrOrtholog
Ensembl Genes ENSRNOG00000046834 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000066885 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000066934 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073042 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000075494 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxn_comp_syst_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C3/4/5_MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement_C3-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MacrogloblnA2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR_complement_C3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24232 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24232 ENTREZGENE
PANTHER PTHR11412:SF81 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TED_complement UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB C3 RGD
PhenoGen C3 PhenoGen
PRINTS ANAPHYLATOXN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C345C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CO3_RAT UniProtKB/Swiss-Prot
  M0RBF1 ENTREZGENE, UniProtKB/TrEMBL
  M0RBJ7_RAT UniProtKB/TrEMBL
  P01026 ENTREZGENE
UniProt Secondary Q9ET19 UniProtKB/Swiss-Prot
  Q9QV57 UniProtKB/Swiss-Prot
  Q9QV58 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C3  complement C3  C3  complement component 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 C3  Complement component 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein is secreted 634673
gene_homology 81 and 90% homologous to human and mouse 634673
gene_protein 180 kDa protein 634673
gene_regulation expression downregulated in ramified primary culture microglial cells, upregulated in primary culture microglial cells upon stimulation with serine and glycine or lipopolysaccharide (LPS) 1299851
gene_regulation expression in uterine epithelial cells is upregulated by estradiol 634673