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Gene: C3 (complement C3) Rattus norvegicus
Symbol: C3
Name: complement C3
Description: Exhibits lipid binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; response to estradiol; and response to steroid hormone. Localizes to extracellular space. Used to study glomerulonephritis; membranous glomerulonephritis; obesity; pneumonia; and pre-eclampsia. Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); pneumocystosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3); PARTICIPATES IN classical complement pathway; Chagas disease pathway; coagulation cascade pathway; INTERACTS WITH (S)-colchicine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: complement component 3
Homo sapiens (human) : C3 (complement C3)  HGNC  Alliance
Mus musculus (house mouse) : C3 (complement component 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : C3 (complement C3)
Pan paniscus (bonobo/pygmy chimpanzee) : C3 (complement C3)
Canis lupus familiaris (dog) : C3 (complement C3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : C3 (complement C3)
Sus scrofa (pig) : C3 (complement C3)
Chlorocebus sabaeus (African green monkey) : C3 (complement C3)
Heterocephalus glaber (naked mole-rat) : C3 (complement C3)
more info ...
Allele / Splice: C3em1Linf  
Genetic Models: F344;SD-C3em1Linf
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.099,721,137 - 9,747,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,728,465 - 8,754,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,407,133 - 6,432,968 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on C3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2232
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.