C3AR1 (complement C3a receptor 1)

Gene: C3AR1 (complement C3a receptor 1) Pan paniscus

Analyze

Symbol:

C3AR1

Name:

complement C3a receptor 1

RGD ID:

11955697

Description:

ENCODES a protein that exhibits complement component C3a binding (ortholog); complement component C3a receptor activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); positive regulation of cell migration (ortholog); positive regulation of cytosolic calcium ion concentration (ortholog); ASSOCIATED WITH adult respiratory distress syndrome (ortholog); asthma (ortholog); atypical hemolytic-uremic syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C3a anaphylatoxin chemotactic receptor

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	13,614,735 - 13,622,861 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	13,611,497 - 13,619,623 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	8,178,064 - 8,186,206 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	8,220,505 - 8,228,480 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	8,220,933 - 8,222,381 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult respiratory distress syndrome (ISO)

asthma (ISO)

atypical hemolytic-uremic syndrome (ISO)

bacterial pneumonia (ISO)

COVID-19 (ISO)

developmental and epileptic encephalopathy 21 (ISO)

genetic disease (ISO)

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

Klippel-Feil syndrome 3 (ISO)

lung disease (ISO)

lymphoproliferative syndrome 2 (ISO)

peroxisome biogenesis disorder 2B (ISO)

pneumonia (ISO)

prostate cancer (ISO)

Reperfusion Injury (ISO)

rhinitis (ISO)

systemic lupus erythematosus (ISO)

Temtamy syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IEA,ISO)

chemotaxis (IEA)

complement component C5a signaling pathway (IEA)

complement receptor mediated signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IEA)

inflammatory response (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA)

positive regulation of angiogenesis (IEA)

positive regulation of cell migration (ISO)

positive regulation of cytosolic calcium ion concentration (IEA,ISO)

positive regulation of DNA biosynthetic process (ISO)

positive regulation of glomerular mesangial cell proliferation (ISO)

positive regulation of macrophage chemotaxis (IEA)

positive regulation of neutrophil chemotaxis (IEA)

positive regulation of smooth muscle cell proliferation (ISO)

positive regulation of vascular endothelial growth factor production (IEA)

regulation of blood pressure (ISO)

regulation of immune system process (IEA)

tolerance induction to nonself antigen (ISO)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

complement component C3a binding (ISO)

complement component C3a receptor activity (IEA,ISO)

complement component C5a receptor activity (IEA)

G protein-coupled receptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

C3AR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	13,614,735 - 13,622,861 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	13,611,497 - 13,619,623 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	8,178,064 - 8,186,206 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	8,220,505 - 8,228,480 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	8,220,933 - 8,222,381 (-)	Ensembl	panpan1.1		panPan2

C3AR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	8,056,844 - 8,066,359 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	8,056,844 - 8,066,359 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	8,209,440 - 8,218,955 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	8,102,186 - 8,110,222 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	8,102,185 - 8,110,222	NCBI
Celera	12	9,787,991 - 9,796,026 (-)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	8,022,647 - 8,030,683 (-)	NCBI		HuRef
CHM1_1	12	8,210,143 - 8,218,179 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	8,070,449 - 8,079,963 (-)	NCBI		T2T-CHM13v2.0

C3ar1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	122,824,099 - 122,833,116 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	122,824,097 - 122,833,120 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	122,847,140 - 122,856,157 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	122,847,138 - 122,856,161 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	122,797,158 - 122,806,175 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	122,813,577 - 122,821,624 (-)	NCBI		MGSCv36	mm8
Celera	6	124,649,306 - 124,658,328 (-)	NCBI		Celera
Cytogenetic Map	6	F2	NCBI
cM Map	6	57.93	NCBI

C3ar1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,747,419 - 157,756,609 (-)	NCBI		GRCr8
mRatBN7.2	4	156,074,747 - 156,084,680 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	156,075,389 - 156,084,701 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	162,347,387 - 162,354,238 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	158,130,613 - 158,137,464 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,775,694 - 156,782,545 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,681,767 - 155,691,240 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	155,684,029 - 155,690,869 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	222,702,646 - 222,711,738 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	159,326,402 - 159,333,433 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	159,571,333 - 159,578,369 (-)	NCBI
Celera	4	144,898,053 - 144,904,840 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

C3ar1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	6,707,689 - 6,715,689 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	6,707,003 - 6,715,689 (-)	NCBI	ChiLan1.0	ChiLan1.0

C3AR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	37,431,745 - 37,439,858 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	37,433,792 - 37,435,246 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	9,176,099 - 9,184,204 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	37,785,758 - 37,793,862 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	37,785,991 - 37,793,787 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	37,660,414 - 37,668,519 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	37,701,675 - 37,709,781 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	8,662,656 - 8,670,749 (+)	NCBI		UU_Cfam_GSD_1.0

C3ar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	99,162,915 - 99,170,683 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936892	347,842 - 349,296 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936892	347,547 - 355,143 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C3AR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	63,088,778 - 63,098,750 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

C3AR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	8,128,192 - 8,135,517 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	8,128,620 - 8,130,062 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666089	222,592 - 230,801 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C3ar1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	5,197,619 - 5,199,043 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624860	5,196,621 - 5,204,686 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003811799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000022590 ⟹ ENSPPAP00000004930

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	8,220,933 - 8,222,381 (-)	Ensembl

RefSeq Acc Id:

XM_003811799 ⟹ XP_003811847

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	13,614,735 - 13,622,861 (-)	NCBI
NHGRI_mPanPan1	12	13,611,497 - 13,619,623 (-)	NCBI
Mhudiblu_PPA_v0	12	8,178,064 - 8,186,206 (-)	NCBI
PanPan1.1	12	8,220,505 - 8,228,480 (-)	NCBI

Sequence:

show sequence

CTGTGAGGTCAGATAGTGGTCTAGAGCATAAGACTTAACTTATTGCCGGAAACAGAGAGAGAAC
AGAAGAAGAGAAAGCTCAGCAAATTTTCTTGCCATACTTCATGACTTCACTGTGGCTAAGTGTG
GGGACCAGACAGGACTCGTGGAGACATCCAGGTGCTGAAGCCTTCAGCTACTGTCTCAGTTTTT
TGAAGTTTAGCAATGGCGTCTTTCTCTGCTGAGACCAATTCAACTGACCTACTCTCACAGCCAT
GGAATGAGCCCCCAGTAATTCTCTCCATGGTCATTCTCAGCCTTACTTTTTTACTGGGATTGCC
AGGCAATGGGCTGGTGCTGTGGGTGGCTGGCCTGAAGATGCAGCGGACAGTGAACACAATTTGG
TTCCTCCACCTCACCTTGGCGGACCTCCTCTGCTGCCTCTCCTTGCCCTTCTCGCTGGCTCACT
TGGCTCTCCAGGGACAGTGGCCCTACGGCAGGTTCCTATGCAAGCTCATCCCCTCCATCATTGT
CCTCAACATGTTTGCCAGTGTCTTCCTGCTTACTGCCATTAGCCTGGATCGCTGTCTTGTGGTA
TTCAAGCCAATCTGGTGTCAGAATCATCGCAATGTAGGGACGGCCTGCTCTATCTGTGGATGTA
TCTGGGTGGTGGCTTTTGTGATGTGCATTCCTGTGTTCGTGTACCGGGAAATCTTCACTACAGA
CAACCATAATAGATGTGGCTACCAATTTGGTCTCTCCAGCTCATTAGATTATCCAGACTTTTAT
GGAGATCCACTAGAAAACAGGTCTCTTGAAAACATTGTTCAGCCGCCTGGAGAAATGAATGATA
GGTTAGATCTTTCCTCTTTCCAAACAAATGATCATCCTTGGACAGTCCCCACTGTCTTCCAACC
TCAAACATTTCAAAGACCTTCTGCAGATTCACTCCCTAGGGATTCTGCTAGATTAACAAGTCAA
AATCTGTATTCTAATGTATTTAAACCTGCTGATGTGGTCTCACCTAAAATCCCCAGTGGGTTTC
CTATTGAAGATCACGAAACTAGCCCACTGGATAACTCTGATGCTTTTCTCTCTACTCATTTAAA
GCTGTTCCCTAGCACTTCTAGCAATTCCTTCTACGAGTCTGAGCTACCACAAGGTTTCCAGGAT
TATTACAATTTAGGCCAATTCACAGATGACAATCAAGTGCCAACACCCCTCGTGGCAATAACGA
TCACTAGGCTAGTGGTGGGTTTCCTGCTGCCCTCTGTTATCATGATAGCCTGTTACAGCTTCAT
TGTCTTCCGAATGCAAAGGGGCCGCTTCGCCAAGTCTCAGAGCAAAACCTTTCGAGTGGCCGTG
GTGGTGGTGGCTGTCTTTCTTGTCTGCTGGACTCCATACCACATTTTTGGAGTCCTGTCATTGC
TTACTGACCCAGAAACTCCCTTGGGGAAAACTCTGATGTCCTGGGATCATGTATGCATTGCTCT
AGCATCTGCCAATAGTTGCTTTAATCCCTTCCTTTATGCCCTCTTGGGGAAAGATTTTAGGAAG
AAAGCAAGGCAGTCCATTCAGGGAATTCTGGAGGCAGCCTTCAGTGAGGAGCTCACACGTTCTA
CCCACTGTCCCTCAAACAATGTCATTTCAGAAAGAAATAGTACAACTGTGTGAAAATGTGGAGC
AGCCAACAAGCAGGGGCTCTTAGGCAATCACATAGTGAAAGTTTATAAGAGGATGAAGTGATAT
GGTGAGCAGCGGACTTCAAAAACTGTCAAAGAATCAATCCAGTGGTTCTCAAAGGGTACACAGA
CTATTGGCATCAGCATCACCTAGAAACTTGTTAGAAATGCAAATTCTCAAGCCGCATCCCAGAC
TTGCTGAATTGGAATCTCTGGGGGTTGGGACCCAGCAAGGGCACTTAACAAACCCTCGTTTCTG
ATTAATGCTAAATGTAAGAATCATTGTAAATATTAGTTCTATTTCTATCCCAAACTAAGCTATG
TGAAATAAGAGAAACTACTTTGTTTTTAAATGATGTTAAATATTTGTCGATATTTCCATCATTA
AATTTTTCCTTAGCATTGTCTAAGTCTTCCAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003811847	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000004930.1

RefSeq Acc Id:

XP_003811847 ⟸ XM_003811799

- UniProtKB:

A0A2R8ZLW9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTIWFLHL
TLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKPI
WCQNHRNVGTACSICGCIWVVAFVMCIPVFVYREIFTTDNHNRCGYQFGLSSSLDYPDFYGDPL
ENRSLENIVQPPGEMNDRLDLSSFQTNDHPWTVPTVFQPQTFQRPSADSLPRDSARLTSQNLYS
NVFKPADVVSPKIPSGFPIEDHETSPLDNSDAFLSTHLKLFPSTSSNSFYESELPQGFQDYYNL
GQFTDDNQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRMQRGRFAKSQSKTFRVAVVVVA
VFLVCWTPYHIFGVLSLLTDPETPLGKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQ
SIQGILEAAFSEELTRSTHCPSNNVISERNSTTV

hide sequence

RefSeq Acc Id:

ENSPPAP00000004930 ⟸ ENSPPAT00000022590

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000020605	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000022590.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Anaphtx_C3AR1	UniProtKB/TrEMBL
	Anphylx_rcpt	UniProtKB/TrEMBL
	Formyl_rcpt-rel	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
KEGG Report	pps:100990231	UniProtKB/TrEMBL
NCBI Gene	C3AR1	ENTREZGENE
PANTHER	PTHR24225	UniProtKB/TrEMBL
	PTHR24225:SF28	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	ANPHYLATOXNR	UniProtKB/TrEMBL
	C3ANPHYLTXNR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A2R8ZLW9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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