Qki (QKI, KH domain containing RNA binding) - Rat Genome Database

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Gene: Qki (QKI, KH domain containing RNA binding) Rattus norvegicus
Analyze
Symbol: Qki
Name: QKI, KH domain containing RNA binding
RGD ID: 1584886
Description: Predicted to enable RNA binding activity; internal N(7)-methylguanine-containing RNA reader activity; and transcription coactivator activity. Involved in several processes, including mRNA stabilization; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of oligodendrocyte differentiation. Predicted to be active in several cellular components, including cytoplasmic stress granule; cytosol; and synapse. Orthologous to human QKI (QKI, KH domain containing RNA binding); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homolog of mouse quaking QKI (KH domain RNA binding protein); KH domain-containing RNA-binding protein QKI; LOC108348175; LOC499022; MGC188205; protein quaking; protein quaking-like; Qk; quaking; quaking homolog, KH domain RNA binding (mouse); quaking, KH domain containing RNA binding; rqkI; similar to quaking homolog, KH domain RNA binding isoform HQK-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,935,357 - 53,047,338 (+)NCBIGRCr8
mRatBN7.2150,387,716 - 50,501,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl150,387,698 - 50,498,831 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0150,983,647 - 51,050,692 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl150,828,134 - 51,052,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,104,976 - 52,207,885 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4144,922,562 - 45,025,572 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera146,204,164 - 46,271,210 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
haloperidol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nicotine  (ISO)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon ensheathment  (ISO)
cell differentiation  (IEA)
intracellular mRNA localization  (IEA,ISO)
long-chain fatty acid biosynthetic process  (IEA,ISO)
microglia differentiation  (IEA,ISO,ISS)
mRNA processing  (IEA,IMP)
mRNA stabilization  (IMP,ISO)
mRNA transport  (IEA,ISO)
myelination  (IEA,ISO)
myofibroblast contraction  (IEA,ISO)
negative regulation of 3'-UTR-mediated mRNA stabilization  (IEA,ISO,ISS)
negative regulation of angiogenesis  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of macrophage differentiation  (ISO,ISS)
negative regulation of miRNA catabolic process  (ISO,ISS)
negative regulation of translation  (IEA,ISO,ISS)
negative regulation of type I interferon production  (ISO)
positive regulation of 3'-UTR-mediated mRNA stabilization  (ISO)
positive regulation of cholesterol biosynthetic process  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of myelination  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of oligodendrocyte differentiation  (IEA,IMP,ISO)
regulation of astrocyte differentiation  (IEA,ISO,ISS)
regulation of epithelial to mesenchymal transition  (IEA,ISO,ISS)
regulation of macrophage differentiation  (IEA,ISO)
regulation of mRNA metabolic process  (IEA)
regulation of mRNA splicing, via spliceosome  (IBA,IEA,ISO,ISS)
regulation of translation  (IEA)
RNA splicing  (IEA)
spermatid development  (IEA,ISO)
spliceosome-depend formation of circular RNA  (IEA,ISO,ISS)
vascular associated smooth muscle cell differentiation  (IEA,ISO,ISS)
vasculogenesis  (IEA,ISO)

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic stress granule  (ISO)
cytosol  (ISO)
nucleus  (IBA,IEA,ISO)
synapse  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation. Chen Y, etal., J Biol Chem. 2007 Aug 10;282(32):23553-60. Epub 2007 Jun 15.
2. The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. Doukhanine E, etal., Mol Biol Cell. 2010 Sep 1;21(17):3029-40. doi: 10.1091/mbc.E10-04-0305. Epub 2010 Jul 14.
3. Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis. Farias AS, etal., Proteomics. 2012 Aug;12(17):2656-62. doi: 10.1002/pmic.201200044.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. RNA binding protein QKI inhibits the ischemia/reperfusion-induced apoptosis in neonatal cardiomyocytes. Guo W, etal., Cell Physiol Biochem. 2011;28(4):593-602. doi: 10.1159/000335755. Epub 2011 Dec 14.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells. Zearfoss NR, etal., PLoS Genet. 2011 Jan 6;7(1):e1001269. doi: 10.1371/journal.pgen.1001269.
10. QKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte development. Zhao L, etal., Mol Biol Cell. 2006 Oct;17(10):4179-86. Epub 2006 Jul 19.
Additional References at PubMed
PMID:1150661   PMID:1373175   PMID:10506177   PMID:11178867   PMID:11892011   PMID:12477932   PMID:14169723   PMID:14706070   PMID:15057822   PMID:15148410   PMID:15568022   PMID:15632090  
PMID:16452087   PMID:19517016   PMID:22681889   PMID:22871113   PMID:23385723   PMID:25145264   PMID:28283792   PMID:34227244   PMID:36627242  


Genomics

Comparative Map Data
Qki
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,935,357 - 53,047,338 (+)NCBIGRCr8
mRatBN7.2150,387,716 - 50,501,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl150,387,698 - 50,498,831 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0150,983,647 - 51,050,692 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl150,828,134 - 51,052,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,104,976 - 52,207,885 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4144,922,562 - 45,025,572 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera146,204,164 - 46,271,210 (+)NCBICelera
Cytogenetic Map1q11NCBI
QKI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386163,414,718 - 163,578,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6163,414,000 - 163,578,592 (+)EnsemblGRCh38hg38GRCh38
GRCh376163,835,750 - 163,999,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366163,755,665 - 163,914,886 (+)NCBINCBI36Build 36hg18NCBI36
Celera6164,606,149 - 164,729,418 (+)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6161,290,590 - 161,453,987 (+)NCBIHuRef
CHM1_16164,097,893 - 164,261,842 (+)NCBICHM1_1
T2T-CHM13v2.06164,779,884 - 164,943,697 (+)NCBIT2T-CHM13v2.0
Qki
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391710,425,480 - 10,538,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1710,421,530 - 10,538,783 (-)EnsemblGRCm39 Ensembl
GRCm381710,206,471 - 10,319,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1710,202,601 - 10,319,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv371710,399,336 - 10,512,226 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361710,053,536 - 10,163,211 (-)NCBIMGSCv36mm8
Celera1710,252,038 - 10,337,960 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map177.75NCBI
Qki
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543917,925,229 - 18,079,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543917,925,205 - 18,079,727 (-)NCBIChiLan1.0ChiLan1.0
QKI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25183,597,079 - 183,756,086 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16181,498,349 - 181,657,357 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06161,361,413 - 161,523,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16166,398,884 - 166,517,389 (+)NCBIpanpan1.1PanPan1.1panPan2
QKI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1151,800,294 - 51,956,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,800,309 - 51,952,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha152,642,145 - 52,797,414 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0151,975,526 - 52,138,964 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,977,027 - 52,136,022 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,867,832 - 52,023,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,727,887 - 51,883,146 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,356,356 - 52,511,535 (+)NCBIUU_Cfam_GSD_1.0
Qki
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946146,649,733 - 146,750,270 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648913,901,754 - 13,999,983 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648913,901,066 - 14,000,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QKI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14,735,514 - 4,883,392 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114,732,575 - 4,883,386 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.216,380,698 - 6,486,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
QKI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11391,045,167 - 91,206,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1391,045,209 - 91,208,471 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604062,921,663 - 63,087,940 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Qki
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478515,739,187 - 15,845,024 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478515,738,231 - 15,845,051 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Qki
134 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:614
Count of miRNA genes:229
Interacting mature miRNAs:276
Transcripts:ENSRNOT00000023290, ENSRNOT00000023304, ENSRNOT00000035402, ENSRNOT00000071865
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
BE111947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2150,497,903 - 50,498,053 (+)MAPPERmRatBN7.2
Rnor_6.0151,057,439 - 51,057,588NCBIRnor6.0
Rnor_5.0152,333,742 - 52,333,891UniSTSRnor5.0
RGSC_v3.4145,032,319 - 45,032,468UniSTSRGSC3.4
Celera146,277,965 - 46,278,114UniSTS
RH 3.4 Map1593.4UniSTS
Cytogenetic Map1q11UniSTS
QKI  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2150,489,724 - 50,489,961 (+)MAPPERmRatBN7.2
Rnor_6.0151,049,261 - 51,049,497NCBIRnor6.0
Rnor_6.0150,930,151 - 50,930,387NCBIRnor6.0
Rnor_5.0152,206,454 - 52,206,690UniSTSRnor5.0
Rnor_5.0152,325,564 - 52,325,800UniSTSRnor5.0
RGSC_v3.4145,024,141 - 45,024,377UniSTSRGSC3.4
Celera146,269,779 - 46,270,015UniSTS
Cytogenetic Map1q11UniSTS
BF394556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2150,409,623 - 50,409,858 (+)MAPPERmRatBN7.2
Rnor_6.0150,850,065 - 50,850,299NCBIRnor6.0
Rnor_6.0150,968,974 - 50,969,208NCBIRnor6.0
Rnor_5.0152,245,277 - 52,245,511UniSTSRnor5.0
Rnor_5.0152,126,368 - 52,126,602UniSTSRnor5.0
RGSC_v3.4144,944,055 - 44,944,289UniSTSRGSC3.4
Celera146,189,690 - 46,189,924UniSTS
RH 3.4 Map1594.3UniSTS
Cytogenetic Map1q11UniSTS
Qk  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0150,828,594 - 50,828,711NCBIRnor6.0
RGSC_v3.4144,922,583 - 44,922,701UniSTSRGSC3.4
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000023290   ⟹   ENSRNOP00000023290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl150,387,698 - 50,492,371 (+)Ensembl
Rnor_6.0 Ensembl150,828,585 - 51,050,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000035402   ⟹   ENSRNOP00000034413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl150,387,698 - 50,493,096 (+)Ensembl
Rnor_6.0 Ensembl150,828,585 - 51,052,340 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086441   ⟹   ENSRNOP00000070460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl150,388,120 - 50,498,831 (+)Ensembl
Rnor_6.0 Ensembl150,828,585 - 50,933,516 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089149   ⟹   ENSRNOP00000069203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl150,387,698 - 50,491,151 (+)Ensembl
Rnor_6.0 Ensembl150,828,134 - 50,931,579 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099441   ⟹   ENSRNOP00000096216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl150,387,698 - 50,497,836 (+)Ensembl
RefSeq Acc Id: NM_001115021   ⟹   NP_001108493
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,632 - 53,043,717 (+)NCBI
mRatBN7.2150,387,923 - 50,496,030 (+)NCBI
Rnor_6.0150,983,647 - 51,050,692 (+)NCBI
Rnor_5.0152,104,976 - 52,207,885 (+)NCBI
RGSC_v3.4144,922,562 - 45,025,572 (+)RGD
Celera146,204,164 - 46,271,210 (+)RGD
Sequence:
RefSeq Acc Id: NM_001414465   ⟹   NP_001401394
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,425 - 53,047,338 (+)NCBI
mRatBN7.2150,387,716 - 50,499,651 (+)NCBI
RefSeq Acc Id: XM_017589896   ⟹   XP_017445385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,357 - 53,047,338 (+)NCBI
mRatBN7.2150,387,929 - 50,501,568 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086917   ⟹   XP_038942845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,357 - 53,043,721 (+)NCBI
mRatBN7.2150,387,929 - 50,496,034 (+)NCBI
RefSeq Acc Id: XM_039086921   ⟹   XP_038942849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,475 - 53,047,338 (+)NCBI
mRatBN7.2150,387,929 - 50,501,568 (+)NCBI
RefSeq Acc Id: XM_039086927   ⟹   XP_038942855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,936,472 - 53,047,338 (+)NCBI
mRatBN7.2150,388,817 - 50,501,568 (+)NCBI
RefSeq Acc Id: XM_039086931   ⟹   XP_038942859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,936,528 - 53,047,338 (+)NCBI
mRatBN7.2150,388,817 - 50,501,568 (+)NCBI
RefSeq Acc Id: XM_039086940   ⟹   XP_038942868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,475 - 53,043,721 (+)NCBI
mRatBN7.2150,387,794 - 50,496,034 (+)NCBI
RefSeq Acc Id: XM_039086942   ⟹   XP_038942870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,475 - 53,043,721 (+)NCBI
mRatBN7.2150,387,929 - 50,496,034 (+)NCBI
RefSeq Acc Id: XM_063270765   ⟹   XP_063126835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,357 - 53,043,721 (+)NCBI
RefSeq Acc Id: NP_001108493   ⟸   NM_001115021
- Peptide Label: isoform 2
- UniProtKB: B0BNF5 (UniProtKB/TrEMBL),   A0A0G2JUS0 (UniProtKB/TrEMBL),   A0A8I6AP33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038942868   ⟸   XM_039086940
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942849   ⟸   XM_039086921
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_017445385   ⟸   XM_017589896
- Peptide Label: isoform X1
- UniProtKB: Q91XU1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038942870   ⟸   XM_039086942
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942845   ⟸   XM_039086917
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942855   ⟸   XM_039086927
- Peptide Label: isoform X6
- UniProtKB: Q91XU1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038942859   ⟸   XM_039086931
- Peptide Label: isoform X6
- UniProtKB: Q91XU1 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000069203   ⟸   ENSRNOT00000089149
Ensembl Acc Id: ENSRNOP00000034413   ⟸   ENSRNOT00000035402
Ensembl Acc Id: ENSRNOP00000023290   ⟸   ENSRNOT00000023290
Ensembl Acc Id: ENSRNOP00000070460   ⟸   ENSRNOT00000086441
Ensembl Acc Id: ENSRNOP00000096216   ⟸   ENSRNOT00000099441
RefSeq Acc Id: NP_001401394   ⟸   NM_001414465
- Peptide Label: isoform 1
- UniProtKB: Q91XU1 (UniProtKB/Swiss-Prot),   A0A0G2JXZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126835   ⟸   XM_063270765
- Peptide Label: isoform X5
- UniProtKB: D4A2X0 (UniProtKB/TrEMBL),   A0A8I6AP33 (UniProtKB/TrEMBL)
Protein Domains
K Homology   KH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXZ5-F1-model_v2 AlphaFold A0A0G2JXZ5 1-340 view protein structure
AF-Q91XU1-F1-model_v2 AlphaFold Q91XU1 1-341 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584886 AgrOrtholog
BioCyc Gene G2FUF-61539 BioCyc
Ensembl Genes ENSRNOG00000048297 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023290.7 UniProtKB/TrEMBL
  ENSRNOT00000035402.6 UniProtKB/TrEMBL
  ENSRNOT00000086441.2 UniProtKB/TrEMBL
  ENSRNOT00000089149.2 UniProtKB/TrEMBL
  ENSRNOT00000099441.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.4010 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Quaking_NLS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAR_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:499022 UniProtKB/TrEMBL
NCBI Gene 499022 ENTREZGENE
PANTHER PROTEIN QUAKING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11208 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Quaking_NLS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAR_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Qki PhenoGen
RatGTEx ENSRNOG00000048297 RatGTEx
SMART SM00322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JUS0 ENTREZGENE
  A0A0G2JXZ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP33 ENTREZGENE, UniProtKB/TrEMBL
  B0BNF5 ENTREZGENE, UniProtKB/TrEMBL
  D4A2X0 ENTREZGENE, UniProtKB/TrEMBL
  F1LMH5_RAT UniProtKB/TrEMBL
  Q91XU1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2JUS0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-22 Qki  QKI, KH domain containing RNA binding  Qk  quaking, KH domain containing RNA binding  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-10-22 Qk  quaking, KH domain containing RNA binding  Qk  quaking  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Qk  quaking  LOC108348175  protein quaking-like  Data merged from RGD:11514364 737654 PROVISIONAL
2016-08-02 LOC108348175  protein quaking-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-15 Qk  quaking  Qki  quaking homolog, KH domain RNA binding (mouse)  Data merged from RGD:628653 737654 APPROVED
2008-03-05 Qk  quaking  LOC499022  similar to quaking homolog, KH domain RNA binding isoform HQK-6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC499022  similar to quaking homolog, KH domain RNA binding isoform HQK-6      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Qki  quaking homolog, KH domain RNA binding (mouse)    homolog of mouse quaking QKI (KH domain RNA binding protein)  Name updated 1299863 APPROVED
2003-02-27 Qki  homolog of mouse quaking QKI (KH domain RNA binding protein)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a KH-domain 625530
gene_process mouse homolog may play a role in localization of myelin basic protein (MBP) in oligodendrocytes 625530
gene_process acts as a marker for regenerating myelinating oligodendrocytes 625530
gene_process cytoplasmic protein may facilitate movement of mRNA to myelin via cytoskeleton prior to translation 625530
gene_product member of the RNA binding protein family 625530
gene_regulation elevated levels found in subsets of actively myelinating oligodendrocytes in adult brain and reduced expression observed in mature oligodendrocytes 625530
gene_transcript three isoforms identified 625530