Pon2 (paraoxonase 2) - Rat Genome Database

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Gene: Pon2 (paraoxonase 2) Rattus norvegicus
Analyze
Symbol: Pon2
Name: paraoxonase 2
RGD ID: 1309954
Description: Predicted to enable arylesterase activity and identical protein binding activity. Involved in response to oxidative stress. Located in lysosome; mitochondrion; and nucleus. Biomarker of non-alcoholic fatty liver disease and obesity. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2); INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A-esterase 2; aromatic esterase 2; LOC296851; PON 2; serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2433,389,702 - 33,425,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl433,389,714 - 33,425,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx438,348,742 - 38,384,154 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0434,274,880 - 34,310,296 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0432,684,666 - 32,720,086 (-)NCBIRnor_WKY
Rnor_6.0430,344,705 - 30,380,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,344,709 - 30,380,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0430,251,589 - 30,287,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4430,033,229 - 30,068,643 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1430,072,559 - 30,107,973 (-)NCBI
Celera428,916,533 - 28,951,951 (-)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
ciprofibrate  (ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarins  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
Diallyl sulfide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diiodine  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenthion  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrogen peroxide  (ISO)
isorhamnetin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (EXP)
mithramycin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(3-oxododecanoyl)homoserine lactone  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
nicotine  (ISO)
omeprazole  (EXP)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenyl acetate  (ISO)
phenylacetic acid  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium perchlorate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. Chen Q, etal., Am J Hum Genet. 2003 Jan;72(1):13-22. Epub 2002 Nov 26.
2. Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia. Choumerianou DM, etal., Clin Chem Lab Med. 2006;44(7):799-806.
3. Polymorphisms in the PON gene cluster are associated with Alzheimer disease. Erlich PM, etal., Hum Mol Genet. 2006 Jan 1;15(1):77-85. Epub 2005 Nov 30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic Fatty liver disease. Hussein O, etal., Int J Hepatol. 2012;2012:265305. doi: 10.1155/2012/265305. Epub 2012 Mar 27.
7. Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias. Janka Z, etal., Mol Psychiatry. 2002;7(1):110-2.
8. Differential expression of adipose tissue proteins between obesity-susceptible and -resistant rats fed a high-fat diet. Joo JI, etal., Proteomics. 2011 Apr;11(8):1429-48. doi: 10.1002/pmic.201000515. Epub 2011 Feb 25.
9. Paraoxonase gene cluster is a genetic marker for early microvascular complications in type 1 diabetes. Kao Y, etal., Diabet Med. 2002 Mar;19(3):212-5.
10. Biological role, protein expression, subcellular localization, and oxidative stress response of paraoxonase 2 in the intestine of humans and rats. Levy E, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1252-61. Epub 2007 Oct 4.
11. Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population. Li XT, etal., J Occup Health. 2013;55(2):56-65. Epub 2013 Jan 18.
12. Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy. Mackness B, etal., Clin Sci (Lond). 2000 Mar;98(3):355-63.
13. Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes. Pinizzotto M, etal., Diabetologia. 2001 Jan;44(1):104-7.
14. The Ser311Cys variation in the paraoxonase 2 gene increases the risk of type 2 diabetes in northern Chinese. Qu Y, etal., J Genet. 2008 Aug;87(2):165-9.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Paraoxonase cluster polymorphisms are associated with sporadic ALS. Saeed M, etal., Neurology. 2006 Sep 12;67(5):771-6. Epub 2006 Jul 5.
20. DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease. Sanghera DK, etal., Am J Hum Genet. 1998 Jan;62(1):36-44.
21. Paraoxonase 2 gene C311S polymorphism is associated with a risk of large vessel disease stroke in a Polish population. Slowik A, etal., Cerebrovasc Dis. 2007;23(5-6):395-400. Epub 2007 Apr 2.
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Wang XY, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Jun;20(3):215-9.
Additional References at PubMed
PMID:15489334   PMID:15772423   PMID:25842176  


Genomics

Comparative Map Data
Pon2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2433,389,702 - 33,425,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl433,389,714 - 33,425,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx438,348,742 - 38,384,154 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0434,274,880 - 34,310,296 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0432,684,666 - 32,720,086 (-)NCBIRnor_WKY
Rnor_6.0430,344,705 - 30,380,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,344,709 - 30,380,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0430,251,589 - 30,287,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4430,033,229 - 30,068,643 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1430,072,559 - 30,107,973 (-)NCBI
Celera428,916,533 - 28,951,951 (-)NCBICelera
Cytogenetic Map4q13NCBI
PON2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38795,404,862 - 95,435,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl795,404,862 - 95,435,329 (-)EnsemblGRCh38hg38GRCh38
GRCh37795,034,174 - 95,064,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,872,110 - 94,902,320 (-)NCBINCBI36Build 36hg18NCBI36
Build 34794,678,825 - 94,708,946NCBI
Celera789,732,873 - 89,763,084 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef789,641,241 - 89,671,460 (-)NCBIHuRef
CHM1_1794,964,201 - 94,994,411 (-)NCBICHM1_1
T2T-CHM13v2.0796,641,007 - 96,671,177 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2794,363,169 - 94,393,380 (-)NCBI
Pon2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3965,264,620 - 5,298,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl65,264,147 - 5,298,455 (-)EnsemblGRCm39 Ensembl
GRCm3865,264,620 - 5,298,345 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl65,264,147 - 5,298,455 (-)EnsemblGRCm38mm10GRCm38
MGSCv3765,214,624 - 5,248,373 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3665,214,624 - 5,248,373 (-)NCBIMGSCv36mm8
Celera65,411,917 - 5,445,790 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.99NCBI
Pon2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543211,987,919 - 12,020,740 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,988,009 - 12,020,702 (-)NCBIChiLan1.0ChiLan1.0
PON2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17100,950,074 - 100,980,433 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7100,950,074 - 100,980,433 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0787,362,447 - 87,392,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PON2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,652,905 - 20,680,945 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,652,905 - 20,680,980 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1420,212,086 - 20,240,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01420,475,174 - 20,503,227 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1420,474,039 - 20,503,262 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11420,619,843 - 20,648,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01420,355,194 - 20,383,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01420,612,464 - 20,640,503 (-)NCBIUU_Cfam_GSD_1.0
Pon2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511833,969,230 - 34,000,895 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365854,862,364 - 4,895,323 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365854,862,378 - 4,894,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PON2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl975,027,097 - 75,051,422 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1975,027,270 - 75,051,441 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2982,405,444 - 82,429,620 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PON2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12153,607,353 - 53,637,056 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2153,607,541 - 53,639,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604250,709,094 - 50,738,898 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pon2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248132,053,310 - 2,086,086 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248132,055,871 - 2,086,046 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pon2
138 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:83
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000036460
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat

Markers in Region
RH134317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2433,389,841 - 33,390,041 (+)MAPPERmRatBN7.2
Rnor_6.0430,344,840 - 30,345,039NCBIRnor6.0
Rnor_5.0430,251,724 - 30,251,923UniSTSRnor5.0
RGSC_v3.4430,033,364 - 30,033,563UniSTSRGSC3.4
Celera428,916,668 - 28,916,867UniSTS
RH 3.4 Map4435.33UniSTS
Cytogenetic Map4q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 57 41 19 41 1 2 74 35 34 11 1
Low 8 7 9 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036460   ⟹   ENSRNOP00000033943
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl433,389,714 - 33,425,248 (-)Ensembl
Rnor_6.0 Ensembl430,344,709 - 30,380,119 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101710   ⟹   ENSRNOP00000093970
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl433,389,714 - 33,416,055 (-)Ensembl
RefSeq Acc Id: NM_001013082   ⟹   NP_001013100
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2433,389,707 - 33,425,128 (-)NCBI
Rnor_6.0430,344,705 - 30,380,119 (-)NCBI
Rnor_5.0430,251,589 - 30,287,330 (-)NCBI
RGSC_v3.4430,033,229 - 30,068,643 (-)RGD
Celera428,916,533 - 28,951,951 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107257   ⟹   XP_038963185
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2433,389,702 - 33,425,186 (-)NCBI
RefSeq Acc Id: XM_039107258   ⟹   XP_038963186
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2433,389,702 - 33,425,136 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001013100   ⟸   NM_001013082
- UniProtKB: Q6AXM8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033943   ⟸   ENSRNOT00000036460
RefSeq Acc Id: XP_038963185   ⟸   XM_039107257
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038963186   ⟸   XM_039107258
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000093970   ⟸   ENSRNOT00000101710

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXM8-F1-model_v2 AlphaFold Q6AXM8 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692859
Promoter ID:EPDNEW_R3384
Type:initiation region
Name:Pon2_1
Description:paraoxonase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0430,380,090 - 30,380,150EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309954 AgrOrtholog
BioCyc Gene G2FUF-45710 BioCyc
Ensembl Genes ENSRNOG00000009112 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000033943 ENTREZGENE
  ENSRNOP00000033943.4 UniProtKB/TrEMBL
  ENSRNOP00000093970.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036460 ENTREZGENE
  ENSRNOT00000036460.4 UniProtKB/TrEMBL
  ENSRNOT00000101710.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122087 IMAGE-MGC_LOAD
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paraoxonase2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:296851 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95017 IMAGE-MGC_LOAD
NCBI Gene 296851 ENTREZGENE
Pfam Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pon2 PhenoGen
PRINTS PARAOXONASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PARAOXONASE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ALH3_RAT UniProtKB/TrEMBL
  A0A8L2QJB7_RAT UniProtKB/TrEMBL
  PON2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Pon2  paraoxonase 2  Pon2_predicted  paraoxonase 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pon2_predicted  paraoxonase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED