Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; neuromuscular synaptic transmission; and positive regulation of intracellular protein transport. Located in asymmetric synapse; axon terminus; and dendrite. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; G protein mediated signaling pathway via Galphaq family; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; acetylcholine.
[Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium and brucine promotes the reaction [Pilocarpine binds to CHRM1 protein]
Pilocarpine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein] and Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
1-oleoyl-2-acetylglycerol promotes the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
[muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased abundance of Nitric Oxide] and [muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased oxidation of Lipids]
Atropine binds to and results in decreased activity of CHRM1 protein and Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in decreased expression of CHAT protein more ...
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine and [[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine and [[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein
Dichlorodiphenyl Dichloroethylene results in increased expression of CHRM1 mRNA and Dichlorodiphenyl Dichloroethylene results in increased expression of CHRM1 protein
Pilocarpine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein] and Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
Misoprostol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein]
[(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein] which results in increased abundance of Nitric Oxide and [muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased abundance of Nitric Oxide]
Pirenzepine binds to and results in decreased activity of CHRM1 protein and Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein] and Pregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]
Progesterone inhibits the reaction [Acetylcholine binds to CHRM1 protein] and Progesterone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein]
Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein] and Propofol inhibits the reaction [Scopolamine Derivatives results in increased activity of CHRM1 protein]
resveratrol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein]
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine and Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
Atropine binds to and results in decreased activity of CHRM1 protein and Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies.