Chrm1 (cholinergic receptor, muscarinic 1) - Rat Genome Database

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Gene: Chrm1 (cholinergic receptor, muscarinic 1) Rattus norvegicus
Analyze
Symbol: Chrm1
Name: cholinergic receptor, muscarinic 1
RGD ID: 2342
Description: Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; neuromuscular synaptic transmission; and positive regulation of intracellular protein transport. Located in several cellular components, including axon terminus; dendrite; and postsynaptic density. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; G protein mediated signaling pathway via Galphaq family; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; acetylcholine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholinergic receptor muscarin 1; cholinergic receptor, muscarin 1; M1 muscarinic acetylcholine receptor; muscarinic acetylcholine receptor M1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21205,567,046 - 205,583,001 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,567,220 - 205,582,356 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1213,986,616 - 213,987,998 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01221,024,093 - 221,025,475 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01213,716,796 - 213,718,178 (+)NCBIRnor_WKY
Rnor_6.01224,869,087 - 224,885,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,882,439 - 224,884,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01231,806,335 - 231,822,359 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,351,738 - 211,353,120 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,510,167 - 211,511,550 (+)NCBI
Celera1203,093,639 - 203,095,021 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(S)-amphetamine  (EXP)
1,2-dichloroethane  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-DAMP(1+)  (ISO)
5-azacytidine  (ISO)
acetylcholine  (EXP,ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
atropine  (ISO)
Bardoxolone methyl  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
bethanechol  (ISO)
bifenthrin  (EXP)
biperiden  (EXP)
bisphenol A  (EXP)
brucine  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
canagliflozin  (EXP)
carbachol  (ISO)
catalpol  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP)
clozapine  (EXP,ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
diazinon  (EXP)
dichlorvos  (EXP)
dieldrin  (EXP)
dimethoate  (EXP)
disulfoton  (EXP)
flufenamic acid  (ISO)
flunarizine  (ISO)
furtrethonium  (ISO)
gadolinium atom  (ISO)
galactose  (ISO)
galanthamine  (EXP)
galanthamine Trifluoroacetic acid  (EXP)
genistein  (ISO)
gentamycin  (EXP)
imidacloprid  (EXP)
iron(III) nitrilotriacetate  (EXP)
ketamine  (ISO)
KT 5720  (ISO)
KT 5823  (ISO)
lanthanum atom  (ISO)
methoctramine tetrahydrochloride  (ISO)
methscopolamine  (EXP,ISO)
misoprostol  (EXP)
nickel atom  (EXP)
nitric oxide  (EXP)
olanzapine  (ISO)
oxotremorine M  (ISO)
pancuronium  (ISO)
paraoxon  (ISO)
parathion-methyl  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
picrotoxin  (EXP)
pioglitazone  (ISO)
Pipecuronium  (ISO)
pirenzepine  (EXP,ISO)
pirinixic acid  (EXP)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propofol  (EXP)
quercetin  (EXP)
reserpine  (EXP)
resveratrol  (EXP)
rocuronium  (ISO)
scopolamine  (EXP,ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
tacrine  (EXP,ISO)
taurolithocholic acid sulfate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
tiotropium bromide  (ISO)
trichloroethene  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
U-73122  (ISO)
vecuronium bromide  (ISO)
xanomeline  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Anagnostaras SG, etal., Nat Neurosci 2003 Jan;6(1):51-8.
2. Identification of a family of muscarinic acetylcholine receptor genes. Bonner TI, etal., Science 1987 Jul 31;237(4814):527-32.
3. Effects of isolation-rearing on serotonin-1A and M1-muscarinic receptor messenger RNA expression in the hipocampal formation of rats. Del-Bel EA, etal., Neurosci Lett 2002 Oct 31;332(2):123-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies. Hersch SM, etal., J Neurosci. 1994 May;14(5 Pt 2):3351-63.
7. Localization of the rat M1 muscarinic receptor gene to chromosome 1q43-51. Klett CP, etal., Mamm Genome 1998 Jun;9(6):476-8.
8. Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects. Maeda Y, etal., Am J Respir Crit Care Med. 2006 Nov 15;174(10):1119-24. Epub 2006 Aug 24.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Modulation of ACh release by presynaptic muscarinic autoreceptors in the neuromuscular junction of the newborn and adult rat. Santafe MM, etal., Eur J Neurosci 2003 Jan;17(1):119-27.
15. Autoantibodies against M1 muscarinic acetylcholine receptor in myasthenic disorders. Takamori M, etal., Eur J Neurol. 2007 Nov;14(11):1230-5. Epub 2007 Aug 31.
16. Muscarinic signaling in the brain. Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.
17. Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus. Tseng J, etal., Hear Res 2002 Dec;174(1-2):86-92.
18. The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons. Willets JM, etal., J Neurochem. 2007 Dec;103(6):2268-80. Epub 2007 Oct 1.
19. The M3-muscarinic cholinoceptor subtype in rat prostate and its down regulation by aging. Yazawa H and Honda K, Jpn J Pharmacol. 1993 Apr;61(4):319-24.
Additional References at PubMed
PMID:1317867   PMID:1759615   PMID:2380182   PMID:10333492   PMID:11752469   PMID:12196552   PMID:14657398   PMID:14675151   PMID:15342646   PMID:15350825   PMID:15474371   PMID:15743771  
PMID:15994335   PMID:16093396   PMID:16160857   PMID:16541262   PMID:16647280   PMID:16758365   PMID:16820015   PMID:17561934   PMID:17709264   PMID:17719699   PMID:17823120   PMID:17960828  
PMID:18247369   PMID:18443764   PMID:18454168   PMID:18480291   PMID:18842902   PMID:18938154   PMID:18991861   PMID:19124535   PMID:19160866   PMID:19309359   PMID:19328480   PMID:19344500  
PMID:19416629   PMID:19427366   PMID:19534762   PMID:19554469   PMID:19558456   PMID:19666081   PMID:19730136   PMID:19765405   PMID:19883739   PMID:20335477   PMID:20433901   PMID:20600670  
PMID:21054404   PMID:21126518   PMID:21247934   PMID:21913336   PMID:22088219   PMID:22513211   PMID:22803069   PMID:22871113   PMID:23085025   PMID:23184186   PMID:23559406   PMID:23678982  
PMID:23988164   PMID:24288746   PMID:24480931   PMID:25008070   PMID:25417050   PMID:25474381   PMID:26472558   PMID:26626425   PMID:27569857   PMID:29030298   PMID:29705702   PMID:31721013  
PMID:32798726  


Genomics

Comparative Map Data
Chrm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21205,567,046 - 205,583,001 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,567,220 - 205,582,356 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1213,986,616 - 213,987,998 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01221,024,093 - 221,025,475 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01213,716,796 - 213,718,178 (+)NCBIRnor_WKY
Rnor_6.01224,869,087 - 224,885,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,882,439 - 224,884,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01231,806,335 - 231,822,359 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,351,738 - 211,353,120 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,510,167 - 211,511,550 (+)NCBI
Celera1203,093,639 - 203,095,021 (+)NCBICelera
Cytogenetic Map1q43NCBI
CHRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,908,679 - 62,921,878 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1162,908,679 - 62,921,807 (-)EnsemblGRCh38hg38GRCh38
GRCh371162,676,151 - 62,688,835 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,432,727 - 62,445,588 (-)NCBINCBI36Build 36hg18NCBI36
Build 341162,432,727 - 62,445,588NCBI
Celera1159,999,724 - 60,012,585 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1159,005,193 - 59,018,054 (-)NCBIHuRef
CHM1_11162,559,164 - 62,572,025 (-)NCBICHM1_1
T2T-CHM13v2.01162,898,039 - 62,910,722 (-)NCBIT2T-CHM13v2.0
Chrm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39198,641,369 - 8,660,970 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl198,641,153 - 8,660,951 (+)EnsemblGRCm39 Ensembl
GRCm38198,664,005 - 8,683,606 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl198,663,789 - 8,683,587 (+)EnsemblGRCm38mm10GRCm38
MGSCv37198,738,495 - 8,758,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36198,723,372 - 8,748,612 (+)NCBIMGSCv36mm8
Celera198,422,264 - 8,441,868 (+)NCBICelera
Cytogenetic Map19ANCBI
Chrm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955599349,744 - 356,714 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955599349,744 - 356,714 (+)NCBIChiLan1.0ChiLan1.0
CHRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11161,612,934 - 61,626,767 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,614,818 - 61,616,200 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01158,261,476 - 58,274,685 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CHRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,783,938 - 53,797,750 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,795,326 - 53,796,708 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,389,834 - 52,403,632 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01854,835,906 - 54,849,703 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,833,743 - 54,849,697 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,933,197 - 53,947,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,507,453 - 53,521,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,299,342 - 54,313,140 (+)NCBIUU_Cfam_GSD_1.0
Chrm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,273,646 - 10,286,998 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581387,705 - 400,740 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936581387,939 - 400,740 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.128,858,765 - 8,872,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,210,975 - 8,225,464 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,978,464 - 10,991,650 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl110,989,207 - 10,990,589 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038108,331,823 - 108,345,191 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249261,326,866 - 1,330,805 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249261,326,851 - 1,335,477 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrm1
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:48
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000024785
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat

Markers in Region
D1Bda47  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21205,581,930 - 205,582,189 (+)MAPPERmRatBN7.2
Rnor_6.01224,884,031 - 224,884,289NCBIRnor6.0
Rnor_5.01231,821,289 - 231,821,547UniSTSRnor5.0
RGSC_v3.41211,353,141 - 211,353,399UniSTSRGSC3.4
Celera1203,095,042 - 203,095,300UniSTS
Cytogenetic Map1q43-q51UniSTS
PMC65026P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21205,580,550 - 205,581,183 (+)MAPPERmRatBN7.2
Rnor_6.01224,882,651 - 224,883,283NCBIRnor6.0
Rnor_5.01231,819,909 - 231,820,541UniSTSRnor5.0
RGSC_v3.41211,351,761 - 211,352,393UniSTSRGSC3.4
Celera1203,093,662 - 203,094,294UniSTS
Cytogenetic Map1q43-q51UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 25
Low 3 7 23 2 6 1
Below cutoff 3 11 7 6 7 5 5 16 24 23 10 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024785   ⟹   ENSRNOP00000024785
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1205,567,220 - 205,582,356 (+)Ensembl
Rnor_6.0 Ensembl1224,882,439 - 224,884,205 (+)Ensembl
RefSeq Acc Id: NM_080773   ⟹   NP_542951
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21205,580,528 - 205,581,910 (+)NCBI
Rnor_6.01224,882,628 - 224,884,010 (+)NCBI
Rnor_5.01231,806,335 - 231,822,359 (+)NCBI
RGSC_v3.41211,351,738 - 211,353,120 (+)RGD
Celera1203,093,639 - 203,095,021 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230974   ⟹   XP_006231036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21205,567,046 - 205,583,001 (+)NCBI
Rnor_6.01224,869,087 - 224,885,101 (+)NCBI
Rnor_5.01231,806,335 - 231,822,359 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008760215   ⟹   XP_008758437
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21205,567,849 - 205,583,001 (+)NCBI
Rnor_6.01224,869,794 - 224,885,101 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_542951   ⟸   NM_080773
- UniProtKB: P08482 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231036   ⟸   XM_006230974
- Peptide Label: isoform X1
- UniProtKB: P08482 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008758437   ⟸   XM_008760215
- Peptide Label: isoform X1
- UniProtKB: P08482 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024785   ⟸   ENSRNOT00000024785

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08482-F1-model_v2 AlphaFold P08482 1-460 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2342 AgrOrtholog
BioCyc Gene G2FUF-56523 BioCyc
Ensembl Genes ENSRNOG00000018385 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000024785 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024785 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Musac_Ach_M1_rcpt UniProtKB/Swiss-Prot
  Musac_Ach_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25229 UniProtKB/Swiss-Prot
NCBI Gene 25229 ENTREZGENE
PANTHER PTHR24248:SF155 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB CHRM1 RGD
PhenoGen Chrm1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  MUSCARINICR UniProtKB/Swiss-Prot
  MUSCRINICM1R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt ACM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Chrm1  cholinergic receptor, muscarinic 1    Cholinergic receptor, muscarin 1  Name updated 625702 APPROVED
2002-06-10 Chrm1  Cholinergic receptor, muscarin 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease spontaneously hypertensive rat (SHR) demonstrates increased expression in most brain stem areas so may be critical for blood pressure regulation 625683
gene_expression expressed in brain 625683
gene_mutations_overexpression no differences found in coding sequence between spontaneously hypertensive SHR and WKY strains 1358988
gene_pathway mediates the regulation of suprachiasmatic circadian clock via guanylyl cyclase, cGMP-dependent protein kinase pathway 734537
gene_process plays a role in stress-adaptive cardiovascular reflexes 625683
gene_process regulates the circadian clock in the hypothalamic suprachiasmatic nucleus by mediating hte cholinergic signals 734538
gene_transcript contains 1 single exon 625683