RGD Reference Report - Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. - Rat Genome Database

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Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice.

Authors: Anagnostaras, SG  Murphy, GG  Hamilton, SE  Mitchell, SL  Rahnama, NP  Nathanson, NM  Silva, AJ 
Citation: Anagnostaras SG, etal., Nat Neurosci 2003 Jan;6(1):51-8.
RGD ID: 734777
Pubmed: PMID:12483218   (View Abstract at PubMed)
DOI: DOI:10.1038/nn992   (Journal Full-text)

Blockade of cholinergic neurotransmission by muscarinic receptor antagonists produces profound deficits in attention and memory. However, the antagonists used in previous studies bind to more than one of the five muscarinic receptor subtypes. Here we examined memory in mice with a null mutation of the gene coding the M1 receptor, the most densely distributed muscarinic receptor in the hippocampus and forebrain. In contrast with previous studies using nonselective pharmacological antagonists, the M1 receptor deletion produced a selective phenotype that included both enhancements and deficits in memory. Long-term potentiation (LTP) in response to theta burst stimulation in the hippocampus was also reduced in mutant mice. M1 null mutant mice showed normal or enhanced memory for tasks that involved matching-to-sample problems, but they were severely impaired in non-matching-to-sample working memory as well as consolidation. Our results suggest that the M1 receptor is specifically involved in memory processes for which the cortex and hippocampus interact.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Memory Disorders  ISOChrm1 (Mus musculus)734777; 734777 RGD 
Memory Disorders  IMP 734777 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Chrm1  (cholinergic receptor, muscarinic 1)

Genes (Mus musculus)
Chrm1  (cholinergic receptor, muscarinic 1, CNS)

Genes (Homo sapiens)
CHRM1  (cholinergic receptor muscarinic 1)


Additional Information