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Gene: Chrm1 (cholinergic receptor, muscarinic 1, CNS) Mus musculus
Symbol: Chrm1
Name: cholinergic receptor, muscarinic 1, CNS
Description: Exhibits neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Involved in regulation of locomotion. Localizes to Schaffer collateral - CA1 synapse; cholinergic synapse; and integral component of postsynaptic membrane. Is expressed in central nervous system; retina; and urinary system. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH (+)-pilocarpine; 1,2-dichloroethane; 1D-myo-inositol 1,4,5-trisphosphate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AChR M1; Chrm-1; M1; m1 muscarinic acetylcholine receptor protein; M1R; muscarinic acetylcholine receptor 1; muscarinic acetylcholine receptor M1
Homo sapiens (human) : CHRM1 (cholinergic receptor muscarinic 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chrm1 (cholinergic receptor, muscarinic 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrm1 (cholinergic receptor muscarinic 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRM1 (cholinergic receptor muscarinic 1)
Canis lupus familiaris (dog) : CHRM1 (cholinergic receptor muscarinic 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrm1 (cholinergic receptor muscarinic 1)
Sus scrofa (pig) : CHRM1 (cholinergic receptor muscarinic 1)
Chlorocebus sabaeus (African green monkey) : CHRM1 (cholinergic receptor muscarinic 1)
Heterocephalus glaber (naked mole-rat) : Chrm1 (cholinergic receptor muscarinic 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl198,663,789 - 8,683,587 (+)EnsemblGRCm38mm10GRCm38
GRCm38198,664,005 - 8,683,606 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37198,738,495 - 8,758,096 (+)NCBIGRCm37mm9NCBIm37
MGSCv36198,723,372 - 8,748,612 (+)NCBImm8
Celera198,422,264 - 8,441,868 (+)NCBICelera
Cytogenetic Map19ANCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Chrm1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731069
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.