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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2342
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrm1
Name: cholinergic receptor, muscarinic 1
Acc ID: CHEBI:8247
Term: pirenzepine
Definition: A pyridobenzodiazepine that has formula C19H21N5O2.
Chemical ID: MESH:D010890
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm1multiple interactionsEXP 6480464CTDPirenzepine binds to and results in decreased activity of CHRM1 protein

PMID:12646291, PMID:8032910
Chrm1affects bindingISORGD:7310686480464CTDPirenzepine analog binds to CHRM1 protein

PMID:15294002
Chrm1multiple interactionsISORGD:7310686480464CTDbrucine affects the reaction [Pirenzepine analog binds to CHRM1 protein], Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein], Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]

PMID:11306684, PMID:15294002, PMID:9846649
Chrm1multiple interactionsISORGD:7310696480464CTDPirenzepine binds to and results in decreased activity of CHRM1 protein, Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]

PMID:18316702
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.