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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2342
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrm1
Name: cholinergic receptor, muscarinic 1
Acc ID: CHEBI:3084
Term: bethanechol
Definition: The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Chemical ID: MESH:D018723
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm1affects bindingISORGD:7310686480464CTDCHRM1 protein binds to Bethanechol

PMID:9224827
Chrm1multiple interactionsISORGD:7310686480464CTDbrucine promotes the reaction [Bethanechol binds to CHRM1 protein]

PMID:9224827
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