Anxa10 (annexin A10) - Rat Genome Database

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Gene: Anxa10 (annexin A10) Rattus norvegicus
Analyze
Symbol: Anxa10
Name: annexin A10
RGD ID: 1560956
Description: Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Orthologous to human ANXA10 (annexin A10); INTERACTS WITH alpha-Zearalanol; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC498622; palladin-like; RGD1560956; similar to annexin A10 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81632,505,025 - 32,571,961 (+)NCBIGRCr8
mRatBN7.21627,738,712 - 27,805,648 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1627,738,712 - 27,805,648 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1631,089,092 - 31,156,028 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01634,523,342 - 34,590,272 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01630,491,937 - 30,558,766 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01629,674,699 - 29,741,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1629,674,793 - 29,741,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01630,974,485 - 30,984,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01629,552,396 - 29,604,476 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41630,713,142 - 30,782,020 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1627,776,001 - 27,843,058 (+)NCBICelera
Cytogenetic Map16p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm. Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.
Additional References at PubMed
PMID:14651853   PMID:28866949   PMID:31208343  


Genomics

Comparative Map Data
Anxa10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81632,505,025 - 32,571,961 (+)NCBIGRCr8
mRatBN7.21627,738,712 - 27,805,648 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1627,738,712 - 27,805,648 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1631,089,092 - 31,156,028 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01634,523,342 - 34,590,272 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01630,491,937 - 30,558,766 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01629,674,699 - 29,741,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1629,674,793 - 29,741,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01630,974,485 - 30,984,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01629,552,396 - 29,604,476 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41630,713,142 - 30,782,020 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1627,776,001 - 27,843,058 (+)NCBICelera
Cytogenetic Map16p12NCBI
ANXA10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384168,092,537 - 168,187,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4168,092,537 - 168,187,736 (+)EnsemblGRCh38hg38GRCh38
GRCh374169,013,688 - 169,108,887 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364169,250,282 - 169,345,468 (+)NCBINCBI36Build 36hg18NCBI36
Build 344169,388,436 - 169,483,623NCBI
Celera4166,343,539 - 166,438,757 (+)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4164,764,944 - 164,862,224 (+)NCBIHuRef
CHM1_14168,990,306 - 169,085,519 (+)NCBICHM1_1
T2T-CHM13v2.04171,451,471 - 171,546,783 (+)NCBIT2T-CHM13v2.0
Anxa10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39862,510,076 - 62,576,227 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl862,510,076 - 62,576,184 (-)EnsemblGRCm39 Ensembl
GRCm38862,057,042 - 62,123,193 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl862,057,042 - 62,123,150 (-)EnsemblGRCm38mm10GRCm38
MGSCv37864,536,318 - 64,601,915 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36864,949,657 - 65,015,235 (-)NCBIMGSCv36mm8
Celera864,630,009 - 64,695,499 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map831.55NCBI
Anxa10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540337,780,044 - 37,845,808 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540337,780,428 - 37,821,212 (-)NCBIChiLan1.0ChiLan1.0
ANXA10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23165,837,603 - 165,952,238 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14166,194,030 - 166,307,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04160,297,246 - 160,394,825 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14172,375,910 - 172,472,033 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4172,412,718 - 172,472,033 (+)Ensemblpanpan1.1panPan2
ANXA10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11563,540,180 - 63,635,643 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1563,540,054 - 63,635,656 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1563,728,947 - 63,827,409 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01564,402,632 - 64,501,373 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1564,402,471 - 64,501,386 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11563,622,596 - 63,724,124 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01563,624,401 - 63,720,132 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01564,009,199 - 64,108,128 (+)NCBIUU_Cfam_GSD_1.0
Anxa10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494320,149,972 - 20,229,721 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936516564,432 - 643,586 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936516584,631 - 644,023 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1421,248,531 - 21,315,190 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11421,249,020 - 21,315,260 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21422,576,754 - 22,642,697 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17114,287,291 - 114,449,532 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7114,388,038 - 114,449,277 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603794,238,836 - 94,335,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anxa10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249321,268,330 - 1,333,965 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249321,268,193 - 1,335,246 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Anxa10
306 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:59
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000059724
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 43 8 11 2 7 5 4 8
Below cutoff 1 48 38 10 38 28 22 32 5

Sequence


RefSeq Acc Id: ENSRNOT00000059724   ⟹   ENSRNOP00000056478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1627,738,712 - 27,805,648 (+)Ensembl
Rnor_6.0 Ensembl1629,674,793 - 29,741,465 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098486   ⟹   ENSRNOP00000091259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1627,738,712 - 27,805,648 (+)Ensembl
RefSeq Acc Id: NM_001109110   ⟹   NP_001102580
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,505,025 - 32,571,961 (+)NCBI
mRatBN7.21627,738,712 - 27,805,648 (+)NCBI
Rnor_6.01629,674,699 - 29,741,521 (+)NCBI
Rnor_5.01630,974,485 - 30,984,960 (-)NCBI
RGSC_v3.41630,713,142 - 30,782,020 (+)RGD
Celera1627,776,001 - 27,843,058 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102580 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75993 (Get FASTA)   NCBI Sequence Viewer  
  EDL75994 (Get FASTA)   NCBI Sequence Viewer  
  EDL75995 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056478
  ENSRNOP00000056478.4
  ENSRNOP00000091259.1
RefSeq Acc Id: NP_001102580   ⟸   NM_001109110
- UniProtKB: D3ZXN8 (UniProtKB/TrEMBL),   A6KFQ2 (UniProtKB/TrEMBL),   A0A8I6AF94 (UniProtKB/TrEMBL),   A6KFQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056478   ⟸   ENSRNOT00000059724
RefSeq Acc Id: ENSRNOP00000091259   ⟸   ENSRNOT00000098486

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXN8-F1-model_v2 AlphaFold D3ZXN8 1-324 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700079
Promoter ID:EPDNEW_R10592
Type:single initiation site
Name:Anxa10_1
Description:annexin A10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01629,674,701 - 29,674,761EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560956 AgrOrtholog
BioCyc Gene G2FUF-11602 BioCyc
Ensembl Genes ENSRNOG00000014339 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059724 ENTREZGENE
  ENSRNOT00000059724.5 UniProtKB/TrEMBL
  ENSRNOT00000098486.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.10 UniProtKB/TrEMBL
InterPro Annexin UniProtKB/TrEMBL
  Annexin_repeat UniProtKB/TrEMBL
  Annexin_repeat_CS UniProtKB/TrEMBL
  Annexin_sf UniProtKB/TrEMBL
  AnnexinX UniProtKB/TrEMBL
KEGG Report rno:498622 UniProtKB/TrEMBL
NCBI Gene 498622 ENTREZGENE
PANTHER ANNEXIN UniProtKB/TrEMBL
  ANNEXIN A10 UniProtKB/TrEMBL
Pfam Annexin UniProtKB/TrEMBL
PhenoGen Anxa10 PhenoGen
PRINTS ANNEXIN UniProtKB/TrEMBL
  ANNEXINX UniProtKB/TrEMBL
PROSITE ANNEXIN UniProtKB/TrEMBL
  ANNEXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014339 RatGTEx
SMART ANX UniProtKB/TrEMBL
Superfamily-SCOP SSF47874 UniProtKB/TrEMBL
UniProt A0A8I6AF94 ENTREZGENE, UniProtKB/TrEMBL
  A6KFQ1 ENTREZGENE, UniProtKB/TrEMBL
  A6KFQ2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXN8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Anxa10  annexin A10  RGD1560956_predicted  similar to annexin A10 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560956_predicted  similar to annexin A10 protein (predicted)  LOC498622  similar to annexin A10 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498622  similar to annexin A10 protein      Symbol and Name status set to provisional 70820 PROVISIONAL