Adk (adenosine kinase) - Rat Genome Database
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Gene: Adk (adenosine kinase) Rattus norvegicus
Analyze
Symbol: Adk
Name: adenosine kinase
RGD ID: 2046
Description: Exhibits adenosine kinase activity. Involved in several processes, including adenosine metabolic process; circadian regulation of gene expression; and type B pancreatic cell proliferation. Localizes to cytoplasm and nucleus. Used to study brain infarction. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4'-hydroxyacetophenone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Adenosin kinase; adenosine 5'-phosphotransferase; AK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2152,863,241 - 3,246,453 (-)NCBI
Rnor_6.0 Ensembl153,033,495 - 3,435,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0153,033,535 - 3,435,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0153,011,935 - 3,414,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,071,412 - 3,458,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1153,071,412 - 3,458,891 (-)NCBI
Celera151,344,739 - 1,727,570 (+)NCBICelera
RH 3.4 Map1549.2RGD
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-phenylprop-2-enal  (ISO)
4'-hydroxyacetophenone  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
glafenine  (EXP)
irinotecan  (EXP)
kainic acid  (ISO)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
menadione  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorododecanoic acid  (EXP)
phenobarbital  (ISO)
Propiverine  (EXP)
protein kinase inhibitor  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
ritodrine  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
tauroursodeoxycholic acid  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
1. Annes JP, etal., Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3915-20. Epub 2012 Feb 15.
2. Aronica E, etal., Epilepsia. 2011 Sep;52(9):1645-55. doi: 10.1111/j.1528-1167.2011.03115.x. Epub 2011 Jun 2.
3. Bauer C, etal., Am J Physiol. 1997 Dec;273(6 Pt 1):G1297-303.
4. Boison D, etal., Proc Natl Acad Sci U S A 2002 May 14;99(10):6985-90. Epub 2002 May 7.
5. Boyle DL, etal., J Pharmacol Exp Ther. 2001 Feb;296(2):495-500.
6. Fassett JT, etal., Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1722-32. Epub 2011 Feb 18.
7. Firestein GS, etal., J Immunol. 1994 Jun 15;152(12):5853-9.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. KEGG
11. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Li T, etal., Glia. 2012 Jan;60(1):83-95. doi: 10.1002/glia.21250. Epub 2011 Sep 30.
13. Lynch JJ 3rd, etal., Eur J Pharmacol. 1999 Jan 8;364(2-3):141-6.
14. Mackiewicz M, etal., J Neurochem. 2003 Apr;85(2):348-57.
15. MGD data from the GO Consortium
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline
18. Pawelczyk T, etal., Exp Cell Res. 2003 May 15;286(1):152-63.
19. Peart JN and Gross GJ, Basic Res Cardiol 2005 Apr 1;.
20. Pignataro G, etal., J Cereb Blood Flow Metab. 2007 Jan;27(1):1-5. Epub 2006 May 10.
21. Pignataro G, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):17-23. Epub 2007 Apr 25.
22. Pipeline to import KEGG annotations from KEGG into RGD
23. Pipeline to import SMPDB annotations from SMPDB into RGD
24. RGD automated data pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Sakowicz M, etal., Acta Biochim Pol 2001;48(3):745-54.
28. Sakowicz-Burkiewicz M, etal., Immunology. 2006 Jul;118(3):402-12.
29. Shen HY, etal., J Cereb Blood Flow Metab. 2011 Jul;31(7):1648-59. doi: 10.1038/jcbfm.2011.30. Epub 2011 Mar 23.
30. Siegmund B, etal., J Pharmacol Exp Ther. 2001 Jan;296(1):99-105.
31. Singer P, etal., Neuroscience. 2012 Apr 18.
32. Singh B, etal., Eur J Biochem 1996 Oct 15;241(2):564-71.
33. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
34. Tatlisumak T, etal., Stroke. 1998 Sep;29(9):1952-8.
35. Zhu CZ, etal., Brain Res. 2001 Jun 29;905(1-2):104-10.
Additional References at PubMed
PMID:227870   PMID:2999129   PMID:6407470   PMID:7323947   PMID:7918681   PMID:9070863   PMID:12163459   PMID:14736855   PMID:15489334   PMID:17065073   PMID:18600555   PMID:20648650  
PMID:22658674   PMID:26983602  


Genomics

Comparative Map Data
Adk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2152,863,241 - 3,246,453 (-)NCBI
Rnor_6.0 Ensembl153,033,495 - 3,435,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0153,033,535 - 3,435,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0153,011,935 - 3,414,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,071,412 - 3,458,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1153,071,412 - 3,458,891 (-)NCBI
Celera151,344,739 - 1,727,570 (+)NCBICelera
RH 3.4 Map1549.2RGD
Cytogenetic Map15p16NCBI
ADK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1074,151,202 - 74,709,963 (+)EnsemblGRCh38hg38GRCh38
GRCh381074,151,185 - 74,709,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371075,910,979 - 76,469,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,580,971 - 76,139,066 (+)NCBINCBI36hg18NCBI36
Build 341075,606,449 - 76,139,066NCBI
Celera1069,196,280 - 69,755,359 (+)NCBI
Cytogenetic Map10q22.2NCBI
HuRef1069,906,246 - 70,465,523 (+)NCBIHuRef
CHM1_11076,192,927 - 76,750,970 (+)NCBICHM1_1
Adk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391421,102,622 - 21,498,637 (+)NCBIGRCm39mm39
GRCm39 Ensembl1421,102,642 - 21,498,637 (+)Ensembl
GRCm381421,052,574 - 21,448,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1421,052,574 - 21,448,569 (+)EnsemblGRCm38mm10GRCm38
MGSCv371421,871,855 - 22,267,769 (+)NCBIGRCm37mm9NCBIm37
MGSCv361419,841,183 - 20,237,099 (+)NCBImm8
Celera1417,431,873 - 17,830,302 (+)NCBICelera
Cytogenetic Map14A3NCBI
Adk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543717,279,240 - 17,786,079 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543717,279,541 - 17,786,140 (-)NCBIChiLan1.0ChiLan1.0
ADK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11073,342,806 - 73,903,071 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1073,342,900 - 73,902,490 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01070,672,967 - 71,236,950 (+)NCBIMhudiblu_PPA_v0panPan3
ADK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl424,540,659 - 25,046,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1424,540,626 - 25,047,032 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365214,560,078 - 5,023,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,836,095 - 77,322,416 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,836,072 - 77,320,586 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,962,349 - 83,442,121 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADK
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1956,659,284 - 57,222,279 (-)NCBI
ChlSab1.1 Ensembl956,660,129 - 57,222,147 (-)Ensembl
Adk
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247547,612,817 - 8,156,038 (+)NCBI

Position Markers
RH94859  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0153,034,152 - 3,034,274NCBIRnor6.0
Rnor_5.0153,012,552 - 3,012,674UniSTSRnor5.0
RGSC_v3.4153,072,029 - 3,072,151UniSTSRGSC3.4
Celera151,726,831 - 1,726,953UniSTS
RH 3.4 Map1549.2UniSTS
Cytogenetic Map15p16UniSTS
Adk  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0153,034,026 - 3,034,164NCBIRnor6.0
Rnor_5.0153,012,426 - 3,012,564UniSTSRnor5.0
RGSC_v3.4153,071,903 - 3,072,041UniSTSRGSC3.4
Celera151,726,941 - 1,727,079UniSTS
Cytogenetic Map15p16UniSTS
BE111570  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0153,341,234 - 3,341,434NCBIRnor6.0
Rnor_5.0153,318,733 - 3,318,933UniSTSRnor5.0
RGSC_v3.4153,375,711 - 3,375,911UniSTSRGSC3.4
Celera151,427,667 - 1,427,867UniSTS
RH 3.4 Map1555.7UniSTS
Cytogenetic Map15p16UniSTS
AW533987  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0153,033,586 - 3,033,774NCBIRnor6.0
Rnor_5.0153,011,986 - 3,012,174UniSTSRnor5.0
RGSC_v3.4153,071,463 - 3,071,651UniSTSRGSC3.4
Celera151,727,331 - 1,727,519UniSTS
RH 3.4 Map1552.5UniSTS
Cytogenetic Map15p16UniSTS
AU046642  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0153,391,937 - 3,393,440NCBIRnor6.0
Rnor_6.0X49,301,432 - 49,301,593NCBIRnor6.0
Rnor_5.0153,370,592 - 3,372,095UniSTSRnor5.0
Rnor_5.0X49,497,636 - 49,497,797UniSTSRnor5.0
RGSC_v3.4X105,447,510 - 105,447,671UniSTSRGSC3.4
RGSC_v3.4153,415,580 - 3,417,083UniSTSRGSC3.4
Celera151,386,531 - 1,388,034UniSTS
CeleraX83,071,973 - 83,072,134UniSTS
Cytogenetic Map15p16UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15112800829Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15130597196Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15110589015828368Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15232787726288802Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15232787726288802Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:69
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000016709
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016709   ⟹   ENSRNOP00000016709
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl153,033,536 - 3,435,888 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080274   ⟹   ENSRNOP00000073983
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl153,033,495 - 3,410,423 (-)Ensembl
RefSeq Acc Id: NM_012895   ⟹   NP_037027
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2152,863,241 - 3,246,453 (-)NCBI
Rnor_6.0153,033,535 - 3,435,888 (-)NCBI
Rnor_5.0153,011,935 - 3,414,198 (-)NCBI
RGSC_v3.4153,071,412 - 3,458,891 (-)RGD
Celera151,344,739 - 1,727,570 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251631   ⟹   XP_006251693
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2152,863,241 - 3,221,571 (-)NCBI
Rnor_6.0153,033,535 - 3,410,397 (-)NCBI
Rnor_5.0153,011,935 - 3,414,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093007   ⟹   XP_038948935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2152,863,241 - 3,147,930 (-)NCBI
RefSeq Acc Id: XM_039093008   ⟹   XP_038948936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2152,863,241 - 3,155,059 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037027   ⟸   NM_012895
- UniProtKB: Q64640 (UniProtKB/Swiss-Prot),   A0A0G2JSL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251693   ⟸   XM_006251631
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6X9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073983   ⟸   ENSRNOT00000080274
RefSeq Acc Id: ENSRNOP00000016709   ⟸   ENSRNOT00000016709
RefSeq Acc Id: XP_038948936   ⟸   XM_039093008
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948935   ⟸   XM_039093007
- Peptide Label: isoform X2
Protein Domains
PfkB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699550
Promoter ID:EPDNEW_R10074
Type:initiation region
Name:Adk_2
Description:adenosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10075  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0153,410,340 - 3,410,400EPDNEW
RGD ID:13699551
Promoter ID:EPDNEW_R10075
Type:multiple initiation site
Name:Adk_1
Description:adenosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10074  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0153,435,898 - 3,435,958EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2046 AgrOrtholog
Ensembl Genes ENSRNOG00000012325 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016709 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000073983 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016709 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000080274 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.1190.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193044 IMAGE-MGC_LOAD
InterPro Adenokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboh/pur_kinase_PfkB_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PfkB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribokinase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25368 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93119 IMAGE-MGC_LOAD
NCBI Gene 25368 ENTREZGENE
Pfam PfkB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adk PhenoGen
PRINTS ADENOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PFKB_KINASES_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K6X9 ENTREZGENE, UniProtKB/TrEMBL
  ADK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O09162 UniProtKB/Swiss-Prot
  Q642G1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Adk  adenosine kinase    Adenosin kinase  Name updated 629478 APPROVED
2002-06-10 Adk  Adenosin kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytosol 631804
gene_drugs In an open chest infraction, 5-iodotubercidin, an Adk inhibitor,protects against regional myocardial ischemia; BNTX a delta-1-opioid receptor antagonist, blocked the infarct-limiting effect of iodotubercidin 1357420
gene_expression mRNA, protein and activity detected in kidney, liver, spleen, brain, and lung 631804
gene_expression mRNA detected in heart and muscle 631804
gene_expression enzyme activity detected in heart and skeletal muscle 631804
gene_function phosphorylates purine nucleosides 631740
gene_process plays a role in purine metabolism 631740
gene_protein multiple protein sizes detected including 38kDa, 40.5kDa 48kDa 631804
gene_regulation activity is not affected by phosphate ions 631804