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Gene: Adk (adenosine kinase) Rattus norvegicus
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Symbol: Adk
Name: adenosine kinase
Description: Exhibits adenosine kinase activity. Involved in several processes, including adenosine metabolic process; circadian regulation of gene expression; and type B pancreatic cell proliferation. Localizes to the cytoplasm and nucleus. Used to study brain infarction. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Adenosin kinase; adenosine 5'-phosphotransferase; AK
Orthologs:
Homo sapiens (human) : ADK (adenosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Adk (adenosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adk (adenosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : ADK (adenosine kinase)
Canis lupus familiaris (dog) : ADK (adenosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adk (adenosine kinase)
Sus scrofa (pig) : ADK (adenosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0153,033,535 - 3,435,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0153,011,935 - 3,414,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,071,412 - 3,458,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1153,071,412 - 3,458,891 (-)NCBI
Celera151,344,739 - 1,727,570 (+)NCBICelera
Cytogenetic Map15p16NCBI
RH 3.4 Map1549.2RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Adk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2046
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.