Adk (adenosine kinase) - Rat Genome Database

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Gene: Adk (adenosine kinase) Rattus norvegicus
Analyze
Symbol: Adk
Name: adenosine kinase
RGD ID: 2046
Description: Enables adenosine kinase activity. Involved in several processes, including adenosine metabolic process; circadian regulation of gene expression; and type B pancreatic cell proliferation. Located in cytoplasm and nucleus. Used to study brain infarction. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4'-hydroxyacetophenone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Adenosin kinase; adenosine 5'-phosphotransferase; AK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2152,863,241 - 3,246,453 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,863,244 - 3,246,510 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,875,460 - 3,256,674 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0154,261,930 - 4,643,162 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0152,874,259 - 3,255,479 (-)NCBIRnor_WKY
Rnor_6.0153,033,535 - 3,435,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,033,495 - 3,435,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0153,011,935 - 3,414,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,071,412 - 3,458,891 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1153,071,412 - 3,458,891 (-)NCBI
Celera151,344,739 - 1,727,570 (+)NCBICelera
RH 3.4 Map1549.2RGD
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-phenylprop-2-enal  (ISO)
4'-hydroxyacetophenone  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
irinotecan  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
menadione  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorododecanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
Propiverine  (EXP)
protein kinase inhibitor  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
T-2 toxin  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication. Annes JP, etal., Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3915-20. Epub 2012 Feb 15.
2. Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. Aronica E, etal., Epilepsia. 2011 Sep;52(9):1645-55. doi: 10.1111/j.1528-1167.2011.03115.x. Epub 2011 Jun 2.
3. Adenosine kinase inhibitor GP515 attenuates hepatic leukocyte adhesion after hemorrhagic hypotension. Bauer C, etal., Am J Physiol. 1997 Dec;273(6 Pt 1):G1297-303.
4. Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Boison D, etal., Proc Natl Acad Sci U S A 2002 May 14;99(10):6985-90. Epub 2002 May 7.
5. Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis. Boyle DL, etal., J Pharmacol Exp Ther. 2001 Feb;296(2):495-500.
6. Adenosine kinase regulation of cardiomyocyte hypertrophy. Fassett JT, etal., Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1722-32. Epub 2011 Feb 18.
7. Protective effect of an adenosine kinase inhibitor in septic shock. Firestein GS, etal., J Immunol. 1994 Jun 15;152(12):5853-9.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis? Li T, etal., Glia. 2012 Jan;60(1):83-95. doi: 10.1002/glia.21250. Epub 2011 Sep 30.
13. An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain. Lynch JJ 3rd, etal., Eur J Pharmacol. 1999 Jan 8;364(2-3):141-6.
14. Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. Mackiewicz M, etal., J Neurochem. 2003 Apr;85(2):348-57.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Insulin induces expression of adenosine kinase gene in rat lymphocytes by signaling through the mitogen-activated protein kinase pathway. Pawelczyk T, etal., Exp Cell Res. 2003 May 15;286(1):152-63.
19. Cardioprotection following adenosine kinase inhibition in rat hearts. Peart JN and Gross GJ, Basic Res Cardiol 2005 Apr 1;.
20. Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. Pignataro G, etal., J Cereb Blood Flow Metab. 2007 Jan;27(1):1-5. Epub 2006 May 10.
21. Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism. Pignataro G, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):17-23. Epub 2007 Apr 25.
22. Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult. Pimentel VC, etal., Mol Cell Biochem. 2015 May;403(1-2):169-77. doi: 10.1007/s11010-015-2347-9. Epub 2015 Feb 27.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Expression level of adenosine kinase in rat tissues. Lack of phosphate effect on the enzyme activity. Sakowicz M, etal., Acta Biochim Pol 2001;48(3):745-54.
29. Diabetes-induced decrease of adenosine kinase expression impairs the proliferation potential of diabetic rat T lymphocytes. Sakowicz-Burkiewicz M, etal., Immunology. 2006 Jul;118(3):402-12.
30. Adenosine kinase determines the degree of brain injury after ischemic stroke in mice. Shen HY, etal., J Cereb Blood Flow Metab. 2011 Jul;31(7):1648-59. doi: 10.1038/jcbfm.2011.30. Epub 2011 Mar 23.
31. Adenosine kinase inhibitor GP515 improves experimental colitis in mice. Siegmund B, etal., J Pharmacol Exp Ther. 2001 Jan;296(1):99-105.
32. Working memory and the homeostatic control of brain adenosine by adenosine kinase. Singer P, etal., Neuroscience. 2012 Apr 18.
33. Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene. Singh B, etal., Eur J Biochem 1996 Oct 15;241(2):564-71.
34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35. Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion. Tatlisumak T, etal., Stroke. 1998 Sep;29(9):1952-8.
36. A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats. Zhu CZ, etal., Brain Res. 2001 Jun 29;905(1-2):104-10.
Additional References at PubMed
PMID:227870   PMID:2999129   PMID:6407470   PMID:7323947   PMID:7918681   PMID:9070863   PMID:12163459   PMID:14736855   PMID:15489334   PMID:17065073   PMID:18600555   PMID:20648650  
PMID:22658674   PMID:26983602  


Genomics

Comparative Map Data
Adk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2152,863,241 - 3,246,453 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,863,244 - 3,246,510 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,875,460 - 3,256,674 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0154,261,930 - 4,643,162 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0152,874,259 - 3,255,479 (-)NCBIRnor_WKY
Rnor_6.0153,033,535 - 3,435,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,033,495 - 3,435,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0153,011,935 - 3,414,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,071,412 - 3,458,891 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1153,071,412 - 3,458,891 (-)NCBI
Celera151,344,739 - 1,727,570 (+)NCBICelera
RH 3.4 Map1549.2RGD
Cytogenetic Map15p16NCBI
ADK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381074,151,221 - 74,709,290 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1074,151,202 - 74,709,963 (+)EnsemblGRCh38hg38GRCh38
GRCh371075,910,979 - 76,469,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,580,971 - 76,139,066 (+)NCBINCBI36Build 36hg18NCBI36
Build 341075,606,449 - 76,139,066NCBI
Celera1069,196,280 - 69,755,359 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1069,906,246 - 70,465,523 (+)NCBIHuRef
CHM1_11076,192,927 - 76,750,970 (+)NCBICHM1_1
T2T-CHM13v2.01075,022,606 - 75,580,765 (+)NCBIT2T-CHM13v2.0
Adk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391421,102,622 - 21,498,637 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1421,102,642 - 21,498,637 (+)EnsemblGRCm39 Ensembl
GRCm381421,052,574 - 21,448,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1421,052,574 - 21,448,569 (+)EnsemblGRCm38mm10GRCm38
MGSCv371421,871,855 - 22,267,769 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,841,183 - 20,237,099 (+)NCBIMGSCv36mm8
Celera1417,431,873 - 17,830,302 (+)NCBICelera
Cytogenetic Map14A3NCBI
Adk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543717,279,240 - 17,786,079 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543717,279,541 - 17,786,140 (-)NCBIChiLan1.0ChiLan1.0
ADK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11073,342,806 - 73,903,071 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1073,342,900 - 73,902,490 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01070,672,967 - 71,236,950 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1424,540,626 - 25,047,032 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl424,540,659 - 25,046,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha424,676,998 - 25,182,573 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0424,822,917 - 25,329,840 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl424,822,951 - 25,330,373 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1424,739,155 - 25,224,845 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0424,918,225 - 25,425,716 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0425,272,740 - 25,780,743 (+)NCBIUU_Cfam_GSD_1.0
Adk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721356,067,293 - 56,531,032 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365214,557,971 - 5,023,800 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365214,560,078 - 5,023,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,836,095 - 77,322,416 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,836,072 - 77,320,586 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,962,349 - 83,442,121 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1956,659,284 - 57,222,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl956,660,129 - 57,222,147 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604817,181,604 - 17,794,628 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247547,612,881 - 8,156,681 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247547,612,817 - 8,156,038 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adk
1983 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:69
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000016709
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat

Markers in Region
RH94859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,863,857 - 2,863,980 (+)MAPPERmRatBN7.2
Rnor_6.0153,034,152 - 3,034,274NCBIRnor6.0
Rnor_5.0153,012,552 - 3,012,674UniSTSRnor5.0
RGSC_v3.4153,072,029 - 3,072,151UniSTSRGSC3.4
Celera151,726,831 - 1,726,953UniSTS
RH 3.4 Map1549.2UniSTS
Cytogenetic Map15p16UniSTS
Adk  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,863,731 - 2,863,870 (+)MAPPERmRatBN7.2
Rnor_6.0153,034,026 - 3,034,164NCBIRnor6.0
Rnor_5.0153,012,426 - 3,012,564UniSTSRnor5.0
RGSC_v3.4153,071,903 - 3,072,041UniSTSRGSC3.4
Celera151,726,941 - 1,727,079UniSTS
Cytogenetic Map15p16UniSTS
BE111570  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,163,281 - 3,163,482 (+)MAPPERmRatBN7.2
Rnor_6.0153,341,234 - 3,341,434NCBIRnor6.0
Rnor_5.0153,318,733 - 3,318,933UniSTSRnor5.0
RGSC_v3.4153,375,711 - 3,375,911UniSTSRGSC3.4
Celera151,427,667 - 1,427,867UniSTS
RH 3.4 Map1555.7UniSTS
Cytogenetic Map15p16UniSTS
AW533987  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,863,291 - 2,863,480 (+)MAPPERmRatBN7.2
Rnor_6.0153,033,586 - 3,033,774NCBIRnor6.0
Rnor_5.0153,011,986 - 3,012,174UniSTSRnor5.0
RGSC_v3.4153,071,463 - 3,071,651UniSTSRGSC3.4
Celera151,727,331 - 1,727,519UniSTS
RH 3.4 Map1552.5UniSTS
Cytogenetic Map15p16UniSTS
AU046642  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,203,110 - 3,204,614 (+)MAPPERmRatBN7.2
mRatBN7.2X81,840,542 - 81,840,704 (+)MAPPERmRatBN7.2
Rnor_6.0X49,301,432 - 49,301,593NCBIRnor6.0
Rnor_6.0153,391,937 - 3,393,440NCBIRnor6.0
Rnor_5.0153,370,592 - 3,372,095UniSTSRnor5.0
Rnor_5.0X49,497,636 - 49,497,797UniSTSRnor5.0
RGSC_v3.4153,415,580 - 3,417,083UniSTSRGSC3.4
RGSC_v3.4X105,447,510 - 105,447,671UniSTSRGSC3.4
CeleraX83,071,973 - 83,072,134UniSTS
Celera151,386,531 - 1,388,034UniSTS
Cytogenetic Map15p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016709   ⟹   ENSRNOP00000016709
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,863,244 - 3,246,510 (-)Ensembl
Rnor_6.0 Ensembl153,033,536 - 3,435,888 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080274   ⟹   ENSRNOP00000073983
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,863,244 - 3,221,610 (-)Ensembl
Rnor_6.0 Ensembl153,033,495 - 3,410,423 (-)Ensembl
RefSeq Acc Id: NM_012895   ⟹   NP_037027
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2152,863,241 - 3,246,453 (-)NCBI
Rnor_6.0153,033,535 - 3,435,888 (-)NCBI
Rnor_5.0153,011,935 - 3,414,198 (-)NCBI
RGSC_v3.4153,071,412 - 3,458,891 (-)RGD
Celera151,344,739 - 1,727,570 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251631   ⟹   XP_006251693
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2152,863,241 - 3,221,571 (-)NCBI
Rnor_6.0153,033,535 - 3,410,397 (-)NCBI
Rnor_5.0153,011,935 - 3,414,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093007   ⟹   XP_038948935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2152,863,241 - 3,147,930 (-)NCBI
RefSeq Acc Id: XM_039093008   ⟹   XP_038948936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2152,863,241 - 3,155,059 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037027   ⟸   NM_012895
- UniProtKB: Q64640 (UniProtKB/Swiss-Prot),   A0A0G2JSL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251693   ⟸   XM_006251631
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6X9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073983   ⟸   ENSRNOT00000080274
RefSeq Acc Id: ENSRNOP00000016709   ⟸   ENSRNOT00000016709
RefSeq Acc Id: XP_038948936   ⟸   XM_039093008
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948935   ⟸   XM_039093007
- Peptide Label: isoform X2
Protein Domains
PfkB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64640-F1-model_v2 AlphaFold Q64640 1-361 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699550
Promoter ID:EPDNEW_R10074
Type:initiation region
Name:Adk_2
Description:adenosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10075  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0153,410,340 - 3,410,400EPDNEW
RGD ID:13699551
Promoter ID:EPDNEW_R10075
Type:multiple initiation site
Name:Adk_1
Description:adenosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10074  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0153,435,898 - 3,435,958EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2046 AgrOrtholog
BioCyc Gene G2FUF-14578 BioCyc
BioCyc Pathway PWY-6619 [adenine and adenosine salvage VI] BioCyc
Ensembl Genes ENSRNOG00000012325 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016709 ENTREZGENE
  ENSRNOP00000016709.4 UniProtKB/TrEMBL
  ENSRNOP00000073983 ENTREZGENE
  ENSRNOP00000073983.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016709 ENTREZGENE
  ENSRNOT00000016709.5 UniProtKB/TrEMBL
  ENSRNOT00000080274 ENTREZGENE
  ENSRNOT00000080274.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1190.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193044 IMAGE-MGC_LOAD
InterPro Adenokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboh/pur_kinase_PfkB_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PfkB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribokinase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25368 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93119 IMAGE-MGC_LOAD
NCBI Gene 25368 ENTREZGENE
PANTHER PTHR45769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PfkB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adk PhenoGen
PRINTS ADENOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PFKB_KINASES_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K6X9 ENTREZGENE, UniProtKB/TrEMBL
  ADK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O09162 UniProtKB/Swiss-Prot
  Q642G1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Adk  adenosine kinase    Adenosin kinase  Name updated 629478 APPROVED
2002-06-10 Adk  Adenosin kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytosol 631804
gene_drugs In an open chest infraction, 5-iodotubercidin, an Adk inhibitor,protects against regional myocardial ischemia; BNTX a delta-1-opioid receptor antagonist, blocked the infarct-limiting effect of iodotubercidin 1357420
gene_expression mRNA, protein and activity detected in kidney, liver, spleen, brain, and lung 631804
gene_expression mRNA detected in heart and muscle 631804
gene_expression enzyme activity detected in heart and skeletal muscle 631804
gene_function phosphorylates purine nucleosides 631740
gene_process plays a role in purine metabolism 631740
gene_protein multiple protein sizes detected including 38kDa, 40.5kDa 48kDa 631804
gene_regulation activity is not affected by phosphate ions 631804