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Gene: Dusp6 (dual specificity phosphatase 6) Rattus norvegicus
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Symbol: Dusp6
Name: dual specificity phosphatase 6
Description: Exhibits protein tyrosine/serine/threonine phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; positive regulation of cell death; and response to growth factor. Localizes to the cytosol. Biomarker of brain ischemia; pancreatitis; and visual epilepsy. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dual specificity protein phosphatase 6; MAP kinase phosphatase 3; MGC93276; mitogen-activated protein kinase phosphatase 3; MKP-3; Mkp3
Orthologs:
Homo sapiens (human) : DUSP6 (dual specificity phosphatase 6)  HGNC  Alliance
Mus musculus (house mouse) : Dusp6 (dual specificity phosphatase 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dusp6 (dual specificity phosphatase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : DUSP6 (dual specificity phosphatase 6)
Canis lupus familiaris (dog) : DUSP6 (dual specificity phosphatase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dusp6 (dual specificity phosphatase 6)
Sus scrofa (pig) : DUSP6 (dual specificity phosphatase 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0741,475,163 - 41,479,393 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0741,506,397 - 41,510,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4736,893,264 - 36,897,494 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1736,913,534 - 36,917,764 (+)NCBI
Celera731,106,671 - 31,110,901 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dusp6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70978
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.