Dusp6 (dual specificity phosphatase 6) - Rat Genome Database

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Gene: Dusp6 (dual specificity phosphatase 6) Rattus norvegicus
Analyze
Symbol: Dusp6
Name: dual specificity phosphatase 6
RGD ID: 70978
Description: Enables protein tyrosine/serine/threonine phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; response to growth factor; and response to xenobiotic stimulus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of brain ischemia and pancreatitis. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity protein phosphatase 6; MAP kinase phosphatase 3; MGC93276; mitogen-activated protein kinase phosphatase 3; MKP-3; Mkp3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8735,979,502 - 35,983,834 (+)NCBIGRCr8
mRatBN7.2734,092,848 - 34,097,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl734,092,943 - 34,097,185 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx736,079,912 - 36,084,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0738,261,675 - 38,265,912 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0737,995,062 - 37,999,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0741,475,163 - 41,479,393 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl741,475,163 - 41,479,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0741,506,397 - 41,510,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4736,893,264 - 36,897,494 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1736,913,534 - 36,917,764 (+)NCBI
Celera731,106,671 - 31,110,901 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (EXP)
ADP  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
ATP  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cefaloridine  (EXP)
ceruletide  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fentin chloride  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
irinotecan  (EXP)
L-ascorbic acid  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
morphine  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-(6-acetamidohexyl)acetamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP)
sevoflurane  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trametinib  (ISO)
triadimefon  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Irinotecan changes gene expression in the small intestine of the rat with breast cancer. Bowen JM, etal., Cancer Chemother Pharmacol. 2007 Feb;59(3):337-48. Epub 2006 Jun 24.
2. Induction of the mitogen-activated protein kinase phosphatase MKP3 by nerve growth factor in differentiating PC12. Camps M, etal., FEBS Lett. 1998 Mar 27;425(2):271-6.
3. Dual-specific phosphatase-6 (Dusp6) and ERK mediate AMPA receptor-induced oligodendrocyte death. Domercq M, etal., J Biol Chem. 2011 Apr 1;286(13):11825-36. doi: 10.1074/jbc.M110.153049. Epub 2011 Feb 7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
7. Mapping gene expression changes in the fetal rat testis following acute dibutyl phthalate exposure defines a complex temporal cascade of responding cell types. Johnson KJ, etal., Biol Reprod. 2007 Dec;77(6):978-89. Epub 2007 Sep 19.
8. Electroconvulsive seizures increase the expression of MAP kinase phosphatases in limbic regions of rat brain. Kodama M, etal., Neuropsychopharmacology. 2005 Feb;30(2):360-71.
9. Regulation of MAP kinases by MAP kinase phosphatases. Kondoh K and Nishida E, Biochim Biophys Acta. 2007 Aug;1773(8):1227-37. Epub 2006 Dec 8.
10. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. Landry RP, etal., J Pain. 2012 Sep;13(9):836-48. doi: 10.1016/j.jpain.2012.05.013. Epub 2012 Aug 14.
11. Gene Data Set MGD Curation, June 12, 2002
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation. Mourey RJ, etal., J Biol Chem 1996 Feb 16;271(7):3795-802.
14. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. Muda M, etal., J Biol Chem 1996 Feb 23;271(8):4319-26.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Changes in gene expression induced by tienilic Acid and sulfamethoxazole: testing the danger hypothesis. Pacitto SR, etal., J Immunotoxicol. 2007 Oct;4(4):253-66.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain. Saha M, etal., J Neurosci. 2013 Oct 23;33(43):17182-7. doi: 10.1523/JNEUROSCI.5605-12.2013.
23. Parallel gene expression monitoring using oligonucleotide probe arrays of multiple transcripts with an animal model of focal ischemia. Soriano MA, etal., J Cereb Blood Flow Metab. 2000 Jul;20(7):1045-55.
24. CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. Srivastava N, etal., J Immunol. 2011 May 15;186(10):5863-72. doi: 10.4049/jimmunol.1003957. Epub 2011 Apr 6.
25. Two kinds of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-3, are differentially activated by acute and chronic methamphetamine treatment in the rat brain. Takaki M, etal., J Neurochem. 2001 Nov;79(3):679-88.
26. Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Wang HY, etal., Cancer Lett. 2003 Mar 10;191(2):229-37.
Additional References at PubMed
PMID:8670865   PMID:9535927   PMID:9788880   PMID:10846176   PMID:12477932   PMID:15284227   PMID:15489334   PMID:17046812   PMID:18753132   PMID:18771677   PMID:23337371   PMID:24861519  
PMID:26435497   PMID:27422819   PMID:30816666   PMID:34676875   PMID:34944046   PMID:35630630   PMID:36335128  


Genomics

Comparative Map Data
Dusp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8735,979,502 - 35,983,834 (+)NCBIGRCr8
mRatBN7.2734,092,848 - 34,097,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl734,092,943 - 34,097,185 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx736,079,912 - 36,084,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0738,261,675 - 38,265,912 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0737,995,062 - 37,999,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0741,475,163 - 41,479,393 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl741,475,163 - 41,479,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0741,506,397 - 41,510,627 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4736,893,264 - 36,897,494 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1736,913,534 - 36,917,764 (+)NCBI
Celera731,106,671 - 31,110,901 (+)NCBICelera
Cytogenetic Map7q13NCBI
DUSP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381289,347,235 - 89,352,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1289,347,235 - 89,352,501 (-)EnsemblGRCh38hg38GRCh38
GRCh371289,741,012 - 89,746,278 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361288,265,968 - 88,270,427 (-)NCBINCBI36Build 36hg18NCBI36
Build 341288,244,306 - 88,248,764NCBI
Celera1289,413,532 - 89,417,991 (-)NCBICelera
Cytogenetic Map12q21.33NCBI
HuRef1286,807,701 - 86,812,160 (-)NCBIHuRef
CHM1_11289,706,790 - 89,711,249 (-)NCBICHM1_1
T2T-CHM13v2.01289,329,179 - 89,334,445 (-)NCBIT2T-CHM13v2.0
Dusp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391099,098,676 - 99,103,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1099,099,093 - 99,103,351 (+)EnsemblGRCm39 Ensembl
GRCm381099,263,231 - 99,267,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1099,263,231 - 99,267,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv371098,725,865 - 98,730,123 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361098,692,919 - 98,697,172 (+)NCBIMGSCv36mm8
Celera10101,235,116 - 101,239,374 (+)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1051.13NCBI
Dusp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540526,662,018 - 26,666,314 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540526,662,018 - 26,666,314 (-)NCBIChiLan1.0ChiLan1.0
DUSP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21097,374,395 - 97,379,496 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11297,370,793 - 97,375,021 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01286,875,289 - 86,879,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11290,195,482 - 90,200,321 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1290,195,482 - 90,200,321 (-)Ensemblpanpan1.1panPan2
DUSP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11530,322,472 - 30,327,221 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1530,323,697 - 30,326,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1530,777,953 - 30,782,527 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01530,967,877 - 30,972,449 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1530,968,620 - 30,972,415 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11530,272,051 - 30,276,623 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01530,333,920 - 30,338,490 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01530,628,124 - 30,632,696 (-)NCBIUU_Cfam_GSD_1.0
Dusp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494529,921,860 - 29,926,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365076,308,886 - 6,313,935 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365076,309,114 - 6,314,512 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl593,302,975 - 93,307,504 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1593,303,058 - 93,307,510 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DUSP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11184,741,957 - 84,747,038 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1184,741,444 - 84,745,886 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037160,455,940 - 160,460,447 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475017,362,515 - 17,367,739 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475017,361,725 - 17,366,907 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dusp6
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:341
Count of miRNA genes:196
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000037844
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat

Markers in Region
RH133891  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2734,096,224 - 34,096,428 (+)MAPPERmRatBN7.2
Rnor_6.0741,478,432 - 41,478,635NCBIRnor6.0
Rnor_5.0741,509,666 - 41,509,869UniSTSRnor5.0
RGSC_v3.4736,896,533 - 36,896,736UniSTSRGSC3.4
Celera731,109,940 - 31,110,143UniSTS
RH 3.4 Map7279.6UniSTS
Cytogenetic Map7q13UniSTS
WI-14395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2734,094,672 - 34,095,830 (+)MAPPERmRatBN7.2
Rnor_6.0741,476,880 - 41,478,037NCBIRnor6.0
Rnor_5.0741,508,114 - 41,509,271UniSTSRnor5.0
RGSC_v3.4736,894,981 - 36,896,138UniSTSRGSC3.4
Celera731,108,388 - 31,109,545UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000037844   ⟹   ENSRNOP00000032969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl734,092,943 - 34,097,185 (+)Ensembl
Rnor_6.0 Ensembl741,475,163 - 41,479,392 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111909   ⟹   ENSRNOP00000087245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl734,093,076 - 34,097,181 (+)Ensembl
RefSeq Acc Id: NM_053883   ⟹   NP_446335
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8735,979,604 - 35,983,834 (+)NCBI
mRatBN7.2734,092,956 - 34,097,186 (+)NCBI
Rnor_6.0741,475,163 - 41,479,393 (+)NCBI
Rnor_5.0741,506,397 - 41,510,627 (+)NCBI
RGSC_v3.4736,893,264 - 36,897,494 (+)RGD
Celera731,106,671 - 31,110,901 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078252   ⟹   XP_038934180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8735,979,502 - 35,983,830 (+)NCBI
mRatBN7.2734,092,848 - 34,097,183 (+)NCBI
RefSeq Acc Id: NP_446335   ⟸   NM_053883
- UniProtKB: Q64346 (UniProtKB/Swiss-Prot),   A6IG82 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032969   ⟸   ENSRNOT00000037844
RefSeq Acc Id: XP_038934180   ⟸   XM_039078252
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QHD1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087245   ⟸   ENSRNOT00000111909
Protein Domains
Rhodanese   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64346-F1-model_v2 AlphaFold Q64346 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695174
Promoter ID:EPDNEW_R5699
Type:multiple initiation site
Name:Dusp6_1
Description:dual specificity phosphatase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0741,475,150 - 41,475,210EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70978 AgrOrtholog
BioCyc Gene G2FUF-34271 BioCyc
Ensembl Genes ENSRNOG00000023896 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037844 ENTREZGENE
  ENSRNOT00000037844.4 UniProtKB/TrEMBL
  ENSRNOT00000111909 ENTREZGENE
  ENSRNOT00000111909.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124105 IMAGE-MGC_LOAD
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MKP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116663 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93276 IMAGE-MGC_LOAD
NCBI Gene 116663 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dusp6 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MAPKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023896 RatGTEx
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QHD1 ENTREZGENE, UniProtKB/TrEMBL
  A6IG82 ENTREZGENE, UniProtKB/TrEMBL
  DUS6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Dusp6  dual specificity phosphatase 6      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to cytoplasm 70726