(+)-catechin multiple interactions ISO RGD:1346464 6480464 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AX protein] CTD PMID:21882252 (-)-ephedrine multiple interactions EXP 6480464 [Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein CTD PMID:15537744 (-)-epigallocatechin 3-gallate increases phosphorylation ISO RGD:1558155 6480464 epigallocatechin gallate results in increased phosphorylation of H2AX protein CTD PMID:25528115 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1558155 6480464 epigallocatechin gallate inhibits the reaction [epigallocatechin gallate results in increased phosphorylation of H2AX protein] CTD PMID:25528115 (-)-epigallocatechin 3-gallate increases expression ISO RGD:1558155 6480464 epigallocatechin gallate results in increased expression of H2AX protein CTD PMID:25585349 , PMID:29175576 (S)-nicotine multiple interactions ISO RGD:1346464 6480464 Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 1,10-phenanthroline multiple interactions ISO RGD:1346464 6480464 [Copper binds to phthalic acid binds to 1, 10-phenanthroline] which results in increased expression of H2AX protein modified form CTD PMID:22659117 1,2-dimethylhydrazine increases expression EXP 6480464 1, 2-Dimethylhydrazine results in increased expression of H2AX protein CTD PMID:32387197 1,2-dimethylhydrazine multiple interactions ISO RGD:1558155 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of H2AX mRNA CTD PMID:22206623 1,3-benzothiazole-2-thiol increases expression ISO RGD:1346464 6480464 captax results in increased expression of H2AX protein CTD PMID:35279910 1,3-benzothiazole-2-thiol multiple interactions ISO RGD:1346464 6480464 1-aminobenzotriazole inhibits the reaction [captax results in increased expression of H2AX protein] more ... CTD PMID:35279910 1,3-dinitrobenzene decreases expression EXP 6480464 3-dinitrobenzene results in decreased expression of H2AX mRNA CTD PMID:21983209 1,4-benzoquinone increases phosphorylation ISO RGD:1346464 6480464 quinone results in increased phosphorylation of H2AX protein CTD PMID:18835433 1,4-benzoquinone multiple interactions ISO RGD:1558155 6480464 Acetylcysteine inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form] more ... CTD PMID:33961949 1,4-benzoquinone increases expression ISO RGD:1558155 6480464 quinone analog results in increased expression of H2AX protein modified form CTD PMID:33961949 1,4-benzoquinone increases phosphorylation ISO RGD:1558155 6480464 quinone results in increased phosphorylation of H2AX protein CTD PMID:31340051 1,4-dioxane increases expression ISO RGD:1558155 6480464 1, 4-dioxane results in increased expression of H2AX protein CTD PMID:33693819 1-fluoro-2,4-dinitrobenzene increases expression ISO RGD:1346464 6480464 Dinitrofluorobenzene results in increased expression of H2AX mRNA CTD PMID:23999411 1-naphthyl isothiocyanate affects expression EXP 6480464 1-Naphthylisothiocyanate affects the expression of H2AX protein CTD PMID:26011634 17alpha-ethynylestradiol increases expression ISO RGD:1558155 6480464 Ethinyl Estradiol results in increased expression of H2AX mRNA CTD PMID:12072388 17beta-estradiol increases expression ISO RGD:1346464 6480464 Estradiol results in increased expression of H2AX mRNA more ... CTD PMID:16462019 more ... 17beta-estradiol increases expression ISO RGD:1558155 6480464 Estradiol results in increased expression of H2AX protein modified form CTD PMID:31939680 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of H2AX protein CTD PMID:23788033 17beta-estradiol multiple interactions EXP 6480464 Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein] CTD PMID:23788033 17beta-estradiol multiple interactions ISO RGD:1346464 6480464 Estradiol promotes the reaction [PCB 180 metabolite results in increased phosphorylation of H2AX protein], Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein modified form] CTD PMID:26148434 , PMID:31939680 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO RGD:1346464 6480464 [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA more ... CTD PMID:21134073 , PMID:23272087 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO RGD:1346464 6480464 Metribolone results in increased expression of H2AX protein CTD PMID:23272087 1H-pyrazole increases expression ISO RGD:1558155 6480464 pyrazole results in increased expression of H2AX mRNA CTD PMID:17945193 2,2'-bipyridine multiple interactions ISO RGD:1346464 6480464 [Copper binds to phthalic acid binds to 2, 2'-Dipyridyl] which results in increased expression of H2AX protein modified form CTD PMID:22659117 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:1558155 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1558155 6480464 Tetrachlorodibenzodioxin results in increased expression of H2AX protein CTD PMID:21846477 , PMID:33823233 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1558155 6480464 NFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of H2AX protein], Tetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in increased expression of H2AX protein] CTD PMID:21846477 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1558155 6480464 Tetrachlorodibenzodioxin affects the expression of H2AX mRNA CTD PMID:21570461 2,3-dimethoxynaphthalene-1,4-dione increases expression ISO RGD:1346464 6480464 2 more ... CTD PMID:19031421 2,4,6-trinitrotoluene affects expression EXP 6480464 Trinitrotoluene affects the expression of H2AX mRNA CTD PMID:21346803 2,4-diaminotoluene decreases expression ISO RGD:1558155 6480464 2, 4-diaminotoluene results in decreased expression of H2AX mRNA CTD PMID:20713471 2,4-diaminotoluene increases phosphorylation ISO RGD:1346464 6480464 2, 4-diaminotoluene results in increased phosphorylation of H2AX protein CTD PMID:34510228 2,4-dibromophenol multiple interactions ISO RGD:1558155 6480464 Acetylcysteine inhibits the reaction [2 more ... CTD PMID:33961949 2,4-dibromophenol increases expression ISO RGD:1558155 6480464 2, 4-dibromophenol metabolite results in increased expression of H2AX protein modified form CTD PMID:33961949 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of H2AX protein CTD PMID:26338220 2-acetamidofluorene increases phosphorylation ISO RGD:1346464 6480464 2-Acetylaminofluorene results in increased phosphorylation of H2AX protein CTD PMID:34510228 2-Amino-3-methyl-9H-pyrido[2,3-b]indole increases expression ISO RGD:1346464 6480464 2-amino-3-methyl-9H-pyrido(2, 3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 2-Amino-9H-pyrido[2,3-b]indole increases expression ISO RGD:1346464 6480464 2-amino-9H-pyrido(2, 3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 2-deoxy-D-glucose decreases expression ISO RGD:1346464 6480464 Deoxyglucose results in decreased expression of H2AX protein CTD PMID:23363784 2-methoxy-17beta-estradiol increases expression ISO RGD:1346464 6480464 2-Methoxyestradiol results in increased expression of H2AX protein modified form CTD PMID:23967052 2-nitroanisole increases expression EXP 6480464 2-nitroanisole results in increased expression of H2AX protein CTD PMID:26338220 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of H2AX mRNA CTD PMID:15890375 2-phenylethylamine multiple interactions ISO RGD:1346464 6480464 [NAT2 protein results in increased susceptibility to phenethylamine] which results in increased expression of H2AX protein CTD PMID:36138126 2-tert-butylhydroquinone multiple interactions EXP 6480464 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein] CTD PMID:28583816 2-tert-butylhydroquinone multiple interactions ISO RGD:1346464 6480464 2-tert-butylhydroquinone inhibits the reaction [hydroquinone results in increased expression of H2AX protein] CTD PMID:35123993 2-tert-butylhydroquinone increases expression ISO RGD:1346464 6480464 2-tert-butylhydroquinone results in increased expression of H2AX protein CTD PMID:35123993 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:1346464 6480464 3 more ... CTD PMID:31733235 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO RGD:1346464 6480464 2 more ... CTD PMID:31733235 3,3',4,4'-tetrachlorobiphenyl increases expression ISO RGD:1346464 6480464 3 more ... CTD PMID:31733235 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:1346464 6480464 2 more ... CTD PMID:31733235 3,3',5-triiodo-L-thyronine increases phosphorylation ISO RGD:1346464 6480464 Triiodothyronine analog results in increased phosphorylation of H2AX protein CTD PMID:22383522 3,3',5-triiodo-L-thyronine multiple interactions ISO RGD:1346464 6480464 Triiodothyronine analog promotes the reaction [Cisplatin results in increased expression of H2AX protein] CTD PMID:22383522 3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine increases expression ISO RGD:1346464 6480464 3 more ... CTD PMID:28160022 3,4-methylenedioxymethamphetamine multiple interactions ISO RGD:1346464 6480464 [NAT2 protein results in increased susceptibility to N-Methyl-3, 4-methylenedioxyamphetamine] which results in increased expression of H2AX protein CTD PMID:36138126 3-Amino-1-methyl-5H-pyrido[4,3-b]indole increases expression ISO RGD:1346464 6480464 3-amino-1-methyl-5H-pyrido(4, 3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine increases expression ISO RGD:1346464 6480464 2-amino-3-methylimidazo(4, 5-f)quinoline results in increased expression of H2AX protein modified form CTD PMID:28160022 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine increases phosphorylation ISO RGD:1346464 6480464 2-amino-3-methylimidazo(4, 5-f)quinoline results in increased phosphorylation of H2AX protein CTD PMID:34510228 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1346464 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with cylindrospermopsin] results in increased expression of H2AX protein CTD PMID:32244372 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of H2AX mRNA CTD PMID:36041667 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO RGD:1346464 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] more ... CTD PMID:21882252 more ... 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO RGD:1346464 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein modified form CTD PMID:34784199 , PMID:35435490 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX mRNA CTD PMID:15890375 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases phosphorylation ISO RGD:1346464 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein CTD PMID:26231820 4-chloroaniline increases phosphorylation ISO RGD:1346464 6480464 4-chloroaniline results in increased phosphorylation of H2AX protein CTD PMID:34510228 4-hydroxynon-2-enal multiple interactions ISO RGD:1558155 6480464 POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein] more ... CTD PMID:22331492 4-hydroxynon-2-enal increases phosphorylation ISO RGD:1558155 6480464 4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein CTD PMID:22331492 4-methoxy-TEMPO multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [4-methoxy-2 more ... CTD PMID:28993908 4-methoxy-TEMPO increases phosphorylation ISO RGD:1346464 6480464 4-methoxy-2 more ... CTD PMID:28993908 4-Nerolidylcatechol increases phosphorylation ISO RGD:1346464 6480464 4-nerolidylcatechol results in increased phosphorylation of H2AX protein CTD PMID:22372875 4-nitroquinoline N-oxide increases expression ISO RGD:1346464 6480464 4-Nitroquinoline-1-oxide results in increased expression of H2AX protein CTD PMID:32087850 4-nitroquinoline N-oxide increases phosphorylation ISO RGD:1346464 6480464 4-Nitroquinoline-1-oxide results in increased phosphorylation of H2AX protein CTD PMID:34510228 4-nonylphenol increases phosphorylation ISO RGD:1346464 6480464 4-nonylphenol results in increased phosphorylation of H2AX protein CTD PMID:32466334 4-tert-Octylphenol increases phosphorylation ISO RGD:1346464 6480464 4-tert-octylphenol results in increased phosphorylation of H2AX protein CTD PMID:32466334 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid multiple interactions ISO RGD:1346464 6480464 pyridoxal phosphate-6-azophenyl-2', 4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]] CTD PMID:32941855 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1346464 6480464 ATM protein affects the reaction [Decitabine results in increased expression of H2AX protein] more ... CTD PMID:17991895 , PMID:19732952 5-aza-2'-deoxycytidine increases phosphorylation ISO RGD:1346464 6480464 Decitabine results in increased phosphorylation of H2AX protein CTD PMID:19215824 , PMID:19732952 5-aza-2'-deoxycytidine increases expression ISO RGD:1346464 6480464 Decitabine results in increased expression of H2AX protein CTD PMID:17991895 , PMID:18223691 5-aza-2'-deoxycytidine affects localization ISO RGD:1346464 6480464 Decitabine affects the localization of H2AX protein CTD PMID:17991895 5-azacytidine increases expression ISO RGD:1346464 6480464 Azacitidine results in increased expression of H2AX protein CTD PMID:17991895 5-azacytidine multiple interactions EXP 6480464 Azacitidine inhibits the reaction [potassium bromate results in increased phosphorylation of H2AX protein] CTD PMID:25015661 5-chloro-7-iodoquinolin-8-ol increases phosphorylation ISO RGD:1346464 6480464 Clioquinol results in increased phosphorylation of H2AX protein CTD PMID:22627294 5-fluorouracil multiple interactions ISO RGD:1346464 6480464 [Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein more ... CTD PMID:15016801 more ... 5-fluorouracil increases phosphorylation ISO RGD:1346464 6480464 Fluorouracil results in increased phosphorylation of H2AX protein CTD PMID:26544897 , PMID:34510228 5-fluorouracil affects expression ISO RGD:1346464 6480464 Fluorouracil affects the expression of H2AX mRNA CTD PMID:16584549 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of H2AX mRNA CTD PMID:24780913 680C91 decreases expression ISO RGD:1346464 6480464 TDO inhibitor LM10 results in decreased expression of H2AX protein modified form CTD PMID:26651356 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:23969067 7,12-dimethyltetraphene increases phosphorylation ISO RGD:1346464 6480464 9 more ... CTD PMID:34510228 7,12-dimethyltetraphene increases expression ISO RGD:1558155 6480464 9 more ... CTD PMID:25448685 , PMID:32553695 7,12-dimethyltetraphene multiple interactions ISO RGD:1558155 6480464 A gene mutant form affects the reaction [9 more ... CTD PMID:25448685 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:1558155 6480464 CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein], NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein] CTD PMID:23619996 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases phosphorylation ISO RGD:1558155 6480464 Uric Acid results in increased phosphorylation of H2AX protein CTD PMID:23619996 9-aminoacridine multiple interactions ISO RGD:1346464 6480464 [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 9-aminoacridine decreases phosphorylation ISO RGD:1346464 6480464 Aminacrine results in decreased phosphorylation of H2AX protein CTD PMID:26928355 [6]-Shogaol multiple interactions ISO RGD:1346464 6480464 shogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein] CTD PMID:23899529 ABT-737 multiple interactions ISO RGD:1346464 6480464 [ABT-737 co-treated with hydroquinone] results in increased expression of H2AX protein CTD PMID:28843007 acetylsalicylic acid decreases expression ISO RGD:1346464 6480464 Aspirin results in decreased expression of H2AX protein CTD PMID:23363784 acrolein increases expression ISO RGD:1346464 6480464 Acrolein results in increased expression of H2AX protein CTD PMID:34958888 acrylonitrile increases expression ISO RGD:1558155 6480464 Acrylonitrile results in increased expression of H2AX protein CTD PMID:35429547 actinomycin D increases expression ISO RGD:1346464 6480464 Dactinomycin results in increased expression of H2AX protein CTD PMID:31226288 adenosine multiple interactions ISO RGD:1346464 6480464 Adenosine promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 adenosine 5'-monophosphate multiple interactions ISO RGD:1346464 6480464 Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 ADP multiple interactions ISO RGD:1346464 6480464 Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] more ... CTD PMID:32941855 aflatoxin B1 multiple interactions ISO RGD:1346464 6480464 2 more ... CTD PMID:28882572 more ... aflatoxin B1 increases expression ISO RGD:1346464 6480464 Aflatoxin B1 analog results in increased expression of H2AX protein more ... CTD PMID:31154085 more ... aflatoxin B1 increases methylation ISO RGD:1346464 6480464 Aflatoxin B1 results in increased methylation of H2AX polyA tail CTD PMID:30157460 aflatoxin B1 increases phosphorylation ISO RGD:1558155 6480464 Aflatoxin B1 results in increased phosphorylation of H2AX protein CTD PMID:19770486 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of H2AX mRNA CTD PMID:15890375 aflatoxin B1 increases phosphorylation ISO RGD:1346464 6480464 Aflatoxin B1 results in increased phosphorylation of H2AX protein CTD PMID:28882572 , PMID:34510228 Aflatoxin G1 increases expression ISO RGD:1346464 6480464 aflatoxin G1 results in increased expression of H2AX protein modified form CTD PMID:23907605 Aflatoxin G1 multiple interactions ISO RGD:1346464 6480464 Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form], Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 aldehydo-D-glucose increases expression ISO RGD:1558155 6480464 Glucose results in increased expression of H2AX protein CTD PMID:31672611 aldehydo-D-glucose multiple interactions ISO RGD:1558155 6480464 Glucose promotes the reaction [Bupivacaine results in increased expression of H2AX protein] CTD PMID:31672611 all-trans-retinoic acid decreases expression ISO RGD:1346464 6480464 Tretinoin results in decreased expression of H2AX mRNA CTD PMID:16249480 all-trans-retinoic acid increases expression ISO RGD:1558155 6480464 Tretinoin results in increased expression of H2AX protein CTD PMID:33823233 alternariol increases expression ISO RGD:1346464 6480464 alternariol results in increased expression of H2AX protein modified form CTD PMID:26341179 alvocidib affects expression ISO RGD:1346464 6480464 alvocidib affects the expression of H2AX protein CTD PMID:15078984 anthocyanin increases phosphorylation ISO RGD:1346464 6480464 Anthocyanins results in increased phosphorylation of H2AX protein CTD PMID:27444805 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1346464 6480464 pyrazolanthrone inhibits the reaction [4-methoxy-2 more ... CTD PMID:25619392 , PMID:28993908 aphidicolin multiple interactions ISO RGD:1346464 6480464 Aphidicolin inhibits the reaction [Docetaxel results in increased expression of H2AX protein] CTD PMID:20878124 aristolochic acid A multiple interactions ISO RGD:1558155 6480464 TRP53 protein affects the reaction [aristolochic acid I results in increased expression of H2AX protein] CTD PMID:31602497 aristolochic acid A increases expression ISO RGD:1558155 6480464 aristolochic acid I results in increased expression of H2AX protein CTD PMID:31602497 arsane increases expression ISO RGD:1346464 6480464 Arsenic results in increased expression of H2AX mRNA, Arsenic results in increased expression of H2AX protein CTD PMID:29161537 more ... arsane increases expression ISO RGD:1558155 6480464 Arsenic results in increased expression of H2AX protein CTD PMID:34998823 arsane multiple interactions ISO RGD:1346464 6480464 [UNG protein affects the susceptibility to Arsenic] which affects the expression of H2AX protein more ... CTD PMID:31822296 , PMID:34998823 arsane multiple interactions EXP 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 arsenic atom increases expression ISO RGD:1346464 6480464 Arsenic results in increased expression of H2AX mRNA, Arsenic results in increased expression of H2AX protein CTD PMID:29161537 more ... arsenic atom increases expression ISO RGD:1558155 6480464 Arsenic results in increased expression of H2AX protein CTD PMID:34998823 arsenic atom multiple interactions ISO RGD:1346464 6480464 [UNG protein affects the susceptibility to Arsenic] which affects the expression of H2AX protein more ... CTD PMID:31822296 , PMID:34998823 arsenic atom multiple interactions EXP 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 arsenite(3-) multiple interactions ISO RGD:1346464 6480464 arsenite promotes the reaction [G3BP1 protein binds to H2AX mRNA] CTD PMID:32406909 arsenous acid multiple interactions ISO RGD:1346464 6480464 [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein more ... CTD PMID:18636201 more ... arsenous acid increases expression ISO RGD:1346464 6480464 Arsenic Trioxide results in increased expression of H2AX protein, Arsenic Trioxide results in increased expression of H2AX protein modified form CTD PMID:28265077 more ... arsenous acid multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased expression of H2AX protein] CTD PMID:23337567 arsenous acid increases expression ISO RGD:1558155 6480464 Arsenic Trioxide results in increased expression of H2AX protein modified form CTD PMID:28265077 arsenous acid increases phosphorylation ISO RGD:1346464 6480464 Arsenic Trioxide results in increased phosphorylation of H2AX protein CTD PMID:16891316 , PMID:23861973 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of H2AX protein CTD PMID:23337567 artesunate increases phosphorylation ISO RGD:1346464 6480464 Artesunate results in increased phosphorylation of H2AX protein CTD PMID:31664825 artesunate multiple interactions ISO RGD:1346464 6480464 APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] CTD PMID:31664825 ATP multiple interactions ISO RGD:1346464 6480464 Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] more ... CTD PMID:32941855 atrazine affects expression ISO RGD:1558155 6480464 Atrazine affects the expression of H2AX protein modified form CTD PMID:26518232 azathioprine decreases expression ISO RGD:1346464 6480464 Azathioprine results in decreased expression of H2AX mRNA CTD PMID:22623647 benzene increases expression ISO RGD:1558155 6480464 Benzene results in increased expression of H2AX mRNA CTD PMID:15120971 , PMID:15122651 benzene increases phosphorylation ISO RGD:1558155 6480464 Benzene results in increased phosphorylation of H2AX protein CTD PMID:35963423 benzo[a]pyrene increases expression ISO RGD:1346464 6480464 Benzo(a)pyrene metabolite results in increased expression of H2AX protein more ... CTD PMID:21873372 more ... benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of H2AX protein modified form CTD PMID:34283317 benzo[a]pyrene increases phosphorylation ISO RGD:1558155 6480464 Benzo(a)pyrene results in increased phosphorylation of H2AX protein CTD PMID:19770486 , PMID:33393179 benzo[a]pyrene increases methylation ISO RGD:1346464 6480464 Benzo(a)pyrene results in increased methylation of H2AX promoter CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1558155 6480464 Benzo(a)pyrene metabolite results in increased expression of H2AX protein modified form CTD PMID:32553695 benzo[a]pyrene increases phosphorylation ISO RGD:1346464 6480464 Benzo(a)pyrene results in increased phosphorylation of H2AX protein CTD PMID:20888899 more ... benzo[a]pyrene multiple interactions ISO RGD:1558155 6480464 pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:33393179 benzo[a]pyrene multiple interactions ISO RGD:1346464 6480464 2 more ... CTD PMID:20888899 more ... benzo[a]pyrene diol epoxide I increases expression ISO RGD:1346464 6480464 7 more ... CTD PMID:19150397 benzo[a]pyrene diol epoxide I increases phosphorylation ISO RGD:1558155 6480464 7 more ... CTD PMID:22331492 benzo[a]pyrene diol epoxide I multiple interactions ISO RGD:1558155 6480464 POLH protein affects the reaction [7 more ... CTD PMID:22331492 benzo[a]pyrene diol epoxide I affects phosphorylation ISO RGD:1346464 6480464 7 more ... CTD PMID:18848825 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1346464 6480464 7 more ... CTD PMID:20382639 benzo[a]pyrene diol epoxide I multiple interactions ISO RGD:1346464 6480464 [Hydrogen Peroxide co-treated with 7 more ... CTD PMID:18848825 benzo[e]pyrene increases methylation ISO RGD:1346464 6480464 benzo(e)pyrene results in increased methylation of H2AX polyA tail CTD PMID:30157460 Benzo[ghi]perylene multiple interactions ISO RGD:1346464 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1, 12-benzoperylene results in increased expression of H2AX protein] CTD PMID:35182551 Benzo[ghi]perylene increases expression ISO RGD:1346464 6480464 1, 12-benzoperylene results in increased expression of H2AX protein CTD PMID:31518672 , PMID:35182551 berberine increases expression ISO RGD:1346464 6480464 Berberine results in increased expression of H2AX protein modified form CTD PMID:23747414 berberine decreases expression ISO RGD:1346464 6480464 Berberine results in decreased expression of H2AX mRNA, Berberine results in decreased expression of H2AX protein CTD PMID:23363784 , PMID:27311644 berberine multiple interactions ISO RGD:1346464 6480464 TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form] CTD PMID:23747414 beta-hexachlorocyclohexane increases phosphorylation ISO RGD:1346464 6480464 beta-hexachlorocyclohexane results in increased phosphorylation of H2AX protein CTD PMID:33207735 biphenyl-4-amine increases expression ISO RGD:1346464 6480464 4-biphenylamine results in increased expression of H2AX protein CTD PMID:32433928 more ... biphenyl-4-amine multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein] more ... CTD PMID:32433928 more ... bis(2-chloroethyl) sulfide increases expression ISO RGD:1346464 6480464 Mustard Gas results in increased expression of H2AX protein modified form CTD PMID:25102026 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1346464 6480464 Mustard Gas results in decreased expression of H2AX mRNA CTD PMID:33491125 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:1346464 6480464 Mustard Gas results in increased phosphorylation of H2AX protein CTD PMID:20435105 , PMID:25448276 bis(2-chloroethyl) sulfide multiple interactions ISO RGD:1346464 6480464 pifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AX protein] CTD PMID:25448276 bis(2-ethylhexyl) phthalate increases phosphorylation EXP 6480464 Diethylhexyl Phthalate results in increased phosphorylation of H2AX protein CTD PMID:30543897 bis(2-ethylhexyl) phthalate increases phosphorylation ISO RGD:1346464 6480464 Diethylhexyl Phthalate results in increased phosphorylation of H2AX protein CTD PMID:30543897 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1346464 6480464 Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form] more ... CTD PMID:30543897 , PMID:30720231 bisphenol A increases expression ISO RGD:1346464 6480464 bisphenol A results in increased expression of H2AX mRNA more ... CTD PMID:16462019 more ... bisphenol A increases expression ISO RGD:1558155 6480464 bisphenol A results in increased expression of H2AX mRNA CTD PMID:32156529 bisphenol A affects expression ISO RGD:1346464 6480464 bisphenol A affects the expression of H2AX mRNA CTD PMID:30903817 bisphenol A increases phosphorylation ISO RGD:1346464 6480464 bisphenol A results in increased phosphorylation of H2AX protein CTD PMID:29128613 , PMID:32466334 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of H2AX mRNA more ... CTD PMID:23788033 more ... bisphenol A multiple interactions ISO RGD:1558155 6480464 bisphenol A inhibits the reaction [[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AX protein] CTD PMID:25693136 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of H2AX protein CTD PMID:23788033 bisphenol A increases phosphorylation EXP 6480464 bisphenol A results in increased phosphorylation of H2AX protein CTD PMID:29128613 bisphenol A decreases expression ISO RGD:1346464 6480464 bisphenol A results in decreased expression of H2AX mRNA, bisphenol A results in decreased expression of H2AX protein CTD PMID:29275510 , PMID:34186270 bisphenol A decreases expression ISO RGD:1558155 6480464 bisphenol A results in decreased expression of H2AX mRNA CTD PMID:30245210 bisphenol A multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of H2AX protein] more ... CTD PMID:23227178 more ... Bisphenol B increases expression ISO RGD:1346464 6480464 bisphenol B results in increased expression of H2AX protein CTD PMID:34186270 bisphenol F increases expression ISO RGD:1558155 6480464 bisphenol F results in increased expression of H2AX protein CTD PMID:29102535 bisphenol F increases expression ISO RGD:1346464 6480464 bisphenol F results in increased expression of H2AX protein CTD PMID:34186270 bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of H2AX mRNA CTD PMID:36041667 bisphenol F multiple interactions ISO RGD:1346464 6480464 [bisphenol F co-treated with cylindrospermopsin] results in increased expression of H2AX protein CTD PMID:32244372 bleomycin A2 increases expression ISO RGD:1346464 6480464 Bleomycin results in increased expression of H2AX protein CTD PMID:25130544 bortezomib multiple interactions ISO RGD:1346464 6480464 [Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AX protein more ... CTD PMID:15173094 , PMID:16778179 bortezomib decreases phosphorylation ISO RGD:1346464 6480464 Bortezomib results in decreased phosphorylation of H2AX protein CTD PMID:32482060 bortezomib multiple interactions EXP 6480464 Bortezomib inhibits the reaction [Doxorubicin results in increased expression of H2AX protein], Bortezomib inhibits the reaction [Etoposide results in increased expression of H2AX protein] CTD PMID:17875725 bortezomib increases expression ISO RGD:1346464 6480464 Bortezomib results in increased expression of H2AX protein modified form CTD PMID:16778179 , PMID:18790767 bupivacaine multiple interactions ISO RGD:1558155 6480464 Glucose promotes the reaction [Bupivacaine results in increased expression of H2AX protein] CTD PMID:31672611 bupivacaine increases expression ISO RGD:1558155 6480464 Bupivacaine results in increased expression of H2AX protein CTD PMID:31672611 busulfan increases phosphorylation ISO RGD:1346464 6480464 Busulfan results in increased phosphorylation of H2AX protein CTD PMID:18339423 busulfan multiple interactions ISO RGD:1346464 6480464 [Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein CTD PMID:20933509 butyric acid decreases expression EXP 6480464 Butyric Acid results in decreased expression of H2AX mRNA CTD PMID:12800193 butyric acid multiple interactions ISO RGD:1346464 6480464 Butyric Acid promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased phosphorylation of H2AX protein] CTD PMID:36399157 butyric acid increases expression EXP 6480464 Butyric Acid results in increased expression of H2AX protein CTD PMID:25070040 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of H2AX protein CTD PMID:27658547 cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein, Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein] CTD PMID:33031904 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of H2AX protein CTD PMID:22457795 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein, Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein] CTD PMID:33031904 cadmium dichloride affects expression ISO RGD:1558155 6480464 Cadmium Chloride affects the expression of H2AX mRNA CTD PMID:18974090 caffeine multiple interactions ISO RGD:1346464 6480464 Caffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein] more ... CTD PMID:15975956 more ... caffeine multiple interactions EXP 6480464 [Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein CTD PMID:15537744 calciol decreases expression ISO RGD:1346464 6480464 Cholecalciferol results in decreased expression of H2AX protein CTD PMID:23363784 calcitriol decreases expression ISO RGD:1346464 6480464 Calcitriol results in decreased expression of H2AX mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1346464 6480464 [salinomycin co-treated with Calcitriol] results in decreased expression of H2AX mRNA, [Testosterone co-treated with Calcitriol] results in decreased expression of H2AX mRNA CTD PMID:21592394 , PMID:35914560 camptothecin multiple interactions ISO RGD:1346464 6480464 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form] more ... CTD PMID:21227924 more ... camptothecin increases expression ISO RGD:1558155 6480464 Camptothecin results in increased expression of H2AX protein CTD PMID:17875725 camptothecin increases expression EXP 6480464 Camptothecin results in increased expression of H2AX protein CTD PMID:17875725 camptothecin increases phosphorylation ISO RGD:1346464 6480464 Camptothecin results in increased phosphorylation of H2AX protein CTD PMID:21646468 , PMID:32482060 camptothecin increases expression ISO RGD:1346464 6480464 Camptothecin results in increased expression of H2AX protein, Camptothecin results in increased expression of H2AX protein modified form CTD PMID:21227924 more ... cannabidiol multiple interactions ISO RGD:1346464 6480464 Cannabidiol promotes the reaction [Dronabinol results in increased expression of H2AX protein modified form], Dronabinol promotes the reaction [Cannabidiol results in increased expression of H2AX protein modified form] CTD PMID:27769052 cannabidiol increases expression ISO RGD:1346464 6480464 Cannabidiol results in increased expression of H2AX protein modified form CTD PMID:27769052 capsaicin increases localization ISO RGD:1346464 6480464 Capsaicin results in increased localization of H2AX protein CTD PMID:22226932 carbamate ester multiple interactions ISO RGD:1346464 6480464 Carbamates analog results in increased phosphorylation of and results in increased activity of H2AX protein CTD PMID:19376255 carbamate ester increases phosphorylation ISO RGD:1346464 6480464 Carbamates analog results in increased phosphorylation of H2AX protein CTD PMID:19111005 carbon nanotube increases expression ISO RGD:1558155 6480464 Nanotubes more ... CTD PMID:25554681 carbon nanotube increases expression ISO RGD:1346464 6480464 Nanotubes, Carbon results in increased expression of H2AX protein CTD PMID:32493873 carboplatin increases expression ISO RGD:1346464 6480464 Carboplatin results in increased expression of H2AX protein CTD PMID:22302033 carboplatin multiple interactions ISO RGD:1346464 6480464 palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein] CTD PMID:22302033 carmustine decreases expression ISO RGD:1346464 6480464 Carmustine results in decreased expression of H2AX mRNA CTD PMID:15980968 carmustine increases phosphorylation ISO RGD:1346464 6480464 Carmustine results in increased phosphorylation of H2AX protein CTD PMID:20472715 carmustine multiple interactions ISO RGD:1346464 6480464 MDM4 protein promotes the reaction [Carmustine affects the localization of H2AX protein], MDM4 protein promotes the reaction [Carmustine results in increased phosphorylation of H2AX protein] CTD PMID:20472715 carmustine affects localization ISO RGD:1346464 6480464 Carmustine affects the localization of H2AX protein CTD PMID:20472715 celecoxib multiple interactions ISO RGD:1346464 6480464 Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] CTD PMID:21745461 chlorambucil increases phosphorylation ISO RGD:1346464 6480464 Chlorambucil analog results in increased phosphorylation of H2AX protein, Chlorambucil results in increased phosphorylation of H2AX protein CTD PMID:16861886 , PMID:32482060 chlordecone increases expression ISO RGD:1558155 6480464 Chlordecone results in increased expression of H2AX protein modified form CTD PMID:31084621 chlorite multiple interactions EXP 6480464 chlorite promotes the reaction [Bromates results in increased phosphorylation of H2AX protein] CTD PMID:21864635 chloropicrin increases phosphorylation ISO RGD:1346464 6480464 chloropicrin results in increased phosphorylation of H2AX protein CTD PMID:31884112 chloropicrin multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [chloropicrin results in increased phosphorylation of H2AX protein] CTD PMID:31884112 chloroprene increases expression ISO RGD:1558155 6480464 Chloroprene results in increased expression of H2AX mRNA CTD PMID:23125180 chlorpyrifos increases expression ISO RGD:1346464 6480464 Chlorpyrifos results in increased expression of H2AX protein CTD PMID:32156659 choline multiple interactions ISO RGD:1558155 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased phosphorylation of H2AX protein CTD PMID:20548288 chromium(6+) increases ubiquitination ISO RGD:1346464 6480464 chromium hexavalent ion results in increased ubiquitination of H2AX protein CTD PMID:25288669 chromium(6+) increases ubiquitination ISO RGD:1558155 6480464 chromium hexavalent ion results in increased ubiquitination of H2AX protein CTD PMID:25288669 chromium(6+) increases phosphorylation ISO RGD:1558155 6480464 chromium hexavalent ion results in increased phosphorylation of H2AX protein CTD PMID:25288669 chromium(6+) increases expression ISO RGD:1558155 6480464 chromium hexavalent ion results in increased expression of H2AX protein CTD PMID:25352572 chromium(6+) multiple interactions ISO RGD:1558155 6480464 [sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein more ... CTD PMID:25288669 , PMID:35643323 chromium(6+) increases phosphorylation ISO RGD:1346464 6480464 chromium hexavalent ion results in increased phosphorylation of H2AX protein CTD PMID:25288669 chromium(6+) multiple interactions ISO RGD:1346464 6480464 ATR protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of H2AX protein], ATR protein affects the reaction [chromium hexavalent ion results in increased ubiquitination of H2AX protein] CTD PMID:25288669 chromone increases expression ISO RGD:1346464 6480464 4-chromone analog results in increased expression of H2AX protein modified form CTD PMID:30256521 Cinobufagin increases expression ISO RGD:1346464 6480464 cinobufagin results in increased expression of H2AX protein CTD PMID:35427566 cisplatin increases expression ISO RGD:1346464 6480464 Cisplatin results in increased expression of H2AX mRNA more ... CTD PMID:21500194 more ... cisplatin increases phosphorylation ISO RGD:1558155 6480464 Cisplatin results in increased phosphorylation of H2AX protein CTD PMID:21285353 more ... cisplatin multiple interactions ISO RGD:1558155 6480464 erdosteine inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein] more ... CTD PMID:21324906 more ... cisplatin increases expression ISO RGD:1558155 6480464 Cisplatin results in increased expression of H2AX protein, Cisplatin results in increased expression of H2AX protein modified form CTD PMID:26723870 , PMID:26739623 cisplatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form] CTD PMID:26739623 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of H2AX protein modified form CTD PMID:26739623 cisplatin increases phosphorylation ISO RGD:1346464 6480464 Cisplatin results in increased phosphorylation of H2AX protein CTD PMID:20145152 more ... cisplatin multiple interactions ISO RGD:1346464 6480464 [MIR138-1 results in decreased expression of H2AX] which results in increased susceptibility to Cisplatin more ... CTD PMID:20145152 more ... clofarabine multiple interactions ISO RGD:1346464 6480464 [Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein CTD PMID:20933509 cobalt dichloride multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]] more ... CTD PMID:22172632 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of H2AX mRNA CTD PMID:24386269 cobalt dichloride decreases expression ISO RGD:1346464 6480464 cobaltous chloride results in decreased expression of H2AX mRNA CTD PMID:19376846 cobalt dichloride increases phosphorylation ISO RGD:1346464 6480464 cobaltous chloride results in increased phosphorylation of H2AX protein CTD PMID:22172632 copper atom multiple interactions ISO RGD:1346464 6480464 [Copper binds to phthalic acid binds to 1 more ... CTD PMID:22659117 copper(0) multiple interactions ISO RGD:1346464 6480464 [Copper binds to phthalic acid binds to 1 more ... CTD PMID:22659117 copper(II) sulfate decreases expression ISO RGD:1346464 6480464 Copper Sulfate results in decreased expression of H2AX mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:1346464 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression ISO RGD:1346464 6480464 Coumestrol results in increased expression of H2AX mRNA, Coumestrol results in increased expression of H2AX protein modified form CTD PMID:19167446 , PMID:28986287 crizotinib multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [Crizotinib results in increased phosphorylation of H2AX protein] CTD PMID:31639374 crizotinib increases phosphorylation ISO RGD:1346464 6480464 Crizotinib results in increased phosphorylation of H2AX protein CTD PMID:31639374 CU-O LINKAGE increases expression ISO RGD:1346464 6480464 cupric oxide analog results in increased expression of H2AX protein CTD PMID:27270449 CU-O LINKAGE decreases expression ISO RGD:1346464 6480464 cupric oxide results in decreased expression of H2AX mRNA CTD PMID:22077320 curcumin multiple interactions ISO RGD:1346464 6480464 [Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein, [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein CTD PMID:21134073 curcumin increases phosphorylation ISO RGD:1346464 6480464 Curcumin results in increased phosphorylation of H2AX protein CTD PMID:19401701 , PMID:21134073 cyclophosphamide increases phosphorylation ISO RGD:1346464 6480464 Cyclophosphamide results in increased phosphorylation of H2AX protein CTD PMID:32482060 , PMID:34510228 cyclophosphamide increases phosphorylation EXP 6480464 Cyclophosphamide results in increased phosphorylation of H2AX protein CTD PMID:33211169 cyclosporin A decreases expression ISO RGD:1346464 6480464 Cyclosporine results in decreased expression of H2AX mRNA CTD PMID:20106945 more ... cyhalothrin multiple interactions ISO RGD:1346464 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein CTD PMID:22389207 cylindrospermopsin increases expression ISO RGD:1346464 6480464 cylindrospermopsin results in increased expression of H2AX protein CTD PMID:30905859 , PMID:32244372 cylindrospermopsin multiple interactions ISO RGD:1346464 6480464 [4 more ... CTD PMID:32244372 cyprodinil multiple interactions ISO RGD:1346464 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein CTD PMID:22389207 cyprodinil increases phosphorylation ISO RGD:1346464 6480464 cyprodinil results in increased phosphorylation of H2AX protein CTD PMID:22389207 cytarabine increases phosphorylation ISO RGD:1346464 6480464 Cytarabine results in increased phosphorylation of H2AX protein CTD PMID:19628630 , PMID:34510228 D-glucose multiple interactions ISO RGD:1558155 6480464 Glucose promotes the reaction [Bupivacaine results in increased expression of H2AX protein] CTD PMID:31672611 D-glucose increases expression ISO RGD:1558155 6480464 Glucose results in increased expression of H2AX protein CTD PMID:31672611 daunorubicin affects expression ISO RGD:1346464 6480464 Daunorubicin affects the expression of H2AX mRNA CTD PMID:27780733 daunorubicin increases expression ISO RGD:1346464 6480464 Daunorubicin results in increased expression of H2AX protein CTD PMID:34963561 decabromodiphenyl ether increases expression ISO RGD:1558155 6480464 decabromobiphenyl ether results in increased expression of H2AX mRNA, decabromobiphenyl ether results in increased expression of H2AX protein CTD PMID:34936917 dexamethasone multiple interactions ISO RGD:1346464 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of H2AX mRNA CTD PMID:26424790 diarsenic trioxide increases expression ISO RGD:1558155 6480464 Arsenic Trioxide results in increased expression of H2AX protein modified form CTD PMID:28265077 diarsenic trioxide increases expression ISO RGD:1346464 6480464 Arsenic Trioxide results in increased expression of H2AX protein, Arsenic Trioxide results in increased expression of H2AX protein modified form CTD PMID:28265077 more ... diarsenic trioxide increases phosphorylation ISO RGD:1346464 6480464 Arsenic Trioxide results in increased phosphorylation of H2AX protein CTD PMID:16891316 , PMID:23861973 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of H2AX protein CTD PMID:23337567 diarsenic trioxide multiple interactions ISO RGD:1346464 6480464 [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein more ... CTD PMID:18636201 more ... diarsenic trioxide multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased expression of H2AX protein] CTD PMID:23337567 dibenzo[a,l]pyrene multiple interactions ISO RGD:1346464 6480464 2-(morpholin-4-yl)benzo(h)chromen-4-one inhibits the reaction [dibenzo(a, l)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:31838185 dibenzo[a,l]pyrene increases phosphorylation ISO RGD:1346464 6480464 dibenzo(a, l)pyrene results in increased phosphorylation of H2AX protein CTD PMID:31838185 dibutyl phthalate decreases expression ISO RGD:1558155 6480464 Dibutyl Phthalate results in decreased expression of H2AX mRNA CTD PMID:17361019 , PMID:21266533 diclofenac increases expression ISO RGD:1346464 6480464 Diclofenac results in increased expression of H2AX protein CTD PMID:32087850 diepoxybutane multiple interactions ISO RGD:1558155 6480464 Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of H2AX protein modified form] CTD PMID:25633853 diepoxybutane increases expression ISO RGD:1558155 6480464 diepoxybutane results in increased expression of H2AX protein modified form CTD PMID:25633853 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of H2AX mRNA CTD PMID:15890375 dihydroxyacetone increases expression ISO RGD:1346464 6480464 Dihydroxyacetone results in increased expression of H2AX protein CTD PMID:32506039 dimethocaine multiple interactions ISO RGD:1346464 6480464 [NAT2 protein results in increased susceptibility to dimethocaine] which results in increased expression of H2AX protein CTD PMID:36138126 dioxygen decreases expression ISO RGD:1346464 6480464 Oxygen deficiency results in decreased expression of H2AX mRNA CTD PMID:26516004 dioxygen multiple interactions ISO RGD:1346464 6480464 Oxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AX protein], Oxygen deficiency inhibits the reaction [nickel monoxide analog results in increased expression of H2AX protein] CTD PMID:27270449 disodium selenite increases expression ISO RGD:1346464 6480464 Sodium Selenite results in increased expression of H2AX mRNA CTD PMID:18175754 Disperse Blue 1 increases phosphorylation EXP 6480464 Disperse Blue 1 results in increased phosphorylation of H2AX protein CTD PMID:33211169 disulfiram multiple interactions ISO RGD:1346464 6480464 Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein], Disulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] CTD PMID:28300663 , PMID:35279910 dorsomorphin increases phosphorylation ISO RGD:1346464 6480464 dorsomorphin results in increased phosphorylation of H2AX protein CTD PMID:23274516 dorsomorphin multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of H2AX protein] CTD PMID:23274516 doxorubicin multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein] more ... CTD PMID:15489221 more ... doxorubicin decreases expression ISO RGD:1346464 6480464 Doxorubicin results in decreased expression of H2AX mRNA CTD PMID:29803840 doxorubicin increases phosphorylation ISO RGD:1558155 6480464 Doxorubicin results in increased phosphorylation of H2AX protein CTD PMID:22712078 , PMID:31368505 doxorubicin multiple interactions EXP 6480464 4 more ... CTD PMID:17875725 more ... doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of H2AX protein, Doxorubicin results in increased expression of H2AX protein modified form CTD PMID:17875725 more ... doxorubicin multiple interactions ISO RGD:1558155 6480464 Lovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form] more ... CTD PMID:17875725 more ... doxorubicin increases expression ISO RGD:1558155 6480464 Doxorubicin results in increased expression of H2AX protein, Doxorubicin results in increased expression of H2AX protein modified form CTD PMID:17875725 , PMID:28710503 doxorubicin affects expression ISO RGD:1346464 6480464 Doxorubicin affects the expression of H2AX mRNA CTD PMID:27780733 doxorubicin increases expression ISO RGD:1346464 6480464 Doxorubicin results in increased expression of H2AX mRNA more ... CTD PMID:22302033 more ... doxorubicin increases phosphorylation ISO RGD:1346464 6480464 Doxorubicin results in increased phosphorylation of H2AX protein CTD PMID:15489221 more ... dronedarone multiple interactions ISO RGD:1346464 6480464 CYP2D6 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein] more ... CTD PMID:29616291 dronedarone increases phosphorylation ISO RGD:1346464 6480464 Dronedarone results in increased phosphorylation of H2AX protein CTD PMID:29616291 Echimidine increases expression ISO RGD:1346464 6480464 echimidine results in increased expression of H2AX protein CTD PMID:31154085 elemental selenium increases expression ISO RGD:1346464 6480464 Selenium results in increased expression of H2AX mRNA CTD PMID:19244175 ellipticine multiple interactions ISO RGD:1346464 6480464 [ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form CTD PMID:30914192 ellipticine increases expression ISO RGD:1346464 6480464 ellipticine results in increased expression of H2AX protein modified form CTD PMID:30914192 emodin increases expression ISO RGD:1346464 6480464 Emodin results in increased expression of H2AX protein, Emodin results in increased expression of H2AX protein modified form CTD PMID:20855424 , PMID:34492313 emodin multiple interactions ISO RGD:1346464 6480464 TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form] CTD PMID:20855424 Enterolactone multiple interactions ISO RGD:1346464 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of H2AX mRNA CTD PMID:19167446 entinostat increases phosphorylation ISO RGD:1346464 6480464 entinostat results in increased phosphorylation of H2AX protein CTD PMID:34665271 epothilone A multiple interactions ISO RGD:1346464 6480464 [epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA CTD PMID:29117515 epothilone A increases expression ISO RGD:1346464 6480464 epothilone A results in increased expression of H2AX mRNA CTD PMID:29117515 erdosteine multiple interactions ISO RGD:1558155 6480464 erdosteine inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein] CTD PMID:26193055 erlotinib hydrochloride multiple interactions ISO RGD:1346464 6480464 Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of H2AX protein modified form], Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of H2AX protein modified form] CTD PMID:25895606 erlotinib hydrochloride increases expression ISO RGD:1346464 6480464 Erlotinib Hydrochloride results in increased expression of H2AX protein modified form CTD PMID:25895606 erucifoline increases expression ISO RGD:1346464 6480464 erucifoline results in increased expression of H2AX protein CTD PMID:31154085 Estragole increases expression EXP 6480464 estragole results in increased expression of H2AX protein modified form CTD PMID:29054680 ethanol increases phosphorylation ISO RGD:1346464 6480464 Ethanol results in increased phosphorylation of H2AX protein CTD PMID:24374569 ethanol multiple interactions ISO RGD:1346464 6480464 CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of H2AX protein modified form]] more ... CTD PMID:34192554 , PMID:34405320 ethanol increases expression ISO RGD:1346464 6480464 Ethanol results in increased expression of H2AX mRNA more ... CTD PMID:34192554 , PMID:34405320 ethanol increases expression ISO RGD:1558155 6480464 Ethanol results in increased expression of H2AX mRNA more ... CTD PMID:34192554 , PMID:34405320 ethanol increases phosphorylation ISO RGD:1558155 6480464 Ethanol results in increased phosphorylation of H2AX protein CTD PMID:26629949 ethanol multiple interactions ISO RGD:1558155 6480464 [BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased phosphorylation of H2AX protein more ... CTD PMID:26629949 more ... ethyl methanesulfonate increases expression ISO RGD:1346464 6480464 Ethyl Methanesulfonate results in increased expression of H2AX protein CTD PMID:35395335 etoposide increases phosphorylation ISO RGD:1346464 6480464 Etoposide results in increased phosphorylation of H2AX protein CTD PMID:20978201 more ... etoposide increases expression ISO RGD:1558155 6480464 Etoposide results in increased expression of H2AX protein CTD PMID:17875725 more ... etoposide multiple interactions ISO RGD:1558155 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide results in increased expression of H2AX protein] more ... CTD PMID:17875725 more ... etoposide multiple interactions EXP 6480464 4 more ... CTD PMID:17875725 etoposide increases expression EXP 6480464 Etoposide results in increased expression of H2AX protein CTD PMID:17875725 etoposide decreases response to substance ISO RGD:1558155 6480464 H2AX protein results in decreased susceptibility to Etoposide CTD PMID:21555580 etoposide increases expression ISO RGD:1346464 6480464 Etoposide results in increased expression of H2AX protein, Etoposide results in increased expression of H2AX protein modified form CTD PMID:22302033 more ... etoposide multiple interactions ISO RGD:1346464 6480464 Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] more ... CTD PMID:21745461 more ... fenbendazole increases expression ISO RGD:1346464 6480464 Fenbendazole analog results in increased expression of H2AX protein, Fenbendazole results in increased expression of H2AX protein CTD PMID:35569513 fenthion increases expression ISO RGD:1346464 6480464 Fenthion results in increased expression of H2AX protein CTD PMID:33221015 ferric oxide multiple interactions ISO RGD:1346464 6480464 Oxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AX protein] CTD PMID:27270449 ferric oxide increases expression ISO RGD:1346464 6480464 ferric oxide analog results in increased expression of H2AX protein CTD PMID:27270449 flavanones multiple interactions ISO RGD:1346464 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein] more ... CTD PMID:21616090 flavanones increases phosphorylation ISO RGD:1346464 6480464 Flavanones results in increased phosphorylation of H2AX protein CTD PMID:21616090 flavokawain B increases phosphorylation ISO RGD:1346464 6480464 flavokawain B results in increased phosphorylation of H2AX protein CTD PMID:30025493 fludioxonil multiple interactions ISO RGD:1346464 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein CTD PMID:22389207 fludioxonil increases phosphorylation ISO RGD:1346464 6480464 fludioxonil results in increased phosphorylation of H2AX protein CTD PMID:22389207 fluoranthene multiple interactions ISO RGD:1558155 6480464 [1-methylanthracene co-treated with fluoranthene] results in decreased expression of H2AX mRNA CTD PMID:28329830 fluoranthene multiple interactions ISO RGD:1346464 6480464 [fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein, [pyrene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein CTD PMID:33249052 flutamide increases expression EXP 6480464 Flutamide results in increased expression of H2AX mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:1558155 6480464 [1 more ... CTD PMID:20548288 , PMID:22206623 folic acid affects phosphorylation ISO RGD:1558155 6480464 Folic Acid deficiency affects the phosphorylation of H2AX protein CTD PMID:28471487 fomepizole multiple interactions ISO RGD:1346464 6480464 Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] CTD PMID:28300663 formaldehyde increases expression ISO RGD:1346464 6480464 Formaldehyde results in increased expression of H2AX protein CTD PMID:22479348 fotemustine increases expression ISO RGD:1346464 6480464 fotemustine results in increased expression of H2AX protein modified form CTD PMID:25125662 fulvestrant multiple interactions EXP 6480464 Fulvestrant inhibits the reaction [bisphenol A results in increased expression of H2AX protein], Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein] CTD PMID:23788033 fulvestrant multiple interactions ISO RGD:1558155 6480464 Fulvestrant inhibits the reaction [4 more ... CTD PMID:36098747 fulvestrant multiple interactions ISO RGD:1346464 6480464 Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein modified form] more ... CTD PMID:31939680 fumonisin B1 decreases expression ISO RGD:1346464 6480464 fumonisin B1 results in decreased expression of H2AX protein CTD PMID:25800559 furan increases methylation EXP 6480464 furan results in increased methylation of H2AX gene CTD PMID:22079235 GDP multiple interactions ISO RGD:1346464 6480464 Guanosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 genistein multiple interactions ISO RGD:1346464 6480464 ATM protein affects the reaction [Genistein results in increased phosphorylation of H2AX protein] CTD PMID:15177039 genistein increases expression ISO RGD:1346464 6480464 Genistein results in increased expression of H2AX mRNA CTD PMID:16474171 genistein increases phosphorylation ISO RGD:1346464 6480464 Genistein results in increased phosphorylation of H2AX protein CTD PMID:15177039 ginsenoside Rg1 multiple interactions ISO RGD:1346464 6480464 ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of H2AX mRNA] CTD PMID:34783124 Glu-P-1 increases expression ISO RGD:1346464 6480464 2-amino-6-methyldipyrido(1 more ... CTD PMID:28160022 Glu-P-2 increases expression ISO RGD:1346464 6480464 Glu-P-2 results in increased expression of H2AX protein modified form CTD PMID:28160022 glucose increases expression ISO RGD:1558155 6480464 Glucose results in increased expression of H2AX protein CTD PMID:31672611 glucose multiple interactions ISO RGD:1558155 6480464 Glucose promotes the reaction [Bupivacaine results in increased expression of H2AX protein] CTD PMID:31672611 glutathione multiple interactions ISO RGD:1558155 6480464 Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AX protein] CTD PMID:21722719 glutathione multiple interactions ISO RGD:1346464 6480464 Glutathione inhibits the reaction [rubimaillin results in increased phosphorylation of H2AX protein] CTD PMID:35007525 glycerol 2-phosphate multiple interactions ISO RGD:1346464 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of H2AX mRNA CTD PMID:26424790 glyphosate increases expression ISO RGD:1558155 6480464 glyphosate results in increased expression of H2AX protein modified form CTD PMID:31352102 GSK690693 multiple interactions ISO RGD:1346464 6480464 GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] CTD PMID:34784199 GTP multiple interactions ISO RGD:1346464 6480464 Guanosine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 guanosine multiple interactions ISO RGD:1346464 6480464 Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 Heliotrine increases expression ISO RGD:1346464 6480464 heliotrine results in increased expression of H2AX protein CTD PMID:31154085 hexachlorobenzene increases expression ISO RGD:1346464 6480464 Hexachlorobenzene results in increased expression of H2AX protein CTD PMID:32156659 hydrogen peroxide multiple interactions ISO RGD:1346464 6480464 [ERCC6 protein affects the susceptibility to Hydrogen Peroxide] which affects the expression of H2AX protein more ... CTD PMID:18848825 more ... hydrogen peroxide increases expression ISO RGD:1558155 6480464 Hydrogen Peroxide results in increased expression of H2AX protein CTD PMID:17875725 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of H2AX protein CTD PMID:17875725 hydrogen peroxide increases phosphorylation ISO RGD:1346464 6480464 Hydrogen Peroxide results in increased phosphorylation of H2AX protein CTD PMID:25460656 , PMID:28300663 hydrogen peroxide increases expression ISO RGD:1346464 6480464 Hydrogen Peroxide results in increased expression of H2AX mRNA more ... CTD PMID:25972194 more ... hydrogen peroxide decreases expression ISO RGD:1346464 6480464 Hydrogen Peroxide results in decreased expression of H2AX protein modified form CTD PMID:27655674 hydroquinone multiple interactions ISO RGD:1346464 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased expression of H2AX protein] more ... CTD PMID:17875398 more ... hydroquinone multiple interactions ISO RGD:1558155 6480464 FAU protein affects the reaction [hydroquinone results in increased expression of H2AX protein] CTD PMID:22687461 hydroquinone increases expression ISO RGD:1558155 6480464 hydroquinone results in increased expression of H2AX protein CTD PMID:22687461 , PMID:23940708 hydroquinone increases phosphorylation ISO RGD:1346464 6480464 hydroquinone results in increased phosphorylation of H2AX protein CTD PMID:18835433 hydroquinone affects localization ISO RGD:1346464 6480464 hydroquinone affects the localization of H2AX protein modified form CTD PMID:20036648 hydroquinone increases expression ISO RGD:1346464 6480464 hydroquinone results in increased expression of H2AX protein, hydroquinone results in increased expression of H2AX protein alternative form CTD PMID:21267443 more ... hydroxyurea increases expression ISO RGD:1346464 6480464 Hydroxyurea results in increased expression of H2AX protein, Hydroxyurea results in increased expression of H2AX protein modified form CTD PMID:25125662 , PMID:25130544 hydroxyurea increases phosphorylation ISO RGD:1346464 6480464 Hydroxyurea results in increased phosphorylation of H2AX protein CTD PMID:32466334 , PMID:32482060 hydroxyurea multiple interactions ISO RGD:1558155 6480464 TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein] CTD PMID:29228353 hydroxyurea increases phosphorylation ISO RGD:1558155 6480464 Hydroxyurea results in increased phosphorylation of H2AX protein CTD PMID:29228353 IDP multiple interactions ISO RGD:1346464 6480464 Inosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 imiquimod decreases expression ISO RGD:1558155 6480464 Imiquimod results in decreased expression of H2AX mRNA CTD PMID:21878529 indicine increases expression ISO RGD:1346464 6480464 indicine analog results in increased expression of H2AX protein CTD PMID:31154085 inosine multiple interactions ISO RGD:1346464 6480464 Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 intermedine increases expression ISO RGD:1346464 6480464 intermedine analog results in increased expression of H2AX protein CTD PMID:31154085 iprodione multiple interactions ISO RGD:1346464 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein CTD PMID:22389207 irinotecan increases expression ISO RGD:1346464 6480464 Irinotecan metabolite results in increased expression of H2AX mRNA more ... CTD PMID:15956246 , PMID:30612311 irinotecan multiple interactions ISO RGD:1346464 6480464 [Irinotecan co-treated with rucaparib] results in increased expression of H2AX protein CTD PMID:30612311 iron(2+) sulfate (anhydrous) increases expression EXP 6480464 ferrous sulfate results in increased expression of H2AX protein CTD PMID:28583816 iron(2+) sulfate (anhydrous) multiple interactions EXP 6480464 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein] CTD PMID:28583816 isocyanates increases phosphorylation ISO RGD:1346464 6480464 Isocyanates analog results in increased phosphorylation of H2AX protein CTD PMID:19111005 isocyanates increases phosphorylation ISO RGD:1558155 6480464 [Isocyanates results in increased phosphorylation of ATM protein] which results in increased phosphorylation of H2AX protein CTD PMID:19197993 isocyanates increases expression ISO RGD:1346464 6480464 Isocyanates results in increased expression of H2AX protein CTD PMID:19283680 isoflavones multiple interactions ISO RGD:1346464 6480464 [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein CTD PMID:21134073 isoprenaline increases expression ISO RGD:1558155 6480464 Isoproterenol results in increased expression of H2AX mRNA CTD PMID:21335049 isotretinoin decreases expression ISO RGD:1346464 6480464 Isotretinoin results in decreased expression of H2AX mRNA CTD PMID:20436886 jacobine increases expression ISO RGD:1346464 6480464 jacobine analog results in increased expression of H2AX protein, jacobine results in increased expression of H2AX protein CTD PMID:31154085 kaempferol increases phosphorylation ISO RGD:1346464 6480464 kaempferol results in increased phosphorylation of H2AX protein CTD PMID:19028473 kaempferol increases expression ISO RGD:1346464 6480464 kaempferol results in increased expression of H2AX protein CTD PMID:35063459 kaempferol increases expression ISO RGD:1558155 6480464 kaempferol results in increased expression of H2AX protein CTD PMID:24595819 L-ascorbic acid multiple interactions ISO RGD:1346464 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of H2AX mRNA, [Ascorbic Acid results in increased reduction of Vitamin K 3] which results in increased phosphorylation of H2AX protein CTD PMID:19482829 , PMID:26424790 L-methionine multiple interactions ISO RGD:1558155 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased phosphorylation of H2AX protein CTD PMID:20548288 Lasiocarpine increases phosphorylation EXP 6480464 lasiocarpine results in increased phosphorylation of H2AX protein CTD PMID:31289892 Lasiocarpine increases expression ISO RGD:1346464 6480464 lasiocarpine results in increased expression of H2AX protein CTD PMID:31154085 Lasiocarpine increases phosphorylation ISO RGD:1346464 6480464 lasiocarpine results in increased phosphorylation of H2AX protein CTD PMID:31289892 lead diacetate multiple interactions ISO RGD:1346464 6480464 [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein, PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein] CTD PMID:31874198 lead(0) multiple interactions ISO RGD:1346464 6480464 [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein, PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein] CTD PMID:31874198 lead(2+) multiple interactions ISO RGD:1346464 6480464 [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein, PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein] CTD PMID:31874198 leflunomide decreases expression ISO RGD:1346464 6480464 Leflunomide results in decreased expression of H2AX mRNA CTD PMID:28988120 leptomycin B multiple interactions ISO RGD:1346464 6480464 leptomycin B promotes the reaction [Bortezomib results in increased expression of H2AX protein modified form] CTD PMID:16778179 Licochalcone B increases expression ISO RGD:1346464 6480464 licochalcone B results in increased expression of H2AX mRNA CTD PMID:33647349 Licochalcone B increases phosphorylation ISO RGD:1346464 6480464 licochalcone B results in increased phosphorylation of H2AX protein CTD PMID:35948134 Longikaurin A increases expression ISO RGD:1346464 6480464 longikaurin A results in increased expression of H2AX protein modified form CTD PMID:28801140 lovastatin multiple interactions ISO RGD:1346464 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein] CTD PMID:21356574 lovastatin multiple interactions ISO RGD:1558155 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form] more ... CTD PMID:22712078 more ... lovastatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form] CTD PMID:26739623 luteolin multiple interactions ISO RGD:1346464 6480464 CYP1A1 protein promotes the reaction [Luteolin results in increased expression of H2AX protein], CYP1A2 protein promotes the reaction [Luteolin results in increased expression of H2AX protein] CTD PMID:33727136 luteolin increases expression ISO RGD:1346464 6480464 Luteolin results in increased expression of H2AX protein CTD PMID:33727136 LY294002 multiple interactions ISO RGD:1346464 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] CTD PMID:34784199 manumycin A increases phosphorylation ISO RGD:1346464 6480464 manumycin results in increased phosphorylation of H2AX protein CTD PMID:19409983 manumycin A multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [manumycin results in increased phosphorylation of H2AX protein] CTD PMID:19409983 mechlorethamine increases expression ISO RGD:1558155 6480464 Mechlorethamine results in increased expression of H2AX protein modified form CTD PMID:25891025 mechlorethamine increases expression EXP 6480464 Mechlorethamine results in increased expression of H2AX protein modified form CTD PMID:33971176 MeIQ increases expression ISO RGD:1346464 6480464 2-amino-3 more ... CTD PMID:28160022 MeIQx increases expression ISO RGD:1346464 6480464 2-amino-3 more ... CTD PMID:28160022 melatonin multiple interactions ISO RGD:1558155 6480464 Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein] CTD PMID:35643323 menadione multiple interactions ISO RGD:1346464 6480464 [Ascorbic Acid results in increased reduction of Vitamin K 3] which results in increased phosphorylation of H2AX protein CTD PMID:19482829 menaquinone increases phosphorylation ISO RGD:1346464 6480464 Vitamin K 2 results in increased phosphorylation of H2AX protein CTD PMID:29432837 mestranol decreases expression ISO RGD:1558155 6480464 Mestranol results in decreased expression of H2AX mRNA, Mestranol results in decreased expression of H2AX protein CTD PMID:36098747 mestranol multiple interactions ISO RGD:1558155 6480464 Fulvestrant inhibits the reaction [Mestranol results in decreased expression of H2AX protein] CTD PMID:36098747 metformin decreases expression ISO RGD:1346464 6480464 Metformin results in decreased expression of H2AX protein CTD PMID:23363784 metformin increases expression ISO RGD:1346464 6480464 Metformin results in increased expression of H2AX mRNA CTD PMID:29117515 metformin multiple interactions ISO RGD:1346464 6480464 [epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA CTD PMID:29117515 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of H2AX mRNA CTD PMID:15890375 methapyrilene increases methylation ISO RGD:1346464 6480464 Methapyrilene results in increased methylation of H2AX polyA tail CTD PMID:30157460 methotrexate affects response to substance ISO RGD:1346464 6480464 H2AX protein affects the susceptibility to Methotrexate CTD PMID:16217747 methotrexate increases phosphorylation ISO RGD:1346464 6480464 Methotrexate results in increased phosphorylation of H2AX protein CTD PMID:21114963 methoxsalen multiple interactions ISO RGD:1346464 6480464 Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 methoxychlor increases phosphorylation ISO RGD:1346464 6480464 Methoxychlor results in increased phosphorylation of H2AX protein CTD PMID:32466334 methyl methanesulfonate increases expression ISO RGD:1346464 6480464 Methyl Methanesulfonate results in increased expression of H2AX protein CTD PMID:32087850 methyl methanesulfonate increases phosphorylation ISO RGD:1346464 6480464 Methyl Methanesulfonate results in increased phosphorylation of H2AX protein CTD PMID:34510228 methyllycaconitine multiple interactions ISO RGD:1346464 6480464 methyllycaconitine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] CTD PMID:34784199 miconazole increases expression ISO RGD:1558155 6480464 Miconazole results in increased expression of H2AX mRNA CTD PMID:27462272 microcystin-LR increases expression ISO RGD:1346464 6480464 cyanoginosin LR results in increased expression of H2AX protein CTD PMID:36435412 mitomycin C increases phosphorylation ISO RGD:1346464 6480464 Mitomycin results in increased phosphorylation of H2AX protein CTD PMID:21386838 more ... mitomycin C increases expression ISO RGD:1346464 6480464 Mitomycin results in increased expression of H2AX protein, Mitomycin results in increased expression of H2AX protein modified form CTD PMID:29928969 , PMID:32087850 mitoxantrone increases expression ISO RGD:1346464 6480464 Mitoxantrone results in increased expression of H2AX protein CTD PMID:24994473 mitoxantrone increases expression EXP 6480464 Mitoxantrone results in increased expression of H2AX protein CTD PMID:29913208 mitoxantrone multiple interactions EXP 6480464 Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein] CTD PMID:29913208 monocrotaline increases expression ISO RGD:1346464 6480464 Monocrotaline results in increased expression of H2AX protein CTD PMID:31154085 myricetin multiple interactions ISO RGD:1346464 6480464 myricetin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein] CTD PMID:32107588 N,N-bis(2-hydroxypropyl)nitrosamine increases phosphorylation EXP 6480464 diisopropanolnitrosamine results in increased phosphorylation of H2AX protein CTD PMID:33211169 N,N-dimethylformamide increases expression ISO RGD:1346464 6480464 Dimethylformamide results in increased expression of H2AX protein CTD PMID:26387567 N-acetyl-L-cysteine multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [2 more ... CTD PMID:15173094 more ... N-acetyl-L-cysteine increases expression ISO RGD:1346464 6480464 Acetylcysteine results in increased expression of H2AX protein CTD PMID:31715134 , PMID:35123993 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein] more ... CTD PMID:26079211 more ... N-acetyl-L-cysteine multiple interactions ISO RGD:1558155 6480464 Acetylcysteine inhibits the reaction [2 more ... CTD PMID:24614525 more ... N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1346464 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]] CTD PMID:21227924 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased expression of H2AX protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Etoposide results in increased expression of H2AX protein] CTD PMID:17875725 N-butyl-N-(4-hydroxybutyl)nitrosamine increases expression EXP 6480464 Butylhydroxybutylnitrosamine results in increased expression of H2AX protein CTD PMID:26338220 , PMID:35771629 N-ethyl-N-nitrosourea increases phosphorylation ISO RGD:1346464 6480464 Ethylnitrosourea results in increased phosphorylation of H2AX protein CTD PMID:34510228 N-methyl-4-phenylpyridinium decreases expression ISO RGD:1346464 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of H2AX mRNA CTD PMID:24810058 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:1346464 6480464 Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form CTD PMID:26921499 , PMID:27233451 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:1346464 6480464 [[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form] more ... CTD PMID:26921499 N-methyl-N-nitrosourea increases expression ISO RGD:1346464 6480464 Methylnitrosourea results in increased expression of H2AX protein modified form CTD PMID:27233451 N-nitroso-N-methyl-4-aminobutyric acid multiple interactions ISO RGD:1346464 6480464 [CYP2A6 protein results in increased metabolism of 4-(N-nitroso-N-methylamino)butyric acid] which results in increased expression of H2AX protein CTD PMID:35882637 N-nitrosodiethylamine increases expression ISO RGD:1558155 6480464 Diethylnitrosamine results in increased expression of H2AX protein modified form CTD PMID:27746196 N-nitrosodiethylamine multiple interactions ISO RGD:1346464 6480464 [CYP2A6 protein results in increased metabolism of Diethylnitrosamine] which results in increased expression of H2AX protein CTD PMID:35882637 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of H2AX protein CTD PMID:26589970 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of H2AX mRNA CTD PMID:15890375 N-nitrosodimethylamine increases phosphorylation ISO RGD:1346464 6480464 Dimethylnitrosamine results in increased phosphorylation of H2AX protein CTD PMID:34510228 N-Nitrosopyrrolidine decreases expression ISO RGD:1346464 6480464 N-Nitrosopyrrolidine results in decreased expression of H2AX mRNA CTD PMID:32234424 N-Phenyl-1-naphthylamine increases expression ISO RGD:1346464 6480464 N-phenyl-1-naphthylamine results in increased expression of H2AX protein CTD PMID:35279910 n-propyl gallate decreases phosphorylation ISO RGD:1346464 6480464 Propyl Gallate results in decreased phosphorylation of H2AX protein CTD PMID:26928355 n-propyl gallate multiple interactions ISO RGD:1346464 6480464 [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 nickel atom increases expression ISO RGD:1346464 6480464 Nickel results in increased expression of H2AX mRNA CTD PMID:25583101 nickel dichloride decreases expression ISO RGD:1346464 6480464 nickel chloride results in decreased expression of H2AX mRNA CTD PMID:17312168 nickel dichloride increases expression ISO RGD:1346464 6480464 nickel chloride results in increased expression of H2AX protein modified form CTD PMID:28552779 nickel dichloride increases phosphorylation ISO RGD:1346464 6480464 nickel chloride results in increased phosphorylation of H2AX protein CTD PMID:22172632 nickel dichloride multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]] more ... CTD PMID:22172632 nicotine multiple interactions ISO RGD:1346464 6480464 Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 nimesulide multiple interactions ISO RGD:1346464 6480464 nimesulide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] CTD PMID:21745461 nimustine increases phosphorylation ISO RGD:1346464 6480464 Nimustine results in increased phosphorylation of H2AX protein CTD PMID:26418950 nitenpyram increases expression ISO RGD:1346464 6480464 nitenpyram results in increased expression of H2AX mRNA CTD PMID:35568224 nitrogen mustard multiple interactions ISO RGD:1346464 6480464 MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of H2AX protein], Nitrogen Mustard Compounds results in decreased expression of and results in increased phosphorylation of H2AX protein CTD PMID:27342729 nitrogen mustard increases expression ISO RGD:1346464 6480464 Nitrogen Mustard Compounds results in increased expression of H2AX mRNA, Nitrogen Mustard Compounds results in increased expression of H2AX protein CTD PMID:27342729 nocodazole increases expression ISO RGD:1346464 6480464 Nocodazole results in increased expression of H2AX protein modified form CTD PMID:26914363 norethisterone increases phosphorylation ISO RGD:1346464 6480464 Norethindrone results in increased phosphorylation of H2AX protein CTD PMID:15905198 NS-398 multiple interactions ISO RGD:1346464 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] CTD PMID:21745461 NSC 23766 multiple interactions ISO RGD:1558155 6480464 NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form] CTD PMID:28710503 O-methyleugenol increases expression EXP 6480464 methyleugenol results in increased expression of H2AX protein CTD PMID:26011634 o-toluidine increases expression ISO RGD:1346464 6480464 2-toluidine results in increased expression of H2AX protein CTD PMID:35279910 ochratoxin A decreases expression ISO RGD:1346464 6480464 ochratoxin A results in decreased expression of H2AX mRNA CTD PMID:19287073 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of H2AX mRNA, ochratoxin A results in increased expression of H2AX protein modified form CTD PMID:23358140 , PMID:24243707 ochratoxin A increases expression ISO RGD:1346464 6480464 ochratoxin A results in increased expression of H2AX protein CTD PMID:28286205 olaparib multiple interactions ISO RGD:1346464 6480464 [Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein more ... CTD PMID:26544897 olaparib increases phosphorylation ISO RGD:1346464 6480464 olaparib results in increased phosphorylation of H2AX protein CTD PMID:25531448 otosenine increases expression ISO RGD:1346464 6480464 otosenine results in increased expression of H2AX protein CTD PMID:31154085 ouabain increases phosphorylation ISO RGD:1346464 6480464 Ouabain results in increased phosphorylation of H2AX protein CTD PMID:31436044 oxaliplatin increases expression ISO RGD:1346464 6480464 Oxaliplatin results in increased expression of H2AX protein modified form CTD PMID:19735649 oxaliplatin multiple interactions EXP 6480464 [Oxaliplatin co-treated with Topotecan] results in decreased expression of H2AX mRNA CTD PMID:25729387 oxaliplatin affects localization ISO RGD:1346464 6480464 Oxaliplatin affects the localization of H2AX protein modified form CTD PMID:19735649 oxaliplatin multiple interactions ISO RGD:1346464 6480464 [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form] more ... CTD PMID:19735649 more ... oxybenzone increases expression ISO RGD:1346464 6480464 oxybenzone results in increased expression of H2AX protein modified form CTD PMID:31939680 oxybenzone increases expression ISO RGD:1558155 6480464 oxybenzone results in increased expression of H2AX protein modified form CTD PMID:31939680 oxybenzone multiple interactions ISO RGD:1346464 6480464 Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form] CTD PMID:31939680 ozone multiple interactions ISO RGD:1558155 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of H2AX mRNA, [Air Pollutants results in increased abundance of Ozone] which results in increased expression of H2AX mRNA CTD PMID:34911549 p-tert-Amylphenol increases phosphorylation ISO RGD:1346464 6480464 4-tert-octylphenol results in increased phosphorylation of H2AX protein CTD PMID:32466334 paclitaxel increases expression ISO RGD:1346464 6480464 Paclitaxel results in increased expression of H2AX protein, Paclitaxel results in increased expression of H2AX protein modified form CTD PMID:18451153 more ... paclitaxel multiple interactions ISO RGD:1346464 6480464 Paclitaxel promotes the reaction [norcantharidin results in increased expression of H2AX protein modified form], palbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AX protein] CTD PMID:22302033 , PMID:34272796 palbociclib multiple interactions ISO RGD:1346464 6480464 Doxorubicin inhibits the reaction [palbociclib results in decreased phosphorylation of H2AX protein] more ... CTD PMID:22302033 , PMID:22751436 palbociclib decreases phosphorylation ISO RGD:1346464 6480464 palbociclib results in decreased phosphorylation of H2AX protein CTD PMID:22751436 palmatine increases expression ISO RGD:1346464 6480464 palmatine results in increased expression of H2AX protein modified form CTD PMID:23747414 panobinostat increases expression ISO RGD:1346464 6480464 Panobinostat results in increased expression of H2AX protein CTD PMID:22923501 panobinostat multiple interactions ISO RGD:1346464 6480464 manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Resveratrol promotes the reaction [Panobinostat results in increased expression of H2AX protein]] more ... CTD PMID:22923501 , PMID:23681230 paracetamol increases expression ISO RGD:1346464 6480464 Acetaminophen results in increased expression of H2AX mRNA, Acetaminophen results in increased expression of H2AX protein CTD PMID:21420995 more ... paracetamol multiple interactions ISO RGD:1346464 6480464 2-(2 more ... CTD PMID:33971260 paracetamol increases expression ISO RGD:1558155 6480464 Acetaminophen results in increased expression of H2AX protein modified form CTD PMID:29540258 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of H2AX protein CTD PMID:26011634 paracetamol affects expression ISO RGD:1558155 6480464 Acetaminophen affects the expression of H2AX mRNA CTD PMID:17562736 paracetamol affects expression ISO RGD:1346464 6480464 Acetaminophen affects the expression of H2AX mRNA CTD PMID:25458485 paraquat increases expression ISO RGD:1558155 6480464 Paraquat results in increased expression of H2AX protein CTD PMID:28012437 paraquat multiple interactions ISO RGD:1558155 6480464 ATG7 protein affects the reaction [Paraquat results in increased expression of H2AX protein] CTD PMID:28012437 pentachlorophenol increases expression ISO RGD:1558155 6480464 Pentachlorophenol results in increased expression of H2AX mRNA CTD PMID:23892564 pentamidine affects localization ISO RGD:1346464 6480464 Pentamidine affects the localization of H2AX protein modified form CTD PMID:20144237 phenanthridone increases expression ISO RGD:1346464 6480464 phenanthridone results in increased expression of H2AX protein modified form CTD PMID:29416738 phenanthridone multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form], TXNRD1 protein inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form] CTD PMID:29416738 phenformin decreases expression EXP 6480464 Phenformin results in decreased expression of H2AX mRNA CTD PMID:31324951 phenobarbital affects expression ISO RGD:1346464 6480464 Phenobarbital affects the expression of H2AX mRNA CTD PMID:19159669 phenobarbital increases expression ISO RGD:1558155 6480464 Phenobarbital results in increased expression of H2AX mRNA CTD PMID:19363144 , PMID:23091169 phenol affects localization ISO RGD:1346464 6480464 Phenol affects the localization of H2AX protein modified form CTD PMID:20096274 PhIP increases expression ISO RGD:1346464 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of H2AX protein modified form CTD PMID:28160022 PhIP increases phosphorylation ISO RGD:1346464 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased phosphorylation of H2AX protein CTD PMID:32466334 , PMID:34510228 phosphoramide mustard increases expression EXP 6480464 phosphoramide mustard results in increased expression of H2AX protein CTD PMID:21439308 phosphoramide mustard multiple interactions EXP 6480464 phosphoramide mustard results in increased phosphorylation of and results in increased expression of H2AX protein CTD PMID:25497287 phosphoramide mustard increases expression ISO RGD:1558155 6480464 phosphoramide mustard results in increased expression of H2AX protein CTD PMID:21439308 phthalic acid multiple interactions ISO RGD:1346464 6480464 [Copper binds to phthalic acid binds to 1 more ... CTD PMID:22659117 pinocembrin multiple interactions ISO RGD:1346464 6480464 pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:33393179 pinocembrin multiple interactions ISO RGD:1558155 6480464 pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:33393179 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of H2AX mRNA CTD PMID:15890375 pirinixic acid decreases expression ISO RGD:1558155 6480464 pirinixic acid results in decreased expression of H2AX mRNA CTD PMID:17426115 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of H2AX mRNA CTD PMID:15890375 , PMID:19162173 piroxicam decreases expression ISO RGD:1346464 6480464 Piroxicam results in decreased expression of H2AX mRNA CTD PMID:21858171 poly(vinylpyrrolidone) multiple interactions ISO RGD:1346464 6480464 [Silver co-treated with Povidone] results in increased expression of H2AX protein modified form CTD PMID:27387714 potassium bromate multiple interactions EXP 6480464 Azacitidine inhibits the reaction [potassium bromate results in increased phosphorylation of H2AX protein], trichostatin A inhibits the reaction [potassium bromate results in increased phosphorylation of H2AX protein] CTD PMID:25015661 potassium bromate multiple interactions ISO RGD:1558155 6480464 [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AX protein, bisphenol A inhibits the reaction [[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AX protein] CTD PMID:25693136 potassium bromate increases phosphorylation EXP 6480464 potassium bromate results in increased phosphorylation of H2AX protein CTD PMID:25015661 potassium dichromate multiple interactions ISO RGD:1346464 6480464 EHMT2 protein promotes the reaction [Potassium Dichromate results in increased expression of H2AX protein modified form] more ... CTD PMID:29391238 potassium dichromate increases expression ISO RGD:1346464 6480464 Potassium Dichromate results in increased expression of H2AX protein modified form CTD PMID:29391238 Pranoprofen increases expression ISO RGD:1346464 6480464 pyranoprofen results in increased expression of H2AX protein CTD PMID:31765691 procymidone multiple interactions ISO RGD:1346464 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein CTD PMID:22389207 promethazine decreases expression EXP 6480464 Promethazine results in decreased expression of H2AX protein CTD PMID:26011634 propiconazole increases expression ISO RGD:1558155 6480464 propiconazole results in increased expression of H2AX mRNA CTD PMID:19363144 , PMID:21278054 propylparaben multiple interactions ISO RGD:1346464 6480464 Fulvestrant inhibits the reaction [propylparaben results in increased expression of H2AX protein modified form] CTD PMID:31939680 propylparaben increases expression ISO RGD:1346464 6480464 propylparaben results in increased expression of H2AX protein modified form CTD PMID:31939680 protein kinase inhibitor increases phosphorylation ISO RGD:1346464 6480464 Protein Kinase Inhibitors results in increased phosphorylation of H2AX protein CTD PMID:21878655 pterostilbene multiple interactions ISO RGD:1346464 6480464 [Resveratrol co-treated with pterostilbene] results in decreased expression of H2AX protein modified form more ... CTD PMID:26459286 , PMID:34405320 pterostilbene multiple interactions ISO RGD:1558155 6480464 CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of H2AX protein modified form]] more ... CTD PMID:34405320 pyrene multiple interactions ISO RGD:1346464 6480464 [pyrene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein, [pyrene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein CTD PMID:33249052 pyrimethamine increases phosphorylation ISO RGD:1346464 6480464 Pyrimethamine results in increased phosphorylation of H2AX protein CTD PMID:19435820 quercetin multiple interactions ISO RGD:1346464 6480464 Quercetin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form] CTD PMID:24999622 quercetin increases expression ISO RGD:1558155 6480464 Quercetin results in increased expression of H2AX protein CTD PMID:24595819 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form] CTD PMID:24902966 quercetin increases phosphorylation ISO RGD:1346464 6480464 Quercetin results in increased phosphorylation of H2AX protein CTD PMID:15177039 quizartinib increases phosphorylation ISO RGD:1346464 6480464 quizartinib results in increased phosphorylation of H2AX protein CTD PMID:34665271 quizartinib multiple interactions ISO RGD:1346464 6480464 quizartinib affects the reaction [RGFP966 results in increased phosphorylation of H2AX protein] more ... CTD PMID:34665271 rac-1,2-dichloropropane increases phosphorylation ISO RGD:1346464 6480464 propylene dichloride results in increased phosphorylation of H2AX protein CTD PMID:28300663 rac-1,2-dichloropropane increases phosphorylation ISO RGD:1558155 6480464 propylene dichloride results in increased phosphorylation of H2AX protein CTD PMID:28300663 rac-1,2-dichloropropane multiple interactions ISO RGD:1346464 6480464 1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] more ... CTD PMID:28300663 razoxane multiple interactions EXP 6480464 Razoxane inhibits the reaction [Doxorubicin results in increased expression of H2AX protein], Razoxane inhibits the reaction [Etoposide results in increased expression of H2AX protein] CTD PMID:17875725 reactive oxygen species decreases response to substance ISO RGD:1558155 6480464 H2AX protein results in decreased susceptibility to Reactive Oxygen Species CTD PMID:21555580 remdesivir increases expression ISO RGD:1346464 6480464 remdesivir results in increased expression of H2AX protein CTD PMID:35417658 resorcinol increases expression ISO RGD:1346464 6480464 resorcinol results in increased expression of H2AX mRNA CTD PMID:22623647 resveratrol multiple interactions ISO RGD:1346464 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein] more ... CTD PMID:15975956 more ... resveratrol decreases expression ISO RGD:1346464 6480464 Resveratrol results in decreased expression of H2AX protein, Resveratrol results in decreased expression of H2AX protein modified form CTD PMID:23363784 , PMID:26459286 resveratrol increases response to substance ISO RGD:1346464 6480464 H2AX protein results in increased susceptibility to Resveratrol CTD PMID:25619392 resveratrol increases phosphorylation ISO RGD:1346464 6480464 Resveratrol results in increased phosphorylation of H2AX protein CTD PMID:15975956 more ... resveratrol increases expression ISO RGD:1346464 6480464 Resveratrol results in increased expression of H2AX protein, Resveratrol results in increased expression of H2AX protein modified form CTD PMID:22923501 more ... Retrorsine increases expression ISO RGD:1346464 6480464 retrorsine results in increased expression of H2AX protein CTD PMID:31154085 ribavirin increases expression ISO RGD:1346464 6480464 Ribavirin results in increased expression of H2AX protein modified form CTD PMID:32112805 riddelliine increases expression ISO RGD:1346464 6480464 riddelliine results in increased expression of H2AX protein CTD PMID:31154085 riddelliine increases phosphorylation EXP 6480464 riddelliine results in increased phosphorylation of H2AX protein CTD PMID:31289892 riddelliine increases phosphorylation ISO RGD:1346464 6480464 riddelliine results in increased phosphorylation of H2AX protein CTD PMID:31289892 romidepsin multiple interactions ISO RGD:1346464 6480464 [Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AX protein more ... CTD PMID:15173094 , PMID:34665271 romidepsin increases phosphorylation ISO RGD:1346464 6480464 romidepsin results in increased phosphorylation of H2AX protein CTD PMID:34665271 rotenone increases phosphorylation ISO RGD:1558155 6480464 Rotenone results in increased phosphorylation of H2AX protein CTD PMID:23619996 rotenone multiple interactions ISO RGD:1346464 6480464 [PSME4 protein affects the susceptibility to Rotenone] which results in decreased expression of H2AX protein modified form CTD PMID:32368861 rotenone multiple interactions ISO RGD:1558155 6480464 CASP1 gene mutant form inhibits the reaction [Rotenone results in increased phosphorylation of H2AX protein], NLRP3 gene mutant form inhibits the reaction [Rotenone results in increased phosphorylation of H2AX protein] CTD PMID:23619996 rotenone decreases response to substance ISO RGD:1558155 6480464 H2AX protein results in decreased susceptibility to Rotenone CTD PMID:21555580 rubimaillin increases phosphorylation ISO RGD:1346464 6480464 rubimaillin results in increased phosphorylation of H2AX protein CTD PMID:35007525 rubimaillin multiple interactions ISO RGD:1346464 6480464 Glutathione inhibits the reaction [rubimaillin results in increased phosphorylation of H2AX protein] CTD PMID:35007525 rubimaillin increases phosphorylation ISO RGD:1558155 6480464 rubimaillin results in increased phosphorylation of H2AX protein CTD PMID:35007525 rucaparib multiple interactions ISO RGD:1346464 6480464 [Irinotecan co-treated with rucaparib] results in increased expression of H2AX protein CTD PMID:30612311 rucaparib affects expression ISO RGD:1346464 6480464 rucaparib affects the expression of H2AX protein CTD PMID:30612311 ruxolitinib multiple interactions ISO RGD:1346464 6480464 [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein CTD PMID:30012499 Salinomycin decreases expression ISO RGD:1346464 6480464 salinomycin results in decreased expression of H2AX mRNA CTD PMID:35914560 Salinomycin multiple interactions ISO RGD:1346464 6480464 [salinomycin co-treated with Calcitriol] results in decreased expression of H2AX mRNA CTD PMID:35914560 Satratoxin H increases phosphorylation EXP 6480464 satratoxin H results in increased phosphorylation of H2AX protein CTD PMID:22863859 selenium atom increases expression ISO RGD:1346464 6480464 Selenium results in increased expression of H2AX mRNA CTD PMID:19244175 selenocystine increases phosphorylation ISO RGD:1558155 6480464 selenocystine results in increased phosphorylation of H2AX protein CTD PMID:35863474 selenocystine increases phosphorylation ISO RGD:1346464 6480464 selenocystine results in increased phosphorylation of H2AX protein CTD PMID:35863474 senecionine increases expression ISO RGD:1346464 6480464 senecionine results in increased expression of H2AX protein CTD PMID:31154085 seneciphylline increases expression ISO RGD:1346464 6480464 seneciphylline results in increased expression of H2AX protein CTD PMID:31154085 Senkirkine increases expression ISO RGD:1346464 6480464 senkirkine results in increased expression of H2AX protein CTD PMID:31154085 silibinin increases phosphorylation ISO RGD:1346464 6480464 Silybin results in increased phosphorylation of H2AX protein CTD PMID:16777994 silibinin multiple interactions ISO RGD:1346464 6480464 Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein] CTD PMID:16777994 silicon dioxide increases expression ISO RGD:1346464 6480464 Silicon Dioxide results in increased expression of H2AX mRNA, Silicon Dioxide results in increased expression of H2AX protein modified form CTD PMID:25351596 , PMID:28757444 silicon dioxide increases phosphorylation EXP 6480464 Silicon Dioxide results in increased phosphorylation of H2AX protein CTD PMID:23178243 silicon dioxide increases phosphorylation ISO RGD:1558155 6480464 Silicon Dioxide results in increased phosphorylation of H2AX protein CTD PMID:23619996 silicon dioxide multiple interactions ISO RGD:1346464 6480464 PARP1 protein inhibits the reaction [Silicon Dioxide results in increased expression of H2AX protein modified form] CTD PMID:28757444 silver atom multiple interactions ISO RGD:1346464 6480464 [Silver analog co-treated with poly(N-vinylpyrrolidine)] results in increased expression of H2AX protein, [Silver co-treated with Povidone] results in increased expression of H2AX protein modified form CTD PMID:26028148 , PMID:27387714 silver(0) multiple interactions ISO RGD:1346464 6480464 [Silver analog co-treated with poly(N-vinylpyrrolidine)] results in increased expression of H2AX protein, [Silver co-treated with Povidone] results in increased expression of H2AX protein modified form CTD PMID:26028148 , PMID:27387714 simvastatin increases phosphorylation ISO RGD:1346464 6480464 Simvastatin results in increased phosphorylation of H2AX protein CTD PMID:20499237 sirolimus decreases expression ISO RGD:1346464 6480464 Sirolimus results in decreased expression of H2AX protein CTD PMID:23363784 sodium arsenite increases expression ISO RGD:1346464 6480464 sodium arsenite results in increased expression of H2AX mRNA more ... CTD PMID:22706169 more ... sodium arsenite multiple interactions EXP 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 sodium arsenite decreases expression ISO RGD:1558155 6480464 sodium arsenite results in decreased expression of H2AX mRNA CTD PMID:16014739 sodium arsenite increases phosphorylation ISO RGD:1558155 6480464 sodium arsenite results in increased phosphorylation of H2AX protein CTD PMID:30456849 sodium arsenite increases expression ISO RGD:1558155 6480464 sodium arsenite results in increased expression of H2AX protein modified form CTD PMID:25787150 sodium arsenite increases phosphorylation ISO RGD:1346464 6480464 sodium arsenite results in increased phosphorylation of H2AX protein CTD PMID:20375080 more ... sodium chromate multiple interactions ISO RGD:1346464 6480464 MUS81 protein mutant form inhibits the reaction [sodium chromate(VI) results in increased expression of H2AX protein modified form] CTD PMID:28318385 sodium chromate multiple interactions ISO RGD:1558155 6480464 [sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein, Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein] CTD PMID:35643323 sodium chromate increases expression ISO RGD:1346464 6480464 sodium chromate(VI) results in increased expression of H2AX protein modified form CTD PMID:28318385 sodium dichromate decreases expression ISO RGD:1558155 6480464 sodium bichromate results in decreased expression of H2AX mRNA CTD PMID:31558096 sodium fluoride decreases expression ISO RGD:1558155 6480464 Sodium Fluoride results in decreased expression of H2AX protein CTD PMID:28918527 sodium fluoride increases expression ISO RGD:1558155 6480464 Sodium Fluoride results in increased expression of H2AX protein CTD PMID:27548804 Sodium salicylate increases expression ISO RGD:1346464 6480464 Sodium Salicylate results in increased expression of H2AX mRNA CTD PMID:29117515 sterigmatocystin increases expression ISO RGD:1346464 6480464 Sterigmatocystin results in increased expression of H2AX protein modified form CTD PMID:26914363 sulindac multiple interactions ISO RGD:1346464 6480464 [Arsenic Trioxide co-treated with Sulindac] results in increased phosphorylation of H2AX protein CTD PMID:18636201 sunitinib decreases expression ISO RGD:1346464 6480464 Sunitinib results in decreased expression of H2AX mRNA CTD PMID:31533062 T-2 toxin multiple interactions ISO RGD:1346464 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [T-2 Toxin results in increased activity of H2AX protein] CTD PMID:20150440 T-2 toxin increases activity ISO RGD:1346464 6480464 T-2 Toxin results in increased activity of H2AX protein CTD PMID:20150440 temozolomide multiple interactions ISO RGD:1346464 6480464 [Temozolomide co-treated with Resveratrol] results in increased phosphorylation of H2AX protein CTD PMID:23522185 temozolomide decreases response to substance ISO RGD:1558155 6480464 H2AX protein results in decreased susceptibility to Temozolomide CTD PMID:21555580 temozolomide increases phosphorylation ISO RGD:1346464 6480464 Temozolomide results in increased phosphorylation of H2AX protein CTD PMID:23522185 , PMID:26418950 TEMPO increases expression ISO RGD:1558155 6480464 TEMPO results in increased expression of H2AX protein CTD PMID:25882087 terbufos increases expression ISO RGD:1346464 6480464 terbufos results in increased expression of H2AX protein CTD PMID:33221015 tert-butyl hydroperoxide decreases expression ISO RGD:1346464 6480464 tert-Butylhydroperoxide results in decreased expression of H2AX mRNA CTD PMID:15336504 tert-butyl hydroperoxide increases phosphorylation ISO RGD:1346464 6480464 tert-Butylhydroperoxide results in increased phosphorylation of H2AX protein CTD PMID:33207735 testosterone multiple interactions ISO RGD:1346464 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of H2AX mRNA CTD PMID:21592394 testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of H2AX mRNA CTD PMID:26496021 testosterone decreases expression ISO RGD:1346464 6480464 Testosterone results in decreased expression of H2AX mRNA CTD PMID:21592394 tetrachloromethane increases expression ISO RGD:1558155 6480464 Carbon Tetrachloride results in increased expression of H2AX mRNA CTD PMID:31919559 tetrachloromethane increases phosphorylation ISO RGD:1558155 6480464 Carbon Tetrachloride results in increased phosphorylation of H2AX protein CTD PMID:36526012 tetrachloromethane multiple interactions ISO RGD:1558155 6480464 ATM protein inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of H2AX protein] CTD PMID:36526012 thapsigargin increases expression ISO RGD:1346464 6480464 Thapsigargin results in increased expression of H2AX mRNA CTD PMID:19442820 thapsigargin decreases phosphorylation ISO RGD:1346464 6480464 Thapsigargin results in decreased phosphorylation of H2AX protein CTD PMID:32482060 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of H2AX mRNA, Thioacetamide results in increased expression of H2AX protein CTD PMID:26011634 , PMID:34492290 thymoquinone increases phosphorylation ISO RGD:1346464 6480464 thymoquinone results in increased phosphorylation of H2AX protein CTD PMID:31298468 Tiron increases phosphorylation ISO RGD:1346464 6480464 1 more ... CTD PMID:22785532 Tiron multiple interactions ISO RGD:1346464 6480464 1 more ... CTD PMID:22785532 titanium dioxide increases expression ISO RGD:1558155 6480464 titanium dioxide results in increased expression of H2AX mRNA CTD PMID:23557971 Tomentosin increases expression ISO RGD:1346464 6480464 tomentosin results in increased expression of H2AX protein CTD PMID:30917517 Tomentosin increases phosphorylation ISO RGD:1346464 6480464 tomentosin results in increased phosphorylation of H2AX protein CTD PMID:27922187 Tomentosin multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [tomentosin results in increased expression of H2AX protein] CTD PMID:30917517 topotecan increases phosphorylation ISO RGD:1346464 6480464 Topotecan results in increased phosphorylation of H2AX protein CTD PMID:16432175 topotecan increases expression ISO RGD:1346464 6480464 Topotecan results in increased expression of H2AX protein modified form CTD PMID:23376119 topotecan multiple interactions ISO RGD:1558155 6480464 APAF1 promotes the reaction [Topotecan results in increased phosphorylation of H2AX protein], TRP53 inhibits the reaction [Topotecan results in increased phosphorylation of H2AX protein] CTD PMID:19812371 topotecan increases phosphorylation ISO RGD:1558155 6480464 Topotecan results in increased phosphorylation of H2AX protein CTD PMID:19812371 topotecan multiple interactions EXP 6480464 [Oxaliplatin co-treated with Topotecan] results in decreased expression of H2AX mRNA CTD PMID:25729387 topotecan multiple interactions ISO RGD:1346464 6480464 [veliparib co-treated with Topotecan] results in increased expression of H2AX protein CTD PMID:21795476 toxaphene decreases expression EXP 6480464 Toxaphene results in decreased expression of H2AX mRNA CTD PMID:23153324 triadimefon increases expression ISO RGD:1558155 6480464 triadimefon results in increased expression of H2AX mRNA CTD PMID:19363144 tributylstannane multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form], Phycocyanin inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form] CTD PMID:26079211 tributylstannane increases phosphorylation ISO RGD:1346464 6480464 tributyltin results in increased phosphorylation of H2AX protein CTD PMID:36319700 tributylstannane increases phosphorylation ISO RGD:1558155 6480464 tributyltin results in increased phosphorylation of H2AX protein CTD PMID:36319700 tributylstannane multiple interactions ISO RGD:1346464 6480464 2-(2, 6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased phosphorylation of H2AX protein] CTD PMID:36319700 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of H2AX protein modified form CTD PMID:26079211 trichostatin A affects expression ISO RGD:1346464 6480464 trichostatin A affects the expression of H2AX mRNA CTD PMID:28542535 trichostatin A multiple interactions EXP 6480464 trichostatin A inhibits the reaction [potassium bromate results in increased phosphorylation of H2AX protein] CTD PMID:25015661 triciribine increases expression ISO RGD:1346464 6480464 triciribine results in increased expression of H2AX mRNA CTD PMID:29117515 trimellitic anhydride increases expression ISO RGD:1558155 6480464 trimellitic anhydride results in increased expression of H2AX mRNA CTD PMID:19042947 triphenyl phosphate increases expression ISO RGD:1346464 6480464 triphenyl phosphate results in increased expression of H2AX protein CTD PMID:36372259 Triptolide increases expression ISO RGD:1558155 6480464 triptolide results in increased expression of H2AX mRNA CTD PMID:32835833 troglitazone decreases expression ISO RGD:1346464 6480464 Troglitazone results in decreased expression of H2AX mRNA CTD PMID:19140230 trovafloxacin multiple interactions ISO RGD:1346464 6480464 [TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form more ... CTD PMID:25748550 trovafloxacin increases phosphorylation ISO RGD:1558155 6480464 trovafloxacin results in increased phosphorylation of H2AX protein CTD PMID:24817034 trovafloxacin increases expression ISO RGD:1346464 6480464 trovafloxacin results in increased expression of H2AX protein modified form CTD PMID:25748550 UDP multiple interactions ISO RGD:1346464 6480464 Uridine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 usnic acid increases expression ISO RGD:1346464 6480464 usnic acid results in increased expression of H2AX protein, usnic acid results in increased expression of H2AX protein modified form CTD PMID:27369375 , PMID:31715134 usnic acid multiple interactions ISO RGD:1346464 6480464 Acetylcysteine inhibits the reaction [usnic acid results in increased expression of H2AX protein], NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form] CTD PMID:27369375 , PMID:31715134 UTP multiple interactions ISO RGD:1346464 6480464 Uridine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 valproic acid affects expression ISO RGD:1346464 6480464 Valproic Acid affects the expression of H2AX mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:1558155 6480464 Valproic Acid results in decreased expression of H2AX mRNA, Valproic Acid results in decreased expression of H2AX protein CTD PMID:21427059 , PMID:21708246 valproic acid increases expression ISO RGD:1558155 6480464 Valproic Acid results in increased expression of H2AX protein CTD PMID:21708246 vancomycin decreases expression ISO RGD:1558155 6480464 Vancomycin results in decreased expression of H2AX mRNA CTD PMID:18930951 veliparib increases expression ISO RGD:1346464 6480464 [veliparib results in increased expression of PARP1 protein] which results in increased expression of H2AX protein more ... CTD PMID:17505006 more ... veliparib multiple interactions ISO RGD:1346464 6480464 [veliparib co-treated with Topotecan] results in increased expression of H2AX protein more ... CTD PMID:21227924 more ... versicolorin A increases expression ISO RGD:1346464 6480464 versicolorin A results in increased expression of H2AX protein CTD PMID:32106047 , PMID:33984424 versicolorin A multiple interactions ISO RGD:1346464 6480464 [Aflatoxin B1 co-treated with versicolorin A] results in increased expression of H2AX protein, versicolorin A promotes the reaction [Aflatoxin B1 results in increased expression of H2AX protein] CTD PMID:33984424 vincristine multiple interactions ISO RGD:1346464 6480464 [CEP 33779 results in increased susceptibility to Vincristine] which results in increased phosphorylation of H2AX protein, [NVP-BSK805 results in increased susceptibility to Vincristine] which results in increased phosphorylation of H2AX protein CTD PMID:28669723 vorinostat increases activity ISO RGD:1346464 6480464 Vorinostat results in increased activity of H2AX protein CTD PMID:20460513 vorinostat increases phosphorylation ISO RGD:1346464 6480464 Vorinostat results in increased phosphorylation of H2AX protein CTD PMID:20531243 vorinostat increases expression ISO RGD:1346464 6480464 Vorinostat results in increased expression of H2AX protein, Vorinostat results in increased expression of H2AX protein modified form CTD PMID:20679231 , PMID:22923501 vorinostat multiple interactions ISO RGD:1346464 6480464 Resveratrol promotes the reaction [Vorinostat results in increased expression of H2AX protein] CTD PMID:22923501 wogonin increases expression ISO RGD:1346464 6480464 wogonin results in increased expression of H2AX protein CTD PMID:32671444 wortmannin multiple interactions ISO RGD:1346464 6480464 Wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] more ... CTD PMID:17991895 more ... Xanthatin increases expression ISO RGD:1346464 6480464 xanthatin results in increased expression of H2AX protein modified form CTD PMID:29074359 yttrium chloride increases phosphorylation EXP 6480464 yttrium chloride results in increased phosphorylation of H2AX protein CTD PMID:35088107 yttrium chloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [yttrium chloride results in increased phosphorylation of H2AX protein] CTD PMID:35088107 zearalenone increases expression ISO RGD:1558155 6480464 Zearalenone results in increased expression of H2AX protein modified form CTD PMID:28089945 more ... zearalenone decreases expression ISO RGD:1558155 6480464 Zearalenone results in decreased expression of H2AX protein CTD PMID:35504548 zebularine increases expression ISO RGD:1346464 6480464 pyrimidin-2-one beta-ribofuranoside results in increased expression of H2AX protein CTD PMID:17991895 zidovudine increases phosphorylation ISO RGD:1346464 6480464 Zidovudine results in increased phosphorylation of H2AX protein CTD PMID:34510228 zinc atom increases expression ISO RGD:1346464 6480464 Zinc deficiency results in increased expression of H2AX mRNA CTD PMID:18356318 zinc atom multiple interactions EXP 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 zinc dichloride increases expression ISO RGD:1346464 6480464 zinc chloride results in increased expression of H2AX mRNA CTD PMID:18947441 zinc oxide increases activity ISO RGD:1558155 6480464 Zinc Oxide analog results in increased activity of H2AX protein CTD PMID:24614525 zinc oxide multiple interactions ISO RGD:1558155 6480464 Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AX protein] CTD PMID:24614525 zinc(0) increases expression ISO RGD:1346464 6480464 Zinc deficiency results in increased expression of H2AX mRNA CTD PMID:18356318 zinc(0) multiple interactions EXP 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 zoledronic acid increases expression ISO RGD:1346464 6480464 Zoledronic Acid results in increased expression of H2AX mRNA CTD PMID:20977926
