H2ax (H2A.X variant histone) - Rat Genome Database

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Gene: H2ax (H2A.X variant histone) Rattus norvegicus
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Symbol: H2ax
Name: H2A.X variant histone
RGD ID: 1566119
Description: Predicted to enable several functions, including DNA binding activity; chromatin-protein adaptor activity; and histone binding activity. Involved in several processes, including cellular response to gamma radiation; cellular senescence; and cerebral cortex development. Predicted to be located in centrosome; chromosome; and nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus and site of double-strand break. Used to study hypertension; status epilepticus; and transient cerebral ischemia. Biomarker of liver benign neoplasm. Orthologous to human H2AX (H2A.X variant histone); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; systemic lupus erythematosus pathway; INTERACTS WITH (-)-ephedrine; 1,2-dimethylhydrazine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H2A histone family, member X; H2afx; LOC500987; RGD1566119; similar to Histone H2A.x (H2a/x)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,568,718 - 53,570,072 (+)NCBIGRCr8
mRatBN7.2844,671,907 - 44,673,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,671,786 - 44,673,239 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx850,167,819 - 50,169,136 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,446,535 - 48,447,852 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,316,913 - 46,318,230 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,665,652 - 48,666,981 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,665,652 - 48,666,981 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,284,623 - 47,285,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,312,609 - 47,313,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera844,258,161 - 44,259,490 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dinitrobenzene  (EXP)
1,4-benzoquinone  (ISO)
1,4-dioxane  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-bipyridine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenol  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (ISO)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-nitroanisole  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
2-palmitoylglycerol  (ISO)
2-phenylethylamine  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-chloroaniline  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methoxy-TEMPO  (ISO)
4-Nerolidylcatechol  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
680C91  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9-aminoacridine  (ISO)
[6]-Shogaol  (ISO)
ABT-737  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
adenosine 5'-monophosphate  (ISO)
ADP  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (ISO)
alizarin  (ISO)
all-trans-retinoic acid  (ISO)
alternariol  (ISO)
alvocidib  (ISO)
amsacrine  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aphidicolin  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
ATP  (ISO)
atrazine  (ISO)
auramine O  (EXP)
azathioprine  (ISO)
Benz[c]acridine  (ISO)
benzene  (ISO)
benzidine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (EXP,ISO)
bromoethene  (EXP)
bupivacaine  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
camptothecin  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamate ester  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carmustine  (ISO)
carteolol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chlorite  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chromone  (ISO)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
CX-5461  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
cyprodinil  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibenz[a,j]acridine  (ISO)
Dibenz[c,h]acridine  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (EXP)
dihydroxyacetone  (ISO)
dimethoate  (ISO)
dimethocaine  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
Disperse Blue 1  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
Echimidine  (ISO)
elemental selenium  (EXP,ISO)
ellipticine  (ISO)
emodin  (ISO)
enilconazole  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epothilone A  (ISO)
erdosteine  (ISO)
erlotinib hydrochloride  (ISO)
erucifoline  (ISO)
estragole  (EXP)
ethanol  (ISO)
Ethyl maltol  (ISO)
ethyl methanesulfonate  (ISO)
Ethylenethiourea  (EXP)
etoposide  (EXP,ISO)
fenbendazole  (ISO)
fenthion  (ISO)
ferric oxide  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
fludioxonil  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fomepizole  (ISO)
formaldehyde  (ISO)
fotemustine  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
GDP  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
ginsenoside Rg1  (ISO)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycerol 2-phosphate  (ISO)
glyphosate  (ISO)
GSK690693  (ISO)
GTP  (ISO)
guanosine  (ISO)
Heliotrine  (ISO)
hexachlorobenzene  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
IDP  (ISO)
imiquimod  (ISO)
indicine  (ISO)
inosine  (ISO)
intermedine  (ISO)
iprodione  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isocyanates  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
jacobine  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
Lasiocarpine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
Licochalcone B  (ISO)
Liensinine  (ISO)
Longikaurin A  (ISO)
lovastatin  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manumycin A  (ISO)
mechlorethamine  (EXP,ISO)
MeIQ  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
melphalan  (ISO)
menadione  (ISO)
menaquinone  (ISO)
mestranol  (ISO)
metformin  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methyllycaconitine  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
mitoxantrone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
myricetin  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitroso-N-methyl-4-aminobutyric acid  (ISO)
N-Nitrosodiethanolamine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosomethylethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N-Phenyl-1-naphthylamine  (ISO)
n-propyl gallate  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nimustine  (ISO)
niraparib  (ISO)
nitenpyram  (ISO)
nitrogen mustard  (ISO)
Nitrosoheptamethyleneimine  (EXP)
NMN zwitterion  (ISO)
nocodazole  (ISO)
NORCANTHARIDIN  (ISO)
norethisterone  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
O-methyleugenol  (EXP)
o-toluidine  (ISO)
ochratoxin A  (EXP,ISO)
olaparib  (ISO)
otosenine  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
palmatine  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pectolinarigenin  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
Phellopterin  (ISO)
phenanthridone  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
PhIP  (ISO)
phosphoramide mustard  (EXP,ISO)
phthalic acid  (ISO)
pifithrin-?  (ISO)
pinocembrin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(vinylpyrrolidone)  (ISO)
potassium bromate  (EXP,ISO)
potassium dichromate  (ISO)
Pranoprofen  (ISO)
procymidone  (ISO)
promethazine  (EXP)
propiconazole  (ISO)
propylparaben  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
pyrene  (ISO)
pyrimethamine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quizartinib  (ISO)
rac-1,2-dichloropropane  (ISO)
razoxane  (EXP)
reactive oxygen species  (ISO)
remdesivir  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
Retrorsine  (ISO)
ribavirin  (ISO)
riddelliine  (EXP,ISO)
romidepsin  (ISO)
rotenone  (ISO)
rubimaillin  (ISO)
rucaparib  (ISO)
ruxolitinib  (ISO)
Salinomycin  (ISO)
Satratoxin H  (EXP)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
selinexor  (ISO)
senecionine  (ISO)
seneciphylline  (ISO)
Senkirkine  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sodium nitrite  (ISO)
Sodium salicylate  (ISO)
sterigmatocystin  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
TEMPO  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thallium(I) acetate  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thymidine  (ISO)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
Tomentosin  (ISO)
topotecan  (EXP,ISO)
toxaphene  (EXP)
triadimefon  (ISO)
triapine  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triciribine  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
UDP  (ISO)
usnic acid  (ISO)
UTP  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
veliparib  (ISO)
versicolorin A  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
Xanthatin  (ISO)
yttrium chloride  (EXP)
zearalenone  (ISO)
zebularine  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pressure overload regulates expression of cytokines, gammaH2AX, and growth arrest- and DNA-damage inducible protein 153 via glycogen synthase kinase-3beta in ischemic-reperfused hearts. Baban B, etal., Hypertension. 2013 Jan;61(1):95-104. doi: 10.1161/HYPERTENSIONAHA.111.00028. Epub 2012 Oct 29.
2. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
3. Cyclosporine-assisted adipose-derived mesenchymal stem cell therapy to mitigate acute kidney ischemia-reperfusion injury. Chen YT, etal., Stem Cell Res Ther. 2013 May 31;4(3):62.
4. Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats. Cho BO, etal., Food Chem. 2013 May 1;138(1):107-15. doi: 10.1016/j.foodchem.2012.10.026. Epub 2012 Nov 6.
5. Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation. Crowe SL, etal., Eur J Neurosci. 2006 May;23(9):2351-61.
6. Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain. Crowe SL, etal., J Neurosci. 2011 May 25;31(21):7648-56. doi: 10.1523/JNEUROSCI.0092-11.2011.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Pretreatment of liver grafts in vivo by gamma-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat. Hori T, etal., Ann Transplant. 2013 Jun 17;18:299-313. doi: 10.12659/AOT.883955.
9. Involvement of multiple cell cycle aberrations in early preneoplastic liver cell lesions by tumor promotion with thioacetamide in a two-stage rat hepatocarcinogenesis model. Kimura M, etal., Exp Toxicol Pathol. 2013 Nov;65(7-8):979-88. doi: 10.1016/j.etp.2013.01.012. Epub 2013 Mar 7.
10. BRCA1 shields vascular smooth muscle cells from oxidative stress. Lovren F, etal., J Thorac Cardiovasc Surg. 2014 Jun;147(6):1946-55, 1955.e1. doi: 10.1016/j.jtcvs.2013.09.060. Epub 2013 Nov 13.
11. Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Maze I, etal., Nat Rev Genet. 2014 Apr;15(4):259-71. doi: 10.1038/nrg3673. Epub 2014 Mar 11.
12. Histone variants in rat spermatogonia and primary spermatocytes. Meistrich ML, etal., Dev Biol. 1985 Nov;112(1):230-40.
13. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Moruno-Manchon JF, etal., Aging (Albany NY). 2017 Sep 12;9(9):1957-1970. doi: 10.18632/aging.101282.
14. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
15. Changes in histones H2A and H3 variant composition in differentiating and mature rat brain cortical neurons. Pina B and Suau P, Dev Biol. 1987 Sep;123(1):51-8.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Pseudo-DNA damage response in senescent cells. Pospelova TV, etal., Cell Cycle. 2009 Dec 15;8(24):4112-8. Epub 2009 Dec 1.
18. Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat. Raz L, etal., PLoS One. 2010 Sep 7;5(9):e12606. doi: 10.1371/journal.pone.0012606.
19. Effect of somatostatin on repair of ionizing radiation-induced DNA damage in pituitary adenoma cells GH3. Rezacova M, etal., Physiol Res. 2008;57(2):225-35. Epub 2007 May 30.
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor. Tarasenko N, etal., PLoS One. 2012;7(2):e31393. doi: 10.1371/journal.pone.0031393. Epub 2012 Feb 23.
23. Expression of DNA doublestrand repair proteins in oral leukoplakia and the risk of malignant transformation. Zhu M, etal., Oncol Lett. 2018 Jun;15(6):9827-9835. doi: 10.3892/ol.2018.8574. Epub 2018 Apr 25.
Additional References at PubMed
PMID:11331621   PMID:11934988   PMID:14611631   PMID:15149599   PMID:15364958   PMID:15604234   PMID:15657431   PMID:16319397   PMID:17475928   PMID:17498979   PMID:17696610   PMID:17912366  
PMID:17974976   PMID:18070917   PMID:18283110   PMID:18316482   PMID:18694567   PMID:19074312   PMID:19176879   PMID:19234442   PMID:19734146   PMID:20360685   PMID:20516196   PMID:20530960  
PMID:20551173   PMID:20577743   PMID:21270334   PMID:21539824   PMID:21630459   PMID:21911473   PMID:21991325   PMID:22164254   PMID:22297488   PMID:22699483   PMID:22711701   PMID:22854038  
PMID:22892076   PMID:23039116   PMID:23133398   PMID:23235539   PMID:23533145   PMID:23555294   PMID:23810942   PMID:24507776   PMID:24610783   PMID:25352572   PMID:25634095   PMID:25675407  
PMID:26338220   PMID:26358182   PMID:26490168   PMID:27248496   PMID:27760146   PMID:37175793  


Genomics

Comparative Map Data
H2ax
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,568,718 - 53,570,072 (+)NCBIGRCr8
mRatBN7.2844,671,907 - 44,673,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,671,786 - 44,673,239 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx850,167,819 - 50,169,136 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,446,535 - 48,447,852 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,316,913 - 46,318,230 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,665,652 - 48,666,981 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,665,652 - 48,666,981 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,284,623 - 47,285,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,312,609 - 47,313,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera844,258,161 - 44,259,490 (+)NCBICelera
Cytogenetic Map8q22NCBI
H2AX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,093,874 - 119,095,465 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11119,093,874 - 119,095,465 (-)EnsemblGRCh38hg38GRCh38
GRCh3711118,964,584 - 118,966,175 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,469,794 - 118,471,387 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411118,469,796 - 118,471,387NCBI
Celera11116,121,998 - 116,123,592 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11114,904,032 - 114,905,625 (-)NCBIHuRef
CHM1_111118,850,886 - 118,852,479 (-)NCBICHM1_1
T2T-CHM13v2.011119,114,257 - 119,115,848 (-)NCBIT2T-CHM13v2.0
H2ax
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,246,012 - 44,247,374 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,245,991 - 44,247,374 (+)EnsemblGRCm39 Ensembl
GRCm38944,334,715 - 44,336,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,334,694 - 44,336,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv37944,142,798 - 44,144,160 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36944,085,710 - 44,087,072 (+)NCBIMGSCv36mm8
Celera941,589,440 - 41,590,802 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
LOC102025775
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,203,772 - 20,204,203 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541220,203,173 - 20,204,714 (-)NCBIChiLan1.0ChiLan1.0
LOC100994157
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29119,798,667 - 119,800,274 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111120,902,366 - 120,903,972 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011113,932,078 - 113,933,679 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111117,862,383 - 117,862,841 (-)NCBIpanpan1.1PanPan1.1panPan2
H2AX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,765,625 - 14,766,590 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,766,126 - 14,766,557 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha514,819,023 - 14,819,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0514,709,362 - 14,710,053 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,709,465 - 14,709,896 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,847,404 - 14,848,095 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,751,426 - 14,752,116 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,791,799 - 14,792,490 (+)NCBIUU_Cfam_GSD_1.0
LOC101966907
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,125,524 - 101,127,552 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365424,047,915 - 4,048,346 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365424,046,930 - 4,049,017 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
H2AX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,309,653 - 46,310,084 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1946,308,824 - 46,310,494 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,343,962 - 51,345,644 (-)NCBISscrofa10.2Sscrofa10.2susScr3
H2AFX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,466,692 - 110,468,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,467,775 - 110,468,206 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604315,565,922 - 15,567,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701891
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,476,730 - 14,477,161 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478414,475,813 - 14,477,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in H2ax
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:72
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000059715
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat

Markers in Region
RH129300  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,670,890 - 44,671,071 (+)MAPPERmRatBN7.2
Rnor_6.0848,664,616 - 48,664,796NCBIRnor6.0
Rnor_5.0847,283,587 - 47,283,767UniSTSRnor5.0
RGSC_v3.4847,311,573 - 47,311,753UniSTSRGSC3.4
Celera844,257,125 - 44,257,305UniSTS
Cytogenetic Map8q22UniSTS
RH128239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,672,919 - 44,673,127 (+)MAPPERmRatBN7.2
Rnor_6.0848,666,644 - 48,666,851NCBIRnor6.0
Rnor_5.0847,285,615 - 47,285,822UniSTSRnor5.0
RGSC_v3.4847,313,601 - 47,313,808UniSTSRGSC3.4
Celera844,259,153 - 44,259,360UniSTS
RH 3.4 Map8428.0UniSTS
Cytogenetic Map8q22UniSTS
RH129538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,670,596 - 44,670,796 (+)MAPPERmRatBN7.2
Rnor_6.0848,664,322 - 48,664,521NCBIRnor6.0
Rnor_5.0847,283,293 - 47,283,492UniSTSRnor5.0
RGSC_v3.4847,311,279 - 47,311,478UniSTSRGSC3.4
Celera844,256,831 - 44,257,030UniSTS
RH 3.4 Map8435.2UniSTS
Cytogenetic Map8q22UniSTS
RH131432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,670,901 - 44,671,121 (+)MAPPERmRatBN7.2
Rnor_6.0848,664,627 - 48,664,846NCBIRnor6.0
Rnor_5.0847,283,598 - 47,283,817UniSTSRnor5.0
RGSC_v3.4847,311,584 - 47,311,803UniSTSRGSC3.4
Celera844,257,136 - 44,257,355UniSTS
RH 3.4 Map8428.0UniSTS
Cytogenetic Map8q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 38 28 19 28 1 3 70 27 41 11 1
Low 7 19 13 13 7 8 4 8 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000059715   ⟹   ENSRNOP00000056469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl844,671,786 - 44,673,239 (+)Ensembl
Rnor_6.0 Ensembl848,665,652 - 48,666,981 (+)Ensembl
RefSeq Acc Id: NM_001109291   ⟹   NP_001102761
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,568,718 - 53,570,072 (+)NCBI
mRatBN7.2844,671,907 - 44,673,262 (+)NCBI
Rnor_6.0848,665,652 - 48,666,981 (+)NCBI
Rnor_5.0847,284,623 - 47,285,952 (+)NCBI
RGSC_v3.4847,312,609 - 47,313,938 (+)RGD
Celera844,258,161 - 44,259,490 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102761 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95294 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056469
  ENSRNOP00000056469.2
  ENSRNOP00000064421.2
RefSeq Acc Id: NP_001102761   ⟸   NM_001109291
- UniProtKB: D3ZXP3 (UniProtKB/TrEMBL),   A6J3X1 (UniProtKB/TrEMBL),   A0A8L2QY15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056469   ⟸   ENSRNOT00000059715
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXP3-F1-model_v2 AlphaFold D3ZXP3 1-143 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695889
Promoter ID:EPDNEW_R6414
Type:single initiation site
Name:H2afx_1
Description:H2A histone family, member X
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0848,665,632 - 48,665,692EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566119 AgrOrtholog
BioCyc Gene G2FUF-30725 BioCyc
Ensembl Genes ENSRNOG00000010386 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000045819 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059715 ENTREZGENE
  ENSRNOT00000059715.3 UniProtKB/TrEMBL
  ENSRNOT00000073287.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/TrEMBL
  Histone_core_D UniProtKB/TrEMBL
  Histone_H2A UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/TrEMBL
  Histone_H2A_CS UniProtKB/TrEMBL
KEGG Report rno:500987 UniProtKB/TrEMBL
NCBI Gene 500987 ENTREZGENE
PANTHER HISTONE H2A TYPE 1-C UniProtKB/TrEMBL
  HISTONE H2AX UniProtKB/TrEMBL
  PTHR23430 UniProtKB/TrEMBL
Pfam Histone UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/TrEMBL
PhenoGen H2ax PhenoGen
PRINTS HISTONEH2A UniProtKB/TrEMBL
PROSITE HISTONE_H2A UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010386 RatGTEx
  ENSRNOG00000045819 RatGTEx
SMART H2A UniProtKB/TrEMBL
Superfamily-SCOP Histone-fold UniProtKB/TrEMBL
UniProt A0A8L2QY15 ENTREZGENE, UniProtKB/TrEMBL
  A6J3X1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXP3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 H2ax  H2A.X variant histone  H2afx  H2A histone family, member X  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 H2afx  H2A histone family, member X  RGD1566119_predicted  similar to Histone H2A.x (H2a/x) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566119_predicted  similar to Histone H2A.x (H2a/x) (predicted)  LOC500987  similar to Histone H2A.x (H2a/x)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500987  similar to Histone H2A.x (H2a/x)      Symbol and Name status set to provisional 70820 PROVISIONAL